P31767 (GAL1_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactokinase
EC=2.7.1.6

Alternative name(s):
Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	HI_0819

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential HAMAP MF_00246.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.
Sequence caution	The sequence AAC22478.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW galactokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Galactokinase HAMAP MF_00246		PRO_0000184612
Regions
	Nucleotide binding	121 – 131	11	ATP Potential
Natural variations
	Natural variant	107	1	D → H in strain: RM 7004.
	Natural variant	145	1	D → N in strain: RM 7004.
	Natural variant	321	1	A → V in strain: RM 7004.
	Natural variant	331	1	A → T in strain: RM 7004.
	Natural variant	353	1	S → A in strain: RM 7004.

Sequences

	Sequence		Length	Mass (Da)
	P31767 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: B28D552832858D34	FASTA	384	42,132
	10 20 30 40 50 60 MTPIQNAQQI FNRQHKNLPE ITVYAPGRVN IIGEHTDYND GFVMPCAINF GTAVSGTKRD 70 80 90 100 110 120 DHIWNVYAAD LDETDEFSLN VEIPKSEHKW ANYVRGVVKF IQERYPDFQQ GANLVISGNV 130 140 150 160 170 180 PLSSGLSSSA ALEVAVGKFC QQLGDLPLSH TDIALNGQKA ENQFVGANCG NMDQLISALG 190 200 210 220 230 240 QENHLLMIDC RSLETTPTPV PQDVAVIIVN SNVPHDLVTG EYNTRRQQCE EAAKFFGVKA 250 260 270 280 290 300 LRDVSVEQFQ KREAELTALS PLAAKRARHV VTENQRVLDA VEALKNNDLT CLGKLMEASH 310 320 330 340 350 360 DSMRDDFEIT VPQIDYLVEL AQLVIGKSGG ARMTGGGFGG CIVALAPHDK VDSVRKIIAD 370 380 NYEKTTGLKE TFYVCTASQG VRVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide." Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R. Mol. Microbiol. 6:3051-3063(1992) [PubMed: 1282642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RM 7004 / Serotype B.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65934 Genomic DNA. Translation: CAA46731.1. L42023 Genomic DNA. Translation: AAC22478.1. Different initiation.
PIR	D64096.
RefSeq	NP_438979.2. NC_000907.1.
3D structure databases
ProteinModelPortal	P31767.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950587.
GenomeReviews	Gene locus HI_0819 in contig L42023_GR.
KEGG	hin:HI0819.
NMPDR	fig|71421.1.peg.787.
PATRIC	20190293. VBIHaeInf48452_0860.
TIGR	HI_0819.
Phylogenomic databases
HOGENOM	HBG725121.
OMA	YNDGFVM.
ProtClustDB	PRK05101.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0819-MONOMER.
Family and domain databases
HAMAP	MF_00246. Galactokinase. [Tree]
InterPro	IPR000705. Galactokinase. IPR022963. Galactokinase_bac. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal-bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR006206. Mevalonate/galactokinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00849.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00131. Gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_HAEIN

Accession

Primary (citable) accession number: P31767

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program