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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

UQCRC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Protein family/group databases

MEROPSiM16.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:UQCRC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000002678535 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei163N6-acetyllysine; alternateBy similarity1
Modified residuei163N6-succinyllysine; alternateBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei248N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP31800.
PeptideAtlasiP31800.
PRIDEiP31800.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

DIPiDIP-1105N.
IntActiP31800. 3 interactors.
MINTiMINT-149960.
STRINGi9913.ENSBTAP00000025422.

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 42Combined sources5
Beta strandi49 – 52Combined sources4
Beta strandi54 – 56Combined sources3
Beta strandi58 – 63Combined sources6
Beta strandi67 – 76Combined sources10
Helixi79 – 81Combined sources3
Turni84 – 88Combined sources5
Helixi89 – 96Combined sources8
Beta strandi97 – 99Combined sources3
Beta strandi101 – 104Combined sources4
Turni105 – 107Combined sources3
Helixi108 – 115Combined sources8
Beta strandi119 – 124Combined sources6
Beta strandi129 – 136Combined sources8
Helixi137 – 139Combined sources3
Helixi140 – 153Combined sources14
Helixi158 – 175Combined sources18
Helixi179 – 191Combined sources13
Turni192 – 194Combined sources3
Helixi196 – 198Combined sources3
Helixi205 – 210Combined sources6
Helixi213 – 223Combined sources11
Helixi226 – 228Combined sources3
Beta strandi229 – 236Combined sources8
Helixi239 – 250Combined sources12
Beta strandi252 – 256Combined sources5
Beta strandi259 – 261Combined sources3
Beta strandi273 – 279Combined sources7
Beta strandi282 – 293Combined sources12
Helixi301 – 311Combined sources11
Beta strandi313 – 315Combined sources3
Helixi321 – 323Combined sources3
Helixi327 – 335Combined sources9
Beta strandi339 – 347Combined sources9
Beta strandi352 – 360Combined sources9
Helixi362 – 364Combined sources3
Helixi365 – 382Combined sources18
Helixi385 – 402Combined sources18
Helixi406 – 419Combined sources14
Helixi426 – 434Combined sources9
Helixi438 – 448Combined sources11
Turni449 – 451Combined sources3
Beta strandi455 – 461Combined sources7
Helixi462 – 464Combined sources3
Helixi468 – 473Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16A35-480[»]
1BE3X-ray3.00A35-480[»]
1BGYX-ray3.00A/M35-480[»]
1L0LX-ray2.35A35-480[»]
1L0NX-ray2.60A35-480[»]
1NTKX-ray2.60A35-480[»]
1NTMX-ray2.40A35-480[»]
1NTZX-ray2.60A35-480[»]
1NU1X-ray3.20A35-480[»]
1PP9X-ray2.10A/N35-480[»]
1PPJX-ray2.10A/N35-480[»]
1QCRX-ray2.70A35-480[»]
1SQBX-ray2.69A1-480[»]
1SQPX-ray2.70A1-480[»]
1SQQX-ray3.00A35-480[»]
1SQVX-ray2.85A35-480[»]
1SQXX-ray2.60A35-480[»]
2A06X-ray2.10A/N35-480[»]
2BCCX-ray3.50A35-480[»]
2FYUX-ray2.26A35-480[»]
2YBBelectron microscopy19.00A/a35-480[»]
3BCCX-ray3.70A35-480[»]
4D6TX-ray3.57A/N1-480[»]
4D6UX-ray4.09A1-480[»]
N1-480[»]
5KLVX-ray2.65A35-480[»]
ProteinModelPortaliP31800.
SMRiP31800.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31800.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiP31800.
KOiK00414.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAVCRAA GAGTRVLLRT RRSPALLRSS DLRGTATYAQ ALQSVPETQV
60 70 80 90 100
SQLDNGLRVA SEQSSQPTCT VGVWIDAGSR YESEKNNGAG YFVEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLADI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILQ ELQENDTSMR DVVFNYLHAT AFQGTPLAQS
210 220 230 240 250
VEGPSENVRK LSRADLTEYL SRHYKAPRMV LAAAGGLEHR QLLDLAQKHF
260 270 280 290 300
SGLSGTYDED AVPTLSPCRF TGSQICHRED GLPLAHVAIA VEGPGWAHPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GAHLSSPLAS IAATNKLCQS FQTFNICYAD
360 370 380 390 400
TGLLGAHFVC DHMSIDDMMF VLQGQWMRLC TSATESEVLR GKNLLRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDARV VREVCSKYFY
460 470 480
DQCPAVAGFG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,736
Last modified:December 1, 2000 - v2
Checksum:i4E54DD28C1905392
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59692 mRNA. Translation: CAA42213.1.
PIRiS16220. ZPBOC1.
RefSeqiNP_777054.1. NM_174629.2.
UniGeneiBt.23164.

Genome annotation databases

GeneIDi282393.
KEGGibta:282393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59692 mRNA. Translation: CAA42213.1.
PIRiS16220. ZPBOC1.
RefSeqiNP_777054.1. NM_174629.2.
UniGeneiBt.23164.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16A35-480[»]
1BE3X-ray3.00A35-480[»]
1BGYX-ray3.00A/M35-480[»]
1L0LX-ray2.35A35-480[»]
1L0NX-ray2.60A35-480[»]
1NTKX-ray2.60A35-480[»]
1NTMX-ray2.40A35-480[»]
1NTZX-ray2.60A35-480[»]
1NU1X-ray3.20A35-480[»]
1PP9X-ray2.10A/N35-480[»]
1PPJX-ray2.10A/N35-480[»]
1QCRX-ray2.70A35-480[»]
1SQBX-ray2.69A1-480[»]
1SQPX-ray2.70A1-480[»]
1SQQX-ray3.00A35-480[»]
1SQVX-ray2.85A35-480[»]
1SQXX-ray2.60A35-480[»]
2A06X-ray2.10A/N35-480[»]
2BCCX-ray3.50A35-480[»]
2FYUX-ray2.26A35-480[»]
2YBBelectron microscopy19.00A/a35-480[»]
3BCCX-ray3.70A35-480[»]
4D6TX-ray3.57A/N1-480[»]
4D6UX-ray4.09A1-480[»]
N1-480[»]
5KLVX-ray2.65A35-480[»]
ProteinModelPortaliP31800.
SMRiP31800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-1105N.
IntActiP31800. 3 interactors.
MINTiMINT-149960.
STRINGi9913.ENSBTAP00000025422.

Protein family/group databases

MEROPSiM16.973.

Proteomic databases

PaxDbiP31800.
PeptideAtlasiP31800.
PRIDEiP31800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282393.
KEGGibta:282393.

Organism-specific databases

CTDi7384.

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiP31800.
KOiK00414.

Miscellaneous databases

EvolutionaryTraceiP31800.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR1_BOVIN
AccessioniPrimary (citable) accession number: P31800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.