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P31693 (SRC_RSVPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Src

EC=2.7.10.2
Alternative name(s):
pp60v-src
Short name=p60-Src
Short name=v-Src
Gene names
Name:V-SRC
OrganismRous sarcoma virus (strain PA101T)
Taxonomic identifier31667 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This phosphoprotein, required for both the initiation and the maintenance of neoplastic transformation, is a protein kinase that catalyzes the phosphorylation of tyrosine residues in vitro.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Homodimer By similarity.

Post-translational modification

The phosphorylated form is termed pp60v-src.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host By similarity
Chain2 – 523522Tyrosine-protein kinase transforming protein Src
PRO_0000088151

Regions

Domain75 – 13965SH3
Domain145 – 24298SH2
Domain264 – 514251Protein kinase
Nucleotide binding270 – 2789ATP By similarity

Sites

Active site3831Proton acceptor By similarity
Binding site2921ATP By similarity

Amino acid modifications

Modified residue4131Phosphotyrosine; by autocatalysis By similarity
Lipidation21N-myristoyl glycine; by host By similarity

Sequences

Sequence LengthMass (Da)Tools
P31693 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 853245739F6B90ED

FASTA52358,778
        10         20         30         40         50         60 
MGSSKSKPKD PSQRRRSLEP PDSTHHGGFP ASQTPNKTAA PDTHRTPSRS FGTVATELKL 

        70         80         90        100        110        120 
FGDFNTSDTV TSPQRAGALA GSVTTFGTRE SRIETDLSFK KRERLQIVNN TEGTWWLAHS 

       130        140        150        160        170        180 
LTTGQTGYIP SNYVAPSDSI QAEEWYFGKI TRRESGRLLL NPENPRGTFL VRESETTKGA 

       190        200        210        220        230        240 
YCLSVSDFDN AKGLNVKHYK IRKLDSGGFY ITSRTQFSSL QQLVAYYSKH ADGLCHRLTN 

       250        260        270        280        290        300 
VCPTSKPQTQ GLAKDAWEIP RESLRLEVKL GQGYFGEVWM GTWNGTTRVA IKTLKPGTMS 

       310        320        330        340        350        360 
PEAFLQEAQV MKKLRHEKLV QLYAMVSEEP IYIVIEYMSK GSLLDFLKGE MGKYLRLPQL 

       370        380        390        400        410        420 
VEMAAQIASG MAYVERMNYV HRDLRAANIL VGENLVCKVA DFGLARLIED NEYTARPGAR 

       430        440        450        460        470        480 
FPVKWTAPEA ALYGRFTIKS DVWSFGILLT ELTTKGRVPY PGMVNGEVLD RVERGYRMPC 

       490        500        510        520 
PPECPESLHD LMCQCWRKDP EERPTFEYLQ AQLLPACVLK IAE 

« Hide

References

[1]"Small deletion in v-src SH3 domain of a transformation defective mutant of Rous sarcoma virus restores wild type transforming properties."
Dezelee P., Barnier J.V., Hampe A., Laugier D., Marx M., Galibert F., Calothy G.
Virology 189:556-567(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84475 Genomic DNA. Translation: AAA42581.1. Sequence problems.
PIRTVFVMT. A42994.

3D structure databases

ProteinModelPortalP31693.
SMRP31693. Positions 90-513.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 5464.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRC_RSVPA
AccessionPrimary (citable) accession number: P31693
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families