Cytochrome c oxidase subunit 1 - Bradyrhizobium japonicum

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Reviewed, UniProtKB/Swiss-Prot P31833 (COX1_BRAJA)

Last modified June 16, 2009. Version 77. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Cytochrome aa3 subunit 1

Gene names

Name:	ctaD
Synonyms:	coxA
Ordered Locus Names:	blr1171

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

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Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Developmental stage	Free in soil (not as bacteroid).
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 541

541

Cytochrome c oxidase subunit 1

PRO_0000183437

Regions

Transmembrane

40 – 60

Potential

Transmembrane

87 – 107

Potential

Transmembrane

124 – 144

Potential

Transmembrane

173 – 193

Potential

Transmembrane

211 – 231

Potential

Transmembrane

262 – 282

Potential

Transmembrane

294 – 314

Potential

Transmembrane

332 – 352

Potential

Transmembrane

365 – 385

Potential

Transmembrane

404 – 424

Potential

Transmembrane

441 – 461

Potential

Transmembrane

483 – 503

Potential

Sites

Metal binding

Iron (heme A axial ligand) Probable

Metal binding

268

Copper B Probable

Metal binding

272

Copper B Probable

Metal binding

317

Copper B Probable

Metal binding

318

Copper B Probable

Metal binding

403

Iron (heme A3 axial ligand) Probable

Metal binding

405

Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link

268 ↔ 272

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P31833-1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 08F9A69D0C90DB85
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FASTA

541

59,265

        10         20         30         40         50         60 
MATSAAAHGD HAQDHGHDEH AHPTGWRRYV YSTNHKDIGT MYLIFAVIAG VIGAAMSIAI 

        70         80         90        100        110        120 
RAELMYPGVQ IFHETHTYNV FVTSHGLIMI FFMVMPAMIG GFGNWFVPLM IGAPDMAFPR 

       130        140        150        160        170        180 
MNNISFWLLP ASFGLLLMST FVEGEPGANG VGAGWTMYVP LSSSGHPGPA VDFAILSLHL 

       190        200        210        220        230        240 
AGASSILGAI NFITTIFNMR APGMTLHKMP LFVWSILVTV FLLLLSLPVL AGAITMLLTD 

       250        260        270        280        290        300 
RNFGTTFFAP DGGGDPVLFQ HLFWFFGHPE VYILILPGFG MISQIVSTFS RKPVFGYLGM 

       310        320        330        340        350        360 
AYAMVAIGGI GFVVWAHHMY TVGMSSATQA YFVAATMVIA VPTGVKIFSW IATMWGGSIE 

       370        380        390        400        410        420 
FRAPMIWAVG FIFLFTVGGV TGVVLANAGV DRVLQETYYV VAHFHYVLSL GAVFAIFAGW 

       430        440        450        460        470        480 
YYWFPKMTGY MYNETLAKAH FWVTFIGVNL VFFPQHFLGL SGMPRRYVDY PDAFAGWNLV 

       490        500        510        520        530        540 
SSVGSYISGF GVLIFLYCVI DAFAKKVPAG DNPWGAGATT LEWTLPSPPP FHQFEVLPRV 


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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum." Gabel C., Maier R.J. Nucleic Acids Res. 18:6143-6143(1990) [PubMed: 2172930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LO.
[2]	"Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain." Bott M., Bolliger M., Hennecke H. Mol. Microbiol. 4:2147-2157(1990) [PubMed: 1965217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4.
[3]	"Factors involved in biogenesis of active cytochrome aa3 encoded by the coxBAEFGC gene cluster from Bradyrhizobium japonicum." Rossmann R., Loferer H., Rossi P., Hennecke H. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4.
[4]	"Extended sequencing of a DNA fragment of B.japonicum adjacent to the cox operon." Mueller P. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: USDA 110spc4.
[5]	"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

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Cross-references

Sequence databases
	X54318 Genomic DNA. Translation: CAA38216.1. X54800 Genomic DNA. Translation: CAA38570.1. AJ242592 Genomic DNA. Translation: CAB56819.1. U33883 Genomic DNA. Translation: AAF78815.1. BA000040 Genomic DNA. Translation: BAC46436.1.
PIR	ODZJ1. S13076.
RefSeq	NP_767811.1.
3D structure databases
HSSP	HSSP built from PDB template 2OCC based on UniProtKB P00396.
ModBase	Search...
Genome annotation databases
GeneID	1049669.
GenomeReviews	Gene locus blr1171 in contig BA000040_GR.
KEGG	bja:blr1171.
NMPDR	fig\|224911.1.peg.1171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P31833.
OMA	P31833. FPKMFGY.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR1171-MON.
BRENDA	1.9.3.1. 280.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. IPR014241. Cyt_c_oxidase_su1_bac. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
TIGRFAMs	TIGR02891. CtaD_CoxA. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COX1_BRAJA

Accession

Primary (citable) accession number: P31833

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents