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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

Kineticsi

  1. KM=0.8 µM for GABA
  2. KM=99 µM for beta-alanine
  3. KM=1.4 mM for taurine

GO - Molecular functioni

  1. gamma-aminobutyric acid:sodium symporter activity Source: Ensembl
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. neurotransmitter binding Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_284770. Reuptake of GABA.
REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 3
Short name:
GAT-3
Alternative name(s):
Sodium- and chloride-dependent GABA transporter 4
Short name:
GAT-4
Solute carrier family 6 member 11
Gene namesi
Name:Slc6a11
Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95630. Slc6a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei82 – 10120Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 22074ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 23919Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei248 – 26518Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei301 – 31818Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei330 – 35122Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei384 – 40320Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei433 – 45119Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei468 – 48821Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei509 – 52820Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei548 – 56619Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini567 – 62761CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Sodium- and chloride-dependent GABA transporter 3PRO_0000214785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP31650.
PaxDbiP31650.
PRIDEiP31650.

PTM databases

PhosphoSiteiP31650.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP31650.
ExpressionAtlasiP31650. baseline and differential.
GenevestigatoriP31650.

Structurei

3D structure databases

ProteinModelPortaliP31650.
SMRiP31650. Positions 53-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31650.
KOiK05039.
OMAiNIYTYPA.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN
60 70 80 90 100
KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF
110 120 130 140 150
LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI
160 170 180 190 200
FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME
210 220 230 240 250
FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY
260 270 280 290 300
VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ
310 320 330 340 350
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV
360 370 380 390 400
LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF
410 420 430 440 450
LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI ISYFLGLVML
460 470 480 490 500
TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG
510 520 530 540 550
YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW
560 570 580 590 600
LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR
610 620
TVTVNDCEAK VKGDGTISAI TEKETHF
Length:627
Mass (Da):69,961
Last modified:July 26, 2011 - v2
Checksum:i7BCCFA2000DB024F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053078 mRNA. Translation: BAC35259.1.
AK140423 mRNA. Translation: BAE24379.1.
CH466523 Genomic DNA. Translation: EDK99507.1.
CCDSiCCDS39597.1.
PIRiB44409.
RefSeqiNP_766478.1. NM_172890.3.
UniGeneiMm.44683.
Mm.448312.

Genome annotation databases

EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
GeneIDi243616.
KEGGimmu:243616.
UCSCiuc009dhs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053078 mRNA. Translation: BAC35259.1.
AK140423 mRNA. Translation: BAE24379.1.
CH466523 Genomic DNA. Translation: EDK99507.1.
CCDSiCCDS39597.1.
PIRiB44409.
RefSeqiNP_766478.1. NM_172890.3.
UniGeneiMm.44683.
Mm.448312.

3D structure databases

ProteinModelPortaliP31650.
SMRiP31650. Positions 53-526.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL3699.

Protein family/group databases

TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteiP31650.

Proteomic databases

MaxQBiP31650.
PaxDbiP31650.
PRIDEiP31650.

Protocols and materials databases

DNASUi243616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
GeneIDi243616.
KEGGimmu:243616.
UCSCiuc009dhs.1. mouse.

Organism-specific databases

CTDi6538.
MGIiMGI:95630. Slc6a11.

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31650.
KOiK05039.
OMAiNIYTYPA.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_284770. Reuptake of GABA.
REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

NextBioi385851.
PROiP31650.
SOURCEiSearch...

Gene expression databases

BgeeiP31650.
ExpressionAtlasiP31650. baseline and differential.
GenevestigatoriP31650.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Medulla oblongata.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 20-35 AND 206-220, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiS6A11_MOUSE
AccessioniPrimary (citable) accession number: P31650
Secondary accession number(s): Q8BWA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1993
Last sequence update: July 26, 2011
Last modified: March 31, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.