P31787 (ACBP_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA-binding protein
Short name=ACBP

Gene names

Name:	ACB1
Synonyms:	ACB
Ordered Locus Names:	YGR037C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Miscellaneous	Present with 8500 molecules/cell in log phase SD medium. Ref.7
Sequence similarities	Belongs to the ACBP family. Contains 1 ACB (acyl-CoA-binding) domain.

Ontologies

Keywords
Biological process	Transport
Ligand	Lipid-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chronological cell aging Inferred from mutant phenotype. Source: SGD fatty acid metabolic process Inferred from direct assay. Source: SGD
Cellular component	cytoplasm Inferred from direct assay. Source: SGD extracellular region Inferred from mutant phenotype. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro long-chain fatty acid transporter activity Inferred from mutant phenotype. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 87

86

Acyl-CoA-binding protein

PRO_0000214013

Regions

Domain

2 – 87

86

ACB

Secondary structure

1

.

.

.

.

.

.

.

.

.

87

Helix Strand Turn

Details...

Helix

3 – 13

11

Helix

22 – 37

16

Helix

50 – 60

11

Turn

61 – 65

5

Helix

66 – 85

20

Sequences

	Sequence		Length	Mass (Da)
	P31787 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 686B186195EA02FC	FASTA	87	10,061
	10 20 30 40 50 60 MVSQLFEEKA KAVNELPTKP STDELLELYA LYKQATVGDN DKEKPGIFNM KDRYKWEAWE 70 80 NLKGKSQEDA EKEYIALVDQ LIAKYSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein." Rose T.M., Schultz E.R., Todaro G.J. Proc. Natl. Acad. Sci. U.S.A. 89:11287-11291(1992) [PubMed: 1454809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis." Borsting C., Hummel R., Schultz E.R., Rose T.M., Pedersen M.B., Knudsen J., Kristiansen K. Yeast 13:1409-1421(1997) [PubMed: 9434347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26109 / X2180.
[3]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed: 16273108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[4]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles." Teilum K., Thormann T., Caterer N.R., Poulsen H.I., Jensen P.H., Knudsen J., Kragelund B.B., Poulsen F.M. Proteins 59:80-90(2005) [PubMed: 15690348] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M99489 Genomic DNA. Translation: AAA34384.1.
Y08687 Genomic DNA. Translation: CAA69944.1.
Y08689 Genomic DNA. Translation: CAA69947.1.
DQ115390 Genomic DNA. Translation: AAZ22453.1.
Z72822 Genomic DNA. Translation: CAA97025.1.
BK006941 Genomic DNA. Translation: DAA08135.1.

PIR

S31247.

RefSeq

NP_011551.1. NM_001181166.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ST7	NMR	-	A	2-87	[»]

ProteinModelPortal

P31787.

SMR

P31787. Positions 2-87.

ModBase

Search...

Protein-protein interaction databases

IntAct

P31787. 26 interactions.

MINT

MINT-2788579.

STRING

P31787.

Proteomic databases

PeptideAtlas

P31787.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YGR037C; YGR037C; YGR037C.

GeneID

852925.

KEGG

sce:YGR037C.

NMPDR

fig|4932.3.peg.2665.

Organism-specific databases

SGD

S000003269. ACB1.

Phylogenomic databases

eggNOG

fuNOG10943.

GeneTree

EFGT00050000003169.

HOGENOM

HBG715417.

OMA

KQASVGD.

OrthoDB

EOG454D8D.

Gene expression databases

ArrayExpress

P31787.

Genevestigator

P31787.

GermOnline

YGR037C. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]

Gene3D

G3DSA:1.20.80.10. ACBP. 1 hit.

Pfam

PF00887. ACBP. 1 hit.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

SUPFAM

SSF47027. ACBP. 1 hit.

PROSITE

PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

972643.

Entry information

Entry name

ACBP_YEAST

Accession

Primary (citable) accession number: P31787
Secondary accession number(s): D6VUH4, Q45U46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program