Skip Header

Contribute Send feedback
Read comments (?) or add your own

P31809 (CEAM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carcinoembryonic antigen-related cell adhesion molecule 1
Alternative name(s):
Biliary glycoprotein 1
Short name=BGP-1
Biliary glycoprotein D
MHVR1
Murine hepatitis virus receptor
Short name=MHV-R
CD_antigen=CD66a
Gene names
Name:Ceacam1
Synonyms:Bgp, Bgp1, Bgpd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein. Ref.2 Ref.7

Subunit structure

Interacts with MHV S1 spike glycoprotein. Ref.1 Ref.2 Ref.10

Subcellular location

Cell membrane; Single-pass type I membrane protein Ref.1.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P31809-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P31809-2)

The sequence of this isoform differs from the canonical sequence as follows:
     455-458: GSDQ → SGSF
     459-521: Missing.
Isoform 3 (identifier: P31809-3)

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: P → Q
     143-322: Missing.
Note: Glycosylated at Asn-153.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Ref.5
Chain35 – 521487Carcinoembryonic antigen-related cell adhesion molecule 1
PRO_0000014563

Regions

Topological domain35 – 428394Extracellular Potential
Transmembrane429 – 44719Helical; Potential
Topological domain448 – 52174Cytoplasmic Potential
Domain35 – 142108Ig-like V-type
Domain147 – 23488Ig-like C2-type 1
Domain239 – 31981Ig-like C2-type 2
Domain323 – 41189Ig-like C2-type 3

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Ref.9 Ref.10
Glycosylation891N-linked (GlcNAc...) Ref.9 Ref.10
Glycosylation1041N-linked (GlcNAc...) Ref.10
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Ref.8
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation2941N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Ref.9
Glycosylation3331N-linked (GlcNAc...) Ref.9 Ref.10
Glycosylation3751N-linked (GlcNAc...) Ref.9
Glycosylation3761N-linked (GlcNAc...) Ref.9
Disulfide bond167 ↔ 217 Probable
Disulfide bond261 ↔ 301 Probable
Disulfide bond346 ↔ 394 Ref.10

Natural variations

Alternative sequence1421P → Q in isoform 3.
VSP_036040
Alternative sequence143 – 322180Missing in isoform 3.
VSP_036041
Alternative sequence455 – 4584GSDQ → SGSF in isoform Short.
VSP_002484
Alternative sequence459 – 52163Missing in isoform Short.
VSP_002485

Experimental info

Sequence conflict361 – 3622SQ → RE in CAA47699. Ref.3

Secondary structure

1 ......................................... 521
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 1C8F71FAC47DD54E

FASTA52157,016
        10         20         30         40         50         60 
MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN VLLLVHNLPL 

        70         80         90        100        110        120 
ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI IYSNGSLLFQ MITMKDMGVY 

       130        140        150        160        170        180 
TLDMTDENYR RTQATVRFHV HPILLKPNIT SNNSNPVEGD DSVSLTCDSY TDPDNINYLW 

       190        200        210        220        230        240 
SRNGESLSEG DRLKLSEGNR TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD 

       250        260        270        280        290        300 
TPIISPSDIY LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT 

       310        320        330        340        350        360 
CFVNNSVTGL SRTTVKNITV LEPVTQPFLQ VTNTTVKELD SVTLTCLSND IGANIQWLFN 

       370        380        390        400        410        420 
SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV SVRRSNSIKL DIIFDPTQGG 

       430        440        450        460        470        480 
LSDGAIAGIV IGVVAGVALI AGLAYFLYSR KSGGGSDQRD LTEHKPSTSN HNLAPSDNSP 

       490        500        510        520 
NKVDDVAYTV LNFNSQQPNR PTSAPSSPRA TETVYSEVKK K

« Hide

Isoform Short [UniParc].

Checksum: 63E0EC6AC58BA660
Show »

FASTA45850,057
Isoform 3 [UniParc].

Checksum: 0ABE851287A77290
Show »

FASTA34137,271

References

« Hide 'large scale' references
[1]"Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59."
Dveksler G.S., Dieffenback C.B., Cardellichio C.B., McCuaig K., Pensiero M.N., Jiang G.-S., Beauchemin N., Holmes K.V.
J. Virol. 67:1-8(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH MHV SPIKE GLYCOPROTEIN.
Strain: CD-1.
Tissue: Colon.
[2]"Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV."
Dveksler G.S., Pensiero M.N., Cardellichio C.B., Williams R.K., Jiang G.-S., Holmes K.V., Dieffenbach C.W.
J. Virol. 65:6881-6891(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), INTERACTION WITH MHV SPIKE GLYCOPROTEIN, CHARACTERIZATION OF MHV RECEPTOR FUNCTION.
Strain: BALB/c and CD-1.
Tissue: Colon and Liver.
[3]"Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms."
McCuaig K., Rosenberg M., Nedellec P., Turbide C., Beauchemin N.
Gene 127:173-183(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND 3).
[4]"A mouse analogue of the human carcinoembryonic antigen."
Beauchemin N., Turbide C., Afar D., Raymond M., Bell J., Stanners C.P., Fuks A.
Cancer Res. 49:2017-2021(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Strain: CD-1.
Tissue: Colon.
[5]"Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins."
Williams R.K., Jiang G.-S., Holmes K.V.
Proc. Natl. Acad. Sci. U.S.A. 88:5533-5536(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 35-59.
[6]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 116-130, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[7]"Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59."
Hemmila E., Turbide C., Olson M., Jothy S., Holmes K.V., Beauchemin N.
J. Virol. 78:10156-10165(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF MHV RECEPTOR FUNCTION.
[8]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Plasma.
[9]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71; ASN-89; ASN-317; ASN-333; ASN-375 AND ASN-376, MASS SPECTROMETRY.
[10]"Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family."
Tan K., Zelus B.D., Meijers R., Liu J.-H., Bergelson J.M., Duke N., Zhang R., Joachimiak A., Holmes K.V., Wang J.-H.
EMBO J. 21:2076-2086(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.32 ANGSTROMS) OF 35-236 (ISOFORM 3), GLYCOSYLATION AT ASN-71; ASN-89; ASN-104 AND ASN-333, DISULFIDE BOND, INTERACTION WITH MURINE CORONAVIRUS MHV S1 SPIKE GLYCOPROTEIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X15351 mRNA. Translation: CAA33409.1.
M77196 mRNA. Translation: AAA37858.1.
X67279 mRNA. Translation: CAA47696.1.
X67282 mRNA. Translation: CAA47699.1.
IPIIPI00108535.
IPI00227804.
IPI00915472.
PIRWMMSR1. JC1505.
JC1508.
JC1511.
RefSeqNP_001034274.1. NM_001039185.1.
NP_001034275.1. NM_001039186.1.
UniGeneMm.322502.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1L6ZX-ray3.32A35-416[»]
3R4DX-ray3.10A/C35-416[»]
ProteinModelPortalP31809.
SMRP31809. Positions 35-440.
ModBaseSearch...

PTM databases

PhosphoSiteP31809.

Proteomic databases

PaxDbP31809.
PRIDEP31809.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000098666; ENSMUSP00000096263; ENSMUSG00000074272.
GeneID26365.
KEGGmmu:26365.

Organism-specific databases

CTD634.
MGIMGI:1347245. Ceacam1.

Phylogenomic databases

eggNOGNOG149650.
GeneTreeENSGT00630000089675.
HOGENOMHOG000233417.
HOVERGENHBG007922.
InParanoidP31809.
KOK06499.

Gene expression databases

ArrayExpressP31809.
BgeeP31809.
CleanExMM_CEACAM1.
GenevestigatorP31809.
GermOnlineENSMUSG00000074272. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 3 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP31809.
NextBio304235.
SOURCESearch...

Entry information

Entry nameCEAM1_MOUSE
AccessionPrimary (citable) accession number: P31809
Secondary accession number(s): Q61353
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents