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Protein

Uncharacterized oxidoreductase YciK

Gene

yciK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521SubstrateBy similarity
Active sitei165 – 1651Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 4025NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:EG11759-MONOMER.
ECOL316407:JW1263-MONOMER.
RETL1328306-WGS:GSTH-1439-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase YciK (EC:1.-.-.-)
Gene namesi
Name:yciK
Ordered Locus Names:b1271, JW1263
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11759. yciK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Uncharacterized oxidoreductase YciKPRO_0000054824Add
BLAST

Proteomic databases

EPDiP31808.
PaxDbiP31808.
PRIDEiP31808.

Interactioni

Protein-protein interaction databases

BioGridi4259576. 44 interactions.
IntActiP31808. 6 interactions.
STRINGi511145.b1271.

Structurei

Secondary structure

1
252
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 126Combined sources
Beta strandi14 – 196Combined sources
Helixi23 – 3412Combined sources
Beta strandi38 – 447Combined sources
Helixi46 – 6015Combined sources
Beta strandi65 – 684Combined sources
Turni71 – 733Combined sources
Helixi76 – 8914Combined sources
Beta strandi94 – 985Combined sources
Turni109 – 1113Combined sources
Helixi114 – 12411Combined sources
Helixi126 – 14015Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi146 – 1505Combined sources
Helixi153 – 1553Combined sources
Helixi163 – 18220Combined sources
Turni183 – 1864Combined sources
Beta strandi188 – 1936Combined sources
Beta strandi196 – 1994Combined sources
Helixi200 – 2056Combined sources
Beta strandi207 – 2093Combined sources
Helixi211 – 2133Combined sources
Helixi218 – 2203Combined sources
Helixi221 – 2288Combined sources
Helixi230 – 2323Combined sources
Beta strandi239 – 2435Combined sources
Beta strandi248 – 2503Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E9QX-ray1.70A/B1-252[»]
3F1KX-ray2.60A1-252[»]
3F1LX-ray0.95A/B1-252[»]
ProteinModelPortaliP31808.
SMRiP31808. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31808.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105UBK. Bacteria.
COG1028. LUCA.
InParanoidiP31808.
OMAiDDIMQIN.
OrthoDBiEOG6N3CR8.
PhylomeDBiP31808.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYQPKQDLL NDRIILVTGA SDGIGREAAM TYARYGATVI LLGRNEEKLR
60 70 80 90 100
QVASHINEET GRQPQWFILD LLTCTSENCQ QLAQRIAVNY PRLDGVLHNA
110 120 130 140 150
GLLGDVCPMS EQNPQVWQDV MQVNVNATFM LTQALLPLLL KSDAGSLVFT
160 170 180 190 200
SSSVGRQGRA NWGAYAASKF ATEGMMQVLA DEYQQRLRVN CINPGGTRTA
210 220 230 240 250
MRASAFPTED PQKLKTPADI MPLYLWLMGD DSRRKTGMTF DAQPGRKPGI

SQ
Length:252
Mass (Da):27,933
Last modified:November 1, 1997 - v3
Checksum:i4F7D860BF8840F7A
GO

Sequence cautioni

The sequence AAB59991.1 differs from that shown. Reason: Frameshift at position 115. Curated
The sequence AAB59992.1 differs from that shown. Reason: Frameshift at position 115. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631Q → P (PubMed:1885549).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74353.1.
AP009048 Genomic DNA. Translation: BAA14808.1.
U17433 Genomic DNA. Translation: AAB59992.1. Frameshift.
U17433 Genomic DNA. Translation: AAB59991.1. Frameshift.
M73320 Genomic DNA. No translation available.
PIRiB64875.
RefSeqiNP_415787.1. NC_000913.3.
WP_000559286.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74353; AAC74353; b1271.
BAA14808; BAA14808; BAA14808.
GeneIDi945838.
KEGGiecj:JW1263.
eco:b1271.
PATRICi32117800. VBIEscCol129921_1320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74353.1.
AP009048 Genomic DNA. Translation: BAA14808.1.
U17433 Genomic DNA. Translation: AAB59992.1. Frameshift.
U17433 Genomic DNA. Translation: AAB59991.1. Frameshift.
M73320 Genomic DNA. No translation available.
PIRiB64875.
RefSeqiNP_415787.1. NC_000913.3.
WP_000559286.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E9QX-ray1.70A/B1-252[»]
3F1KX-ray2.60A1-252[»]
3F1LX-ray0.95A/B1-252[»]
ProteinModelPortaliP31808.
SMRiP31808. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259576. 44 interactions.
IntActiP31808. 6 interactions.
STRINGi511145.b1271.

Proteomic databases

EPDiP31808.
PaxDbiP31808.
PRIDEiP31808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74353; AAC74353; b1271.
BAA14808; BAA14808; BAA14808.
GeneIDi945838.
KEGGiecj:JW1263.
eco:b1271.
PATRICi32117800. VBIEscCol129921_1320.

Organism-specific databases

EchoBASEiEB1709.
EcoGeneiEG11759. yciK.

Phylogenomic databases

eggNOGiENOG4105UBK. Bacteria.
COG1028. LUCA.
InParanoidiP31808.
OMAiDDIMQIN.
OrthoDBiEOG6N3CR8.
PhylomeDBiP31808.

Enzyme and pathway databases

BioCyciEcoCyc:EG11759-MONOMER.
ECOL316407:JW1263-MONOMER.
RETL1328306-WGS:GSTH-1439-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP31808.
PROiP31808.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Milkman R., McKane M.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Identification of the Escherichia coli sohB gene, a multicopy suppressor of the HtrA (DegP) null phenotype."
    Baird L., Lipinska B., Raina S., Georgopoulos C.
    J. Bacteriol. 173:5763-5770(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.

Entry informationi

Entry nameiYCIK_ECOLI
AccessioniPrimary (citable) accession number: P31808
Secondary accession number(s): P77516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.