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Protein

Chaperone protein FimC

Gene

fimC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.

GO - Molecular functioni

  • protein binding involved in protein folding Source: EcoCyc

GO - Biological processi

  • cell wall organization Source: InterPro
  • chaperone-mediated protein folding Source: EcoCyc
  • pilus organization Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:EG10310-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein FimC
Gene namesi
Name:fimC
Ordered Locus Names:b4316, JW4279
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10310 fimC

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 361 PublicationAdd BLAST36
ChainiPRO_000000927337 – 241Chaperone protein FimCAdd BLAST205

Proteomic databases

PaxDbiP31697
PRIDEiP31697

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding involved in protein folding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262754, 253 interactors
DIPiDIP-9611N
IntActiP31697, 8 interactors
MINTiP31697
STRINGi316407.85677059

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi43 – 48Combined sources6
Beta strandi52 – 60Combined sources9
Beta strandi66 – 75Combined sources10
Beta strandi76 – 78Combined sources3
Beta strandi82 – 105Combined sources24
Beta strandi113 – 115Combined sources3
Beta strandi117 – 127Combined sources11
Helixi131 – 135Combined sources5
Beta strandi138 – 152Combined sources15
Beta strandi156 – 158Combined sources3
Helixi160 – 162Combined sources3
Helixi164 – 166Combined sources3
Beta strandi168 – 171Combined sources4
Beta strandi173 – 180Combined sources8
Beta strandi182 – 184Combined sources3
Beta strandi186 – 193Combined sources8
Beta strandi194 – 196Combined sources3
Beta strandi201 – 203Combined sources3
Beta strandi207 – 212Combined sources6
Beta strandi215 – 217Combined sources3
Beta strandi221 – 226Combined sources6
Beta strandi236 – 239Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BF8NMR-A37-241[»]
1KIUX-ray3.00A/C/E/G/I/K/M/O37-241[»]
1KLFX-ray2.79A/C/E/G/I/K/M/O37-241[»]
1QUNX-ray2.80A/C/E/G/I/K/M/O37-241[»]
1ZE3X-ray1.84C37-241[»]
3BWUX-ray1.76C37-241[»]
3JWNX-ray2.69C/I37-241[»]
3RFZX-ray2.80C/F37-241[»]
3SQBX-ray3.20A/C/E/G37-241[»]
4DWHX-ray2.50A/C37-241[»]
4J3OX-ray3.80C37-241[»]
ProteinModelPortaliP31697
SMRiP31697
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31697

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108NAE Bacteria
ENOG410ZYUF LUCA
HOGENOMiHOG000260152
InParanoidiP31697
KOiK07346
OMAiLFAMQGK
PhylomeDBiP31697

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
IPR036316 Pili_assmbl_chap_C_dom_sf
IPR001829 Pili_assmbl_chaperone_bac
IPR016148 Pili_assmbl_chaperone_C
IPR018046 Pili_assmbl_chaperone_CS
IPR016147 Pili_assmbl_chaperone_N
PfamiView protein in Pfam
PF02753 PapD_C, 1 hit
PF00345 PapD_N, 1 hit
PRINTSiPR00969 CHAPERONPILI
SUPFAMiSSF49354 SSF49354, 1 hit
SSF49584 SSF49584, 1 hit
PROSITEiView protein in PROSITE
PS00635 PILI_CHAPERONE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKNVNVRK SQEITFCLLA GILMFMAMMV AGRAEAGVAL GATRVIYPAG
60 70 80 90 100
QKQEQLAVTN NDENSTYLIQ SWVENADGVK DGRFIVTPPL FAMKGKKENT
110 120 130 140 150
LRILDATNNQ LPQDRESLFW MNVKAIPSMD KSKLTENTLQ LAIISRIKLY
160 170 180 190 200
YRPAKLALPP DQAAEKLRFR RSANSLTLIN PTPYYLTVTE LNAGTRVLEN
210 220 230 240
ALVPPMGEST VKLPSDAGSN ITYRTINDYG ALTPKMTGVM E
Length:241
Mass (Da):26,689
Last modified:February 1, 1995 - v3
Checksum:iB1AD63C33C8FACB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81D → G in CAA35967 (PubMed:1363735).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29M → V in strain: Clinical isolate 149 and O2:K1:H+ / MT78. 1
Natural varianti54E → V in strain: Clinical isolate 149 and O2:K1:H+ / MT78. 1
Natural varianti210T → A in strain: Clinical isolate 149 and O2:K1:H+ / MT78. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51655 Genomic DNA Translation: CAA35967.1
L14598 Genomic DNA No translation available.
Z37500 Genomic DNA Translation: CAA85729.1
U14003 Genomic DNA Translation: AAA97212.1
U00096 Genomic DNA Translation: AAC77272.1
AP009048 Genomic DNA Translation: BAE78309.1
PIRiS56541
RefSeqiNP_418736.3, NC_000913.3
WP_000066547.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77272; AAC77272; b4316
BAE78309; BAE78309; BAE78309
GeneIDi948843
KEGGiecj:JW4279
eco:b4316
PATRICifig|1411691.4.peg.2376

Similar proteinsi

Entry informationi

Entry nameiFIMC_ECOLI
AccessioniPrimary (citable) accession number: P31697
Secondary accession number(s): P71220, Q2M5Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health