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P31719

- KAX52_ANDMA

UniProt

P31719 - KAX52_ANDMA

Protein

Potassium channel toxin alpha-KTx 5.2

Gene
N/A
Organism
Androctonus mauretanicus mauretanicus (Scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocker for the small conductance calcium-activated potassium channels (SK-Ca); also known as apamine-sensitive potassium channel.

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 5.2
    Alternative name(s):
    AmP05
    Leiurotoxin I-like toxin P05
    OrganismiAndroctonus mauretanicus mauretanicus (Scorpion)
    Taxonomic identifieri6860 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3131Potassium channel toxin alpha-KTx 5.2PRO_0000044928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 211 Publication
    Disulfide bondi8 ↔ 261 Publication
    Disulfide bondi12 ↔ 281 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    31
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 139
    Beta strandi16 – 227
    Beta strandi25 – 295

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PNHNMR-A1-31[»]
    ProteinModelPortaliP31719.
    SMRiP31719. Positions 1-31.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP31719.

    Family & Domainsi

    Domaini

    Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31719-1 [UniParc]FASTAAdd to Basket

    « Hide

    TVCNLRRCQL SCRSLGLLGK CIGVKCECVK H                       31
    Length:31
    Mass (Da):3,421
    Last modified:July 1, 1993 - v1
    Checksum:i94B06CDC5CFB46FE
    GO

    Sequence databases

    PIRiA49078.

    Cross-referencesi

    Sequence databases

    PIRi A49078.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PNH NMR - A 1-31 [» ]
    ProteinModelPortali P31719.
    SMRi P31719. Positions 1-31.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P31719.

    Family and domain databases

    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a new leiurotoxin I-like scorpion toxin. PO5 from Androctonus mauretanicus mauretanicus."
      Zerrouk H., Mansuelle P., Benslimane A., Rochat H., Martin-Eauclaire M.-F.
      FEBS Lett. 320:189-192(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "P05, a new leiurotoxin I-like scorpion toxin: synthesis and structure-activity relationships of the alpha-amidated analog, a ligand of Ca(2+)-activated K+ channels with increased affinity."
      Sabatier J.-M., Zerrouk H., Darbon H., Mabrouk K., Benslimane A., Rochat H., Martin-Eauclaire M.-F., van Rietschoten J.
      Biochemistry 32:2763-2770(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SYNTHESIS.
    3. "Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel."
      Meunier S., Bernassau J.-M., Sabatier J.-M., Martin-Eauclaire M.-F., van Rietschoten J., Cambillau C., Darbon H.
      Biochemistry 32:11969-11976(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKAX52_ANDMA
    AccessioniPrimary (citable) accession number: P31719
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3