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Protein

AKT kinase-transforming protein

Gene

V-AKT

Organism
AKT8 murine leukemia virus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This protein is synthesized as a Gag-Akt polyprotein.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei200ATPPROSITE-ProRule annotation1
Active sitei295Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 185ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AKT kinase-transforming protein (EC:2.7.11.1)
Gene namesi
Name:V-AKT
OrganismiAKT8 murine leukemia virus
Taxonomic identifieri11790 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Chemistry databases

ChEMBLiCHEMBL3627590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856141 – 501AKT kinase-transforming proteinAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated on threonine and serine residues.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with mouse THEM4.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP31748
SMRiP31748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129PHPROSITE-ProRule annotationAdd BLAST104
Domaini171 – 429Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini430 – 501AGC-kinase C-terminalAdd BLAST72

Domaini

The AGC-kinase C-terminal mediates interaction with THEM4.

Sequence similaritiesi

Family and domain databases

CDDicd05594 STKc_PKB_alpha, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR034676 Akt1
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P31748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AREETLIIIP GLPLSLGATD TMNDVAIVKE GWLHKRGEYI KTWRPRYFLL
60 70 80 90 100
KNDGTFIGYK ERPQDVDQRE SPLNNFSVAQ CQLMKTERPR PNTFIIRCLQ
110 120 130 140 150
WTTVIERTFH VETPEEREEW ATAIQTVADG LKRQEEETMD FRSGSPSDNS
160 170 180 190 200
GAEEMEVSLA KPKHRVTMNE FEYLKLLGKG TFGKVILVKE KATGRYYAMK
210 220 230 240 250
ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF LTALKYSFQT HDRLCFVMEY
260 270 280 290 300
ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN VVYRDLKLEN
310 320 330 340 350
LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA
360 370 380 390 400
VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLGPEAKSL
410 420 430 440 450
LSGLLKKDPT QRLGGGSEDA KEIMQHRFFA NIVWQDVYEK KLSPPFKPQV
460 470 480 490 500
TSETDTRYFD EEFTAQMITI TPPDQDDSME CVDSERRPHF PQFSYSASGT

A
Length:501
Mass (Da):57,870
Last modified:July 1, 1993 - v1
Checksum:i5AEFDE58CD42F773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80675 Genomic DNA Translation: AAA42545.1

Similar proteinsi

Entry informationi

Entry nameiAKT_MLVAT
AccessioniPrimary (citable) accession number: P31748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health