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Protein

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Gene namesi
Name:NCAM1
Synonyms:NCAM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 719700ExtracellularSequence analysisAdd
BLAST
Transmembranei720 – 73718HelicalSequence analysisAdd
BLAST
Topological domaini738 – 853116CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 853834Neural cell adhesion molecule 1PRO_0000015008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 96PROSITE-ProRule annotation
Disulfide bondi139 ↔ 189PROSITE-ProRule annotation
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi235 ↔ 286PROSITE-ProRule annotation
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi328 ↔ 394PROSITE-ProRule annotation
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi435 ↔ 488PROSITE-ProRule annotation
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence analysis
Modified residuei778 – 7781PhosphoserineBy similarity
Modified residuei782 – 7821PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31836.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049952.

Structurei

3D structure databases

ProteinModelPortaliP31836.
SMRiP31836. Positions 20-306, 503-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like C2-type 1Add
BLAST
Domaini116 – 20590Ig-like C2-type 2Add
BLAST
Domaini212 – 30089Ig-like C2-type 3Add
BLAST
Domaini307 – 412106Ig-like C2-type 4Add
BLAST
Domaini415 – 50086Ig-like C2-type 5Add
BLAST
Domaini508 – 607100Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini609 – 70496Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1565Heparin-bindingSequence analysis
Regioni161 – 1655Heparin-bindingSequence analysis

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
HOGENOMiHOG000074124.
HOVERGENiHBG052579.
InParanoidiP31836.
KOiK06491.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 2 hits.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.

Isoform 1 (identifier: P31836-1) [UniParc]FASTAAdd to basket

Also known as: N-CAM 140

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTKNLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTA
110 120 130 140 150
EDGTESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLT NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCNAEGF PEPTVSWTKD
260 270 280 290 300
GEQIENEEDE KYLFSDDSSE LTIRKVDKND EAEYVCIAEN KAGEQDASIH
310 320 330 340 350
LKVFAKPKIT YVENQTAMEL EEQVTLTCEA SGDPIPSITW RTSTRNISSE
360 370 380 390 400
EKASWTRPEK QETLDGHMVV RSHARVSSLT LKSIQYTDAG EYVCTASNTI
410 420 430 440 450
GQDSQSMYLE VQYAPKLQGP VAVYTWEGNQ VNITCEVFAY PSATISWFRD
460 470 480 490 500
GQLLPSSNYS NIKIYNTPSA SYLEVTPDSE NDFGNYNCTA VNRIGQESLE
510 520 530 540 550
FVLVQADTPS SPSIDQVEPY SSTAQVQFDE PEATGGVPIL KYKAEWRAMG
560 570 580 590 600
EEVWHSKWYD AKEASMEGIV TIVGLKPETT YAVRLAALNG KGLGEISAAS
610 620 630 640 650
EFKTQPVREP SAPKLEGQMG EDGNSIKVKL IKQDDGGSPI RHYLVKYRAL
660 670 680 690 700
SSEWKPEIRL PSGSDHVMLK SLDWNAEYEV YVVAENQQGK SKAAHFVFRT
710 720 730 740 750
SAQPTAIPAN GSPTSGLSTG AIVGILVVTF VLLLVAVDVT CYFLNKCGLL
760 770 780 790 800
MCIAVNLCGK AGPGAKGKDM EEGKAAFSKD ESKEPIVEVR TEEERTPNHD
810 820 830 840 850
GGKHTEPNET TPLTEPEKGP VEAKPETETK PAPAEVQTVP NDATQIKVNE

SKA
Length:853
Mass (Da):93,894
Last modified:July 1, 1993 - v1
Checksum:iE12FD49231A7A368
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16451 mRNA. Translation: CAA34470.1.
PIRiA32976. IJBONC.
RefSeqiNP_776824.1. NM_174399.1.
UniGeneiBt.40343.

Genome annotation databases

GeneIDi281941.
KEGGibta:281941.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16451 mRNA. Translation: CAA34470.1.
PIRiA32976. IJBONC.
RefSeqiNP_776824.1. NM_174399.1.
UniGeneiBt.40343.

3D structure databases

ProteinModelPortaliP31836.
SMRiP31836. Positions 20-306, 503-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049952.

Proteomic databases

PaxDbiP31836.

Protocols and materials databases

DNASUi281941.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281941.
KEGGibta:281941.

Organism-specific databases

CTDi4684.

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
HOGENOMiHOG000074124.
HOVERGENiHBG052579.
InParanoidiP31836.
KOiK06491.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 2 hits.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Calmodulin-independent bovine brain adenylate cyclase. Amino acid sequence and nucleotide sequence of the corresponding cDNA."
    Lipkin V.M., Khramtsov N.V., Andreeva S.G., Moshnyakov M.V., Petukhova G.V., Rakitina T.V., Feshchenko E.A., Ishchenko K.A., Mirzoeva S.F., Chernova M.N., Dranytsyna S.M.
    FEBS Lett. 254:69-73(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain cortex.
  2. "Structural and immunological characterization of the amino-terminal domain of mammalian neural cell adhesion molecules."
    Rougon G., Marshak D.R.
    J. Biol. Chem. 261:3396-3401(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-36.
  3. "A bovine brain cDNA purported to encode calmodulin-insensitive adenylyl cyclase has extensive identity with neural cell adhesion molecules (N-CAMs)."
    Premont R.T.
    FEBS Lett. 295:230-231(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS N-CAM.

Entry informationi

Entry nameiNCAM1_BOVIN
AccessioniPrimary (citable) accession number: P31836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a calmodulin-independent adenylate cyclase.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.