Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Kineticsi

  1. KM=0.8 µM for GABA
  2. KM=99 µM for beta-alanine
  3. KM=1.4 mM for taurine

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.
    R-MMU-888593. Reuptake of GABA.

    Protein family/group databases

    TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Sodium- and chloride-dependent GABA transporter 4
    Short name:
    GAT-4
    Solute carrier family 6 member 11
    Gene namesi
    Name:Slc6a11
    Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 6

    Organism-specific databases

    MGIiMGI:95630. Slc6a11.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
    Transmembranei54 – 74Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei82 – 101Helical; Name=2Sequence analysisAdd BLAST20
    Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini147 – 220ExtracellularSequence analysisAdd BLAST74
    Transmembranei221 – 239Helical; Name=4Sequence analysisAdd BLAST19
    Transmembranei248 – 265Helical; Name=5Sequence analysisAdd BLAST18
    Transmembranei301 – 318Helical; Name=6Sequence analysisAdd BLAST18
    Transmembranei330 – 351Helical; Name=7Sequence analysisAdd BLAST22
    Transmembranei384 – 403Helical; Name=8Sequence analysisAdd BLAST20
    Transmembranei433 – 451Helical; Name=9Sequence analysisAdd BLAST19
    Transmembranei468 – 488Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei509 – 528Helical; Name=11Sequence analysisAdd BLAST20
    Transmembranei548 – 566Helical; Name=12Sequence analysisAdd BLAST19
    Topological domaini567 – 627CytoplasmicSequence analysisAdd BLAST61

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Chemistry databases

    ChEMBLiCHEMBL3699.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002147851 – 627Sodium- and chloride-dependent GABA transporter 3Add BLAST627

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei21PhosphoserineBy similarity1
    Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi193N-linked (GlcNAc...)Sequence analysis1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP31650.
    PaxDbiP31650.
    PeptideAtlasiP31650.
    PRIDEiP31650.

    PTM databases

    iPTMnetiP31650.
    PhosphoSitePlusiP31650.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiENSMUSG00000030307.
    GenevisibleiP31650. MM.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032451.

    Chemistry databases

    BindingDBiP31650.

    Structurei

    3D structure databases

    ProteinModelPortaliP31650.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3659. Eukaryota.
    COG0733. LUCA.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31650.
    KOiK05039.
    OMAiPYIMLMI.
    OrthoDBiEOG091G08PX.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31650-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN
    60 70 80 90 100
    KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF
    110 120 130 140 150
    LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI
    160 170 180 190 200
    FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME
    210 220 230 240 250
    FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY
    260 270 280 290 300
    VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ
    310 320 330 340 350
    IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV
    360 370 380 390 400
    LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF
    410 420 430 440 450
    LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI ISYFLGLVML
    460 470 480 490 500
    TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG
    510 520 530 540 550
    YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW
    560 570 580 590 600
    LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR
    610 620
    TVTVNDCEAK VKGDGTISAI TEKETHF
    Length:627
    Mass (Da):69,961
    Last modified:July 27, 2011 - v2
    Checksum:i7BCCFA2000DB024F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1.
    AK140423 mRNA. Translation: BAE24379.1.
    CH466523 Genomic DNA. Translation: EDK99507.1.
    CCDSiCCDS39597.1.
    PIRiB44409.
    RefSeqiNP_766478.1. NM_172890.3.
    UniGeneiMm.44683.
    Mm.448312.

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
    GeneIDi243616.
    KEGGimmu:243616.
    UCSCiuc009dhs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1.
    AK140423 mRNA. Translation: BAE24379.1.
    CH466523 Genomic DNA. Translation: EDK99507.1.
    CCDSiCCDS39597.1.
    PIRiB44409.
    RefSeqiNP_766478.1. NM_172890.3.
    UniGeneiMm.44683.
    Mm.448312.

    3D structure databases

    ProteinModelPortaliP31650.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032451.

    Chemistry databases

    BindingDBiP31650.
    ChEMBLiCHEMBL3699.

    Protein family/group databases

    TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    iPTMnetiP31650.
    PhosphoSitePlusiP31650.

    Proteomic databases

    MaxQBiP31650.
    PaxDbiP31650.
    PeptideAtlasiP31650.
    PRIDEiP31650.

    Protocols and materials databases

    DNASUi243616.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
    GeneIDi243616.
    KEGGimmu:243616.
    UCSCiuc009dhs.1. mouse.

    Organism-specific databases

    CTDi6538.
    MGIiMGI:95630. Slc6a11.

    Phylogenomic databases

    eggNOGiKOG3659. Eukaryota.
    COG0733. LUCA.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31650.
    KOiK05039.
    OMAiPYIMLMI.
    OrthoDBiEOG091G08PX.
    TreeFamiTF343812.

    Enzyme and pathway databases

    ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.
    R-MMU-888593. Reuptake of GABA.

    Miscellaneous databases

    PROiP31650.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSMUSG00000030307.
    GenevisibleiP31650. MM.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiS6A11_MOUSE
    AccessioniPrimary (citable) accession number: P31650
    Secondary accession number(s): Q8BWA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: November 2, 2016
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.