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Protein

Sugar efflux transporter A

Gene

setA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents.

GO - Molecular functioni

  • sugar efflux transmembrane transporter activity Source: EcoliWiki

GO - Biological processi

  • cellular response to glucose-phosphate stress Source: EcoCyc
  • glucose transport Source: EcoliWiki
  • lactose transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0070-MONOMER.
ECOL316407:JW0069-MONOMER.
MetaCyc:B0070-MONOMER.

Protein family/group databases

TCDBi2.A.1.20.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar efflux transporter A
Gene namesi
Name:setA
Synonyms:yabM
Ordered Locus Names:b0070, JW0069
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11754. setA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 48PeriplasmicSequence analysisAdd BLAST17
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 81CytoplasmicSequence analysisAdd BLAST12
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 106PeriplasmicSequence analysis4
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171PeriplasmicSequence analysis1
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 219CytoplasmicSequence analysisAdd BLAST27
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 251PeriplasmicSequence analysisAdd BLAST11
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 282CytoplasmicSequence analysis10
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 308PeriplasmicSequence analysis5
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 342CytoplasmicSequence analysisAdd BLAST13
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 365PeriplasmicSequence analysis2
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 392CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093591 – 392Sugar efflux transporter AAdd BLAST392

Proteomic databases

PaxDbiP31675.
PRIDEiP31675.

Interactioni

Protein-protein interaction databases

STRINGi511145.b0070.

Structurei

3D structure databases

ProteinModelPortaliP31675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31675.
KOiK03291.
OMAiQPFWVGL.
PhylomeDBiP31675.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWIMTMARR MNGVYAAFML VAFMMGVAGA LQAPTLSLFL SREVGAQPFW
60 70 80 90 100
IGLFYTVNAI AGIGVSLWLA KRSDSQGDRR KLIIFCCLMA IGNALLFAFN
110 120 130 140 150
RHYLTLITCG VLLASLANTA MPQLFALARE YADNSAREVV MFSSVMRAQL
160 170 180 190 200
SLAWVIGPPL AFMLALNYGF TVMFSIAAGI FTLSLVLIAF MLPSVARVEL
210 220 230 240 250
PSENALSMQG GWQDSNVRML FVASTLMWTC NTMYIIDMPL WISSELGLPD
260 270 280 290 300
KLAGFLMGTA AGLEIPAMIL AGYYVKRYGK RRMMVIAVAA GVLFYTGLIF
310 320 330 340 350
FNSRMALMTL QLFNAVFIGI VAGIGMLWFQ DLMPGRAGAA TTLFTNSIST
360 370 380 390
GVILAGVIQG AIAQSWGHFA VYWVIAVISV VALFLTAKVK DV
Length:392
Mass (Da):42,713
Last modified:October 11, 2004 - v3
Checksum:i8CBD368BBC448460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48123.1.
AP009048 Genomic DNA. Translation: BAB96639.2.
PIRiF64728.
RefSeqiWP_000637847.1. NZ_LN832404.1.
YP_025293.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48123; AAT48123; b0070.
BAB96639; BAB96639; BAB96639.
GeneIDi944793.
KEGGiecj:JW0069.
eco:b0070.
PATRICi32115243. VBIEscCol129921_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAT48123.1.
AP009048 Genomic DNA. Translation: BAB96639.2.
PIRiF64728.
RefSeqiWP_000637847.1. NZ_LN832404.1.
YP_025293.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP31675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b0070.

Protein family/group databases

TCDBi2.A.1.20.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP31675.
PRIDEiP31675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48123; AAT48123; b0070.
BAB96639; BAB96639; BAB96639.
GeneIDi944793.
KEGGiecj:JW0069.
eco:b0070.
PATRICi32115243. VBIEscCol129921_0073.

Organism-specific databases

EchoBASEiEB1704.
EcoGeneiEG11754. setA.

Phylogenomic databases

eggNOGiENOG4105S8Q. Bacteria.
ENOG410XTE9. LUCA.
HOGENOMiHOG000281090.
InParanoidiP31675.
KOiK03291.
OMAiQPFWVGL.
PhylomeDBiP31675.

Enzyme and pathway databases

BioCyciEcoCyc:B0070-MONOMER.
ECOL316407:JW0069-MONOMER.
MetaCyc:B0070-MONOMER.

Miscellaneous databases

PROiP31675.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004750. Sugar_efflux.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00899. 2A0120. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETA_ECOLI
AccessioniPrimary (citable) accession number: P31675
Secondary accession number(s): P75639, Q6BF91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.