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Protein

Probable zinc protease PqqL

Gene

pqqL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80ZincPROSITE-ProRule annotation1
Active sitei83Proton acceptorPROSITE-ProRule annotation1
Metal bindingi84ZincPROSITE-ProRule annotation1
Metal bindingi160ZincPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11744-MONOMER

Protein family/group databases

MEROPSiM16.A05

Names & Taxonomyi

Protein namesi
Recommended name:
Probable zinc protease PqqL (EC:3.4.24.-)
Gene namesi
Name:pqqL
Synonyms:yddC
Ordered Locus Names:b1494, JW1489
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11744 pqqL

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000744151 – 931Probable zinc protease PqqLAdd BLAST931

Proteomic databases

PaxDbiP31828
PRIDEiP31828

Interactioni

Protein-protein interaction databases

BioGridi4260787, 22 interactors
DIPiDIP-10556N
IntActiP31828, 12 interactors
STRINGi316385.ECDH10B_1625

Structurei

3D structure databases

ProteinModelPortaliP31828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Phylogenomic databases

eggNOGiENOG4107RAN Bacteria
COG0612 LUCA
HOGENOMiHOG000120686
InParanoidiP31828
KOiK07263
OMAiRDINAFT
PhylomeDBiP31828

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
SUPFAMiSSF63411 SSF63411, 4 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P31828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIMRNLCF LLTLVATLLL PGRLIAAALP QDEKLITGQL DNGLRYMIYP
60 70 80 90 100
HAHPKDQVNL WLQIHTGSLQ EEDNELGVAH FVEHMMFNGT KTWPGNKVIE
110 120 130 140 150
TFESMGLRFG RDVNAYTSYD ETVYQVSLPT TQKQNLQQVM AIFSEWSNAA
160 170 180 190 200
TFEKLEVDAE RGVITEEWRA HQDAKWRTSQ ARRPFLLANT RNLDREPIGL
210 220 230 240 250
MDTVATVTPA QLRQFYQRWY QPNNMTFIVV GDIDSKEALA LIKDNLSKLP
260 270 280 290 300
ANKAAENRVW PTKAENHLRF NIINDKENRV NGIALYYRLP MVQVNDEQSF
310 320 330 340 350
IEQAEWSMLV QLFNQRLQER IQSGELKTIS GGTARSVKIA PDYQSLFFRV
360 370 380 390 400
NARDDNMQDA ANALMAELAT IDQHGFSAEE LDDVKSTRLT WLKNAVDQQA
410 420 430 440 450
ERDLRMLTSR LASSSLNNTP FLSPEETYQL SKRLWQQITV QSLAEKWQQL
460 470 480 490 500
RKNQDAFWEQ MVNNEVAAKK ALSPAAILAL EKEYANKKLA AYVFPGRNLS
510 520 530 540 550
LTVDADPQAE ISSKETLAEN LTSLTLSNGA RVILAKSAGE EQKLQIIAVS
560 570 580 590 600
NKGDLSFPAQ QKSLIALANK AVSGSGVGEL SSSSLKRWSA ENSVTMSSKV
610 620 630 640 650
SGMNTLLSVS ARTNNPEPGF QLINQRITHS TINDNIWASL QNAQIQALKT
660 670 680 690 700
LDQRPAEKFA QQMYETRYAD DRTKLLQENQ IAQFTAADAL AADRQLFSSP
710 720 730 740 750
ADITFVIVGN VAEDKLVALI TRYLGSIKHS DSPLAAGKPL TRATDNASVT
760 770 780 790 800
VKEQNEPVAQ VSQWKRYDSR TPVNLPTRMA LDAFNVALAK DLRVNIREQA
810 820 830 840 850
SGAYSVSSRL SVDPQAKDIS HLLAFTCQPE RHDELLTLAN EVMVKRLAKG
860 870 880 890 900
ISEQELNEYQ QNVQRSLDIQ QRSVQQLANT IVNSLIQYDD PAAWTEQEQL
910 920 930
LKQMTVENVN TAVKQYLSHP VNTYTGVLLP K
Length:931
Mass (Da):104,656
Last modified:November 1, 1997 - v2
Checksum:i94A340CA83DB6D1E
GO

Sequence cautioni

The sequence CAA50735 differs from that shown. Reason: Frameshift at position 651. Produces two separate ORFs.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360A → V in CAA50734 (PubMed:9116051).Curated1
Sequence conflicti867L → V in CAA50735 (PubMed:9116051).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71917 Genomic DNA Translation: CAA50734.1 Frameshift.
X71917 Genomic DNA Translation: CAA50735.1 Frameshift.
U00096 Genomic DNA Translation: AAC74567.1
AP009048 Genomic DNA Translation: BAA15164.2
PIRiA64903
RefSeqiNP_416011.1, NC_000913.3
WP_010723101.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74567; AAC74567; b1494
BAA15164; BAA15164; BAA15164
GeneIDi946059
KEGGiecj:JW1489
eco:b1494
PATRICifig|511145.12.peg.1561

Similar proteinsi

Entry informationi

Entry nameiPQQL_ECOLI
AccessioniPrimary (citable) accession number: P31828
Secondary accession number(s): P31829, P76132, P78158
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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