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Protein

Sodium-dependent neutral amino acid transporter SLC6A17

Gene

Slc6a17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent.1 Publication

Kineticsi

  1. KM=1.72 mM for glycine1 Publication
  2. KM=0.86 mM for proline1 Publication
  1. Vmax=199 pmol/min/mg enzyme for glycine1 Publication
  2. Vmax=172 pmol/min/mg enzyme for proline1 Publication

pH dependencei

Optimum pH is 8.5.2 Publications

GO - Molecular functioni

GO - Biological processi

  • alanine transport Source: UniProtKB
  • brain development Source: UniProtKB
  • glycine transport Source: UniProtKB
  • leucine transport Source: UniProtKB
  • neutral amino acid transport Source: UniProtKB
  • proline transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Protein family/group databases

TCDBi2.A.22.6.2. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter SLC6A17
Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17
Gene namesi
Name:Slc6a17
Synonyms:Ntt4, Rxt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1587185. Slc6a17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini90 – 96ExtracellularSequence analysis7
Transmembranei97 – 116Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini117 – 140CytoplasmicSequence analysisAdd BLAST24
Transmembranei141 – 161Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini162 – 224ExtracellularSequence analysisAdd BLAST63
Transmembranei225 – 243Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini244 – 251CytoplasmicSequence analysis8
Transmembranei252 – 269Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini270 – 304ExtracellularSequence analysisAdd BLAST35
Transmembranei305 – 322Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini323 – 333CytoplasmicSequence analysisAdd BLAST11
Transmembranei334 – 355Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini356 – 451ExtracellularSequence analysisAdd BLAST96
Transmembranei452 – 471Helical; Name=8Sequence analysisAdd BLAST20
Topological domaini472 – 494CytoplasmicSequence analysisAdd BLAST23
Transmembranei495 – 513Helical; Name=9Sequence analysisAdd BLAST19
Topological domaini514 – 528ExtracellularSequence analysisAdd BLAST15
Transmembranei529 – 549Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini550 – 569CytoplasmicSequence analysisAdd BLAST20
Transmembranei570 – 591Helical; Name=11Sequence analysisAdd BLAST22
Topological domaini592 – 618ExtracellularSequence analysisAdd BLAST27
Transmembranei619 – 641Helical; Name=12Sequence analysisAdd BLAST23
Topological domaini642 – 727CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148051 – 727Sodium-dependent neutral amino acid transporter SLC6A17Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Modified residuei377PhosphotyrosineBy similarity1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Modified residuei665PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31662.
PRIDEiP31662.

PTM databases

iPTMnetiP31662.
PhosphoSitePlusiP31662.
SwissPalmiP31662.

Expressioni

Tissue specificityi

Found exclusively in the central nervous system and is more abundant in the cerebellum and the cerebral cortex. Expressed in PC-12 cell line.2 Publications

Gene expression databases

BgeeiENSRNOG00000050090.
GenevisibleiP31662. RN.

Interactioni

Protein-protein interaction databases

BioGridi565981. 1 interactor.
STRINGi10116.ENSRNOP00000065179.

Structurei

3D structure databases

ProteinModelPortaliP31662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOVERGENiHBG071421.
InParanoidiP31662.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG091G08PX.
PhylomeDBiP31662.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNSKVTQR EHSNEHVTES VADLLALEEP VDYKQSVLNV AGETGGKQKV
60 70 80 90 100
AEEELDAEDR PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV
110 120 130 140 150
PYLVLLIIIG IPLFFLELAV GQRIRRGSIG VWHYVCPRLG GIGFSSCIVC
160 170 180 190 200
LFVGLYYNVI IGWSVFYFFK SFQYPLPWSE CPVIRNGTVA VVEPECEKSS
210 220 230 240 250
ATTYFWYREA LDISNSISES GGLNWKMTVC LLVAWSIVGM AVVKGIQSSG
260 270 280 290 300
KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE
310 320 330 340 350
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV
360 370 380 390 400
VFAVLGFKAN IMNEKCVVEN AEKILGYLNS NVLSRDLIPP HVNFSHLTTK
410 420 430 440 450
DYSEMYNVIM TVKEKQFSAL GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT
460 470 480 490 500
HFPASPFWSV MFFLMLINLG LGSMIGTMAG ITTPIIDTFK VPKEMFTVGC
510 520 530 540 550
CVFAFFVGLL FVQRSGNYFV TMFDDYSATL PLTVIVILEN IAVAWIYGTK
560 570 580 590 600
KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVSPPGYSA
610 620 630 640 650
WIKEEAAERY LYFPNWAMAL LITLIAVATL PIPVVFILRH FHLLSDGSNT
660 670 680 690 700
LSVSYKKGRM MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST
710 720
SPLESSSHPN GRYGSGYLLA STPESEL
Length:727
Mass (Da):81,055
Last modified:July 1, 1993 - v1
Checksum:iC676048C0A6BDF7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261Y → C in AAC60673 (PubMed:8294906).Curated1
Sequence conflicti499G → S in AAC60673 (PubMed:8294906).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06434 mRNA. Translation: AAB24776.1.
S68944 mRNA. Translation: AAC60673.1.
PIRiI56506.
S27043.
RefSeqiNP_001028251.1. NM_001033079.1.
UniGeneiRn.186904.

Genome annotation databases

EnsembliENSRNOT00000075653; ENSRNOP00000065179; ENSRNOG00000050090.
GeneIDi613226.
KEGGirno:613226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06434 mRNA. Translation: AAB24776.1.
S68944 mRNA. Translation: AAC60673.1.
PIRiI56506.
S27043.
RefSeqiNP_001028251.1. NM_001033079.1.
UniGeneiRn.186904.

3D structure databases

ProteinModelPortaliP31662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi565981. 1 interactor.
STRINGi10116.ENSRNOP00000065179.

Protein family/group databases

TCDBi2.A.22.6.2. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiP31662.
PhosphoSitePlusiP31662.
SwissPalmiP31662.

Proteomic databases

PaxDbiP31662.
PRIDEiP31662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075653; ENSRNOP00000065179; ENSRNOG00000050090.
GeneIDi613226.
KEGGirno:613226.

Organism-specific databases

CTDi388662.
RGDi1587185. Slc6a17.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOVERGENiHBG071421.
InParanoidiP31662.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG091G08PX.
PhylomeDBiP31662.

Miscellaneous databases

PROiP31662.

Gene expression databases

BgeeiENSRNOG00000050090.
GenevisibleiP31662. RN.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A17_RAT
AccessioniPrimary (citable) accession number: P31662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.