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Protein

AKT kinase-transforming protein

Gene

V-AKT

Organism
AKT8 murine leukemia virus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

This protein is synthesized as a Gag-Akt polyprotein.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei200ATPPROSITE-ProRule annotation1
Active sitei295Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 185ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AKT kinase-transforming protein (EC:2.7.11.1)
Gene namesi
Name:V-AKT
OrganismiAKT8 murine leukemia virus
Taxonomic identifieri11790 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusMurine leukemia virus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Chemistry databases

ChEMBLiCHEMBL3627590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856141 – 501AKT kinase-transforming proteinAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated on threonine and serine residues.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with mouse THEM4.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP31748.
SMRiP31748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129PHPROSITE-ProRule annotationAdd BLAST104
Domaini171 – 429Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini430 – 501AGC-kinase C-terminalAdd BLAST72

Domaini

The AGC-kinase C-terminal mediates interaction with THEM4.

Sequence similaritiesi

Family and domain databases

CDDicd05594. STKc_PKB_alpha. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR034676. Akt1.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P31748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AREETLIIIP GLPLSLGATD TMNDVAIVKE GWLHKRGEYI KTWRPRYFLL
60 70 80 90 100
KNDGTFIGYK ERPQDVDQRE SPLNNFSVAQ CQLMKTERPR PNTFIIRCLQ
110 120 130 140 150
WTTVIERTFH VETPEEREEW ATAIQTVADG LKRQEEETMD FRSGSPSDNS
160 170 180 190 200
GAEEMEVSLA KPKHRVTMNE FEYLKLLGKG TFGKVILVKE KATGRYYAMK
210 220 230 240 250
ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF LTALKYSFQT HDRLCFVMEY
260 270 280 290 300
ANGGELFFHL SRERVFSEDR ARFYGAEIVS ALDYLHSEKN VVYRDLKLEN
310 320 330 340 350
LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA
360 370 380 390 400
VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLGPEAKSL
410 420 430 440 450
LSGLLKKDPT QRLGGGSEDA KEIMQHRFFA NIVWQDVYEK KLSPPFKPQV
460 470 480 490 500
TSETDTRYFD EEFTAQMITI TPPDQDDSME CVDSERRPHF PQFSYSASGT

A
Length:501
Mass (Da):57,870
Last modified:July 1, 1993 - v1
Checksum:i5AEFDE58CD42F773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80675 Genomic DNA. Translation: AAA42545.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAKT_MLVAT
AccessioniPrimary (citable) accession number: P31748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 12, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families