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Protein

Acyl-CoA-binding protein

Gene

Dbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Acyl-CoABy similarity
Binding sitei51 – 511Acyl-CoABy similarity
Binding sitei55 – 551Acyl-CoABy similarity
Binding sitei74 – 741Acyl-CoABy similarity

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI
  • hair follicle development Source: MGI
  • lateral ventricle development Source: MGI
  • learning or memory Source: MGI
  • long-term synaptic potentiation Source: MGI
  • phosphatidylcholine acyl-chain remodeling Source: MGI
  • regulation of synaptic transmission, GABAergic Source: MGI
  • skin development Source: MGI
  • transport Source: UniProtKB-KW
  • triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Gene namesi
Name:Dbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:94865. Dbi.

Subcellular locationi

  • Endoplasmic reticulum By similarity
  • Golgi apparatus By similarity

  • Note: Golgi localization is dependent on ligand binding.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 8786Acyl-CoA-binding proteinPRO_0000214005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei8 – 81N6-acetyllysine; alternateBy similarity
Modified residuei8 – 81N6-succinyllysine; alternateCombined sources
Modified residuei17 – 171N6-succinyllysineCombined sources
Modified residuei29 – 291PhosphotyrosineCombined sources
Modified residuei51 – 511N6-acetyllysineCombined sources
Modified residuei55 – 551N6-acetyllysine; alternateCombined sources
Modified residuei55 – 551N6-malonyllysine; alternateBy similarity
Modified residuei55 – 551N6-succinyllysine; alternateCombined sources
Modified residuei61 – 611N6-succinyllysineCombined sources
Modified residuei77 – 771N6-acetyllysine; alternateBy similarity
Modified residuei77 – 771N6-succinyllysine; alternateCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31786.
PaxDbiP31786.
PeptideAtlasiP31786.
PRIDEiP31786.
TopDownProteomicsiP31786.

2D gel databases

SWISS-2DPAGEP31786.

PTM databases

iPTMnetiP31786.
PhosphoSiteiP31786.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026385.
CleanExiMM_DBI.
ExpressionAtlasiP31786. baseline and differential.
GenevisibleiP31786. MM.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP31786. 3 interactions.
MINTiMINT-1855961.
STRINGi10090.ENSMUSP00000114705.

Structurei

3D structure databases

ProteinModelPortaliP31786.
SMRiP31786. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8786ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 335Acyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiP31786.
KOiK08762.
TreeFamiTF335802.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKESA MKTYVEKVDE LKKKYGI
Length:87
Mass (Da):10,000
Last modified:January 23, 2007 - v2
Checksum:i86F725C998785675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA. Translation: CAA43673.1.
AK018720 mRNA. Translation: BAB31366.1.
AK027906 mRNA. Translation: BAC25658.1.
BC028874 mRNA. Translation: AAH28874.1.
CCDSiCCDS15230.1.
PIRiA60059.
RefSeqiNP_031856.1. NM_007830.4.
UniGeneiMm.2785.

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385.
GeneIDi13167.
KEGGimmu:13167.
UCSCiuc007cjf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA. Translation: CAA43673.1.
AK018720 mRNA. Translation: BAB31366.1.
AK027906 mRNA. Translation: BAC25658.1.
BC028874 mRNA. Translation: AAH28874.1.
CCDSiCCDS15230.1.
PIRiA60059.
RefSeqiNP_031856.1. NM_007830.4.
UniGeneiMm.2785.

3D structure databases

ProteinModelPortaliP31786.
SMRiP31786. Positions 2-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP31786. 3 interactions.
MINTiMINT-1855961.
STRINGi10090.ENSMUSP00000114705.

PTM databases

iPTMnetiP31786.
PhosphoSiteiP31786.

2D gel databases

SWISS-2DPAGEP31786.

Proteomic databases

EPDiP31786.
PaxDbiP31786.
PeptideAtlasiP31786.
PRIDEiP31786.
TopDownProteomicsiP31786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385.
GeneIDi13167.
KEGGimmu:13167.
UCSCiuc007cjf.2. mouse.

Organism-specific databases

CTDi1622.
MGIiMGI:94865. Dbi.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiP31786.
KOiK08762.
TreeFamiTF335802.

Miscellaneous databases

ChiTaRSiDbi. mouse.
PROiP31786.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026385.
CleanExiMM_DBI.
ExpressionAtlasiP31786. baseline and differential.
GenevisibleiP31786. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBP_MOUSE
AccessioniPrimary (citable) accession number: P31786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.