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Protein

Acyl-CoA-binding protein

Gene

ACB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511Acyl-CoABy similarity
Binding sitei55 – 551Acyl-CoABy similarity
Binding sitei74 – 741Acyl-CoABy similarity

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: SGD
  • lipid binding Source: UniProtKB-KW
  • long-chain fatty acid transporter activity Source: SGD

GO - Biological processi

  • chronological cell aging Source: SGD
  • long-chain fatty acid transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30758-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Gene namesi
Name:ACB1
Synonyms:ACB
Ordered Locus Names:YGR037C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR037C.
SGDiS000003269. ACB1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Acyl-CoA-binding proteinPRO_0000214013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki51 – 51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki72 – 72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP31787.

Interactioni

Protein-protein interaction databases

BioGridi33282. 63 interactions.
IntActiP31787. 17 interactions.
MINTiMINT-2788579.

Structurei

Secondary structure

1
87
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311Combined sources
Helixi22 – 3716Combined sources
Helixi50 – 6011Combined sources
Turni61 – 655Combined sources
Helixi66 – 8520Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ST7NMR-A2-87[»]
ProteinModelPortaliP31787.
SMRiP31787. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31787.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8786ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 335Acyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
InParanoidiP31787.
OMAiRYKFEAW.
OrthoDBiEOG092C5VJZ.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQLFEEKA KAVNELPTKP STDELLELYA LYKQATVGDN DKEKPGIFNM
60 70 80
KDRYKWEAWE NLKGKSQEDA EKEYIALVDQ LIAKYSS
Length:87
Mass (Da):10,061
Last modified:January 23, 2007 - v3
Checksum:i686B186195EA02FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99489 Genomic DNA. Translation: AAA34384.1.
Y08687 Genomic DNA. Translation: CAA69944.1.
Y08689 Genomic DNA. Translation: CAA69947.1.
DQ115390 Genomic DNA. Translation: AAZ22453.1.
Z72822 Genomic DNA. Translation: CAA97025.1.
BK006941 Genomic DNA. Translation: DAA08135.1.
PIRiS31247.
RefSeqiNP_011551.3. NM_001181166.3.

Genome annotation databases

EnsemblFungiiYGR037C; YGR037C; YGR037C.
GeneIDi852925.
KEGGisce:YGR037C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99489 Genomic DNA. Translation: AAA34384.1.
Y08687 Genomic DNA. Translation: CAA69944.1.
Y08689 Genomic DNA. Translation: CAA69947.1.
DQ115390 Genomic DNA. Translation: AAZ22453.1.
Z72822 Genomic DNA. Translation: CAA97025.1.
BK006941 Genomic DNA. Translation: DAA08135.1.
PIRiS31247.
RefSeqiNP_011551.3. NM_001181166.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ST7NMR-A2-87[»]
ProteinModelPortaliP31787.
SMRiP31787. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33282. 63 interactions.
IntActiP31787. 17 interactions.
MINTiMINT-2788579.

Proteomic databases

MaxQBiP31787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR037C; YGR037C; YGR037C.
GeneIDi852925.
KEGGisce:YGR037C.

Organism-specific databases

EuPathDBiFungiDB:YGR037C.
SGDiS000003269. ACB1.

Phylogenomic databases

GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
InParanoidiP31787.
OMAiRYKFEAW.
OrthoDBiEOG092C5VJZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-30758-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP31787.
PROiP31787.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBP_YEAST
AccessioniPrimary (citable) accession number: P31787
Secondary accession number(s): D6VUH4, Q45U46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.