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P31793

- ENV_FRSFB

UniProt

P31793 - ENV_FRSFB

Protein

Glycoprotein 42

Gene

env

Organism
Friend spleen focus-forming virus (strain BB6) (FSFFV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    This envelope-like membrane glycoprotein is responsible for ligand-independent activation of the erythropoietin receptor EPOR leading to the abnormally rapid proliferation of erythroid precursor cells. In the first stage of Friend disease, constitutive activation of the EPOR by gp42 causes uncontrolled, polyclonal proliferation of infected erythroblasts, leading to polycythemia (massive increase in the number of mature red cells). Host susceptibility to SSFV-induced erythroblastosis usually depends on the expression of the truncated isoform of MST1R receptor tyrosine kinase (MST1R isoform sf-Stk), but the deletion mutant BB6 apparently can overcome its absence.

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycoprotein 42
    Short name:
    gp42
    Gene namesi
    Name:env
    OrganismiFriend spleen focus-forming virus (strain BB6) (FSFFV)
    Taxonomic identifieri31692 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Subcellular locationi

    Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Virion membrane; Single-pass type I membrane protein
    Note: The envelope-like membrane glycoprotein gp55 is defective in its transport to the cell surface and remains associated predominantly with the rough endoplasmic reticulum (RER) membrane. It is almost not incorporated into virions. Host cell surface expression appears to be a prerequisite for its leukemogenicity By similarity.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral capsid Source: InterPro
    5. viral envelope Source: UniProtKB-KW
    6. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane, Viral envelope protein, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 356324Glycoprotein 42PRO_0000040722Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi58 – 581N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi328 – 3281N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homooligomer. Forms heterooligomers with mouse EPOR, probably via their respective transmembrane domains. BB6 deletion mutant does not interact with mouse MST1R isoform sf-Stk.

    Structurei

    3D structure databases

    ProteinModelPortaliP31793.
    SMRiP31793. Positions 38-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 331299Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini353 – 3564IntravirionSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi306 – 3094CXXC

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi229 – 27850Pro-richAdd
    BLAST

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.90.310.10. 1 hit.
    InterProiIPR008981. FMuLV_rcpt-bd.
    IPR018154. TLV/ENV_coat_polyprotein.
    [Graphical view]
    PANTHERiPTHR10424. PTHR10424. 1 hit.
    PfamiPF00429. TLV_coat. 2 hits.
    [Graphical view]
    SUPFAMiSSF49830. SSF49830. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31793-1 [UniParc]FASTAAdd to Basket

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    MEGPAFSKPL KDKINPWGPL IVLGILIRAG VSVQRDSPHQ VFNVTWRVTN    50
    LMTGQTANAT SLLGTMTDAF PKLYFDLCDL IGNDWDETRL GCRTPGEGKR 100
    ARTFDLYVCP GHTVPTGCGG PREGYCGKWG CETTGQAYWK PSSSWDLISL 150
    KRGNTPKDRG PCYDSSVSSG VQGATPGGRC NPLVLKFTDA GKKASWDAPK 200
    VWGLRLYRST GTDPVTRFSL TRQVLNIGPR VPIGPNPVIS DQLPPSRPAQ 250
    IMLPRPPQPP PPGTASIVPE TAPPSQQPGT RDRLLNLVNK AYQALNLTSP 300
    DKTQECWLCL VSRPPYYEGV AVLGTNSNHT TLISTIMGLL IILLLLLILL 350
    LWTLHS 356
    Length:356
    Mass (Da):38,778
    Last modified:July 1, 1993 - v1
    Checksum:i0C7893BE2794F980
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90673 Genomic DNA. No translation available.
    PIRiA41995. VCVWB6.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M90673 Genomic DNA. No translation available.
    PIRi A41995. VCVWB6.

    3D structure databases

    ProteinModelPortali P31793.
    SMRi P31793. Positions 38-229.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.310.10. 1 hit.
    InterProi IPR008981. FMuLV_rcpt-bd.
    IPR018154. TLV/ENV_coat_polyprotein.
    [Graphical view ]
    PANTHERi PTHR10424. PTHR10424. 1 hit.
    Pfami PF00429. TLV_coat. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49830. SSF49830. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia."
      Majumdar M.K., Cho C.L., Fox M.T., Eckner K.L., Kozak S., Kabat D., Geib R.W.
      J. Virol. 66:3652-3660(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiENV_FRSFB
    AccessioniPrimary (citable) accession number: P31793
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Compared to other gammaretroviruses which possess 2 envelope proteins (gp70 and p15E), FSFFV gp55 corresponds to a gp70-p15E fusion protein with a deletion of a portion of p15E. It is encoded by the defective env gene of the virus. Strain BB6 gp42 is a truncated form of gp55.
    The Friend murine leukemia virus complex induces a rapid and fatal erythroleukemia in adult mice. It is the replication-defective spleen focus-forming virus (SFFV) contained in this complex that causes foci of proliferating erythroid cells in spleens of infected mice. The second component is a replication competent Friend murine leukemia virus (F-MuLV) that serves as a helper virus for SFFV.

    External Data

    Dasty 3