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P31833

- COX1_BRADU

UniProt

P31833 - COX1_BRADU

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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron (heme A axial ligand)Curated
Metal bindingi268 – 2681Copper BCurated
Metal bindingi272 – 2721Copper BCurated
Metal bindingi317 – 3171Copper BCurated
Metal bindingi318 – 3181Copper BCurated
Metal bindingi403 – 4031Iron (heme A3 axial ligand)Curated
Metal bindingi405 – 4051Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-1181-MONOMER.
RETL1328306-WGS:GSTH-968-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxA
Ordered Locus Names:blr1171
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence AnalysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence AnalysisAdd
BLAST
Transmembranei483 – 50321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Cytochrome c oxidase subunit 1PRO_0000183437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

Expressioni

Developmental stagei

Free in soil (not as bacteroid).

Interactioni

Protein-protein interaction databases

STRINGi224911.blr1171.

Structurei

3D structure databases

ProteinModelPortaliP31833.
SMRiP31833. Positions 28-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
InParanoidiP31833.
KOiK02274.
OrthoDBiEOG6B35XR.
PhylomeDBiP31833.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31833-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSAAAHGD HAQDHGHDEH AHPTGWRRYV YSTNHKDIGT MYLIFAVIAG
60 70 80 90 100
VIGAAMSIAI RAELMYPGVQ IFHETHTYNV FVTSHGLIMI FFMVMPAMIG
110 120 130 140 150
GFGNWFVPLM IGAPDMAFPR MNNISFWLLP ASFGLLLMST FVEGEPGANG
160 170 180 190 200
VGAGWTMYVP LSSSGHPGPA VDFAILSLHL AGASSILGAI NFITTIFNMR
210 220 230 240 250
APGMTLHKMP LFVWSILVTV FLLLLSLPVL AGAITMLLTD RNFGTTFFAP
260 270 280 290 300
DGGGDPVLFQ HLFWFFGHPE VYILILPGFG MISQIVSTFS RKPVFGYLGM
310 320 330 340 350
AYAMVAIGGI GFVVWAHHMY TVGMSSATQA YFVAATMVIA VPTGVKIFSW
360 370 380 390 400
IATMWGGSIE FRAPMIWAVG FIFLFTVGGV TGVVLANAGV DRVLQETYYV
410 420 430 440 450
VAHFHYVLSL GAVFAIFAGW YYWFPKMTGY MYNETLAKAH FWVTFIGVNL
460 470 480 490 500
VFFPQHFLGL SGMPRRYVDY PDAFAGWNLV SSVGSYISGF GVLIFLYCVI
510 520 530 540
DAFAKKVPAG DNPWGAGATT LEWTLPSPPP FHQFEVLPRV Q
Length:541
Mass (Da):59,265
Last modified:July 1, 1993 - v1
Checksum:i08F9A69D0C90DB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54318 Genomic DNA. Translation: CAA38216.1.
X54800 Genomic DNA. Translation: CAA38570.1.
AJ242592 Genomic DNA. Translation: CAB56819.1.
U33883 Genomic DNA. Translation: AAF78815.1.
BA000040 Genomic DNA. Translation: BAC46436.1.
PIRiS13076. ODZJ1.
RefSeqiNP_767811.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC46436; BAC46436; BAC46436.
GeneIDi1049669.
KEGGibja:blr1171.
PATRICi21185882. VBIBraJap65052_1211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54318 Genomic DNA. Translation: CAA38216.1 .
X54800 Genomic DNA. Translation: CAA38570.1 .
AJ242592 Genomic DNA. Translation: CAB56819.1 .
U33883 Genomic DNA. Translation: AAF78815.1 .
BA000040 Genomic DNA. Translation: BAC46436.1 .
PIRi S13076. ODZJ1.
RefSeqi NP_767811.1. NC_004463.1.

3D structure databases

ProteinModelPortali P31833.
SMRi P31833. Positions 28-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr1171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC46436 ; BAC46436 ; BAC46436 .
GeneIDi 1049669.
KEGGi bja:blr1171.
PATRICi 21185882. VBIBraJap65052_1211.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
InParanoidi P31833.
KOi K02274.
OrthoDBi EOG6B35XR.
PhylomeDBi P31833.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci BJAP224911:GJEJ-1181-MONOMER.
RETL1328306-WGS:GSTH-968-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the coxA gene encoding subunit I of cytochrome aa3 of Bradyrhizobium japonicum."
    Gabel C., Maier R.J.
    Nucleic Acids Res. 18:6143-6143(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LO.
  2. "Genetic analysis of the cytochrome c-aa3 branch of the Bradyrhizobium japonicum respiratory chain."
    Bott M., Bolliger M., Hennecke H.
    Mol. Microbiol. 4:2147-2157(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  3. "Factors involved in biogenesis of active cytochrome aa3 encoded by the coxBAEFGC gene cluster from Bradyrhizobium japonicum."
    Rossmann R., Loferer H., Rossi P., Hennecke H.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  4. "Extended sequencing of a DNA fragment of B.japonicum adjacent to the cox operon."
    Mueller P.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiCOX1_BRADU
AccessioniPrimary (citable) accession number: P31833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3