Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31865

- KPYK_HYPJE

UniProt

P31865 - KPYK_HYPJE

Protein

Pyruvate kinase

Gene

pki1

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721SubstrateBy similarity
    Metal bindingi74 – 741PotassiumBy similarity
    Metal bindingi76 – 761PotassiumBy similarity
    Metal bindingi107 – 1071PotassiumBy similarity
    Metal bindingi108 – 1081Potassium; via carbonyl oxygenBy similarity
    Sitei263 – 2631Transition state stabilizerBy similarity
    Metal bindingi265 – 2651MagnesiumBy similarity
    Binding sitei288 – 2881Substrate; via amide nitrogenBy similarity
    Metal bindingi289 – 2891MagnesiumBy similarity
    Binding sitei289 – 2891Substrate; via amide nitrogenBy similarity
    Binding sitei321 – 3211SubstrateBy similarity
    Binding sitei360 – 3601ADPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pki1
    OrganismiHypocrea jecorina (Trichoderma reesei)
    Taxonomic identifieri51453 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Pyruvate kinasePRO_0000112119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451PhosphoserineSequence Analysis

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP31865.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi51453.JGI78439.

    Structurei

    3D structure databases

    ProteinModelPortaliP31865.
    SMRiP31865. Positions 35-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    OMAiCVTRNEQ.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31865-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQISRTQSI MATTAQEHLE TGGRINWLAS LNTAFTPARN FRRTSIICTI    50
    GPKTNSVEAL NKLRDAGLNV ARMNFSHGSY EYHQSVIDNV RASVAAHPGR 100
    PVAIALDTKG PEIRTGNTAG DVDIPISAGT VMNFTTDEKY ATACDTQNMY 150
    VDYKNITKVI QPGRVIYVDD GVLAFDVLSI KDDQTVEVRA RNNGFISSRK 200
    GVNLPNTDVD LPALSEKDKA DLRFGVKNNV DMVFASFIRR AQDIKDIRDV 250
    LGPEGKQIQI IAKIENRQGL NNFAEILEET DGVMVARGDL GIEIPAAEVF 300
    AAQKKMIAMC NIAGKPVICA TQMLESMIKN PRPTRAEISD VGNAVTDGAD 350
    CVMLSGETAK GNYPAESIHE MHEASLKAEN TIPYVSHFEE MCTLVKRPVS 400
    TVESCAMAAV RASLDLGAGG IIVLSTSGDS ARLLSKYRPV CPIFMVTRNP 450
    TTSRFSHLYR GVYPFLYPEQ KPDFDTVNWQ EDVDKRIKWA VTRAIELKTL 500
    TAGDTVVVVQ GWKGGMGNTN TLRIVRADPD HLGIGQME 538
    Length:538
    Mass (Da):58,888
    Last modified:July 1, 1993 - v1
    Checksum:iE9C26AC0E8186FE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07060 Unassigned DNA. Translation: AAA02922.1.
    PIRiJN0780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07060 Unassigned DNA. Translation: AAA02922.1 .
    PIRi JN0780.

    3D structure databases

    ProteinModelPortali P31865.
    SMRi P31865. Positions 35-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 51453.JGI78439.

    Proteomic databases

    PRIDEi P31865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0469.
    OMAi CVTRNEQ.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the pyruvate kinase-encoding gene (pki1) of Trichoderma reesei."
      Schindler M., Mach R.L., Vollenhofer S.K., Hodits R., Gruber F., Visser J., de Graaff L., Kubicek C.P.
      Gene 130:271-275(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKPYK_HYPJE
    AccessioniPrimary (citable) accession number: P31865
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3