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Protein

Nitrate/nitrite response regulator protein NarP

Gene

narP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi171 – 190H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processNitrate assimilation, Transcription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:NARP-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrate/nitrite response regulator protein NarP
Gene namesi
Name:narP
Ordered Locus Names:b2193, JW2181
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11527 narP

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811491 – 215Nitrate/nitrite response regulator protein NarPAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP31802
PRIDEiP31802

PTM databases

iPTMnetiP31802

Interactioni

Protein-protein interaction databases

BioGridi4263485, 18 interactors
DIPiDIP-10317N
IntActiP31802, 5 interactors
STRINGi316385.ECDH10B_2350

Structurei

3D structure databases

ProteinModelPortaliP31802
SMRiP31802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 124Response regulatoryPROSITE-ProRule annotationAdd BLAST117
Domaini147 – 212HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4105WH1 Bacteria
COG2197 LUCA
HOGENOMiHOG000034813
InParanoidiP31802
KOiK07685
OMAiDICIMDI
PhylomeDBiP31802

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
cd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR000792 Tscrpt_reg_LuxR_C
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PF00072 Response_reg, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P31802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEATPFQVM IVDDHPLMRR GVRQLLELDP GSEVVAEAGD GASAIDLANR
60 70 80 90 100
LDIDVILLDL NMKGMSGLDT LNALRRDGVT AQIIILTVSD ASSDVFALID
110 120 130 140 150
AGADGYLLKD SDPEVLLEAI RAGAKGSKVF SERVNQYLRE REMFGAEEDP
160 170 180 190 200
FSVLTERELD VLHELAQGLS NKQIASVLNI SEQTVKVHIR NLLRKLNVRS
210
RVAATILFLQ QRGAQ
Length:215
Mass (Da):23,575
Last modified:July 1, 1993 - v1
Checksum:iC7121668E3130956
GO

Sequence cautioni

The sequence AAA16411 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11273 Genomic DNA Translation: AAA24200.1
U00008 Genomic DNA Translation: AAA16411.1 Different initiation.
U00096 Genomic DNA Translation: AAC75253.1
AP009048 Genomic DNA Translation: BAE76656.1
PIRiA40584
RefSeqiNP_416697.1, NC_000913.3
WP_001113639.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75253; AAC75253; b2193
BAE76656; BAE76656; BAE76656
GeneIDi949081
KEGGiecj:JW2181
eco:b2193
PATRICifig|1411691.4.peg.43

Similar proteinsi

Entry informationi

Entry nameiNARP_ECOLI
AccessioniPrimary (citable) accession number: P31802
Secondary accession number(s): Q2MAQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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