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Protein

Acyl-CoA-binding protein

Gene

Dbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Acyl-CoABy similarity
Binding sitei51 – 511Acyl-CoABy similarity
Binding sitei55 – 551Acyl-CoABy similarity
Binding sitei74 – 741Acyl-CoABy similarity

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI
  • hair follicle development Source: MGI
  • lateral ventricle development Source: MGI
  • learning or memory Source: MGI
  • long-term synaptic potentiation Source: MGI
  • phosphatidylcholine acyl-chain remodeling Source: MGI
  • regulation of synaptic transmission, GABAergic Source: MGI
  • skin development Source: MGI
  • transport Source: UniProtKB-KW
  • triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Gene namesi
Name:Dbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:94865. Dbi.

Subcellular locationi

  • Endoplasmic reticulum By similarity
  • Golgi apparatus By similarity

  • Note: Golgi localization is dependent on ligand binding.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 8786Acyl-CoA-binding proteinPRO_0000214005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei8 – 81N6-acetyllysine; alternateBy similarity
Modified residuei8 – 81N6-succinyllysine; alternateCombined sources
Modified residuei17 – 171N6-succinyllysineCombined sources
Modified residuei29 – 291PhosphotyrosineCombined sources
Modified residuei51 – 511N6-acetyllysineCombined sources
Modified residuei55 – 551N6-acetyllysine; alternateCombined sources
Modified residuei55 – 551N6-malonyllysine; alternateBy similarity
Modified residuei55 – 551N6-succinyllysine; alternateCombined sources
Modified residuei61 – 611N6-succinyllysineCombined sources
Modified residuei77 – 771N6-acetyllysine; alternateBy similarity
Modified residuei77 – 771N6-succinyllysine; alternateCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31786.
PaxDbiP31786.
PeptideAtlasiP31786.
PRIDEiP31786.
TopDownProteomicsiP31786.

2D gel databases

SWISS-2DPAGEP31786.

PTM databases

iPTMnetiP31786.
PhosphoSiteiP31786.

Expressioni

Gene expression databases

BgeeiP31786.
CleanExiMM_DBI.
ExpressionAtlasiP31786. baseline and differential.
GenevisibleiP31786. MM.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP31786. 3 interactions.
MINTiMINT-1855961.
STRINGi10090.ENSMUSP00000114705.

Structurei

3D structure databases

ProteinModelPortaliP31786.
SMRiP31786. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8786ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 335Acyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiP31786.
KOiK08762.
OrthoDBiEOG7SN8G8.
TreeFamiTF335802.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKESA MKTYVEKVDE LKKKYGI
Length:87
Mass (Da):10,000
Last modified:January 23, 2007 - v2
Checksum:i86F725C998785675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA. Translation: CAA43673.1.
AK018720 mRNA. Translation: BAB31366.1.
AK027906 mRNA. Translation: BAC25658.1.
BC028874 mRNA. Translation: AAH28874.1.
CCDSiCCDS15230.1.
PIRiA60059.
RefSeqiNP_031856.1. NM_007830.4.
UniGeneiMm.2785.

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385.
GeneIDi13167.
KEGGimmu:13167.
UCSCiuc007cjf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA. Translation: CAA43673.1.
AK018720 mRNA. Translation: BAB31366.1.
AK027906 mRNA. Translation: BAC25658.1.
BC028874 mRNA. Translation: AAH28874.1.
CCDSiCCDS15230.1.
PIRiA60059.
RefSeqiNP_031856.1. NM_007830.4.
UniGeneiMm.2785.

3D structure databases

ProteinModelPortaliP31786.
SMRiP31786. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP31786. 3 interactions.
MINTiMINT-1855961.
STRINGi10090.ENSMUSP00000114705.

PTM databases

iPTMnetiP31786.
PhosphoSiteiP31786.

2D gel databases

SWISS-2DPAGEP31786.

Proteomic databases

EPDiP31786.
PaxDbiP31786.
PeptideAtlasiP31786.
PRIDEiP31786.
TopDownProteomicsiP31786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385.
GeneIDi13167.
KEGGimmu:13167.
UCSCiuc007cjf.2. mouse.

Organism-specific databases

CTDi1622.
MGIiMGI:94865. Dbi.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiP31786.
KOiK08762.
OrthoDBiEOG7SN8G8.
TreeFamiTF335802.

Miscellaneous databases

ChiTaRSiDbi. mouse.
PROiP31786.
SOURCEiSearch...

Gene expression databases

BgeeiP31786.
CleanExiMM_DBI.
ExpressionAtlasiP31786. baseline and differential.
GenevisibleiP31786. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression of the murine diazepam binding inhibitor."
    Owens G.P., Sinha A.K., Sikela J.M., Hahn W.E.
    Brain Res. Mol. Brain Res. 6:101-108(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 34-51, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-17; LYS-55; LYS-61 AND LYS-77, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-51 AND LYS-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACBP_MOUSE
AccessioniPrimary (citable) accession number: P31786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.