P31787 (ACBP_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 103.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acyl-CoA-binding protein Short name=ACBP | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 87 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. |
| Miscellaneous | Present with 8500 molecules/cell in log phase SD medium. Ref.7 |
| Sequence similarities | Belongs to the ACBP family. Contains 1 ACB (acyl-CoA-binding) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Ligand | Lipid-binding |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | chronological cell aging Inferred from mutant phenotype. Source: SGD fatty acid metabolic processInferred from direct assay. Source: SGD |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD extracellular regionInferred from mutant phenotype. Source: SGD nucleusInferred from direct assay. Source: SGD |
| Molecular function | fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro long-chain fatty acid transporter activityInferred from mutant phenotype. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||
Molecule processing | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||||||||||
| Chain | 2 – 87 | 86 | Acyl-CoA-binding protein | PRO_0000214013 | |||||||||||||
Regions | |||||||||||||||||
| Domain | 2 – 87 | 86 | ACB | ||||||||||||||
Secondary structure | |||||||||||||||||
Helix Strand Turn | |||||||||||||||||
| Helix | 3 – 13 | 11 | |||||||||||||||
| Helix | 22 – 37 | 16 | |||||||||||||||
| Helix | 50 – 60 | 11 | |||||||||||||||
| Turn | 61 – 65 | 5 | |||||||||||||||
| Helix | 66 – 85 | 20 | |||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein." Rose T.M., Schultz E.R., Todaro G.J. Proc. Natl. Acad. Sci. U.S.A. 89:11287-11291(1992) [PubMed: 1454809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis." Borsting C., Hummel R., Schultz E.R., Rose T.M., Pedersen M.B., Knudsen J., Kristiansen K. Yeast 13:1409-1421(1997) [PubMed: 9434347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26109 / X2180. |
| [3] | "Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed: 16273108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1. |
| [4] | "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed: 9290212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [5] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K.Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [6] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [7] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [8] | "Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles." Teilum K., Thormann T., Caterer N.R., Poulsen H.I., Jensen P.H., Knudsen J., Kragelund B.B., Poulsen F.M. Proteins 59:80-90(2005) [PubMed: 15690348] [Abstract] Cited for: STRUCTURE BY NMR. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M99489 Genomic DNA. Translation: AAA34384.1. Y08687 Genomic DNA. Translation: CAA69944.1. Y08689 Genomic DNA. Translation: CAA69947.1. DQ115390 Genomic DNA. Translation: AAZ22453.1. Z72822 Genomic DNA. Translation: CAA97025.1. BK006941 Genomic DNA. Translation: DAA08135.1. | ||||||||||||
| PIR | S31247. | ||||||||||||
| RefSeq | NP_011551.1. NM_001181166.1. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P31787. | ||||||||||||
| SMR | P31787. Positions 2-87. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P31787. 26 interactions. | ||||||||||||
| MINT | MINT-2788579. | ||||||||||||
| STRING | P31787. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P31787. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| EnsemblFungi | YGR037C; YGR037C; YGR037C. | ||||||||||||
| GeneID | 852925. | ||||||||||||
| KEGG | sce:YGR037C. | ||||||||||||
| NMPDR | fig|4932.3.peg.2665. | ||||||||||||
Organism-specific databases | |||||||||||||
| SGD | S000003269. ACB1. | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | fuNOG10943. | ||||||||||||
| GeneTree | EFGT00050000003169. | ||||||||||||
| HOGENOM | HBG715417. | ||||||||||||
| OMA | KQASVGD. | ||||||||||||
| OrthoDB | EOG454D8D. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P31787. | ||||||||||||
| Genevestigator | P31787. | ||||||||||||
| GermOnline | YGR037C. Saccharomyces cerevisiae. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR022408. Acyl-CoA-binding_prot_CS. IPR000582. Acyl-CoA-binding_protein. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.20.80.10. ACBP. 1 hit. | ||||||||||||
| Pfam | PF00887. ACBP. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00689. ACOABINDINGP. | ||||||||||||
| SUPFAM | SSF47027. ACBP. 1 hit. | ||||||||||||
| PROSITE | PS00880. ACB_1. 1 hit. PS51228. ACB_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 972643. | ||||||||||||
Entry information
| Entry name | ACBP_YEAST | ||||||||
| Accession | Primary (citable) accession number: P31787 Secondary accession number(s): D6VUH4, Q45U46 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VII Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with