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P31754

- UMPS_BOVIN

UniProt

P31754 - UMPS_BOVIN

Protein

Uridine 5'-monophosphate synthase

Gene

UMPS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
    Orotidine 5'-phosphate = UMP + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei314 – 3141For OMPdecase activityBy similarity
    Active sitei317 – 3171For OMPdecase activityBy similarity

    GO - Molecular functioni

    1. orotate phosphoribosyltransferase activity Source: UniProtKB-EC
    2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Glycosyltransferase, Lyase, Transferase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_216864. Pyrimidine biosynthesis.
    UniPathwayiUPA00070; UER00119.
    UPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Including the following 2 domains:
    Orotate phosphoribosyltransferase (EC:2.4.2.10)
    Short name:
    OPRTase
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMPdecase
    Gene namesi
    Name:UMPS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 480479Uridine 5'-monophosphate synthasePRO_0000139648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei214 – 2141PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP31754.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018248.

    Structurei

    3D structure databases

    ProteinModelPortaliP31754.
    SMRiP31754. Positions 223-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 214213OPRTaseAdd
    BLAST
    Regioni215 – 2206Domain linker
    Regioni221 – 480260OMPdecaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
    In the C-terminal section; belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    GeneTreeiENSGT00390000001856.
    HOVERGENiHBG000870.
    InParanoidiP31754.
    KOiK13421.
    OrthoDBiEOG754HPB.
    TreeFamiTF314694.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPiMF_01208. PyrE.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR004467. Or_phspho_trans_dom.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR00336. pyrE. 1 hit.
    TIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31754-1 [UniParc]FASTAAdd to Basket

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    MAAADALLGS LVTGLYDVQA FKFGNFVLKS GLSSPVYIDL RGIISRPSIL    50
    NQVAEMLFQT AENAEINFDT VCGVPYTALP LATIVCSTHE IPMLIRRKEK 100
    KDYGTKRLIE GAVNPGDTCL IIEDVVSSGS SVWETAEVLQ KEGLKVTDAV 150
    VLVDREQGGR DNLQARGIRL HSVCTLSTVL CILEQQKKIN AETVERVKRF 200
    IQENAFVAAN PNDSLPSVKK EPKELSFGAR AELPGTHPVA AKLLRLMQKK 250
    ETNLCLSADV SESRELLQLA DALGSRICLL KIHVDILNDF TLDVMKELTT 300
    LAKRHEFLIF EDRKFADIGN TVKKQYEGGV FKIASWADLV NAHAVPGSGV 350
    VKGLEEVGLP LHRACLLVAE MSSAGTLATG SYTEAAVQMA EEHSEFVIGF 400
    ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYHSPQEVIG KRGSDIIIVG 450
    RGIIASANQL EAAKMYRKAA WEAYLSRLAV 480
    Length:480
    Mass (Da):52,229
    Last modified:July 1, 1993 - v1
    Checksum:i7BDD5964C340940B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811C → R in AAI12873. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65125 mRNA. Translation: CAA46253.1.
    BC112872 mRNA. Translation: AAI12873.1.
    PIRiJN0558.
    RefSeqiNP_803474.1. NM_177508.1.
    UniGeneiBt.2379.

    Genome annotation databases

    EnsembliENSBTAT00000018248; ENSBTAP00000018248; ENSBTAG00000013727.
    GeneIDi281568.
    KEGGibta:281568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65125 mRNA. Translation: CAA46253.1 .
    BC112872 mRNA. Translation: AAI12873.1 .
    PIRi JN0558.
    RefSeqi NP_803474.1. NM_177508.1.
    UniGenei Bt.2379.

    3D structure databases

    ProteinModelPortali P31754.
    SMRi P31754. Positions 223-479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018248.

    Proteomic databases

    PRIDEi P31754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018248 ; ENSBTAP00000018248 ; ENSBTAG00000013727 .
    GeneIDi 281568.
    KEGGi bta:281568.

    Organism-specific databases

    CTDi 7372.

    Phylogenomic databases

    eggNOGi COG0284.
    GeneTreei ENSGT00390000001856.
    HOVERGENi HBG000870.
    InParanoidi P31754.
    KOi K13421.
    OrthoDBi EOG754HPB.
    TreeFami TF314694.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00119 .
    UPA00070 ; UER00120 .
    Reactomei REACT_216864. Pyrimidine biosynthesis.

    Miscellaneous databases

    NextBioi 20805518.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPi MF_01208. PyrE.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR004467. Or_phspho_trans_dom.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR00336. pyrE. 1 hit.
    TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the cDNA encoding bovine uridine monophosphate synthase."
      Schoeber S., Detlef S., Schwenger B.
      Gene 124:307-308(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene."
      Schwenger B., Schoeber S., Simon D.
      Genomics 16:241-244(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Heart ventricle.

    Entry informationi

    Entry nameiUMPS_BOVIN
    AccessioniPrimary (citable) accession number: P31754
    Secondary accession number(s): Q2KHV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3