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Protein

Acyl-CoA-binding protein

Gene

Dbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI
  • hair follicle development Source: MGI
  • lateral ventricle development Source: MGI
  • learning or memory Source: MGI
  • long-term synaptic potentiation Source: MGI
  • phosphatidylcholine acyl-chain remodeling Source: MGI
  • regulation of synaptic transmission, GABAergic Source: MGI
  • skin development Source: MGI
  • triglyceride metabolic process Source: MGI

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Gene namesi
Name:Dbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:94865 Dbi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002140052 – 87Acyl-CoA-binding proteinAdd BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateCombined sources1
Modified residuei17N6-succinyllysineCombined sources1
Modified residuei29PhosphotyrosineCombined sources1
Modified residuei51N6-acetyllysineCombined sources1
Modified residuei55N6-acetyllysine; alternateCombined sources1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateCombined sources1
Modified residuei61N6-succinyllysineCombined sources1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31786
PaxDbiP31786
PeptideAtlasiP31786
PRIDEiP31786
TopDownProteomicsiP31786

2D gel databases

SWISS-2DPAGEP31786

PTM databases

iPTMnetiP31786
PhosphoSitePlusiP31786

Expressioni

Gene expression databases

BgeeiENSMUSG00000026385
CleanExiMM_DBI
ExpressionAtlasiP31786 baseline and differential
GenevisibleiP31786 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP31786, 3 interactors
MINTiP31786
STRINGi10090.ENSMUSP00000114705

Structurei

3D structure databases

ProteinModelPortaliP31786
SMRiP31786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiP31786
KOiK08762
TreeFamiTF335802

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKESA MKTYVEKVDE LKKKYGI
Length:87
Mass (Da):10,000
Last modified:January 23, 2007 - v2
Checksum:i86F725C998785675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA Translation: CAA43673.1
AK018720 mRNA Translation: BAB31366.1
AK027906 mRNA Translation: BAC25658.1
BC028874 mRNA Translation: AAH28874.1
CCDSiCCDS15230.1
PIRiA60059
RefSeqiNP_031856.1, NM_007830.4
UniGeneiMm.2785

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385
GeneIDi13167
KEGGimmu:13167
UCSCiuc007cjf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiACBP_MOUSE
AccessioniPrimary (citable) accession number: P31786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health