Reviewed,
UniProtKB/Swiss-Prot P31833 (COX1_BRAJA)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c oxidase subunit 1 EC=1.9.3.1 Alternative name(s): Cytochrome c oxidase polypeptide I Cytochrome aa3 subunit 1 | ||||||
| Gene names |
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| Organism | Bradyrhizobium japonicum [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 375 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium |
Protein attributes
| Sequence length | 541 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. |
| Catalytic activity | 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| Pathway | |
| Subcellular location | |
| Developmental stage | Free in soil (not as bacteroid). |
| Sequence similarities | Belongs to the heme-copper respiratory oxidase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 541 | 541 | Cytochrome c oxidase subunit 1 | PRO_0000183437 | |||||||
Regions | |||||||||||
| Transmembrane | 40 – 60 | 21 | Potential | ||||||||
| Transmembrane | 87 – 107 | 21 | Potential | ||||||||
| Transmembrane | 124 – 144 | 21 | Potential | ||||||||
| Transmembrane | 173 – 193 | 21 | Potential | ||||||||
| Transmembrane | 211 – 231 | 21 | Potential | ||||||||
| Transmembrane | 262 – 282 | 21 | Potential | ||||||||
| Transmembrane | 294 – 314 | 21 | Potential | ||||||||
| Transmembrane | 332 – 352 | 21 | Potential | ||||||||
| Transmembrane | 365 – 385 | 21 | Potential | ||||||||
| Transmembrane | 404 – 424 | 21 | Potential | ||||||||
| Transmembrane | 441 – 461 | 21 | Potential | ||||||||
| Transmembrane | 483 – 503 | 21 | Potential | ||||||||
Sites | |||||||||||
| Metal binding | 85 | 1 | Iron (heme A axial ligand) Probable | ||||||||
| Metal binding | 268 | 1 | Copper B Probable | ||||||||
| Metal binding | 272 | 1 | Copper B Probable | ||||||||
| Metal binding | 317 | 1 | Copper B Probable | ||||||||
| Metal binding | 318 | 1 | Copper B Probable | ||||||||
| Metal binding | 403 | 1 | Iron (heme A3 axial ligand) Probable | ||||||||
| Metal binding | 405 | 1 | Iron (heme A axial ligand) Probable | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 268 ↔ 272 | 1'-histidyl-3'-tyrosine (His-Tyr) By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum." Gabel C., Maier R.J. Nucleic Acids Res. 18:6143-6143(1990) [PubMed: 2172930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LO. |
| [2] | "Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain." Bott M., Bolliger M., Hennecke H. Mol. Microbiol. 4:2147-2157(1990) [PubMed: 1965217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4. |
| [3] | "Factors involved in biogenesis of active cytochrome aa3 encoded by the coxBAEFGC gene cluster from Bradyrhizobium japonicum." Rossmann R., Loferer H., Rossi P., Hennecke H. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4. |
| [4] | "Extended sequencing of a DNA fragment of B.japonicum adjacent to the cox operon." Mueller P. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4. |
| [5] | "Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110. |
Cross-references
Sequence databases | |
|---|---|
| X54318 Genomic DNA. Translation: CAA38216.1. X54800 Genomic DNA. Translation: CAA38570.1. AJ242592 Genomic DNA. Translation: CAB56819.1. U33883 Genomic DNA. Translation: AAF78815.1. BA000040 Genomic DNA. Translation: BAC46436.1. | |
| PIR | ODZJ1. S13076. |
| RefSeq | NP_767811.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2OCC based on UniProtKB P00396. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1049669. |
| GenomeReviews | Gene locus blr1171 in contig BA000040_GR. |
| KEGG | bja:blr1171. |
| NMPDR | fig|224911.1.peg.1171. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P31833. |
| OMA | P31833. FPKMFGY. |
Enzyme and pathway databases | |
| BioCyc | BJAP224911:BLR1171-MON. |
| BRENDA | 1.9.3.1. 280. |
Family and domain databases | |
| InterPro | IPR000883. Cyt_c_oxidase_su1. IPR014241. Cyt_c_oxidase_su1_bac. [Graphical view] |
| Gene3D | G3DSA:1.20.210.10. COX1. 1 hit. |
| PANTHER | PTHR10422. COX1. 1 hit. |
| Pfam | PF00115. COX1. 1 hit. [Graphical view] |
| PRINTS | PR01165. CYCOXIDASEI. |
| TIGRFAMs | TIGR02891. CtaD_CoxA. 1 hit. |
| PROSITE | PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COX1_BRAJA | ||||||||
| Accession | Primary (citable) accession number: P31833 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


