Reviewed,
UniProtKB/Swiss-Prot P31809 (CEAM1_MOUSE)
Last modified
June 16, 2009.
Version 86.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 1 Alternative name(s): Biliary glycoprotein 1 Short name=BGP-1 Murine hepatitis virus receptor Short name=MHV-R MHVR1 Biliary glycoprotein D CD_antigen=CD66a | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein. Ref.2 Ref.7 |
| Subunit structure | |
| Subcellular location | |
| Sequence similarities | Belongs to the immunoglobulin superfamily. CEA family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Host-virus interaction |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Immunoglobulin domain Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | receptor activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Long (identifier: P31809-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Short (identifier: P31809-2) The sequence of this isoform differs from the canonical sequence as follows: 455-458: GSDQ → SGSF 459-521: Missing. | ||||||
| Isoform 3 (identifier: P31809-3) The sequence of this isoform differs from the canonical sequence as follows: 142-142: P → Q 143-322: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 34 | 34 | Ref.5 | ||||||||
| Chain | 35 – 521 | 487 | Carcinoembryonic antigen-related cell adhesion molecule 1 | PRO_0000014563 | |||||||
Regions | |||||||||||
| Topological domain | 35 – 428 | 394 | Extracellular Potential | ||||||||
| Transmembrane | 429 – 447 | 19 | Potential | ||||||||
| Topological domain | 448 – 521 | 74 | Cytoplasmic Potential | ||||||||
| Domain | 35 – 142 | 108 | Ig-like V-type | ||||||||
| Domain | 147 – 234 | 88 | Ig-like C2-type 1 | ||||||||
| Domain | 239 – 319 | 81 | Ig-like C2-type 2 | ||||||||
| Domain | 323 – 411 | 89 | Ig-like C2-type 3 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...) Ref.9 | ||||||||
| Glycosylation | 89 | 1 | N-linked (GlcNAc...) Ref.9 | ||||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Ref.9 | ||||||||
| Glycosylation | 148 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 152 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 199 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 206 | 1 | N-linked (GlcNAc...) Ref.8 | ||||||||
| Glycosylation | 210 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 226 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 258 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 290 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 294 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 304 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 317 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 333 | 1 | N-linked (GlcNAc...) Ref.9 | ||||||||
| Glycosylation | 375 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 167 ↔ 217 | Probable | |||||||||
| Disulfide bond | 261 ↔ 301 | Probable | |||||||||
| Disulfide bond | 346 ↔ 394 | Ref.9 | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 142 | 1 | P → Q in isoform 3. | VSP_036040 | |||||||
| Alternative sequence | 143 – 322 | 180 | Missing in isoform 3. | VSP_036041 | |||||||
| Alternative sequence | 455 – 458 | 4 | GSDQ → SGSF in isoform Short. | VSP_002484 | |||||||
| Alternative sequence | 459 – 521 | 63 | Missing in isoform Short. | VSP_002485 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 361 – 362 | 2 | SQ → RE in CAA47699. Ref.3 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59." Dveksler G.S., Dieffenback C.B., Cardellichio C.B., McCuaig K., Pensiero M.N., Jiang G.-S., Beauchemin N., Holmes K.V. J. Virol. 67:1-8(1993) [PubMed: 8380065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH MHV SPIKE GLYCOPROTEIN. Strain: CD-1. Tissue: Colon. |
| [2] | "Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV." Dveksler G.S., Pensiero M.N., Cardellichio C.B., Williams R.K., Jiang G.-S., Holmes K.V., Dieffenbach C.W. J. Virol. 65:6881-6891(1991) [PubMed: 1719235] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), INTERACTION WITH MHV SPIKE GLYCOPROTEIN, CHARACTERIZATION OF MHV RECEPTOR FUNCTION. Strain: BALB/c and CD-1. Tissue: Colon and Liver. |
| [3] | "Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms." McCuaig K., Rosenberg M., Nedellec P., Turbide C., Beauchemin N. Gene 127:173-183(1993) [PubMed: 8500759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND 3). |
| [4] | "A mouse analogue of the human carcinoembryonic antigen." Beauchemin N., Turbide C., Afar D., Raymond M., Bell J., Stanners C.P., Fuks A. Cancer Res. 49:2017-2021(1989) [PubMed: 2702644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Strain: CD-1. Tissue: Colon. |
| [5] | "Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins." Williams R.K., Jiang G.-S., Holmes K.V. Proc. Natl. Acad. Sci. U.S.A. 88:5533-5536(1991) [PubMed: 1648219] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-59. |
| [6] | Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 116-130, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus. |
| [7] | "Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59." Hemmila E., Turbide C., Olson M., Jothy S., Holmes K.V., Beauchemin N. J. Virol. 78:10156-10165(2004) [PubMed: 15331748] [Abstract] Cited for: CHARACTERIZATION OF MHV RECEPTOR FUNCTION. |
| [8] | "Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res. 5:2438-2447(2006) [PubMed: 16944957] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206, MASS SPECTROMETRY. Tissue: Plasma. |
| [9] | "Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family." Tan K., Zelus B.D., Meijers R., Liu J.-H., Bergelson J.M., Duke N., Zhang R., Joachimiak A., Holmes K.V., Wang J.-H. EMBO J. 21:2076-2086(2002) [PubMed: 11980704] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.32 ANGSTROMS) OF 35-236 (ISOFORM 3), GLYCOSYLATION AT ASN-71; ASN-89; ASN-104 AND ASN-333, DISULFIDE BOND, INTERACTION WITH MURINE CORONAVIRUS MHV S1 SPIKE GLYCOPROTEIN. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X15351 mRNA. Translation: CAA33409.1. M77196 mRNA. Translation: AAA37858.1. X67279 mRNA. Translation: CAA47696.1. X67282 mRNA. Translation: CAA47699.1. | |||||||||||||
| IPI | IPI00108535. IPI00227804. IPI00915472. | ||||||||||||
| PIR | WMMSR1. JC1505. JC1508. JC1511. | ||||||||||||
| RefSeq | NP_001034274.1. NP_001034275.1. | ||||||||||||
| UniGene | Mm.322502 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P31809. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P31809. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSMUSG00000074272. Mus musculus. [Contig view] | ||||||||||||
| GeneID | 26365. | ||||||||||||
| KEGG | mmu:26365. | ||||||||||||
Organism-specific databases | |||||||||||||
| MGI | MGI:1347245. Ceacam1. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P31809. | ||||||||||||
| HOVERGEN | P31809. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P31809. | ||||||||||||
| Bgee | P31809. | ||||||||||||
| CleanEx | MM_CEACAM1. | ||||||||||||
| GermOnline | ENSMUSG00000074272. Mus musculus. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 4 hits. | ||||||||||||
| Pfam | PF00047. ig. 3 hits. PF07686. V-set. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00408. IGc2. 3 hits. [Graphical view] | ||||||||||||
| PROSITE | PS50835. IG_LIKE. 3 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 304235. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CEAM1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P31809 Secondary accession number(s): Q61353 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


