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P31650 (S6A11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent GABA transporter 3

Short name=GAT-3
Alternative name(s):
Sodium- and chloride-dependent GABA transporter 4
Short name=GAT-4
Solute carrier family 6 member 11
Gene names
Name:Slc6a11
Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Brain.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. [View classification]

Biophysicochemical properties

Kinetic parameters:

KM=0.8 µM for GABA

KM=99 µM for beta-alanine

KM=1.4 mM for taurine

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Sodium- and chloride-dependent GABA transporter 3
PRO_0000214785

Regions

Topological domain1 – 5353Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=1; Potential
Transmembrane82 – 10120Helical; Name=2; Potential
Transmembrane126 – 14621Helical; Name=3; Potential
Topological domain147 – 22074Extracellular Potential
Transmembrane221 – 23919Helical; Name=4; Potential
Transmembrane248 – 26518Helical; Name=5; Potential
Transmembrane301 – 31818Helical; Name=6; Potential
Transmembrane330 – 35122Helical; Name=7; Potential
Transmembrane384 – 40320Helical; Name=8; Potential
Transmembrane433 – 45119Helical; Name=9; Potential
Transmembrane468 – 48821Helical; Name=10; Potential
Transmembrane509 – 52820Helical; Name=11; Potential
Transmembrane548 – 56619Helical; Name=12; Potential
Topological domain567 – 62761Cytoplasmic Potential

Amino acid modifications

Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P31650 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7BCCFA2000DB024F

FASTA62769,961
        10         20         30         40         50         60 
MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN KVEFVLSVAG 

        70         80         90        100        110        120 
EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF LETALGQFTS EGGITCWRRV 

       130        140        150        160        170        180 
CPLFEGIGYA TQVIEAHLNV YYIIILAWAI FYLSNCFTTE LPWATCGHEW NTEKCVEFQK 

       190        200        210        220        230        240 
LNFSNYSHVS LQNATSPVME FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK 

       250        260        270        280        290        300 
GTKSTGKVVY VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 

       310        320        330        340        350        360 
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV LGFMAYEQGV 

       370        380        390        400        410        420 
PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF LGLDSQFVCV ESLVTAVVDM 

       430        440        450        460        470        480 
YPKVFRRGYR RELLILALSI ISYFLGLVML TEGGMYIFQL FDSYAASGMC LLFVAIFECV 

       490        500        510        520        530        540 
CIGWVYGSNR FYDNIEDMIG YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT 

       550        560        570        580        590        600 
YPAWGYGIGW LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 

       610        620 
TVTVNDCEAK VKGDGTISAI TEKETHF 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head and Medulla oblongata.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 20-35 AND 206-220, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK053078 mRNA. Translation: BAC35259.1.
AK140423 mRNA. Translation: BAE24379.1.
CH466523 Genomic DNA. Translation: EDK99507.1.
CCDSCCDS39597.1.
PIRB44409.
RefSeqNP_766478.1. NM_172890.3.
UniGeneMm.44683.
Mm.448312.

3D structure databases

ProteinModelPortalP31650.
SMRP31650. Positions 43-588.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP31650.
ChEMBLCHEMBL2096685.

Protein family/group databases

TCDB2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteP31650.

Proteomic databases

MaxQBP31650.
PaxDbP31650.
PRIDEP31650.

Protocols and materials databases

DNASU243616.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
GeneID243616.
KEGGmmu:243616.
UCSCuc009dhs.1. mouse.

Organism-specific databases

CTD6538.
MGIMGI:95630. Slc6a11.

Phylogenomic databases

eggNOGCOG0733.
GeneTreeENSGT00730000110461.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ8BWA7.
KOK05039.
OMANIYTYPA.
OrthoDBEOG793B71.
TreeFamTF343812.

Gene expression databases

BgeeP31650.
GenevestigatorP31650.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385851.
PROP31650.
SOURCESearch...

Entry information

Entry nameS6A11_MOUSE
AccessionPrimary (citable) accession number: P31650
Secondary accession number(s): Q8BWA7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot