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P31793

- ENV_FRSFB

UniProt

P31793 - ENV_FRSFB

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Protein

Glycoprotein 42

Gene
env
Organism
Friend spleen focus-forming virus (strain BB6) (FSFFV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

This envelope-like membrane glycoprotein is responsible for ligand-independent activation of the erythropoietin receptor EPOR leading to the abnormally rapid proliferation of erythroid precursor cells. In the first stage of Friend disease, constitutive activation of the EPOR by gp42 causes uncontrolled, polyclonal proliferation of infected erythroblasts, leading to polycythemia (massive increase in the number of mature red cells). Host susceptibility to SSFV-induced erythroblastosis usually depends on the expression of the truncated isoform of MST1R receptor tyrosine kinase (MST1R isoform sf-Stk), but the deletion mutant BB6 apparently can overcome its absence.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host plasma membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein 42
Short name:
gp42
Gene namesi
Name:env
OrganismiFriend spleen focus-forming virus (strain BB6) (FSFFV)
Taxonomic identifieri31692 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Virion membrane; Single-pass type I membrane protein
Note: The envelope-like membrane glycoprotein gp55 is defective in its transport to the cell surface and remains associated predominantly with the rough endoplasmic reticulum (RER) membrane. It is almost not incorporated into virions. Host cell surface expression appears to be a prerequisite for its leukemogenicity By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 331299Virion surface Reviewed predictionAdd
BLAST
Transmembranei332 – 35221Helical; Reviewed predictionAdd
BLAST
Topological domaini353 – 3564Intravirion Reviewed prediction

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral capsid Source: InterPro
  5. viral envelope Source: UniProtKB-KW
  6. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed predictionAdd
BLAST
Chaini33 – 356324Glycoprotein 42PRO_0000040722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi328 – 3281N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homooligomer. Forms heterooligomers with mouse EPOR, probably via their respective transmembrane domains. BB6 deletion mutant does not interact with mouse MST1R isoform sf-Stk.

Structurei

3D structure databases

ProteinModelPortaliP31793.
SMRiP31793. Positions 38-229.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi306 – 3094CXXC

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi229 – 27850Pro-richAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.90.310.10. 1 hit.
InterProiIPR008981. FMuLV_rcpt-bd.
IPR018154. TLV/ENV_coat_polyprotein.
[Graphical view]
PANTHERiPTHR10424. PTHR10424. 1 hit.
PfamiPF00429. TLV_coat. 2 hits.
[Graphical view]
SUPFAMiSSF49830. SSF49830. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31793-1 [UniParc]FASTAAdd to Basket

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MEGPAFSKPL KDKINPWGPL IVLGILIRAG VSVQRDSPHQ VFNVTWRVTN    50
LMTGQTANAT SLLGTMTDAF PKLYFDLCDL IGNDWDETRL GCRTPGEGKR 100
ARTFDLYVCP GHTVPTGCGG PREGYCGKWG CETTGQAYWK PSSSWDLISL 150
KRGNTPKDRG PCYDSSVSSG VQGATPGGRC NPLVLKFTDA GKKASWDAPK 200
VWGLRLYRST GTDPVTRFSL TRQVLNIGPR VPIGPNPVIS DQLPPSRPAQ 250
IMLPRPPQPP PPGTASIVPE TAPPSQQPGT RDRLLNLVNK AYQALNLTSP 300
DKTQECWLCL VSRPPYYEGV AVLGTNSNHT TLISTIMGLL IILLLLLILL 350
LWTLHS 356
Length:356
Mass (Da):38,778
Last modified:July 1, 1993 - v1
Checksum:i0C7893BE2794F980
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M90673 Genomic DNA. No translation available.
PIRiA41995. VCVWB6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M90673 Genomic DNA. No translation available.
PIRi A41995. VCVWB6.

3D structure databases

ProteinModelPortali P31793.
SMRi P31793. Positions 38-229.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.310.10. 1 hit.
InterProi IPR008981. FMuLV_rcpt-bd.
IPR018154. TLV/ENV_coat_polyprotein.
[Graphical view ]
PANTHERi PTHR10424. PTHR10424. 1 hit.
Pfami PF00429. TLV_coat. 2 hits.
[Graphical view ]
SUPFAMi SSF49830. SSF49830. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia."
    Majumdar M.K., Cho C.L., Fox M.T., Eckner K.L., Kozak S., Kabat D., Geib R.W.
    J. Virol. 66:3652-3660(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiENV_FRSFB
AccessioniPrimary (citable) accession number: P31793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Compared to other gammaretroviruses which possess 2 envelope proteins (gp70 and p15E), FSFFV gp55 corresponds to a gp70-p15E fusion protein with a deletion of a portion of p15E. It is encoded by the defective env gene of the virus. Strain BB6 gp42 is a truncated form of gp55.
The Friend murine leukemia virus complex induces a rapid and fatal erythroleukemia in adult mice. It is the replication-defective spleen focus-forming virus (SFFV) contained in this complex that causes foci of proliferating erythroid cells in spleens of infected mice. The second component is a replication competent Friend murine leukemia virus (F-MuLV) that serves as a helper virus for SFFV.

External Data

Dasty 3

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