Reviewed, UniProtKB/Swiss-Prot P31719 (KAX52_ANDMA)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 5.2 Alternative name(s):     Leiurotoxin I-like toxin P05     AmP05
Organism	Androctonus mauretanicus mauretanicus (Scorpion)
Taxonomic identifier	6860 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus

Protein attributes

Sequence length	31 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocker for the small conductance calcium-activated potassium channels (SK-Ca); also known as apamine-sensitive potassium channel.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 5 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Peptide

1 – 31

31

Potassium channel toxin alpha-KTx 5.2

PRO_0000044928

Amino acid modifications

Disulfide bond

3 ↔ 21

Ref.3

Disulfide bond

8 ↔ 26

Ref.3

Disulfide bond

12 ↔ 28

Ref.3

Secondary structure

1

.

.

.

.

.

.

.

31

Helix Strand Turn

Details...

Helix

5 – 13

9

Beta strand

16 – 22

7

Beta strand

25 – 29

5

Sequences

	Sequence		Length	Mass (Da)
	P31719-1 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 94B06CDC5CFB46FE	FASTA	31	3,421
	10 20 30 TVCNLRRCQL SCRSLGLLGK CIGVKCECVK H

References

[1]	"Characterization of a new leiurotoxin I-like scorpion toxin. PO5 from Androctonus mauretanicus mauretanicus." Zerrouk H., Mansuelle P., Benslimane A., Rochat H., Martin-Eauclaire M.-F. FEBS Lett. 320:189-192(1993) [PubMed: 8385026] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.
[2]	"P05, a new leiurotoxin I-like scorpion toxin: synthesis and structure-activity relationships of the alpha-amidated analog, a ligand of Ca(2+)-activated K+ channels with increased affinity." Sabatier J.-M., Zerrouk H., Darbon H., Mabrouk K., Benslimane A., Rochat H., Martin-Eauclaire M.-F., van Rietschoten J. Biochemistry 32:2763-2770(1993) [PubMed: 8457543] [Abstract] Cited for: SYNTHESIS.
[3]	"Solution structure of P05-NH2, a scorpion toxin analog with high affinity for the apamin-sensitive potassium channel." Meunier S., Bernassau J.-M., Sabatier J.-M., Martin-Eauclaire M.-F., van Rietschoten J., Cambillau C., Darbon H. Biochemistry 32:11969-11976(1993) [PubMed: 8218272] [Abstract] Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

Sequence databases

PIR

A49078.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PNH	NMR	-	A	1-31	[»]

ModBase

Search...

Family and domain databases

InterPro

IPR001947. Scorpion_toxinS.
[Graphical view]

Pfam

PF00451. Toxin_2. 1 hit.
[Graphical view]

PROSITE

PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

KAX52_ANDMA

Accession

Primary (citable) accession number: P31719

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)