P31766 (GALR_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator GalR

Alternative name(s):
Galactose operon repressor

Gene names

Name:	galR
Synonyms:	galS
Ordered Locus Names:	HI_0821

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Repressor of the galactose operon. Binds galactose as an inducer.
Pathway	Carbohydrate metabolism; galactose metabolism [regulation].
Sequence similarities	Contains 1 HTH lacI-type DNA-binding domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	HTH-type transcriptional regulator GalR		PRO_0000107953
Regions
	Domain	1 – 56	56	HTH lacI-type
	DNA binding	4 – 23	20	H-T-H motif Potential
Experimental info
	Sequence conflict	35	1	V → A in CAA46729. Ref.1
	Sequence conflict	38	1	Q → R in CAA46729. Ref.1
	Sequence conflict	208	1	P → L in CAA46729. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P31766 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 0F431000946AF8A5	FASTA	332	36,708
	10 20 30 40 50 60 MSTIRDVAKL ANVSVATVSR VLNHSLSVSE NTRLVVEQAI AQLAYQPNAN AQALAVQNTD 70 80 90 100 110 120 TIGVVVTDVT DAFFAILVKA VDKVAEAHQK TILIGIGYHH AEKEREAINT LLRKRCSSLV 130 140 150 160 170 180 VHSKALSDDE LSHYLNTVQG MVIINRVIKG YEHRCVSLDN QKGTYLATEM LIRYGHQHIA 190 200 210 220 230 240 YIGSNHAIFD EVERRNGYLA ALKDHNYPII EQAITLNSPD FEGGEKAMID LLSYNKNLTA 250 260 270 280 290 300 VVAYNDSMAA GAISVLNENN ISVPSQFSII GFDDMPIARY LIPKLTTIRY PIDLMATYAA 310 320 330 KLALSLTDEK IITPPVVQFN PTLVRRFSVE SR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide." Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R. Mol. Microbiol. 6:3051-3063(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RM 7004 / Serotype B.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65934 Genomic DNA. Translation: CAA46729.1. L42023 Genomic DNA. Translation: AAC22480.1.
PIR	F64096.
RefSeq	NP_438981.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P31766.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0821.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22480; AAC22480; HI_0821.
GeneID	949832.
KEGG	hin:HI0821.
PATRIC	20190297. VBIHaeInf48452_0862.
Phylogenomic databases
eggNOG	COG1609.
KO	K02529.
OMA	QGYEHRC.
ProtClustDB	CLSK789635.
Enzyme and pathway databases
UniPathway	UPA00214.
Family and domain databases
Gene3D	1.10.260.40. 1 hit.
InterPro	IPR010982. Lambda_DNA-bd_dom. IPR000843. Tscrpt_reg_HTH_LacI. [Graphical view]
Pfam	PF00356. LacI. 1 hit. [Graphical view]
PRINTS	PR00036. HTHLACI.
SMART	SM00354. HTH_LACI. 1 hit. [Graphical view]
SUPFAM	SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS00356. HTH_LACI_1. 1 hit. PS50932. HTH_LACI_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALR_HAEIN

Accession

Primary (citable) accession number: P31766

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program