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Protein

Co-chaperone protein DjlA

Gene

djlA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.UniRule annotation3 Publications

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciEcoCyc:EG11570-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Co-chaperone protein DjlAUniRule annotationCurated
Alternative name(s):
DnaJ-like protein DjlACurated
Gene namesi
Name:djlA1 PublicationUniRule annotation
Synonyms:yabH
Ordered Locus Names:b0055, JW0054
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11570 djlA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6PeriplasmicUniRule annotation2 Publications6
Transmembranei7 – 31HelicalUniRule annotationAdd BLAST25
Topological domaini32 – 271CytoplasmicUniRule annotation2 PublicationsAdd BLAST240

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15L → R: Loss of activation of rcs. 1 Publication1
Mutagenesisi16M → R: Only partial activation of rcs. 1 Publication1
Mutagenesisi233H → Q: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002094241 – 271Co-chaperone protein DjlAAdd BLAST271

Proteomic databases

PaxDbiP31680
PRIDEiP31680

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261616, 19 interactors
IntActiP31680, 7 interactors
STRINGi316385.ECDH10B_0056

Structurei

3D structure databases

ProteinModelPortaliP31680
SMRiP31680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 271JUniRule annotationAdd BLAST67

Domaini

The transmembrane domain is a dimerization domain.UniRule annotation1 Publication

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41066UG Bacteria
COG1076 LUCA
HOGENOMiHOG000272779
InParanoidiP31680
KOiK05801
OMAiMQYWGKL

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.10.3680.10, 1 hit
HAMAPiMF_01153 DjlA, 1 hit
InterProiView protein in InterPro
IPR023749 DjlA
IPR007791 DjlA_N
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR029024 TerB-like
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF05099 TerB, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYWGKIIGV AVALLMGGGF WGVVLGLLIG HMFDKARSRK MAWFANQRER
60 70 80 90 100
QALFFATTFE VMGHLTKSKG RVTEADIHIA SQLMDRMNLH GASRTAAQNA
110 120 130 140 150
FRVGKSDNYP LREKMRQFRS VCFGRFDLIR MFLEIQIQAA FADGSLHPNE
160 170 180 190 200
RAVLYVIAEE LGISRAQFDQ FLRMMQGGAQ FGGGYQQQTG GGNWQQAQRG
210 220 230 240 250
PTLEDACNVL GVKPTDDATT IKRAYRKLMS EHHPDKLVAK GLPPEMMEMA
260 270
KQKAQEIQQA YELIKQQKGF K
Length:271
Mass (Da):30,579
Last modified:July 1, 1993 - v1
Checksum:i80A0FC28F6D470DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195Q → L in AAT42473 (PubMed:12664169).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73166.1
AP009048 Genomic DNA Translation: BAB96623.1
AY625119 Genomic DNA Translation: AAT42473.1
PIRiG64726
RefSeqiNP_414597.1, NC_000913.3
WP_001200579.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73166; AAC73166; b0055
BAB96623; BAB96623; BAB96623
GeneIDi948992
KEGGiecj:JW0054
eco:b0055
PATRICifig|1411691.4.peg.2228

Similar proteinsi

Entry informationi

Entry nameiDJLA_ECOLI
AccessioniPrimary (citable) accession number: P31680
Secondary accession number(s): Q6IU30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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