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P31766

- GALR_HAEIN

UniProt

P31766 - GALR_HAEIN

Protein

HTH-type transcriptional regulator GalR

Gene

galR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Repressor of the galactose operon. Binds galactose as an inducer.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi4 – 2320H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. galactose metabolic process Source: UniProtKB-UniPathway
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00214.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator GalR
    Alternative name(s):
    Galactose operon repressor
    Gene namesi
    Name:galR
    Synonyms:galS
    Ordered Locus Names:HI_0821
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332HTH-type transcriptional regulator GalRPRO_0000107953Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0821.

    Structurei

    3D structure databases

    ProteinModelPortaliP31766.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5656HTH lacI-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1609.
    KOiK02529.
    OMAiAFDDAPW.
    OrthoDBiEOG6SJJMM.
    PhylomeDBiP31766.

    Family and domain databases

    Gene3Di1.10.260.40. 1 hit.
    InterProiIPR010982. Lambda_DNA-bd_dom.
    IPR028082. Peripla_BP_I.
    IPR000843. Tscrpt_reg_HTH_LacI.
    [Graphical view]
    PfamiPF00356. LacI. 1 hit.
    [Graphical view]
    PRINTSiPR00036. HTHLACI.
    SMARTiSM00354. HTH_LACI. 1 hit.
    [Graphical view]
    SUPFAMiSSF47413. SSF47413. 1 hit.
    SSF53822. SSF53822. 1 hit.
    PROSITEiPS00356. HTH_LACI_1. 1 hit.
    PS50932. HTH_LACI_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31766-1 [UniParc]FASTAAdd to Basket

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    MSTIRDVAKL ANVSVATVSR VLNHSLSVSE NTRLVVEQAI AQLAYQPNAN    50
    AQALAVQNTD TIGVVVTDVT DAFFAILVKA VDKVAEAHQK TILIGIGYHH 100
    AEKEREAINT LLRKRCSSLV VHSKALSDDE LSHYLNTVQG MVIINRVIKG 150
    YEHRCVSLDN QKGTYLATEM LIRYGHQHIA YIGSNHAIFD EVERRNGYLA 200
    ALKDHNYPII EQAITLNSPD FEGGEKAMID LLSYNKNLTA VVAYNDSMAA 250
    GAISVLNENN ISVPSQFSII GFDDMPIARY LIPKLTTIRY PIDLMATYAA 300
    KLALSLTDEK IITPPVVQFN PTLVRRFSVE SR 332
    Length:332
    Mass (Da):36,708
    Last modified:November 1, 1995 - v2
    Checksum:i0F431000946AF8A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351V → A in CAA46729. (PubMed:1282642)Curated
    Sequence conflicti38 – 381Q → R in CAA46729. (PubMed:1282642)Curated
    Sequence conflicti208 – 2081P → L in CAA46729. (PubMed:1282642)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65934 Genomic DNA. Translation: CAA46729.1.
    L42023 Genomic DNA. Translation: AAC22480.1.
    PIRiF64096.
    RefSeqiNP_438981.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22480; AAC22480; HI_0821.
    GeneIDi949832.
    KEGGihin:HI0821.
    PATRICi20190297. VBIHaeInf48452_0862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65934 Genomic DNA. Translation: CAA46729.1 .
    L42023 Genomic DNA. Translation: AAC22480.1 .
    PIRi F64096.
    RefSeqi NP_438981.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P31766.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22480 ; AAC22480 ; HI_0821 .
    GeneIDi 949832.
    KEGGi hin:HI0821.
    PATRICi 20190297. VBIHaeInf48452_0862.

    Phylogenomic databases

    eggNOGi COG1609.
    KOi K02529.
    OMAi AFDDAPW.
    OrthoDBi EOG6SJJMM.
    PhylomeDBi P31766.

    Enzyme and pathway databases

    UniPathwayi UPA00214 .

    Family and domain databases

    Gene3Di 1.10.260.40. 1 hit.
    InterProi IPR010982. Lambda_DNA-bd_dom.
    IPR028082. Peripla_BP_I.
    IPR000843. Tscrpt_reg_HTH_LacI.
    [Graphical view ]
    Pfami PF00356. LacI. 1 hit.
    [Graphical view ]
    PRINTSi PR00036. HTHLACI.
    SMARTi SM00354. HTH_LACI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47413. SSF47413. 1 hit.
    SSF53822. SSF53822. 1 hit.
    PROSITEi PS00356. HTH_LACI_1. 1 hit.
    PS50932. HTH_LACI_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide."
      Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R.
      Mol. Microbiol. 6:3051-3063(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RM 7004 / Serotype B.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiGALR_HAEIN
    AccessioniPrimary (citable) accession number: P31766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3