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P31865

- KPYK_HYPJE

UniProt

P31865 - KPYK_HYPJE

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Protein
Pyruvate kinase
Gene
pki1
Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721Substrate By similarity
Metal bindingi74 – 741Potassium By similarity
Metal bindingi76 – 761Potassium By similarity
Metal bindingi107 – 1071Potassium By similarity
Metal bindingi108 – 1081Potassium; via carbonyl oxygen By similarity
Sitei263 – 2631Transition state stabilizer By similarity
Metal bindingi265 – 2651Magnesium By similarity
Binding sitei288 – 2881Substrate; via amide nitrogen By similarity
Metal bindingi289 – 2891Magnesium By similarity
Binding sitei289 – 2891Substrate; via amide nitrogen By similarity
Binding sitei321 – 3211Substrate By similarity
Binding sitei360 – 3601ADP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pki1
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Pyruvate kinase
PRO_0000112119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine Reviewed prediction

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP31865.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi51453.JGI78439.

Structurei

3D structure databases

ProteinModelPortaliP31865.
SMRiP31865. Positions 35-524.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
OMAiCVTRNEQ.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31865-1 [UniParc]FASTAAdd to Basket

« Hide

MSQISRTQSI MATTAQEHLE TGGRINWLAS LNTAFTPARN FRRTSIICTI    50
GPKTNSVEAL NKLRDAGLNV ARMNFSHGSY EYHQSVIDNV RASVAAHPGR 100
PVAIALDTKG PEIRTGNTAG DVDIPISAGT VMNFTTDEKY ATACDTQNMY 150
VDYKNITKVI QPGRVIYVDD GVLAFDVLSI KDDQTVEVRA RNNGFISSRK 200
GVNLPNTDVD LPALSEKDKA DLRFGVKNNV DMVFASFIRR AQDIKDIRDV 250
LGPEGKQIQI IAKIENRQGL NNFAEILEET DGVMVARGDL GIEIPAAEVF 300
AAQKKMIAMC NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD 350
CVMLSGETAK GNYPAESIHE MHEASLKAEN TIPYVSHFEE MCTLVKRPVS 400
TVESCAMAAV RASLDLGAGG IIVLSTSGDS ARLLSKYRPV CPIFMVTRNP 450
TTSRFSHLYR GVYPFLYPEQ KPDFDTVNWQ EDVDKRIKWA VTRAIELKTL 500
TAGDTVVVVQ GWKGGMGNTN TLRIVRADPD HLGIGQME 538
Length:538
Mass (Da):58,888
Last modified:July 1, 1993 - v1
Checksum:iE9C26AC0E8186FE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07060 Unassigned DNA. Translation: AAA02922.1.
PIRiJN0780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07060 Unassigned DNA. Translation: AAA02922.1 .
PIRi JN0780.

3D structure databases

ProteinModelPortali P31865.
SMRi P31865. Positions 35-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 51453.JGI78439.

Proteomic databases

PRIDEi P31865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0469.
OMAi CVTRNEQ.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the pyruvate kinase-encoding gene (pki1) of Trichoderma reesei."
    Schindler M., Mach R.L., Vollenhofer S.K., Hodits R., Gruber F., Visser J., de Graaff L., Kubicek C.P.
    Gene 130:271-275(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKPYK_HYPJE
AccessioniPrimary (citable) accession number: P31865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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