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Protein

Carcinoembryonic antigen-related cell adhesion molecule 1

Gene

Ceacam1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein.

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: UniProtKB
  • filamin binding Source: MGI
  • granulocyte colony-stimulating factor receptor binding Source: UniProtKB
  • kinase binding Source: MGI
  • protein dimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein phosphatase binding Source: MGI
  • protein tyrosine kinase binding Source: UniProtKB
  • Toll-like receptor binding Source: UniProtKB
  • virion binding Source: MGI
  • virus receptor activity Source: MGI

GO - Biological processi

  • bile acid and bile salt transport Source: UniProtKB
  • blood vessel development Source: UniProtKB
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: MGI
  • cell-cell junction organization Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • common myeloid progenitor cell proliferation Source: UniProtKB
  • granulocyte colony-stimulating factor signaling pathway Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  • insulin catabolic process Source: UniProtKB
  • insulin receptor internalization Source: UniProtKB
  • negative regulation by host of viral genome replication Source: MGI
  • negative regulation by host of viral process Source: MGI
  • negative regulation of bone resorption Source: MGI
  • negative regulation of cytokine production Source: MGI
  • negative regulation of cytotoxic T cell degranulation Source: UniProtKB
  • negative regulation of fatty acid biosynthetic process Source: UniProtKB
  • negative regulation of granulocyte differentiation Source: UniProtKB
  • negative regulation of hepatocyte proliferation Source: UniProtKB
  • negative regulation of interleukin-1 production Source: UniProtKB
  • negative regulation of interleukin-2 production Source: MGI
  • negative regulation of JNK cascade Source: MGI
  • negative regulation of lipid biosynthetic process Source: UniProtKB
  • negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: UniProtKB
  • negative regulation of osteoclast differentiation Source: MGI
  • negative regulation of platelet aggregation Source: UniProtKB
  • negative regulation of protein kinase activity Source: UniProtKB
  • negative regulation of T cell mediated cytotoxicity Source: UniProtKB
  • negative regulation of T cell proliferation Source: MGI
  • negative regulation of T cell receptor signaling pathway Source: UniProtKB
  • negative regulation of vascular permeability Source: UniProtKB
  • Peyer's patch development Source: MGI
  • positive regulation by host of viral process Source: MGI
  • positive regulation of activation-induced cell death of T cells Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell activation Source: MGI
  • positive regulation of CD4-positive, alpha-beta T cell proliferation Source: MGI
  • positive regulation of CD8-positive, alpha-beta T cell activation Source: MGI
  • positive regulation of immunoglobulin secretion Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • positive regulation of MAP kinase activity Source: MGI
  • positive regulation of NFAT protein import into nucleus Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of vasculogenesis Source: UniProtKB
  • regulation of blood vessel remodeling Source: UniProtKB
  • regulation of cell growth Source: UniProtKB
  • regulation of endothelial cell differentiation Source: UniProtKB
  • regulation of endothelial cell migration Source: UniProtKB
  • regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • regulation of homophilic cell adhesion Source: UniProtKB
  • regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • regulation of sprouting angiogenesis Source: UniProtKB
  • viral entry into host cell Source: MGI
  • wound healing, spreading of cells Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-MMU-1566977. Fibronectin matrix formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 1
Alternative name(s):
Biliary glycoprotein 1
Short name:
BGP-1
Biliary glycoprotein D
MHVR1
Murine hepatitis virus receptor
Short name:
MHV-R
CD_antigen: CD66a
Gene namesi
Name:Ceacam1
Synonyms:Bgp, Bgp1, Bgpd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347245. Ceacam1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 428394ExtracellularSequence analysisAdd
BLAST
Transmembranei429 – 44719HelicalSequence analysisAdd
BLAST
Topological domaini448 – 52174CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • brush border membrane Source: MGI
  • cell-cell junction Source: UniProtKB
  • cell junction Source: UniProtKB
  • cell surface Source: UniProtKB
  • ciliary membrane Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • integral component of membrane Source: MGI
  • lateral plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 521487Carcinoembryonic antigen-related cell adhesion molecule 1PRO_0000014563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)2 Publications
Glycosylationi89 – 891N-linked (GlcNAc...)2 Publications
Glycosylationi104 – 1041N-linked (GlcNAc...)1 Publication
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi167 ↔ 2171 Publication
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)1 Publication
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi261 ↔ 3011 Publication
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)1 Publication
Glycosylationi333 – 3331N-linked (GlcNAc...)2 Publications
Disulfide bondi346 ↔ 394PROSITE-ProRule annotation1 Publication
Glycosylationi375 – 3751N-linked (GlcNAc...)1 Publication
Glycosylationi376 – 3761N-linked (GlcNAc...); atypical1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP31809.
PaxDbiP31809.
PeptideAtlasiP31809.
PRIDEiP31809.

PTM databases

iPTMnetiP31809.
PhosphoSiteiP31809.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074272.
CleanExiMM_CEACAM1.
ExpressionAtlasiP31809. baseline and differential.
GenevisibleiP31809. MM.

Interactioni

Subunit structurei

Interacts with MHV S1 spike glycoprotein.3 Publications

GO - Molecular functioni

  • filamin binding Source: MGI
  • granulocyte colony-stimulating factor receptor binding Source: UniProtKB
  • kinase binding Source: MGI
  • protein dimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein phosphatase binding Source: MGI
  • protein tyrosine kinase binding Source: UniProtKB
  • Toll-like receptor binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-61461N.
IntActiP31809. 1 interaction.
MINTiMINT-4590618.
STRINGi10090.ENSMUSP00000096266.

Structurei

Secondary structure

1
521
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610Combined sources
Beta strandi51 – 566Combined sources
Beta strandi63 – 719Combined sources
Helixi75 – 773Combined sources
Beta strandi78 – 836Combined sources
Helixi84 – 863Combined sources
Beta strandi88 – 914Combined sources
Beta strandi97 – 1015Combined sources
Beta strandi107 – 1093Combined sources
Helixi114 – 1163Combined sources
Beta strandi118 – 1258Combined sources
Beta strandi130 – 14112Combined sources
Beta strandi328 – 3325Combined sources
Beta strandi334 – 3363Combined sources
Beta strandi342 – 3476Combined sources
Beta strandi354 – 3596Combined sources
Beta strandi368 – 3736Combined sources
Turni374 – 3774Combined sources
Beta strandi378 – 3836Combined sources
Helixi386 – 3883Combined sources
Beta strandi390 – 3978Combined sources
Beta strandi408 – 4103Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L6ZX-ray3.32A35-416[»]
3R4DX-ray3.10A/C35-416[»]
ProteinModelPortaliP31809.
SMRiP31809. Positions 35-417.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31809.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 142108Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini239 – 31981Ig-like C2-type 2Add
BLAST
Domaini323 – 41189Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31809.
KOiK06499.
PhylomeDBiP31809.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P31809-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELASAHLHK GQVPWGGLLL TASLLASWSP ATTAEVTIEA VPPQVAEDNN
60 70 80 90 100
VLLLVHNLPL ALGAFAWYKG NTTAIDKEIA RFVPNSNMNF TGQAYSGREI
110 120 130 140 150
IYSNGSLLFQ MITMKDMGVY TLDMTDENYR RTQATVRFHV HPILLKPNIT
160 170 180 190 200
SNNSNPVEGD DSVSLTCDSY TDPDNINYLW SRNGESLSEG DRLKLSEGNR
210 220 230 240 250
TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD TPIISPSDIY
260 270 280 290 300
LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT
310 320 330 340 350
CFVNNSVTGL SRTTVKNITV LEPVTQPFLQ VTNTTVKELD SVTLTCLSND
360 370 380 390 400
IGANIQWLFN SQSLQLTERM TLSQNNSILR IDPIKREDAG EYQCEISNPV
410 420 430 440 450
SVRRSNSIKL DIIFDPTQGG LSDGAIAGIV IGVVAGVALI AGLAYFLYSR
460 470 480 490 500
KSGGGSDQRD LTEHKPSTSN HNLAPSDNSP NKVDDVAYTV LNFNSQQPNR
510 520
PTSAPSSPRA TETVYSEVKK K
Length:521
Mass (Da):57,016
Last modified:July 1, 1993 - v1
Checksum:i1C8F71FAC47DD54E
GO
Isoform Short (identifier: P31809-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-458: GSDQ → SGSF
     459-521: Missing.

Show »
Length:458
Mass (Da):50,057
Checksum:i63E0EC6AC58BA660
GO
Isoform 3 (identifier: P31809-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-142: P → Q
     143-322: Missing.

Note: Glycosylated at Asn-153.
Show »
Length:341
Mass (Da):37,271
Checksum:i0ABE851287A77290
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3622SQ → RE in CAA47699 (PubMed:8500759).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 1421P → Q in isoform 3. 1 PublicationVSP_036040
Alternative sequencei143 – 322180Missing in isoform 3. 1 PublicationVSP_036041Add
BLAST
Alternative sequencei455 – 4584GSDQ → SGSF in isoform Short. 2 PublicationsVSP_002484
Alternative sequencei459 – 52163Missing in isoform Short. 2 PublicationsVSP_002485Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15351 mRNA. Translation: CAA33409.1.
M77196 mRNA. Translation: AAA37858.1.
X67279 mRNA. Translation: CAA47696.1.
X67282 mRNA. Translation: CAA47699.1.
CCDSiCCDS20984.1. [P31809-1]
CCDS20985.1. [P31809-3]
CCDS39839.1. [P31809-2]
PIRiJC1505. WMMSR1.
JC1508.
JC1511.
RefSeqiNP_001034274.1. NM_001039185.1.
NP_001034275.1. NM_001039186.1. [P31809-2]
UniGeneiMm.322502.
Mm.439731.

Genome annotation databases

EnsembliENSMUST00000098666; ENSMUSP00000096263; ENSMUSG00000074272. [P31809-2]
ENSMUST00000206171; ENSMUSP00000145584; ENSMUSG00000074272. [P31809-2]
GeneIDi26365.
KEGGimmu:26365.
UCSCiuc009fsv.1. mouse. [P31809-2]
uc009fta.1. mouse. [P31809-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15351 mRNA. Translation: CAA33409.1.
M77196 mRNA. Translation: AAA37858.1.
X67279 mRNA. Translation: CAA47696.1.
X67282 mRNA. Translation: CAA47699.1.
CCDSiCCDS20984.1. [P31809-1]
CCDS20985.1. [P31809-3]
CCDS39839.1. [P31809-2]
PIRiJC1505. WMMSR1.
JC1508.
JC1511.
RefSeqiNP_001034274.1. NM_001039185.1.
NP_001034275.1. NM_001039186.1. [P31809-2]
UniGeneiMm.322502.
Mm.439731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L6ZX-ray3.32A35-416[»]
3R4DX-ray3.10A/C35-416[»]
ProteinModelPortaliP31809.
SMRiP31809. Positions 35-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61461N.
IntActiP31809. 1 interaction.
MINTiMINT-4590618.
STRINGi10090.ENSMUSP00000096266.

PTM databases

iPTMnetiP31809.
PhosphoSiteiP31809.

Proteomic databases

MaxQBiP31809.
PaxDbiP31809.
PeptideAtlasiP31809.
PRIDEiP31809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098666; ENSMUSP00000096263; ENSMUSG00000074272. [P31809-2]
ENSMUST00000206171; ENSMUSP00000145584; ENSMUSG00000074272. [P31809-2]
GeneIDi26365.
KEGGimmu:26365.
UCSCiuc009fsv.1. mouse. [P31809-2]
uc009fta.1. mouse. [P31809-1]

Organism-specific databases

CTDi634.
MGIiMGI:1347245. Ceacam1.

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31809.
KOiK06499.
PhylomeDBiP31809.

Enzyme and pathway databases

ReactomeiR-MMU-1566977. Fibronectin matrix formation.
R-MMU-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP31809.
PROiP31809.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074272.
CleanExiMM_CEACAM1.
ExpressionAtlasiP31809. baseline and differential.
GenevisibleiP31809. MM.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM1_MOUSE
AccessioniPrimary (citable) accession number: P31809
Secondary accession number(s): Q61353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.