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P31754

- UMPS_BOVIN

UniProt

P31754 - UMPS_BOVIN

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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei314 – 3141For OMPdecase activityBy similarity
Active sitei317 – 3171For OMPdecase activityBy similarity

GO - Molecular functioni

  1. orotate phosphoribosyltransferase activity Source: UniProtKB-EC
  2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Glycosyltransferase, Lyase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiREACT_216864. Pyrimidine biosynthesis.
UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:UMPS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 480479Uridine 5'-monophosphate synthasePRO_0000139648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei214 – 2141PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP31754.

Expressioni

Gene expression databases

ExpressionAtlasiP31754. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018248.

Structurei

3D structure databases

ProteinModelPortaliP31754.
SMRiP31754. Positions 223-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 214213OPRTaseAdd
BLAST
Regioni215 – 2206Domain linker
Regioni221 – 480260OMPdecaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
GeneTreeiENSGT00390000001856.
HOVERGENiHBG000870.
InParanoidiP31754.
KOiK13421.
OrthoDBiEOG754HPB.
TreeFamiTF314694.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31754-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAADALLGS LVTGLYDVQA FKFGNFVLKS GLSSPVYIDL RGIISRPSIL
60 70 80 90 100
NQVAEMLFQT AENAEINFDT VCGVPYTALP LATIVCSTHE IPMLIRRKEK
110 120 130 140 150
KDYGTKRLIE GAVNPGDTCL IIEDVVSSGS SVWETAEVLQ KEGLKVTDAV
160 170 180 190 200
VLVDREQGGR DNLQARGIRL HSVCTLSTVL CILEQQKKIN AETVERVKRF
210 220 230 240 250
IQENAFVAAN PNDSLPSVKK EPKELSFGAR AELPGTHPVA AKLLRLMQKK
260 270 280 290 300
ETNLCLSADV SESRELLQLA DALGSRICLL KIHVDILNDF TLDVMKELTT
310 320 330 340 350
LAKRHEFLIF EDRKFADIGN TVKKQYEGGV FKIASWADLV NAHAVPGSGV
360 370 380 390 400
VKGLEEVGLP LHRACLLVAE MSSAGTLATG SYTEAAVQMA EEHSEFVIGF
410 420 430 440 450
ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYHSPQEVIG KRGSDIIIVG
460 470 480
RGIIASANQL EAAKMYRKAA WEAYLSRLAV
Length:480
Mass (Da):52,229
Last modified:July 1, 1993 - v1
Checksum:i7BDD5964C340940B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811C → R in AAI12873. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65125 mRNA. Translation: CAA46253.1.
BC112872 mRNA. Translation: AAI12873.1.
PIRiJN0558.
RefSeqiNP_803474.1. NM_177508.1.
UniGeneiBt.2379.

Genome annotation databases

EnsembliENSBTAT00000018248; ENSBTAP00000018248; ENSBTAG00000013727.
GeneIDi281568.
KEGGibta:281568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65125 mRNA. Translation: CAA46253.1 .
BC112872 mRNA. Translation: AAI12873.1 .
PIRi JN0558.
RefSeqi NP_803474.1. NM_177508.1.
UniGenei Bt.2379.

3D structure databases

ProteinModelPortali P31754.
SMRi P31754. Positions 223-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018248.

Proteomic databases

PRIDEi P31754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018248 ; ENSBTAP00000018248 ; ENSBTAG00000013727 .
GeneIDi 281568.
KEGGi bta:281568.

Organism-specific databases

CTDi 7372.

Phylogenomic databases

eggNOGi COG0284.
GeneTreei ENSGT00390000001856.
HOVERGENi HBG000870.
InParanoidi P31754.
KOi K13421.
OrthoDBi EOG754HPB.
TreeFami TF314694.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00119 .
UPA00070 ; UER00120 .
Reactomei REACT_216864. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi 20805518.

Gene expression databases

ExpressionAtlasi P31754. baseline and differential.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPi MF_01208. PyrE.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the cDNA encoding bovine uridine monophosphate synthase."
    Schoeber S., Detlef S., Schwenger B.
    Gene 124:307-308(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene."
    Schwenger B., Schoeber S., Simon D.
    Genomics 16:241-244(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiUMPS_BOVIN
AccessioniPrimary (citable) accession number: P31754
Secondary accession number(s): Q2KHV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3