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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Kineticsi

  1. KM=0.8 µM for GABA
  2. KM=99 µM for beta-alanine
  3. KM=1.4 mM for taurine

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_284770. Reuptake of GABA.
    REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

    Protein family/group databases

    TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Sodium- and chloride-dependent GABA transporter 4
    Short name:
    GAT-4
    Solute carrier family 6 member 11
    Gene namesi
    Name:Slc6a11
    Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589 Componenti: Chromosome 6

    Organism-specific databases

    MGIiMGI:95630. Slc6a11.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10120Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Topological domaini147 – 22074ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei221 – 23919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26518Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 31818Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 35122Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei384 – 40320Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45119Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei468 – 48821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52820Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei548 – 56619Helical; Name=12Sequence AnalysisAdd
    BLAST
    Topological domaini567 – 62761CytoplasmicSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Sodium- and chloride-dependent GABA transporter 3PRO_0000214785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP31650.
    PaxDbiP31650.
    PRIDEiP31650.

    PTM databases

    PhosphoSiteiP31650.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP31650.
    ExpressionAtlasiP31650. baseline and differential.
    GenevisibleiP31650. MM.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032451.

    Structurei

    3D structure databases

    ProteinModelPortaliP31650.
    SMRiP31650. Positions 53-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31650.
    KOiK05039.
    OMAiPRDKRDK.
    OrthoDBiEOG793B71.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31650-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN
    60 70 80 90 100
    KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF
    110 120 130 140 150
    LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI
    160 170 180 190 200
    FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME
    210 220 230 240 250
    FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY
    260 270 280 290 300
    VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ
    310 320 330 340 350
    IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV
    360 370 380 390 400
    LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF
    410 420 430 440 450
    LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI ISYFLGLVML
    460 470 480 490 500
    TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG
    510 520 530 540 550
    YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW
    560 570 580 590 600
    LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR
    610 620
    TVTVNDCEAK VKGDGTISAI TEKETHF
    Length:627
    Mass (Da):69,961
    Last modified:July 27, 2011 - v2
    Checksum:i7BCCFA2000DB024F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1.
    AK140423 mRNA. Translation: BAE24379.1.
    CH466523 Genomic DNA. Translation: EDK99507.1.
    CCDSiCCDS39597.1.
    PIRiB44409.
    RefSeqiNP_766478.1. NM_172890.3.
    UniGeneiMm.44683.
    Mm.448312.

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
    GeneIDi243616.
    KEGGimmu:243616.
    UCSCiuc009dhs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1.
    AK140423 mRNA. Translation: BAE24379.1.
    CH466523 Genomic DNA. Translation: EDK99507.1.
    CCDSiCCDS39597.1.
    PIRiB44409.
    RefSeqiNP_766478.1. NM_172890.3.
    UniGeneiMm.44683.
    Mm.448312.

    3D structure databases

    ProteinModelPortaliP31650.
    SMRiP31650. Positions 53-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032451.

    Chemistry

    ChEMBLiCHEMBL3699.

    Protein family/group databases

    TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSiteiP31650.

    Proteomic databases

    MaxQBiP31650.
    PaxDbiP31650.
    PRIDEiP31650.

    Protocols and materials databases

    DNASUi243616.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
    GeneIDi243616.
    KEGGimmu:243616.
    UCSCiuc009dhs.1. mouse.

    Organism-specific databases

    CTDi6538.
    MGIiMGI:95630. Slc6a11.

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31650.
    KOiK05039.
    OMAiPRDKRDK.
    OrthoDBiEOG793B71.
    TreeFamiTF343812.

    Enzyme and pathway databases

    ReactomeiREACT_284770. Reuptake of GABA.
    REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    NextBioi385851.
    PROiP31650.
    SOURCEiSearch...

    Gene expression databases

    BgeeiP31650.
    ExpressionAtlasiP31650. baseline and differential.
    GenevisibleiP31650. MM.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Medulla oblongata.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 20-35 AND 206-220, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiS6A11_MOUSE
    AccessioniPrimary (citable) accession number: P31650
    Secondary accession number(s): Q8BWA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: July 22, 2015
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.