Reviewed, UniProtKB/Swiss-Prot P31759 (FRZF_MYXXA)

Names and origin

Protein names

Recommended name:
    Protein methyltransferase frzF
    EC=2.1.1.80

Gene names

Name:

frzF

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	593 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	This methyltransferase is one of the proteins required for the normal aggregation of M.xanthus cells during fruiting body formation. It is also a component of a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. It may methylate frzCD to form gamma-glutamyl methyl ester residues.
Catalytic activity	S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
Sequence similarities	Contains 1 cheR-type methyltransferase domain. Contains 3 TPR repeats.

Ontologies

Keywords
Biological process	Chemotaxis
Domain	Repeat TPR repeat
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro protein-glutamate O-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 593	593	Protein methyltransferase frzF		PRO_0000176046
Regions
	Domain	1 – 276	276	CheR-type methyltransferase
	Repeat	423 – 456	34	TPR 1
	Repeat	457 – 490	34	TPR 2
	Repeat	491 – 524	34	TPR 3

Sequences

	Sequence		Length	Mass (Da)
	P31759-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: B38BA5F481A082B9	FASTA	593	64,669
	10 20 30 40 50 60 MLTASQKVLQ QLAALLLERA GLKITPDGFH SLRLALSARM PVLGLEEPEH YIQRLTGAGG 70 80 90 100 110 120 EEELRSLLPL VTVGHTEFFR DAKQFRALEK SVLPDLVSRS RREMRKVSIW SAGCATGEEP 130 140 150 160 170 180 YSLAMVLAEL GALSLEVDLW ATDLNLAAVE AAKQGRFTSR RAISINQARL TRFFKPVEEG 190 200 210 220 230 240 YEALPALREY IRFDGQNLAV PVFDKVALSS LDLILCRNVI IYFDLPTIRG LMDRFLAALR 250 260 270 280 290 300 PGGLLFLGYS ESLFKVYDRF EMIEVDGAFV YRRPLNDKSM RAPPLRITPY PGEPDVAARR 310 320 330 340 350 360 PVPADAFTAD LRKRMLPEDV PLTTRLPAVS ASSVAAPGSP SVTLPALGAS SSPRSVVPGR 370 380 390 400 410 420 LPAVSPHSPL PAIAARSRVT AELPTVGSVD SARPRITTEL PAVATTPRAP TVEVPAWPTL 430 440 450 460 470 480 LPPAERLAMA VRKMAQGDFS AAIAGVQRLL ADEPSDLDGL LTLGNLFSLT GRIPEAREAF 490 500 510 520 530 540 AQAIQREPLC VEARVFGGVA ALQAGELSEA RSELSKALFL EPTLAIGHYL LAQVHERTQD 550 560 570 580 590 HEAARRSYRN AIAQLRFPQR PLAGHYPEMP DSADAISRAA RYALAALEEQ PLR

References

[1]	"Developmental sensory transduction in Myxococcus xanthus involves methylation and demethylation of FrzCD." McCleary W.R., McBride M.J., Zusman D.R. J. Bacteriol. 172:4877-4887(1990) [PubMed: 2168368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DZF1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M35200 Genomic DNA. Translation: AAA25398.1.
PIR	XYYZFG. B36707.
3D structure databases
HSSP	HSSP built from PDB template 1BC5 based on UniProtKB P07801.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.1.1.80. 926.
Family and domain databases
InterPro	IPR000780. CheR_MeTrfase. IPR011990. TPR-like_helical. IPR013026. TPR_region. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF01739. CheR. 1 hit. PF03705. CheR_N. 1 hit. [Graphical view]
PRINTS	PR00996. CHERMTFRASE.
SMART	SM00138. MeTrc. 1 hit. SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS50123. CHER. 1 hit. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRZF_MYXXA

Accession

Primary (citable) accession number: P31759

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 5, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)