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P31756

- ALLN_ALLCG

UniProt

P31756 - ALLN_ALLCG

Protein

Alliin lyase

Gene
N/A
Organism
Allium cepa var. aggregatum (Shallot) (Allium ascalonicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate.

    Cofactori

    Pyridoxal phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961ChlorideBy similarity
    Binding sitei100 – 1001ChlorideBy similarity
    Binding sitei102 – 1021ChlorideBy similarity

    GO - Molecular functioni

    1. alliin lyase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Chloride, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13494.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alliin lyase (EC:4.4.1.4)
    Short name:
    Alliinase
    Alternative name(s):
    Cysteine sulphoxide lyase
    OrganismiAllium cepa var. aggregatum (Shallot) (Allium ascalonicum)
    Taxonomic identifieri28911 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesAmaryllidaceaeAllioideaeAllieaeAllium

    Subcellular locationi

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    Pathology & Biotechi

    Protein family/group databases

    Allergomei1254. All a Alliin lyase.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei‹1 – 2›2PRO_0000020681
    Chaini3 – 447445Alliin lyasePRO_0000020682Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi22 ↔ 41By similarity
    Disulfide bondi43 ↔ 52By similarity
    Disulfide bondi46 ↔ 59By similarity
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Modified residuei253 – 2531N6-(pyridoxal phosphate)lysineBy similarity
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi370 ↔ 378By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP31756.
    SMRiP31756. Positions 3-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 6147EGF-like; atypicalAdd
    BLAST

    Domaini

    The 6 Cys residues of the EGF-like domain are arranged in a disulfide pattern different from the one found in the canonical EGFs. The function of this domain is unclear. It may be a binding site for other proteins or the docking site for a putative alliinase receptor By similarity.By similarity

    Sequence similaritiesi

    Belongs to the alliinase family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain

    Family and domain databases

    Gene3Di2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF04864. Alliinase_C. 1 hit.
    PF04863. EGF_alliinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31756-1 [UniParc]FASTAAdd to Basket

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    QAKVTWSLKA AEEAEAVANI NCSGHGRAFL DGILSDGSPK CECNTCYTGA    50
    DCSQKITGCS ADVASGDGLF LEEYWQQHKE NSAVLVSGWH RTSYFFNPVS 100
    NFISFELEKT IKELHEIVGN AAAKDRYIVF GVGVTQLIHG LVISLSPNMT 150
    ATPCAPQSKV VAHAPYYPVF REQTKYFDKK GYEWKGNAAD YVNTSTPEQF 200
    IEMVTSPNNP EGLLRHEVIK GCKSIYDMVY YWPHYTPIKY KADEDIMLFT 250
    MSKYTGHSGS RFGWALIKDE TVYNKLLNYM TKNTEGTSRE TQLRSLKILK 300
    EVTAMIKTQK GTMRDLNTFG FQKLRERWVN ITALLDKSDR FSYQKLPQSE 350
    YCNYFRRMRP PSPSYAWVKC EWEEDKDCYQ TFQNGRINTQ SGEGFEAGSR 400
    YVRLSLIKTK DDFDQLMYYL KIMVEAKRKT PLIKQLSNDQ ISRRPFI 447
    Length:447
    Mass (Da):51,261
    Last modified:July 1, 1993 - v1
    Checksum:iC4B389C81CCD45E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12620 mRNA. Translation: CAA78266.1.
    PIRiS29300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12620 mRNA. Translation: CAA78266.1 .
    PIRi S29300.

    3D structure databases

    ProteinModelPortali P31756.
    SMRi P31756. Positions 3-429.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1254. All a Alliin lyase.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-13494.

    Family and domain databases

    Gene3Di 2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF04864. Alliinase_C. 1 hit.
    PF04863. EGF_alliinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of alliinase cDNA clones from garlic (Allium sativum L.) and related species."
      van Damme E.J.M., Smeets K., Torrekens S., van Leuven F., Peumans W.J.
      Eur. J. Biochem. 209:751-757(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Shoot.

    Entry informationi

    Entry nameiALLN_ALLCG
    AccessioniPrimary (citable) accession number: P31756
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3