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P31754 (UMPS_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine 5'-monophosphate synthase

Short name=UMP synthase

Including the following 2 domains:

  1. Orotate phosphoribosyltransferase
    Short name=OPRTase
    EC=2.4.2.10
  2. Orotidine 5'-phosphate decarboxylase
    EC=4.1.1.23
    Alternative name(s):
    OMPdecase
Gene names
Name:UMPS
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01208

Sequence similarities

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

In the C-terminal section; belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 480479Uridine 5'-monophosphate synthase HAMAP-Rule MF_01208
PRO_0000139648

Regions

Region2 – 214213OPRTase HAMAP-Rule MF_01208
Region215 – 2206Domain linker HAMAP-Rule MF_01208
Region221 – 480260OMPdecase HAMAP-Rule MF_01208

Sites

Active site3141For OMPdecase activity By similarity
Active site3171For OMPdecase activity By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2141Phosphoserine By similarity

Experimental info

Sequence conflict1811C → R in AAI12873. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P31754 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 7BDD5964C340940B

FASTA48052,229
        10         20         30         40         50         60 
MAAADALLGS LVTGLYDVQA FKFGNFVLKS GLSSPVYIDL RGIISRPSIL NQVAEMLFQT 

        70         80         90        100        110        120 
AENAEINFDT VCGVPYTALP LATIVCSTHE IPMLIRRKEK KDYGTKRLIE GAVNPGDTCL 

       130        140        150        160        170        180 
IIEDVVSSGS SVWETAEVLQ KEGLKVTDAV VLVDREQGGR DNLQARGIRL HSVCTLSTVL 

       190        200        210        220        230        240 
CILEQQKKIN AETVERVKRF IQENAFVAAN PNDSLPSVKK EPKELSFGAR AELPGTHPVA 

       250        260        270        280        290        300 
AKLLRLMQKK ETNLCLSADV SESRELLQLA DALGSRICLL KIHVDILNDF TLDVMKELTT 

       310        320        330        340        350        360 
LAKRHEFLIF EDRKFADIGN TVKKQYEGGV FKIASWADLV NAHAVPGSGV VKGLEEVGLP 

       370        380        390        400        410        420 
LHRACLLVAE MSSAGTLATG SYTEAAVQMA EEHSEFVIGF ISGSRVSMKP EFLHLTPGVQ 

       430        440        450        460        470        480 
LEAGGDNLGQ QYHSPQEVIG KRGSDIIIVG RGIIASANQL EAAKMYRKAA WEAYLSRLAV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of the cDNA encoding bovine uridine monophosphate synthase."
Schoeber S., Detlef S., Schwenger B.
Gene 124:307-308(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene."
Schwenger B., Schoeber S., Simon D.
Genomics 16:241-244(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Heart ventricle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65125 mRNA. Translation: CAA46253.1.
BC112872 mRNA. Translation: AAI12873.1.
PIRJN0558.
RefSeqNP_803474.1. NM_177508.1.
UniGeneBt.2379.

3D structure databases

ProteinModelPortalP31754.
SMRP31754. Positions 223-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000018248.

Proteomic databases

PRIDEP31754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018248; ENSBTAP00000018248; ENSBTAG00000013727.
GeneID281568.
KEGGbta:281568.

Organism-specific databases

CTD7372.

Phylogenomic databases

eggNOGCOG0284.
GeneTreeENSGT00390000001856.
HOVERGENHBG000870.
InParanoidP31754.
KOK13421.
OrthoDBEOG754HPB.
TreeFamTF314694.

Enzyme and pathway databases

UniPathwayUPA00070; UER00119.
UPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPMF_01208. PyrE.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805518.

Entry information

Entry nameUMPS_BOVIN
AccessionPrimary (citable) accession number: P31754
Secondary accession number(s): Q2KHV1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways