Reviewed, UniProtKB/Swiss-Prot P31809 (CEAM1_MOUSE)

Names and origin

Protein names

Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 1
Alternative name(s):
    Biliary glycoprotein 1
      Short name=BGP-1
    Murine hepatitis virus receptor
      Short name=MHV-R
    MHVR1
    Biliary glycoprotein D
    CD_antigen=CD66a

Gene names

Name:	Ceacam1
Synonyms:	Bgp, Bgp1, Bgpd

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein. Ref.2 Ref.7
Subunit structure	Interacts with MHV S1 spike glycoprotein. Ref.2 Ref.1 Ref.9
Subcellular location	Cell membrane; Single-pass type I membrane protein. Ref.1
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P31809-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P31809-2)

The sequence of this isoform differs from the canonical sequence as follows:
     455-458: GSDQ → SGSF
     459-521: Missing.

Isoform 3 (identifier: P31809-3)

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: P → Q
     143-322: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Ref.5
	Chain	35 – 521	487	Carcinoembryonic antigen-related cell adhesion molecule 1		PRO_0000014563
Regions
	Topological domain	35 – 428	394	Extracellular Potential
	Transmembrane	429 – 447	19	Potential
	Topological domain	448 – 521	74	Cytoplasmic Potential
	Domain	35 – 142	108	Ig-like V-type
	Domain	147 – 234	88	Ig-like C2-type 1
	Domain	239 – 319	81	Ig-like C2-type 2
	Domain	323 – 411	89	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	89	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	104	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	148	1	N-linked (GlcNAc...) Potential
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	206	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	226	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	290	1	N-linked (GlcNAc...) Potential
	Glycosylation	294	1	N-linked (GlcNAc...) Potential
	Glycosylation	304	1	N-linked (GlcNAc...) Potential
	Glycosylation	317	1	N-linked (GlcNAc...) Potential
	Glycosylation	333	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Disulfide bond	167 ↔ 217		Probable
	Disulfide bond	261 ↔ 301		Probable
	Disulfide bond	346 ↔ 394		Ref.9
Natural variations
	Alternative sequence	142	1	P → Q in isoform 3.		VSP_036040
	Alternative sequence	143 – 322	180	Missing in isoform 3.		VSP_036041
	Alternative sequence	455 – 458	4	GSDQ → SGSF in isoform Short.		VSP_002484
	Alternative sequence	459 – 521	63	Missing in isoform Short.		VSP_002485
Experimental info
	Sequence conflict	361 – 362	2	SQ → RE in CAA47699. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 1C8F71FAC47DD54E	FASTA	521	57,016
	10 20 30 40 50 60 MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN VLLLVHNLPL 70 80 90 100 110 120 ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI IYSNGSLLFQ MITMKDMGVY 130 140 150 160 170 180 TLDMTDENYR RTQATVRFHV HPILLKPNIT SNNSNPVEGD DSVSLTCDSY TDPDNINYLW 190 200 210 220 230 240 SRNGESLSEG DRLKLSEGNR TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD 250 260 270 280 290 300 TPIISPSDIY LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT 310 320 330 340 350 360 CFVNNSVTGL SRTTVKNITV LEPVTQPFLQ VTNTTVKELD SVTLTCLSND IGANIQWLFN 370 380 390 400 410 420 SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV SVRRSNSIKL DIIFDPTQGG 430 440 450 460 470 480 LSDGAIAGIV IGVVAGVALI AGLAYFLYSR KSGGGSDQRD LTEHKPSTSN HNLAPSDNSP 490 500 510 520 NKVDDVAYTV LNFNSQQPNR PTSAPSSPRA TETVYSEVKK K
	Isoform Short. Checksum: 63E0EC6AC58BA660	FASTA	458	50,057
	10 20 30 40 50 60 MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN VLLLVHNLPL 70 80 90 100 110 120 ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI IYSNGSLLFQ MITMKDMGVY 130 140 150 160 170 180 TLDMTDENYR RTQATVRFHV HPILLKPNIT SNNSNPVEGD DSVSLTCDSY TDPDNINYLW 190 200 210 220 230 240 SRNGESLSEG DRLKLSEGNR TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD 250 260 270 280 290 300 TPIISPSDIY LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT 310 320 330 340 350 360 CFVNNSVTGL SRTTVKNITV LEPVTQPFLQ VTNTTVKELD SVTLTCLSND IGANIQWLFN 370 380 390 400 410 420 SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV SVRRSNSIKL DIIFDPTQGG 430 440 450 LSDGAIAGIV IGVVAGVALI AGLAYFLYSR KSGGSGSF
	Isoform 3. Checksum: 0ABE851287A77290	FASTA	341	37,271
	10 20 30 40 50 60 MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN VLLLVHNLPL 70 80 90 100 110 120 ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI IYSNGSLLFQ MITMKDMGVY 130 140 150 160 170 180 TLDMTDENYR RTQATVRFHV HQPVTQPFLQ VTNTTVKELD SVTLTCLSND IGANIQWLFN 190 200 210 220 230 240 SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV SVRRSNSIKL DIIFDPTQGG 250 260 270 280 290 300 LSDGAIAGIV IGVVAGVALI AGLAYFLYSR KSGGGSDQRD LTEHKPSTSN HNLAPSDNSP 310 320 330 340 NKVDDVAYTV LNFNSQQPNR PTSAPSSPRA TETVYSEVKK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59." Dveksler G.S., Dieffenback C.B., Cardellichio C.B., McCuaig K., Pensiero M.N., Jiang G.-S., Beauchemin N., Holmes K.V. J. Virol. 67:1-8(1993) [PubMed: 8380065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH MHV SPIKE GLYCOPROTEIN. Strain: CD-1. Tissue: Colon.
[2]	"Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV." Dveksler G.S., Pensiero M.N., Cardellichio C.B., Williams R.K., Jiang G.-S., Holmes K.V., Dieffenbach C.W. J. Virol. 65:6881-6891(1991) [PubMed: 1719235] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), INTERACTION WITH MHV SPIKE GLYCOPROTEIN, CHARACTERIZATION OF MHV RECEPTOR FUNCTION. Strain: BALB/c and CD-1. Tissue: Colon and Liver.
[3]	"Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms." McCuaig K., Rosenberg M., Nedellec P., Turbide C., Beauchemin N. Gene 127:173-183(1993) [PubMed: 8500759] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND 3).
[4]	"A mouse analogue of the human carcinoembryonic antigen." Beauchemin N., Turbide C., Afar D., Raymond M., Bell J., Stanners C.P., Fuks A. Cancer Res. 49:2017-2021(1989) [PubMed: 2702644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Strain: CD-1. Tissue: Colon.
[5]	"Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins." Williams R.K., Jiang G.-S., Holmes K.V. Proc. Natl. Acad. Sci. U.S.A. 88:5533-5536(1991) [PubMed: 1648219] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-59.
[6]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 116-130, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[7]	"Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59." Hemmila E., Turbide C., Olson M., Jothy S., Holmes K.V., Beauchemin N. J. Virol. 78:10156-10165(2004) [PubMed: 15331748] [Abstract] Cited for: CHARACTERIZATION OF MHV RECEPTOR FUNCTION.
[8]	"Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res. 5:2438-2447(2006) [PubMed: 16944957] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-206, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family." Tan K., Zelus B.D., Meijers R., Liu J.-H., Bergelson J.M., Duke N., Zhang R., Joachimiak A., Holmes K.V., Wang J.-H. EMBO J. 21:2076-2086(2002) [PubMed: 11980704] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.32 ANGSTROMS) OF 35-236 (ISOFORM 3), GLYCOSYLATION AT ASN-71; ASN-89; ASN-104 AND ASN-333, DISULFIDE BOND, INTERACTION WITH MURINE CORONAVIRUS MHV S1 SPIKE GLYCOPROTEIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X15351 mRNA. Translation: CAA33409.1.
M77196 mRNA. Translation: AAA37858.1.
X67279 mRNA. Translation: CAA47696.1.
X67282 mRNA. Translation: CAA47699.1.

IPI

IPI00108535.
IPI00227804.
IPI00915472.

PIR

WMMSR1. JC1505.
JC1508.
JC1511.

RefSeq

NP_001034274.1.
NP_001034275.1.

UniGene

Mm.322502

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1L6Z	X-ray	3.32	A	35-416	[»]

ModBase

Search...

PTM databases

PhosphoSite

P31809.

Proteomic databases

PRIDE

P31809.

Genome annotation databases

Ensembl

ENSMUSG00000074272. Mus musculus. [Contig view]

GeneID

26365.

KEGG

mmu:26365.

Organism-specific databases

MGI

MGI:1347245. Ceacam1.

Phylogenomic databases

HOGENOM

P31809.

HOVERGEN

P31809.

Gene expression databases

ArrayExpress

P31809.

Bgee

P31809.

CleanEx

MM_CEACAM1.

GermOnline

ENSMUSG00000074272. Mus musculus.

Family and domain databases

InterPro

IPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 4 hits.

Pfam

PF00047. ig. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00408. IGc2. 3 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

304235.

SOURCE

Search...

Entry information

Entry name

CEAM1_MOUSE

Accession

Primary (citable) accession number: P31809
Secondary accession number(s): Q61353

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)