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P31650

- S6A11_MOUSE

UniProt

P31650 - S6A11_MOUSE

Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Can also transport beta-alanine and taurine.

    Kineticsi

    1. KM=0.8 µM for GABA
    2. KM=99 µM for beta-alanine
    3. KM=1.4 mM for taurine

    GO - Molecular functioni

    1. gamma-aminobutyric acid:sodium symporter activity Source: Ensembl
    2. neurotransmitter:sodium symporter activity Source: InterPro
    3. neurotransmitter binding Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. response to drug Source: Ensembl

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Sodium- and chloride-dependent GABA transporter 4
    Short name:
    GAT-4
    Solute carrier family 6 member 11
    Gene namesi
    Name:Slc6a11
    Synonyms:Gabt3, Gabt4, Gat-4, Gat3, Gat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:95630. Slc6a11.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Sodium- and chloride-dependent GABA transporter 3PRO_0000214785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP31650.
    PaxDbiP31650.
    PRIDEiP31650.

    PTM databases

    PhosphoSiteiP31650.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiP31650.
    GenevestigatoriP31650.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP31650.
    SMRiP31650. Positions 43-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 22074ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini567 – 62761CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10120Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 23919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26518Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 31818Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 35122Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei384 – 40320Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45119Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei468 – 48821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52820Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei548 – 56619Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00730000110461.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ8BWA7.
    KOiK05039.
    OMAiNIYTYPA.
    OrthoDBiEOG793B71.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31650-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAEQALPLG NGKAAEEARG SETLGGGGGG AAGTREARDK AVHERGHWNN    50
    KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF 100
    LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI 150
    FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME 200
    FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY 250
    VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 300
    IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV 350
    LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF 400
    LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI ISYFLGLVML 450
    TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG 500
    YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW 550
    LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 600
    TVTVNDCEAK VKGDGTISAI TEKETHF 627
    Length:627
    Mass (Da):69,961
    Last modified:July 27, 2011 - v2
    Checksum:i7BCCFA2000DB024F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1.
    AK140423 mRNA. Translation: BAE24379.1.
    CH466523 Genomic DNA. Translation: EDK99507.1.
    CCDSiCCDS39597.1.
    PIRiB44409.
    RefSeqiNP_766478.1. NM_172890.3.
    UniGeneiMm.44683.
    Mm.448312.

    Genome annotation databases

    EnsembliENSMUST00000032451; ENSMUSP00000032451; ENSMUSG00000030307.
    GeneIDi243616.
    KEGGimmu:243616.
    UCSCiuc009dhs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053078 mRNA. Translation: BAC35259.1 .
    AK140423 mRNA. Translation: BAE24379.1 .
    CH466523 Genomic DNA. Translation: EDK99507.1 .
    CCDSi CCDS39597.1.
    PIRi B44409.
    RefSeqi NP_766478.1. NM_172890.3.
    UniGenei Mm.44683.
    Mm.448312.

    3D structure databases

    ProteinModelPortali P31650.
    SMRi P31650. Positions 43-588.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P31650.
    ChEMBLi CHEMBL2096685.

    Protein family/group databases

    TCDBi 2.A.22.3.7. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei P31650.

    Proteomic databases

    MaxQBi P31650.
    PaxDbi P31650.
    PRIDEi P31650.

    Protocols and materials databases

    DNASUi 243616.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032451 ; ENSMUSP00000032451 ; ENSMUSG00000030307 .
    GeneIDi 243616.
    KEGGi mmu:243616.
    UCSCi uc009dhs.1. mouse.

    Organism-specific databases

    CTDi 6538.
    MGIi MGI:95630. Slc6a11.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00730000110461.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q8BWA7.
    KOi K05039.
    OMAi NIYTYPA.
    OrthoDBi EOG793B71.
    TreeFami TF343812.

    Miscellaneous databases

    NextBioi 385851.
    PROi P31650.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31650.
    Genevestigatori P31650.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Medulla oblongata.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 20-35 AND 206-220, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiS6A11_MOUSE
    AccessioniPrimary (citable) accession number: P31650
    Secondary accession number(s): Q8BWA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3