Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Iron (heme A axial ligand)Curated1
Metal bindingi268Copper BCurated1
Metal bindingi272Copper BCurated1
Metal bindingi317Copper BCurated1
Metal bindingi318Copper BCurated1
Metal bindingi403Iron (heme A3 axial ligand)Curated1
Metal bindingi405Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:blr1171
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834371 – 541Cytochrome c oxidase subunit 1Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

Expressioni

Developmental stagei

Free in soil (not as bacteroid).

Interactioni

Protein-protein interaction databases

STRINGi224911.blr1171.

Structurei

3D structure databases

ProteinModelPortaliP31833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP31833.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.
PhylomeDBiP31833.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSAAAHGD HAQDHGHDEH AHPTGWRRYV YSTNHKDIGT MYLIFAVIAG
60 70 80 90 100
VIGAAMSIAI RAELMYPGVQ IFHETHTYNV FVTSHGLIMI FFMVMPAMIG
110 120 130 140 150
GFGNWFVPLM IGAPDMAFPR MNNISFWLLP ASFGLLLMST FVEGEPGANG
160 170 180 190 200
VGAGWTMYVP LSSSGHPGPA VDFAILSLHL AGASSILGAI NFITTIFNMR
210 220 230 240 250
APGMTLHKMP LFVWSILVTV FLLLLSLPVL AGAITMLLTD RNFGTTFFAP
260 270 280 290 300
DGGGDPVLFQ HLFWFFGHPE VYILILPGFG MISQIVSTFS RKPVFGYLGM
310 320 330 340 350
AYAMVAIGGI GFVVWAHHMY TVGMSSATQA YFVAATMVIA VPTGVKIFSW
360 370 380 390 400
IATMWGGSIE FRAPMIWAVG FIFLFTVGGV TGVVLANAGV DRVLQETYYV
410 420 430 440 450
VAHFHYVLSL GAVFAIFAGW YYWFPKMTGY MYNETLAKAH FWVTFIGVNL
460 470 480 490 500
VFFPQHFLGL SGMPRRYVDY PDAFAGWNLV SSVGSYISGF GVLIFLYCVI
510 520 530 540
DAFAKKVPAG DNPWGAGATT LEWTLPSPPP FHQFEVLPRV Q
Length:541
Mass (Da):59,265
Last modified:July 1, 1993 - v1
Checksum:i08F9A69D0C90DB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54318 Genomic DNA. Translation: CAA38216.1.
X54800 Genomic DNA. Translation: CAA38570.1.
AJ242592 Genomic DNA. Translation: CAB56819.1.
U33883 Genomic DNA. Translation: AAF78815.1.
BA000040 Genomic DNA. Translation: BAC46436.1.
PIRiS13076. ODZJ1.
RefSeqiNP_767811.1. NC_004463.1.
WP_011083990.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC46436; BAC46436; BAC46436.
GeneIDi1049669.
KEGGibja:blr1171.
PATRICi21185882. VBIBraJap65052_1211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54318 Genomic DNA. Translation: CAA38216.1.
X54800 Genomic DNA. Translation: CAA38570.1.
AJ242592 Genomic DNA. Translation: CAB56819.1.
U33883 Genomic DNA. Translation: AAF78815.1.
BA000040 Genomic DNA. Translation: BAC46436.1.
PIRiS13076. ODZJ1.
RefSeqiNP_767811.1. NC_004463.1.
WP_011083990.1. NZ_CP011360.1.

3D structure databases

ProteinModelPortaliP31833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr1171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC46436; BAC46436; BAC46436.
GeneIDi1049669.
KEGGibja:blr1171.
PATRICi21185882. VBIBraJap65052_1211.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP31833.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.
PhylomeDBiP31833.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_BRADU
AccessioniPrimary (citable) accession number: P31833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.