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Protein

Sugar efflux transporter A

Gene

setA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents.

GO - Molecular functioni

  • sugar efflux transmembrane transporter activity Source: EcoliWiki

GO - Biological processi

  • cellular response to glucose-phosphate stress Source: EcoCyc
  • glucose transport Source: EcoliWiki
  • lactose transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0070-MONOMER.
ECOL316407:JW0069-MONOMER.
MetaCyc:B0070-MONOMER.

Protein family/group databases

TCDBi2.A.1.20.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter A
Gene namesi
Name:setA
Synonyms:yabM
Ordered Locus Names:b0070, JW0069
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11754. setA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 4817PeriplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 8112CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 1064PeriplasmicSequence analysis
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 1711PeriplasmicSequence analysis
Transmembranei172 – 19221HelicalSequence analysisAdd
BLAST
Topological domaini193 – 21927CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Topological domaini241 – 25111PeriplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST
Topological domaini273 – 28210CytoplasmicSequence analysis
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Topological domaini304 – 3085PeriplasmicSequence analysis
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Topological domaini330 – 34213CytoplasmicSequence analysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Topological domaini364 – 3652PeriplasmicSequence analysis
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Topological domaini387 – 3926CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Sugar efflux transporter APRO_0000209359Add
BLAST

Proteomic databases

PaxDbiP31675.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0070.

Structurei

3D structure databases

ProteinModelPortaliP31675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31675.
KOiK03291.
OMAiQPFWVGL.
PhylomeDBiP31675.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWIMTMARR MNGVYAAFML VAFMMGVAGA LQAPTLSLFL SREVGAQPFW
60 70 80 90 100
IGLFYTVNAI AGIGVSLWLA KRSDSQGDRR KLIIFCCLMA IGNALLFAFN
110 120 130 140 150
RHYLTLITCG VLLASLANTA MPQLFALARE YADNSAREVV MFSSVMRAQL
160 170 180 190 200
SLAWVIGPPL AFMLALNYGF TVMFSIAAGI FTLSLVLIAF MLPSVARVEL
210 220 230 240 250
PSENALSMQG GWQDSNVRML FVASTLMWTC NTMYIIDMPL WISSELGLPD
260 270 280 290 300
KLAGFLMGTA AGLEIPAMIL AGYYVKRYGK RRMMVIAVAA GVLFYTGLIF
310 320 330 340 350
FNSRMALMTL QLFNAVFIGI VAGIGMLWFQ DLMPGRAGAA TTLFTNSIST
360 370 380 390
GVILAGVIQG AIAQSWGHFA VYWVIAVISV VALFLTAKVK DV
Length:392
Mass (Da):42,713
Last modified:October 11, 2004 - v3
Checksum:i8CBD368BBC448460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48123.1.
AP009048 Genomic DNA. Translation: BAB96639.2.
PIRiF64728.
RefSeqiWP_000637847.1. NZ_LN832404.1.
YP_025293.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48123; AAT48123; b0070.
BAB96639; BAB96639; BAB96639.
GeneIDi944793.
KEGGiecj:JW0069.
eco:b0070.
PATRICi32115243. VBIEscCol129921_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48123.1.
AP009048 Genomic DNA. Translation: BAB96639.2.
PIRiF64728.
RefSeqiWP_000637847.1. NZ_LN832404.1.
YP_025293.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP31675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b0070.

Protein family/group databases

TCDBi2.A.1.20.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48123; AAT48123; b0070.
BAB96639; BAB96639; BAB96639.
GeneIDi944793.
KEGGiecj:JW0069.
eco:b0070.
PATRICi32115243. VBIEscCol129921_0073.

Organism-specific databases

EchoBASEiEB1704.
EcoGeneiEG11754. setA.

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31675.
KOiK03291.
OMAiQPFWVGL.
PhylomeDBiP31675.

Enzyme and pathway databases

BioCyciEcoCyc:B0070-MONOMER.
ECOL316407:JW0069-MONOMER.
MetaCyc:B0070-MONOMER.

Miscellaneous databases

PROiP31675.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETA_ECOLI
AccessioniPrimary (citable) accession number: P31675
Secondary accession number(s): P75639, Q6BF91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.