Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31833

- COX1_BRADU

UniProt

P31833 - COX1_BRADU

Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron (heme A axial ligand)Curated
    Metal bindingi268 – 2681Copper BCurated
    Metal bindingi272 – 2721Copper BCurated
    Metal bindingi317 – 3171Copper BCurated
    Metal bindingi318 – 3181Copper BCurated
    Metal bindingi403 – 4031Iron (heme A3 axial ligand)Curated
    Metal bindingi405 – 4051Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-1181-MONOMER.
    RETL1328306-WGS:GSTH-968-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    Synonyms:coxA
    Ordered Locus Names:blr1171
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Cytochrome c oxidase subunit 1PRO_0000183437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Expressioni

    Developmental stagei

    Free in soil (not as bacteroid).

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.blr1171.

    Structurei

    3D structure databases

    ProteinModelPortaliP31833.
    SMRiP31833. Positions 28-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei441 – 46121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02274.
    OrthoDBiEOG6B35XR.
    PhylomeDBiP31833.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31833-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSAAAHGD HAQDHGHDEH AHPTGWRRYV YSTNHKDIGT MYLIFAVIAG    50
    VIGAAMSIAI RAELMYPGVQ IFHETHTYNV FVTSHGLIMI FFMVMPAMIG 100
    GFGNWFVPLM IGAPDMAFPR MNNISFWLLP ASFGLLLMST FVEGEPGANG 150
    VGAGWTMYVP LSSSGHPGPA VDFAILSLHL AGASSILGAI NFITTIFNMR 200
    APGMTLHKMP LFVWSILVTV FLLLLSLPVL AGAITMLLTD RNFGTTFFAP 250
    DGGGDPVLFQ HLFWFFGHPE VYILILPGFG MISQIVSTFS RKPVFGYLGM 300
    AYAMVAIGGI GFVVWAHHMY TVGMSSATQA YFVAATMVIA VPTGVKIFSW 350
    IATMWGGSIE FRAPMIWAVG FIFLFTVGGV TGVVLANAGV DRVLQETYYV 400
    VAHFHYVLSL GAVFAIFAGW YYWFPKMTGY MYNETLAKAH FWVTFIGVNL 450
    VFFPQHFLGL SGMPRRYVDY PDAFAGWNLV SSVGSYISGF GVLIFLYCVI 500
    DAFAKKVPAG DNPWGAGATT LEWTLPSPPP FHQFEVLPRV Q 541
    Length:541
    Mass (Da):59,265
    Last modified:July 1, 1993 - v1
    Checksum:i08F9A69D0C90DB85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54318 Genomic DNA. Translation: CAA38216.1.
    X54800 Genomic DNA. Translation: CAA38570.1.
    AJ242592 Genomic DNA. Translation: CAB56819.1.
    U33883 Genomic DNA. Translation: AAF78815.1.
    BA000040 Genomic DNA. Translation: BAC46436.1.
    PIRiS13076. ODZJ1.
    RefSeqiNP_767811.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC46436; BAC46436; BAC46436.
    GeneIDi1049669.
    KEGGibja:blr1171.
    PATRICi21185882. VBIBraJap65052_1211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54318 Genomic DNA. Translation: CAA38216.1 .
    X54800 Genomic DNA. Translation: CAA38570.1 .
    AJ242592 Genomic DNA. Translation: CAB56819.1 .
    U33883 Genomic DNA. Translation: AAF78815.1 .
    BA000040 Genomic DNA. Translation: BAC46436.1 .
    PIRi S13076. ODZJ1.
    RefSeqi NP_767811.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P31833.
    SMRi P31833. Positions 28-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr1171.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC46436 ; BAC46436 ; BAC46436 .
    GeneIDi 1049669.
    KEGGi bja:blr1171.
    PATRICi 21185882. VBIBraJap65052_1211.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02274.
    OrthoDBi EOG6B35XR.
    PhylomeDBi P31833.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci BJAP224911:GJEJ-1181-MONOMER.
    RETL1328306-WGS:GSTH-968-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum."
      Gabel C., Maier R.J.
      Nucleic Acids Res. 18:6143-6143(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LO.
    2. "Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain."
      Bott M., Bolliger M., Hennecke H.
      Mol. Microbiol. 4:2147-2157(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    3. "Factors involved in biogenesis of active cytochrome aa3 encoded by the coxBAEFGC gene cluster from Bradyrhizobium japonicum."
      Rossmann R., Loferer H., Rossi P., Hennecke H.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    4. "Extended sequencing of a DNA fragment of B.japonicum adjacent to the cox operon."
      Mueller P.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiCOX1_BRADU
    AccessioniPrimary (citable) accession number: P31833
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3