P31810 (DSBA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:	dsbA
Synonyms:	por
Ordered Locus Names:	HI_0846

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in disulfide-bond formation. Required for HI transformation. Acts by transferring its disulfide bond to other proteins.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 205	183	Thiol:disulfide interchange protein DsbA		PRO_0000034260
Regions
	Domain	23 – 201	179	Thioredoxin
Amino acid modifications
	Disulfide bond	52 ↔ 55		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P31810 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 37469B216976969C	FASTA	205	22,964
	10 20 30 40 50 60 MKKVLLALGL GVSTLMSVNS FAADLQEGKQ YVQVSQQASQ QKEVIEFFSF YCPHCYAFEM 70 80 90 100 110 120 EYKIPQQVVD ALPKDVKFKQ YHVNFLGHQS ENLTRAWALA MALGAESKVK SPLFEAAQKD 130 140 150 160 170 180 ALKSMDDIRA IFLSNGITAE QFDGGINSFA VNGLVNKQVN AAEQFKVRGV PDFYVNGKFR 190 200 VNPEGLNYDD FVKDYVQTVK GLLQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A periplasmic protein disulfide oxidoreductase is required for transformation of Haemophilus influenzae Rd." Tomb J.-F. Proc. Natl. Acad. Sci. U.S.A. 89:10252-10256(1992) [PubMed: 1438213] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94205 Genomic DNA. Translation: AAA24956.1. L42023 Genomic DNA. Translation: AAC22503.1.
PIR	B46411. B64098.
RefSeq	NP_439006.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P31810.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	949506.
GenomeReviews	Gene locus HI_0846 in contig L42023_GR.
KEGG	hin:HI0846.
PATRIC	20190347. VBIHaeInf48452_0887.
TIGR	HI_0846.
Phylogenomic databases
HOGENOM	HBG680642.
OMA	MFEAVQK.
ProtClustDB	CLSK870622.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0846-MONOMER.
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
KO	K03673.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_HAEIN

Accession

Primary (citable) accession number: P31810

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program