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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Kineticsi

  1. KM=0.8 µM for GABA
  2. KM=99 µM for beta-alanine
  3. KM=1.4 mM for taurine

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Biological processNeurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiR-MMU-442660 Na+/Cl- dependent neurotransmitter transporters
    R-MMU-71288 Creatine metabolism
    R-MMU-888593 Reuptake of GABA

    Protein family/group databases

    TCDBi2.A.22.3.7 the neurotransmitter:sodium symporter (nss) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Sodium- and chloride-dependent GABA transporter 4
    Short name:
    GAT-4
    Solute carrier family 6 member 11
    Gene namesi
    Name:Slc6a11
    Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 6

    Organism-specific databases

    MGIiMGI:95630 Slc6a11

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
    Transmembranei54 – 74Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei82 – 101Helical; Name=2Sequence analysisAdd BLAST20
    Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini147 – 220ExtracellularSequence analysisAdd BLAST74
    Transmembranei221 – 239Helical; Name=4Sequence analysisAdd BLAST19
    Transmembranei248 – 265Helical; Name=5Sequence analysisAdd BLAST18
    Transmembranei301 – 318Helical; Name=6Sequence analysisAdd BLAST18
    Transmembranei330 – 351Helical; Name=7Sequence analysisAdd BLAST22
    Transmembranei384 – 403Helical; Name=8Sequence analysisAdd BLAST20
    Transmembranei433 – 451Helical; Name=9Sequence analysisAdd BLAST19
    Transmembranei468 – 488Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei509 – 528Helical; Name=11Sequence analysisAdd BLAST20
    Transmembranei548 – 566Helical; Name=12Sequence analysisAdd BLAST19
    Topological domaini567 – 627CytoplasmicSequence analysisAdd BLAST61

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Chemistry databases

    ChEMBLiCHEMBL3699

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002147851 – 627Sodium- and chloride-dependent GABA transporter 3Add BLAST627

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei21PhosphoserineBy similarity1
    Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP31650
    PaxDbiP31650
    PeptideAtlasiP31650
    PRIDEiP31650

    PTM databases

    iPTMnetiP31650
    PhosphoSitePlusiP31650
    SwissPalmiP31650

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiENSMUSG00000030307
    GenevisibleiP31650 MM

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032451

    Chemistry databases

    BindingDBiP31650

    Structurei

    3D structure databases

    ProteinModelPortaliP31650
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3659 Eukaryota
    COG0733 LUCA
    GeneTreeiENSGT00760000118857
    HOGENOMiHOG000116406
    HOVERGENiHBG071421
    InParanoidiP31650
    KOiK05039
    OMAiIKWCWKI
    OrthoDBiEOG091G08PX
    TreeFamiTF343812

    Family and domain databases

    CDDicd11508 SLC6sbd_GAT3, 1 hit
    InterProiView protein in InterPro
    IPR000175 Na/ntran_symport
    IPR002982 Na/ntran_symport_GABA_GAT3
    IPR037272 SNS_sf
    PANTHERiPTHR11616 PTHR11616, 1 hit
    PfamiView protein in Pfam
    PF00209 SNF, 1 hit
    PRINTSiPR01197 GAT3TRNSPORT
    PR00176 NANEUSMPORT
    SUPFAMiSSF161070 SSF161070, 1 hit
    PROSITEiView protein in PROSITE
    PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
    PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
    PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P31650-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN
    60 70 80 90 100
    KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF
    110 120 130 140 150
    LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI
    160 170 180 190 200
    FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME
    210 220 230 240 250
    FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY
    260 270 280 290 300
    VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ
    310 320 330 340 350
    IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV
    360 370 380 390 400
    LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF
    410 420 430 440 450
    LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI ISYFLGLVML
    460 470 480 490 500
    TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG
    510 520 530 540 550
    YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW
    560 570 580 590 600
    LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR
    610 620
    TVTVNDCEAK VKGDGTISAI TEKETHF
    Length:627
    Mass (Da):69,961
    Last modified:July 27, 2011 - v2
    Checksum:i7BCCFA2000DB024F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK053078 mRNA Translation: BAC35259.1
    AK140423 mRNA Translation: BAE24379.1
    CH466523 Genomic DNA Translation: EDK99507.1
    CCDSiCCDS39597.1
    PIRiB44409
    RefSeqiNP_766478.1, NM_172890.3
    UniGeneiMm.44683
    Mm.448312

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307
    GeneIDi243616
    KEGGimmu:243616
    UCSCiuc009dhs.1 mouse

    Similar proteinsi

    Entry informationi

    Entry nameiS6A11_MOUSE
    AccessioniPrimary (citable) accession number: P31650
    Secondary accession number(s): Q8BWA7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: May 23, 2018
    This is version 128 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

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