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Protein

Uncharacterized oxidoreductase YciK

Gene

yciK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152SubstrateBy similarity1
Active sitei165Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 40NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:EG11759-MONOMER.
ECOL316407:JW1263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase YciK (EC:1.-.-.-)
Gene namesi
Name:yciK
Ordered Locus Names:b1271, JW1263
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11759. yciK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548241 – 252Uncharacterized oxidoreductase YciKAdd BLAST252

Proteomic databases

EPDiP31808.
PaxDbiP31808.
PRIDEiP31808.

Interactioni

Protein-protein interaction databases

BioGridi4259576. 44 interactors.
IntActiP31808. 6 interactors.
STRINGi511145.b1271.

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni7 – 12Combined sources6
Beta strandi14 – 19Combined sources6
Helixi23 – 34Combined sources12
Beta strandi38 – 44Combined sources7
Helixi46 – 60Combined sources15
Beta strandi65 – 68Combined sources4
Turni71 – 73Combined sources3
Helixi76 – 89Combined sources14
Beta strandi94 – 98Combined sources5
Turni109 – 111Combined sources3
Helixi114 – 124Combined sources11
Helixi126 – 140Combined sources15
Beta strandi142 – 144Combined sources3
Beta strandi146 – 150Combined sources5
Helixi153 – 155Combined sources3
Helixi163 – 182Combined sources20
Turni183 – 186Combined sources4
Beta strandi188 – 193Combined sources6
Beta strandi196 – 199Combined sources4
Helixi200 – 205Combined sources6
Beta strandi207 – 209Combined sources3
Helixi211 – 213Combined sources3
Helixi218 – 220Combined sources3
Helixi221 – 228Combined sources8
Helixi230 – 232Combined sources3
Beta strandi239 – 243Combined sources5
Beta strandi248 – 250Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E9QX-ray1.70A/B1-252[»]
3F1KX-ray2.60A1-252[»]
3F1LX-ray0.95A/B1-252[»]
ProteinModelPortaliP31808.
SMRiP31808.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31808.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105UBK. Bacteria.
COG1028. LUCA.
InParanoidiP31808.
OMAiLAHEYED.
PhylomeDBiP31808.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYQPKQDLL NDRIILVTGA SDGIGREAAM TYARYGATVI LLGRNEEKLR
60 70 80 90 100
QVASHINEET GRQPQWFILD LLTCTSENCQ QLAQRIAVNY PRLDGVLHNA
110 120 130 140 150
GLLGDVCPMS EQNPQVWQDV MQVNVNATFM LTQALLPLLL KSDAGSLVFT
160 170 180 190 200
SSSVGRQGRA NWGAYAASKF ATEGMMQVLA DEYQQRLRVN CINPGGTRTA
210 220 230 240 250
MRASAFPTED PQKLKTPADI MPLYLWLMGD DSRRKTGMTF DAQPGRKPGI

SQ
Length:252
Mass (Da):27,933
Last modified:November 1, 1997 - v3
Checksum:i4F7D860BF8840F7A
GO

Sequence cautioni

The sequence AAB59991 differs from that shown. Reason: Frameshift at position 115.Curated
The sequence AAB59992 differs from that shown. Reason: Frameshift at position 115.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63Q → P (PubMed:1885549).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74353.1.
AP009048 Genomic DNA. Translation: BAA14808.1.
U17433 Genomic DNA. Translation: AAB59992.1. Frameshift.
U17433 Genomic DNA. Translation: AAB59991.1. Frameshift.
M73320 Genomic DNA. No translation available.
PIRiB64875.
RefSeqiNP_415787.1. NC_000913.3.
WP_000559286.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74353; AAC74353; b1271.
BAA14808; BAA14808; BAA14808.
GeneIDi945838.
KEGGiecj:JW1263.
eco:b1271.
PATRICi32117800. VBIEscCol129921_1320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74353.1.
AP009048 Genomic DNA. Translation: BAA14808.1.
U17433 Genomic DNA. Translation: AAB59992.1. Frameshift.
U17433 Genomic DNA. Translation: AAB59991.1. Frameshift.
M73320 Genomic DNA. No translation available.
PIRiB64875.
RefSeqiNP_415787.1. NC_000913.3.
WP_000559286.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E9QX-ray1.70A/B1-252[»]
3F1KX-ray2.60A1-252[»]
3F1LX-ray0.95A/B1-252[»]
ProteinModelPortaliP31808.
SMRiP31808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259576. 44 interactors.
IntActiP31808. 6 interactors.
STRINGi511145.b1271.

Proteomic databases

EPDiP31808.
PaxDbiP31808.
PRIDEiP31808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74353; AAC74353; b1271.
BAA14808; BAA14808; BAA14808.
GeneIDi945838.
KEGGiecj:JW1263.
eco:b1271.
PATRICi32117800. VBIEscCol129921_1320.

Organism-specific databases

EchoBASEiEB1709.
EcoGeneiEG11759. yciK.

Phylogenomic databases

eggNOGiENOG4105UBK. Bacteria.
COG1028. LUCA.
InParanoidiP31808.
OMAiLAHEYED.
PhylomeDBiP31808.

Enzyme and pathway databases

BioCyciEcoCyc:EG11759-MONOMER.
ECOL316407:JW1263-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP31808.
PROiP31808.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYCIK_ECOLI
AccessioniPrimary (citable) accession number: P31808
Secondary accession number(s): P77516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.