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Protein

Chaperone protein FimC

Gene

fimC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.

GO - Molecular functioni

  • protein binding involved in protein folding Source: EcoCyc

GO - Biological processi

  • cell wall organization Source: InterPro
  • chaperone-mediated protein folding Source: EcoCyc
  • pilus organization Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:EG10310-MONOMER.
ECOL316407:JW4279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein FimC
Gene namesi
Name:fimC
Ordered Locus Names:b4316, JW4279
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10310. fimC.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36361 PublicationAdd
BLAST
Chaini37 – 241205Chaperone protein FimCPRO_0000009273Add
BLAST

Proteomic databases

PaxDbiP31697.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fimAQ83UM22EBI-1028005,EBI-8548126From a different organism.
fimHP081916EBI-1028005,EBI-1028015

GO - Molecular functioni

  • protein binding involved in protein folding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262754. 253 interactions.
DIPiDIP-9611N.
IntActiP31697. 8 interactions.
MINTiMINT-2831193.
STRINGi511145.b4316.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 414Combined sources
Beta strandi43 – 486Combined sources
Beta strandi52 – 609Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi76 – 783Combined sources
Beta strandi82 – 10524Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi117 – 12711Combined sources
Helixi131 – 1355Combined sources
Beta strandi138 – 15215Combined sources
Beta strandi156 – 1583Combined sources
Helixi160 – 1623Combined sources
Helixi164 – 1663Combined sources
Beta strandi168 – 1714Combined sources
Beta strandi173 – 1808Combined sources
Beta strandi182 – 1843Combined sources
Beta strandi186 – 1938Combined sources
Beta strandi194 – 1963Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi207 – 2126Combined sources
Beta strandi215 – 2173Combined sources
Beta strandi221 – 2266Combined sources
Beta strandi236 – 2394Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BF8NMR-A37-241[»]
1KIUX-ray3.00A/C/E/G/I/K/M/O37-241[»]
1KLFX-ray2.79A/C/E/G/I/K/M/O37-241[»]
1QUNX-ray2.80A/C/E/G/I/K/M/O37-241[»]
1ZE3X-ray1.84C37-241[»]
3BWUX-ray1.76C37-241[»]
3JWNX-ray2.69C/I37-241[»]
3RFZX-ray2.80C/F37-241[»]
3SQBX-ray3.20A/C/E/G37-241[»]
4DWHX-ray2.50A/C37-241[»]
4J3OX-ray3.80C37-241[»]
ProteinModelPortaliP31697.
SMRiP31697. Positions 37-241.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31697.

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108NAE. Bacteria.
ENOG410ZYUF. LUCA.
HOGENOMiHOG000260152.
InParanoidiP31697.
KOiK07346.
OMAiPPLFAMQ.
PhylomeDBiP31697.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKNVNVRK SQEITFCLLA GILMFMAMMV AGRAEAGVAL GATRVIYPAG
60 70 80 90 100
QKQEQLAVTN NDENSTYLIQ SWVENADGVK DGRFIVTPPL FAMKGKKENT
110 120 130 140 150
LRILDATNNQ LPQDRESLFW MNVKAIPSMD KSKLTENTLQ LAIISRIKLY
160 170 180 190 200
YRPAKLALPP DQAAEKLRFR RSANSLTLIN PTPYYLTVTE LNAGTRVLEN
210 220 230 240
ALVPPMGEST VKLPSDAGSN ITYRTINDYG ALTPKMTGVM E
Length:241
Mass (Da):26,689
Last modified:February 1, 1995 - v3
Checksum:iB1AD63C33C8FACB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811D → G in CAA35967 (PubMed:1363735).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291M → V in strain: Clinical isolate 149 and O2:K1:H+ / MT78.
Natural varianti54 – 541E → V in strain: Clinical isolate 149 and O2:K1:H+ / MT78.
Natural varianti210 – 2101T → A in strain: Clinical isolate 149 and O2:K1:H+ / MT78.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51655 Genomic DNA. Translation: CAA35967.1.
L14598 Genomic DNA. No translation available.
Z37500 Genomic DNA. Translation: CAA85729.1.
U14003 Genomic DNA. Translation: AAA97212.1.
U00096 Genomic DNA. Translation: AAC77272.1.
AP009048 Genomic DNA. Translation: BAE78309.1.
PIRiS56541.
RefSeqiNP_418736.3. NC_000913.3.
WP_000066547.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77272; AAC77272; b4316.
BAE78309; BAE78309; BAE78309.
GeneIDi948843.
KEGGiecj:JW4279.
eco:b4316.
PATRICi32124228. VBIEscCol129921_4457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51655 Genomic DNA. Translation: CAA35967.1.
L14598 Genomic DNA. No translation available.
Z37500 Genomic DNA. Translation: CAA85729.1.
U14003 Genomic DNA. Translation: AAA97212.1.
U00096 Genomic DNA. Translation: AAC77272.1.
AP009048 Genomic DNA. Translation: BAE78309.1.
PIRiS56541.
RefSeqiNP_418736.3. NC_000913.3.
WP_000066547.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BF8NMR-A37-241[»]
1KIUX-ray3.00A/C/E/G/I/K/M/O37-241[»]
1KLFX-ray2.79A/C/E/G/I/K/M/O37-241[»]
1QUNX-ray2.80A/C/E/G/I/K/M/O37-241[»]
1ZE3X-ray1.84C37-241[»]
3BWUX-ray1.76C37-241[»]
3JWNX-ray2.69C/I37-241[»]
3RFZX-ray2.80C/F37-241[»]
3SQBX-ray3.20A/C/E/G37-241[»]
4DWHX-ray2.50A/C37-241[»]
4J3OX-ray3.80C37-241[»]
ProteinModelPortaliP31697.
SMRiP31697. Positions 37-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262754. 253 interactions.
DIPiDIP-9611N.
IntActiP31697. 8 interactions.
MINTiMINT-2831193.
STRINGi511145.b4316.

Proteomic databases

PaxDbiP31697.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77272; AAC77272; b4316.
BAE78309; BAE78309; BAE78309.
GeneIDi948843.
KEGGiecj:JW4279.
eco:b4316.
PATRICi32124228. VBIEscCol129921_4457.

Organism-specific databases

EchoBASEiEB0306.
EcoGeneiEG10310. fimC.

Phylogenomic databases

eggNOGiENOG4108NAE. Bacteria.
ENOG410ZYUF. LUCA.
HOGENOMiHOG000260152.
InParanoidiP31697.
KOiK07346.
OMAiPPLFAMQ.
PhylomeDBiP31697.

Enzyme and pathway databases

BioCyciEcoCyc:EG10310-MONOMER.
ECOL316407:JW4279-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP31697.
PROiP31697.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIMC_ECOLI
AccessioniPrimary (citable) accession number: P31697
Secondary accession number(s): P71220, Q2M5Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.