Reviewed, UniProtKB/Swiss-Prot P31810 (DSBA_HAEIN)

Names and origin

Protein names

Recommended name:
    Thiol:disulfide interchange protein dsbA

Gene names

Name:	dsbA
Synonyms:	por
Ordered Locus Names:	HI0846

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in disulfide-bond formation. Required for HI transformation. Acts by transferring its disulfide bond to other proteins.
Subcellular location	Periplasm.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 205	183	Thiol:disulfide interchange protein dsbA		PRO_0000034260
Regions
	Domain	23 – 201	179	Thioredoxin
Amino acid modifications
	Disulfide bond	52 ↔ 55		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P31810-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 37469B216976969C	FASTA	205	22,964
	10 20 30 40 50 60 MKKVLLALGL GVSTLMSVNS FAADLQEGKQ YVQVSQQASQ QKEVIEFFSF YCPHCYAFEM 70 80 90 100 110 120 EYKIPQQVVD ALPKDVKFKQ YHVNFLGHQS ENLTRAWALA MALGAESKVK SPLFEAAQKD 130 140 150 160 170 180 ALKSMDDIRA IFLSNGITAE QFDGGINSFA VNGLVNKQVN AAEQFKVRGV PDFYVNGKFR 190 200 VNPEGLNYDD FVKDYVQTVK GLLQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A periplasmic protein disulfide oxidoreductase is required for transformation of Haemophilus influenzae Rd." Tomb J.-F. Proc. Natl. Acad. Sci. U.S.A. 89:10252-10256(1992) [PubMed: 1438213] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M94205 Genomic DNA. Translation: AAA24956.1. L42023 Genomic DNA. Translation: AAC22503.1.
PIR	B46411. B64098.
RefSeq	NP_439006.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVK based on UniProtKB P24991.
ModBase	Search...
Genome annotation databases
GeneID	949506.
GenomeReviews	Gene locus HI0846 in contig L42023_GR.
KEGG	hin:HI0846.
TIGR	HI0846.
Phylogenomic databases
HOGENOM	P31810.
OMA	P31810. EGVHYEV.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0846-MON.
Family and domain databases
InterPro	IPR001853. OxRdtase_DSBA. IPR017936. Thioredoxin-like. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_HAEIN

Accession

Primary (citable) accession number: P31810

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)