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Protein

HTH-type transcriptional regulator GalR

Gene

galR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Repressor of the galactose operon. Binds galactose as an inducer.

Pathway: galactose metabolism

This protein regulates the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi4 – 2320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GalR
Alternative name(s):
Galactose operon repressor
Gene namesi
Name:galR
Synonyms:galS
Ordered Locus Names:HI_0821
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332HTH-type transcriptional regulator GalRPRO_0000107953Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0821.

Structurei

3D structure databases

ProteinModelPortaliP31766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5656HTH lacI-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1609.
KOiK02529.
OMAiHEVTVIH.
OrthoDBiEOG6SJJMM.
PhylomeDBiP31766.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIRDVAKL ANVSVATVSR VLNHSLSVSE NTRLVVEQAI AQLAYQPNAN
60 70 80 90 100
AQALAVQNTD TIGVVVTDVT DAFFAILVKA VDKVAEAHQK TILIGIGYHH
110 120 130 140 150
AEKEREAINT LLRKRCSSLV VHSKALSDDE LSHYLNTVQG MVIINRVIKG
160 170 180 190 200
YEHRCVSLDN QKGTYLATEM LIRYGHQHIA YIGSNHAIFD EVERRNGYLA
210 220 230 240 250
ALKDHNYPII EQAITLNSPD FEGGEKAMID LLSYNKNLTA VVAYNDSMAA
260 270 280 290 300
GAISVLNENN ISVPSQFSII GFDDMPIARY LIPKLTTIRY PIDLMATYAA
310 320 330
KLALSLTDEK IITPPVVQFN PTLVRRFSVE SR
Length:332
Mass (Da):36,708
Last modified:November 1, 1995 - v2
Checksum:i0F431000946AF8A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351V → A in CAA46729 (PubMed:1282642).Curated
Sequence conflicti38 – 381Q → R in CAA46729 (PubMed:1282642).Curated
Sequence conflicti208 – 2081P → L in CAA46729 (PubMed:1282642).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65934 Genomic DNA. Translation: CAA46729.1.
L42023 Genomic DNA. Translation: AAC22480.1.
PIRiF64096.
RefSeqiNP_438981.1. NC_000907.1.
WP_005663077.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22480; AAC22480; HI_0821.
GeneIDi949832.
KEGGihin:HI0821.
PATRICi20190297. VBIHaeInf48452_0862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65934 Genomic DNA. Translation: CAA46729.1.
L42023 Genomic DNA. Translation: AAC22480.1.
PIRiF64096.
RefSeqiNP_438981.1. NC_000907.1.
WP_005663077.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP31766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22480; AAC22480; HI_0821.
GeneIDi949832.
KEGGihin:HI0821.
PATRICi20190297. VBIHaeInf48452_0862.

Phylogenomic databases

eggNOGiCOG1609.
KOiK02529.
OMAiHEVTVIH.
OrthoDBiEOG6SJJMM.
PhylomeDBiP31766.

Enzyme and pathway databases

UniPathwayiUPA00214.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide."
    Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R.
    Mol. Microbiol. 6:3051-3063(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RM 7004 / Serotype B.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiGALR_HAEIN
AccessioniPrimary (citable) accession number: P31766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.