P31773 (COMF_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Competence protein F

Alternative name(s):
DNA transformation protein ComF
Protein COM101A

Gene names

Name:	comF
Ordered Locus Names:	HI_0434

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in transformation (competence for DNA uptake).
Sequence similarities	Belongs to the ComF/GntX family.

Ontologies

Keywords
Biological process	Competence
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	establishment of competence for transformation Inferred from electronic annotation. Source: UniProtKB-KW nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Competence protein F		PRO_0000209456
Regions
	Compositional bias	9 – 54	46	Cys-rich

Sequences

	Sequence		Length	Mass (Da)
	P31773 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 2F5B72B6C8C79503	FASTA	229	26,791
	10 20 30 40 50 60 MMNFFNFRCI HCRGNLHIAK NGLCSGCQKQ IKSFPYCGHC GSELQYYAQH CGNCLKQEPS 70 80 90 100 110 120 WDKMVIIGHY IEPLSILIQR FKFQNQFWID RTLARLLYLA VRDAKRTHQL KLPEAIIPVP 130 140 150 160 170 180 LYHFRQWRRG YNQADLLSQQ LSRWLDIPNL NNIVKRVKHT YTQRGLSAKD RRQNLKNAFS 190 200 210 220 LAVSKNEFPY RRVALVDDVI TTGSTLNEIS KLLRKLGVEE IQVWGLARA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a cluster of genes involved in the transformation of Haemophilus influenzae Rd." Tomb J.-F., El-Hajj H., Smith H.O. Gene 104:1-10(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Sequence and transcriptional regulation of com101A, a locus required for genetic transformation in Haemophilus influenzae." Larson T.G., Goodgal S.H. J. Bacteriol. 173:4683-4691(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M62809 Genomic DNA. Translation: AAA25014.1. M59751 Genomic DNA. Translation: AAA24949.1. L42023 Genomic DNA. Translation: AAC22093.1.
PIR	JH0435.
RefSeq	NP_438595.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P31773.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0434.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22093; AAC22093; HI_0434.
GeneID	950316.
KEGG	hin:HI0434.
PATRIC	20189421. VBIHaeInf48452_0454.
Phylogenomic databases
eggNOG	COG1040.
OMA	LARWLGC.
ProtClustDB	CLSK870528.
Family and domain databases
InterPro	IPR005222. Competence_ComF. IPR000836. PRibTrfase_dom. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR00201. comF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMF_HAEIN

Accession

Primary (citable) accession number: P31773

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program