P31787 (ACBP_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA-binding protein
Short name=ACBP

Gene names

Name:	ACB1
Synonyms:	ACB
Ordered Locus Names:	YGR037C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
Miscellaneous	Present with 8500 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ACBP family. Contains 1 ACB (acyl-CoA-binding) domain.

Ontologies

Keywords
Biological process	Transport
Ligand	Lipid-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chronological cell aging Inferred from mutant phenotype PubMed 20657825. Source: SGD fatty acid metabolic process Inferred from mutant phenotype PubMed 8798418. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD extracellular region Inferred from mutant phenotype PubMed 20156967. Source: SGD nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	fatty-acyl-CoA binding Inferred from sequence or structural similarity Ref.1. Source: SGD lipid binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid transporter activity Inferred from mutant phenotype PubMed 11294913. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 87

86

Acyl-CoA-binding protein

PRO_0000214013

Regions

Domain

2 – 87

86

ACB

Region

29 – 33

5

Acyl-CoA binding By similarity

Sites

Binding site

51

1

Acyl-CoA By similarity

Binding site

55

1

Acyl-CoA By similarity

Binding site

74

1

Acyl-CoA By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

87

Helix Strand Turn

Details...

Helix

3 – 13

11

Helix

22 – 37

16

Helix

50 – 60

11

Turn

61 – 65

5

Helix

66 – 85

20

Sequences

	Sequence		Length	Mass (Da)
	P31787 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 686B186195EA02FC	FASTA	87	10,061
	10 20 30 40 50 60 MVSQLFEEKA KAVNELPTKP STDELLELYA LYKQATVGDN DKEKPGIFNM KDRYKWEAWE 70 80 NLKGKSQEDA EKEYIALVDQ LIAKYSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein." Rose T.M., Schultz E.R., Todaro G.J. Proc. Natl. Acad. Sci. U.S.A. 89:11287-11291(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Saccharomyces carlsbergensis contains two functional genes encoding the acyl-CoA binding protein, one similar to the ACB1 gene from S. cerevisiae and one identical to the ACB1 gene from S. monacensis." Borsting C., Hummel R., Schultz E.R., Rose T.M., Pedersen M.B., Knudsen J., Kristiansen K. Yeast 13:1409-1421(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26109 / X2180.
[3]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[4]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles." Teilum K., Thormann T., Caterer N.R., Poulsen H.I., Jensen P.H., Knudsen J., Kragelund B.B., Poulsen F.M. Proteins 59:80-90(2005) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M99489 Genomic DNA. Translation: AAA34384.1.
Y08687 Genomic DNA. Translation: CAA69944.1.
Y08689 Genomic DNA. Translation: CAA69947.1.
DQ115390 Genomic DNA. Translation: AAZ22453.1.
Z72822 Genomic DNA. Translation: CAA97025.1.
BK006941 Genomic DNA. Translation: DAA08135.1.

PIR

S31247.

RefSeq

NP_011551.3. NM_001181166.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ST7	NMR	-	A	2-87	[»]

ProteinModelPortal

P31787.

SMR

P31787. Positions 2-87.

ModBase

Search...

Protein-protein interaction databases

IntAct

P31787. 9 interactions.

MINT

MINT-2788579.

STRING

4932.YGR037C.

Proteomic databases

PaxDb

P31787.

PeptideAtlas

P31787.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YGR037C; YGR037C; YGR037C.

GeneID

852925.

KEGG

sce:YGR037C.
sce:YGR041W.

Organism-specific databases

SGD

S000003269. ACB1.

Phylogenomic databases

eggNOG

COG4281.

GeneTree

ENSGT00680000099745.

HOGENOM

HOG000261845.

OMA

GDNTTDK.

OrthoDB

EOG454D8D.

Gene expression databases

Genevestigator

P31787.

GermOnline

YGR037C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

1.20.80.10. 1 hit.

InterPro

IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]

Pfam

PF00887. ACBP. 1 hit.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

SUPFAM

SSF47027. ACBP. 1 hit.

PROSITE

PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P31787.

NextBio

972643.

Entry information

Entry name

ACBP_YEAST

Accession

Primary (citable) accession number: P31787
Secondary accession number(s): D6VUH4, Q45U46

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program