Reviewed, UniProtKB/Swiss-Prot P31764 (GAL7_HAEIN)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	HI0820

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Galactose-1-phosphate uridylyltransferase		PRO_0000169895
Sites
	Active site	167	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	53	1	Zinc By similarity
	Metal binding	56	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity
	Metal binding	165	1	Zinc By similarity
	Metal binding	183	1	Iron By similarity
	Metal binding	282	1	Iron By similarity
	Metal binding	297	1	Iron By similarity
	Metal binding	299	1	Iron By similarity
Natural variations
	Natural variant	221	1	I → V in strain: RM 7004.
	Natural variant	229	1	I → V in strain: RM 7004.
	Natural variant	334	1	E → D in strain: RM 7004.

Sequences

	Sequence		Length	Mass (Da)
	P31764-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 3BAB24B417E5ECBF	FASTA	349	40,758
	10 20 30 40 50 60 MTALFEPTEH PHRRYNPLID QWVLVSPHRA KRPWQGQQEK VNEEQKPSYD PTCYLCPSNK 70 80 90 100 110 120 RITGELNPDY RKPYVFKNDF SALLEDTPAP EKSSDPLFQS SQARGESRVI CFSPDHSKTL 130 140 150 160 170 180 PLLTALEIEE VIKVWQEQLR ELGAKYQWVQ IFENKGAAMG CSNPHPHGQI WANSFLPNEV 190 200 210 220 230 240 AREDRTQRDY LLKHGSVMLV DYVKRELALK ERIVVETEHW IALVPYWAIW PFETLLLPKT 250 260 270 280 290 300 HVKRLTELSD EQSKDLAVIL KKLTTKYDNL FETSFPYSMG FHAAPFNGED NEHWQLHAHF 310 320 330 340 YPPLLRSATV RKFMVGYEML GENQRDLTAE QAAERLRALS EVHYKERTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide." Maskell D.J., Szabo M.J., Deadman M.E., Moxon E.R. Mol. Microbiol. 6:3051-3063(1992) [PubMed: 1282642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: RM 7004 / Serotype B.
[2]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65934 Genomic DNA. Translation: CAA46730.1. L42023 Genomic DNA. Translation: AAC22479.1.
PIR	E64096.
RefSeq	NP_438980.1.
3D structure databases
HSSP	HSSP built from PDB template 1HXQ based on UniProtKB P09148.
ModBase	Search...
Genome annotation databases
GeneID	950798.
GenomeReviews	Gene locus HI0820 in contig L42023_GR.
KEGG	hin:HI0820.
NMPDR	fig|71421.1.peg.788.
TIGR	HI0820.
Phylogenomic databases
HOGENOM	P31764.
OMA	P31764. DHWQLHA.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0820-MON.
BRENDA	2.7.7.12. 109.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
ProDom	PD005051. GalP_Utransf. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_HAEIN

Accession

Primary (citable) accession number: P31764

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)