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Protein

Cytokine receptor common subunit gamma

Gene

IL2RG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Common subunit for the receptors for a variety of interleukins.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: ProtInc
  • interleukin-2-mediated signaling pathway Source: GOC
  • interleukin-4-mediated signaling pathway Source: GOC
  • interleukin-7-mediated signaling pathway Source: GOC
  • MAPK cascade Source: Reactome
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147168-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-449147. Signaling by Interleukins.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP31785.
SIGNORiP31785.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor common subunit gamma
Alternative name(s):
Interleukin-2 receptor subunit gamma
Short name:
IL-2 receptor subunit gamma
Short name:
IL-2R subunit gamma
Short name:
IL-2RG
gammaC
p64
CD_antigen: CD132
Gene namesi
Name:IL2RG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6010. IL2RG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 262ExtracellularSequence analysisAdd BLAST240
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 369CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

  • external side of plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
See also OMIM:300400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00266839D → N in XSCID. 1 Publication1
Natural variantiVAR_00266962C → G in XSCID. 1
Natural variantiVAR_00267068E → G in XSCID. 1
Natural variantiVAR_00267168E → K in XSCID. 1 Publication1
Natural variantiVAR_00267284N → K in XSCID. 1
Natural variantiVAR_00267389Y → C in XSCID. 1
Natural variantiVAR_002674105Y → C in XSCID. Corresponds to variant rs193922347dbSNPEnsembl.1
Natural variantiVAR_002675114G → D in XSCID. 1 PublicationCorresponds to variant rs111033620dbSNPEnsembl.1
Natural variantiVAR_002676115C → F in XSCID. 1 Publication1
Natural variantiVAR_002677115C → R in XSCID; atypical. 1 PublicationCorresponds to variant rs111033622dbSNPEnsembl.1
Natural variantiVAR_002678123H → P in XSCID. 1
Natural variantiVAR_002679125Y → N in XSCID. 1
Natural variantiVAR_002680144Q → P in XSCID. 1
Natural variantiVAR_002681153I → N in XSCID. 1 PublicationCorresponds to variant rs111033621dbSNPEnsembl.1
Natural variantiVAR_002682156A → V in XSCID. 1
Natural variantiVAR_002683162L → H in XSCID. 1 Publication1
Natural variantiVAR_002684172L → P in XSCID. 1
Natural variantiVAR_002685172L → Q in XSCID. 1
Natural variantiVAR_002686182C → R in XSCID. 1
Natural variantiVAR_002687183L → S in XSCID. 1 Publication1
Natural variantiVAR_002689224R → W in XSCID. 1 Publication1
Natural variantiVAR_002690226R → C in XSCID. 1 Publication1
Natural variantiVAR_002691226R → H in XSCID. 1 Publication1
Natural variantiVAR_002692227F → C in XSCID. 1
Natural variantiVAR_002693230L → P in XSCID. 1
Natural variantiVAR_002694231C → Y in XSCID. 1
Natural variantiVAR_002695232G → R in XSCID. 1
Natural variantiVAR_002696237W → WQHW in XSCID. 1 Publication1
Natural variantiVAR_002697240W → C in XSCID. 1 Publication1
Natural variantiVAR_002698241S → I in XSCID. 1 Publication1
Natural variantiVAR_002699270M → R in XSCID. 1
Natural variantiVAR_002701285R → Q in XSCID. 1 PublicationCorresponds to variant rs111033617dbSNPEnsembl.1
X-linked combined immunodeficiency (XCID)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLess severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.
See also OMIM:312863
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002688222R → C in XCID. 1 PublicationCorresponds to variant rs111033618dbSNPEnsembl.1
Natural variantiVAR_002702293L → Q in XCID. 1 PublicationCorresponds to variant rs137852510dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, SCID

Organism-specific databases

DisGeNETi3561.
MalaCardsiIL2RG.
MIMi300400. phenotype.
312863. phenotype.
OpenTargetsiENSG00000147168.
Orphaneti39041. Omenn syndrome.
276. T-B+ severe combined immunodeficiency due to gamma chain deficiency.
PharmGKBiPA196.

Chemistry databases

ChEMBLiCHEMBL2364167.
DrugBankiDB00041. Aldesleukin.
DB00004. Denileukin diftitox.

Polymorphism and mutation databases

BioMutaiIL2RG.
DMDMi400048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001086623 – 369Cytokine receptor common subunit gammaAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi62 ↔ 72
Glycosylationi71N-linked (GlcNAc...)2 Publications1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)2 Publications1
Disulfide bondi102 ↔ 115
Glycosylationi159N-linked (GlcNAc...)2 Publications1
Disulfide bondi182 ↔ 231
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Modified residuei292PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP31785.
MaxQBiP31785.
PaxDbiP31785.
PeptideAtlasiP31785.
PRIDEiP31785.

PTM databases

iPTMnetiP31785.
PhosphoSitePlusiP31785.

Miscellaneous databases

PMAP-CutDBP31785.

Expressioni

Gene expression databases

BgeeiENSG00000147168.
CleanExiHS_IL2RG.
ExpressionAtlasiP31785. baseline and differential.
GenevisibleiP31785. HS.

Organism-specific databases

HPAiHPA046641.

Interactioni

Subunit structurei

The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL7P132322EBI-80475,EBI-80516
NOTCH2NLQ7Z3S93EBI-80475,EBI-945833

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109776. 19 interactors.
DIPiDIP-173N.
IntActiP31785. 14 interactors.
MINTiMINT-1524852.
STRINGi9606.ENSP00000363318.

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi61 – 65Combined sources5
Turni66 – 68Combined sources3
Beta strandi69 – 73Combined sources5
Beta strandi78 – 81Combined sources4
Beta strandi86 – 91Combined sources6
Beta strandi94 – 96Combined sources3
Beta strandi103 – 108Combined sources6
Beta strandi111 – 118Combined sources8
Helixi119 – 121Combined sources3
Beta strandi124 – 126Combined sources3
Beta strandi128 – 133Combined sources6
Beta strandi135 – 137Combined sources3
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Beta strandi151 – 153Combined sources3
Beta strandi158 – 166Combined sources9
Beta strandi169 – 175Combined sources7
Helixi180 – 182Combined sources3
Beta strandi184 – 191Combined sources8
Beta strandi198 – 202Combined sources5
Beta strandi207 – 210Combined sources4
Beta strandi215 – 217Combined sources3
Beta strandi219 – 226Combined sources8
Beta strandi229 – 231Combined sources3
Beta strandi244 – 246Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILLmodel-G57-248[»]
1ILMmodel-G57-248[»]
1ILNmodel-G57-248[»]
1ITEmodel-B23-254[»]
2B5IX-ray2.30C56-254[»]
2ERJX-ray3.00C/G23-255[»]
3BPLX-ray2.93C56-254[»]
3QAZX-ray3.80C/F/I/L/O/R/U/X/a/d/g/j56-254[»]
3QB7X-ray3.24C/D55-254[»]
4GS7X-ray2.35C55-254[»]
ProteinModelPortaliP31785.
SMRiP31785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 253Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi237 – 241WSXWS motif5
Motifi286 – 294Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGNI. Eukaryota.
ENOG4111N9N. LUCA.
GeneTreeiENSGT00510000048979.
HOGENOMiHOG000276891.
HOVERGENiHBG052111.
InParanoidiP31785.
KOiK05070.
OMAiCNQHSPY.
OrthoDBiEOG091G07RI.
PhylomeDBiP31785.
TreeFamiTF333657.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31785-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL
60 70 80 90 100
SVSTLPLPEV QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ
110 120 130 140 150
KCSHYLFSEE ITSGCQLQKK EIHLYQTFVV QLQDPREPRR QATQMLKLQN
160 170 180 190 200
LVIPWAPENL TLHKLSESQL ELNWNNRFLN HCLEHLVQYR TDWDHSWTEQ
210 220 230 240 250
SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW SHPIHWGSNT
260 270 280 290 300
SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV
310 320 330 340 350
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP
360
CNQHSPYWAP PCYTLKPET
Length:369
Mass (Da):42,287
Last modified:July 1, 1993 - v1
Checksum:i3B6215246D610215
GO
Isoform 2 (identifier: P31785-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MLKPSLPF → MGMKTPQL
     9-198: Missing.

Show »
Length:179
Mass (Da):20,088
Checksum:i4A3D790462553D0A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00266839D → N in XSCID. 1 Publication1
Natural variantiVAR_05930144T → S.Corresponds to variant rs7885041dbSNPEnsembl.1
Natural variantiVAR_00266962C → G in XSCID. 1
Natural variantiVAR_00267068E → G in XSCID. 1
Natural variantiVAR_00267168E → K in XSCID. 1 Publication1
Natural variantiVAR_00267284N → K in XSCID. 1
Natural variantiVAR_00267389Y → C in XSCID. 1
Natural variantiVAR_002674105Y → C in XSCID. Corresponds to variant rs193922347dbSNPEnsembl.1
Natural variantiVAR_020611109E → K.1 PublicationCorresponds to variant rs17875899dbSNPEnsembl.1
Natural variantiVAR_002675114G → D in XSCID. 1 PublicationCorresponds to variant rs111033620dbSNPEnsembl.1
Natural variantiVAR_002676115C → F in XSCID. 1 Publication1
Natural variantiVAR_002677115C → R in XSCID; atypical. 1 PublicationCorresponds to variant rs111033622dbSNPEnsembl.1
Natural variantiVAR_002678123H → P in XSCID. 1
Natural variantiVAR_002679125Y → N in XSCID. 1
Natural variantiVAR_002680144Q → P in XSCID. 1
Natural variantiVAR_002681153I → N in XSCID. 1 PublicationCorresponds to variant rs111033621dbSNPEnsembl.1
Natural variantiVAR_002682156A → V in XSCID. 1
Natural variantiVAR_002683162L → H in XSCID. 1 Publication1
Natural variantiVAR_002684172L → P in XSCID. 1
Natural variantiVAR_002685172L → Q in XSCID. 1
Natural variantiVAR_002686182C → R in XSCID. 1
Natural variantiVAR_002687183L → S in XSCID. 1 Publication1
Natural variantiVAR_002688222R → C in XCID. 1 PublicationCorresponds to variant rs111033618dbSNPEnsembl.1
Natural variantiVAR_002689224R → W in XSCID. 1 Publication1
Natural variantiVAR_002690226R → C in XSCID. 1 Publication1
Natural variantiVAR_002691226R → H in XSCID. 1 Publication1
Natural variantiVAR_002692227F → C in XSCID. 1
Natural variantiVAR_002693230L → P in XSCID. 1
Natural variantiVAR_002694231C → Y in XSCID. 1
Natural variantiVAR_002695232G → R in XSCID. 1
Natural variantiVAR_002696237W → WQHW in XSCID. 1 Publication1
Natural variantiVAR_002697240W → C in XSCID. 1 Publication1
Natural variantiVAR_002698241S → I in XSCID. 1 Publication1
Natural variantiVAR_002699270M → R in XSCID. 1
Natural variantiVAR_002701285R → Q in XSCID. 1 PublicationCorresponds to variant rs111033617dbSNPEnsembl.1
Natural variantiVAR_002702293L → Q in XCID. 1 PublicationCorresponds to variant rs137852510dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475811 – 8MLKPSLPF → MGMKTPQL in isoform 2. 1 Publication8
Alternative sequenceiVSP_0475829 – 198Missing in isoform 2. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11086 mRNA. Translation: BAA01857.1.
L12183
, L12178, L12176, L12177, L12179, L12180, L12181, L12182 Genomic DNA. Translation: AAA59145.1.
L19546 Genomic DNA. Translation: AAC37524.1.
AB102794 mRNA. Translation: BAD89385.1.
AY692262 Genomic DNA. Translation: AAT85803.1.
AL590764 Genomic DNA. No translation available.
BC014972 mRNA. Translation: AAH14972.1.
CCDSiCCDS14406.1. [P31785-1]
PIRiA42565.
RefSeqiNP_000197.1. NM_000206.2. [P31785-1]
UniGeneiHs.84.

Genome annotation databases

EnsembliENST00000374202; ENSP00000363318; ENSG00000147168. [P31785-1]
ENST00000456850; ENSP00000388967; ENSG00000147168. [P31785-2]
GeneIDi3561.
KEGGihsa:3561.
UCSCiuc004dyw.4. human. [P31785-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

IL2RGbase

X-linked SCID mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11086 mRNA. Translation: BAA01857.1.
L12183
, L12178, L12176, L12177, L12179, L12180, L12181, L12182 Genomic DNA. Translation: AAA59145.1.
L19546 Genomic DNA. Translation: AAC37524.1.
AB102794 mRNA. Translation: BAD89385.1.
AY692262 Genomic DNA. Translation: AAT85803.1.
AL590764 Genomic DNA. No translation available.
BC014972 mRNA. Translation: AAH14972.1.
CCDSiCCDS14406.1. [P31785-1]
PIRiA42565.
RefSeqiNP_000197.1. NM_000206.2. [P31785-1]
UniGeneiHs.84.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILLmodel-G57-248[»]
1ILMmodel-G57-248[»]
1ILNmodel-G57-248[»]
1ITEmodel-B23-254[»]
2B5IX-ray2.30C56-254[»]
2ERJX-ray3.00C/G23-255[»]
3BPLX-ray2.93C56-254[»]
3QAZX-ray3.80C/F/I/L/O/R/U/X/a/d/g/j56-254[»]
3QB7X-ray3.24C/D55-254[»]
4GS7X-ray2.35C55-254[»]
ProteinModelPortaliP31785.
SMRiP31785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109776. 19 interactors.
DIPiDIP-173N.
IntActiP31785. 14 interactors.
MINTiMINT-1524852.
STRINGi9606.ENSP00000363318.

Chemistry databases

ChEMBLiCHEMBL2364167.
DrugBankiDB00041. Aldesleukin.
DB00004. Denileukin diftitox.

PTM databases

iPTMnetiP31785.
PhosphoSitePlusiP31785.

Polymorphism and mutation databases

BioMutaiIL2RG.
DMDMi400048.

Proteomic databases

EPDiP31785.
MaxQBiP31785.
PaxDbiP31785.
PeptideAtlasiP31785.
PRIDEiP31785.

Protocols and materials databases

DNASUi3561.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374202; ENSP00000363318; ENSG00000147168. [P31785-1]
ENST00000456850; ENSP00000388967; ENSG00000147168. [P31785-2]
GeneIDi3561.
KEGGihsa:3561.
UCSCiuc004dyw.4. human. [P31785-1]

Organism-specific databases

CTDi3561.
DisGeNETi3561.
GeneCardsiIL2RG.
GeneReviewsiIL2RG.
HGNCiHGNC:6010. IL2RG.
HPAiHPA046641.
MalaCardsiIL2RG.
MIMi300400. phenotype.
308380. gene.
312863. phenotype.
neXtProtiNX_P31785.
OpenTargetsiENSG00000147168.
Orphaneti39041. Omenn syndrome.
276. T-B+ severe combined immunodeficiency due to gamma chain deficiency.
PharmGKBiPA196.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGNI. Eukaryota.
ENOG4111N9N. LUCA.
GeneTreeiENSGT00510000048979.
HOGENOMiHOG000276891.
HOVERGENiHBG052111.
InParanoidiP31785.
KOiK05070.
OMAiCNQHSPY.
OrthoDBiEOG091G07RI.
PhylomeDBiP31785.
TreeFamiTF333657.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147168-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-449147. Signaling by Interleukins.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP31785.
SIGNORiP31785.

Miscellaneous databases

ChiTaRSiIL2RG. human.
EvolutionaryTraceiP31785.
GeneWikiiCommon_gamma_chain.
GenomeRNAii3561.
PMAP-CutDBP31785.
PROiP31785.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147168.
CleanExiHS_IL2RG.
ExpressionAtlasiP31785. baseline and differential.
GenevisibleiP31785. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RG_HUMAN
AccessioniPrimary (citable) accession number: P31785
Secondary accession number(s): Q5FC12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 195 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.