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P31833 (COX1_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Synonyms:coxA
Ordered Locus Names:blr1171
OrganismBradyrhizobium japonicum (strain USDA 110) [Reference proteome] [HAMAP]
Taxonomic identifier224911 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium ›

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Developmental stage

Free in soil (not as bacteroid).

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541Cytochrome c oxidase subunit 1
PRO_0000183437

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane294 – 31421Helical; Potential
Transmembrane332 – 35221Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane404 – 42421Helical; Potential
Transmembrane441 – 46121Helical; Potential
Transmembrane483 – 50321Helical; Potential

Sites

Metal binding851Iron (heme A axial ligand) Probable
Metal binding2681Copper B Probable
Metal binding2721Copper B Probable
Metal binding3171Copper B Probable
Metal binding3181Copper B Probable
Metal binding4031Iron (heme A3 axial ligand) Probable
Metal binding4051Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P31833 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 08F9A69D0C90DB85

FASTA54159,265
        10         20         30         40         50         60 
MATSAAAHGD HAQDHGHDEH AHPTGWRRYV YSTNHKDIGT MYLIFAVIAG VIGAAMSIAI 

        70         80         90        100        110        120 
RAELMYPGVQ IFHETHTYNV FVTSHGLIMI FFMVMPAMIG GFGNWFVPLM IGAPDMAFPR 

       130        140        150        160        170        180 
MNNISFWLLP ASFGLLLMST FVEGEPGANG VGAGWTMYVP LSSSGHPGPA VDFAILSLHL 

       190        200        210        220        230        240 
AGASSILGAI NFITTIFNMR APGMTLHKMP LFVWSILVTV FLLLLSLPVL AGAITMLLTD 

       250        260        270        280        290        300 
RNFGTTFFAP DGGGDPVLFQ HLFWFFGHPE VYILILPGFG MISQIVSTFS RKPVFGYLGM 

       310        320        330        340        350        360 
AYAMVAIGGI GFVVWAHHMY TVGMSSATQA YFVAATMVIA VPTGVKIFSW IATMWGGSIE 

       370        380        390        400        410        420 
FRAPMIWAVG FIFLFTVGGV TGVVLANAGV DRVLQETYYV VAHFHYVLSL GAVFAIFAGW 

       430        440        450        460        470        480 
YYWFPKMTGY MYNETLAKAH FWVTFIGVNL VFFPQHFLGL SGMPRRYVDY PDAFAGWNLV 

       490        500        510        520        530        540 
SSVGSYISGF GVLIFLYCVI DAFAKKVPAG DNPWGAGATT LEWTLPSPPP FHQFEVLPRV 


Q

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum."
Gabel C., Maier R.J.
Nucleic Acids Res. 18:6143-6143(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LO.
[2]"Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain."
Bott M., Bolliger M., Hennecke H.
Mol. Microbiol. 4:2147-2157(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: USDA 110spc4.
[3]"Factors involved in biogenesis of active cytochrome aa3 encoded by the coxBAEFGC gene cluster from Bradyrhizobium japonicum."
Rossmann R., Loferer H., Rossi P., Hennecke H.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: USDA 110spc4.
[4]"Extended sequencing of a DNA fragment of B.japonicum adjacent to the cox operon."
Mueller P.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: USDA 110spc4.
[5]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X54318 Genomic DNA. Translation: CAA38216.1.
X54800 Genomic DNA. Translation: CAA38570.1.
AJ242592 Genomic DNA. Translation: CAB56819.1.
U33883 Genomic DNA. Translation: AAF78815.1.
BA000040 Genomic DNA. Translation: BAC46436.1.
PIRODZJ1. S13076.
RefSeqNP_767811.1. NC_004463.1.

3D structure databases

ProteinModelPortalP31833.
SMRP31833. Positions 28-539.
ModBaseSearch...

Protein-protein interaction databases

STRING224911.blr1171.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC46436; BAC46436; BAC46436.
GeneID1049669.
KEGGbja:blr1171.
PATRIC21185882. VBIBraJap65052_1211.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02274.
OMATVTMVLT.
ProtClustDBCLSK818454.

Enzyme and pathway databases

BioCycBJAP224911:GJEJ-1181-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_BRAJA
AccessionPrimary (citable) accession number: P31833
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents