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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

  1. gamma-aminobutyric acid:sodium symporter activity Source: RGD
  2. neurotransmitter:sodium symporter activity Source: InterPro
  3. neurotransmitter binding Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. gamma-aminobutyric acid transport Source: GOC
  3. neurotransmitter transport Source: RGD
  4. response to drug Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_319222. Na+/Cl- dependent neurotransmitter transporters.
REACT_340081. Reuptake of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 3
Short name:
GAT-3
Alternative name(s):
Solute carrier family 6 member 11
Gene namesi
Name:Slc6a11
Synonyms:Gabt3, Gat-3, Gat-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi628737. Slc6a11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei82 – 10120Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 22074ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 23919Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei248 – 26518Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei301 – 31818Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei330 – 35122Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei384 – 40320Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei433 – 45119Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei468 – 48821Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei509 – 52820Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei548 – 56619Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini567 – 62761CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: RGD
  2. cytoplasm Source: RGD
  3. integral component of plasma membrane Source: InterPro
  4. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Sodium- and chloride-dependent GABA transporter 3PRO_0000214786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP31647.
PRIDEiP31647.

PTM databases

PhosphoSiteiP31647.

Expressioni

Tissue specificityi

Brain and retina.

Gene expression databases

GenevestigatoriP31647.

Interactioni

Protein-protein interaction databases

BioGridi249422. 1 interaction.
STRINGi10116.ENSRNOP00000008342.

Structurei

3D structure databases

ProteinModelPortaliP31647.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31647.
KOiK05039.
OMAiNIYTYPA.
OrthoDBiEOG793B71.
PhylomeDBiP31647.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEQALPLG NGKAAEEARG SEALGGGGGG AAGTREARDK AVHERGHWNN
60 70 80 90 100
KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF
110 120 130 140 150
LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI
160 170 180 190 200
FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME
210 220 230 240 250
FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY
260 270 280 290 300
VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ
310 320 330 340 350
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV
360 370 380 390 400
LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF
410 420 430 440 450
LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI VSYFLGLVML
460 470 480 490 500
TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG
510 520 530 540 550
YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW
560 570 580 590 600
LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR
610 620
MVTVNDCEAK VKGDGTISAI TEKETHF
Length:627
Mass (Da):69,947
Last modified:July 1, 1993 - v1
Checksum:iB0B3CC2F8B6D4327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95738 mRNA. Translation: AAA41183.1.
M95763 mRNA. Translation: AAA40607.1.
S42358 mRNA. Translation: AAB22850.1.
PIRiJH0695.
RefSeqiNP_077348.1. NM_024372.2.
UniGeneiRn.10545.

Genome annotation databases

EnsembliENSRNOT00000008342; ENSRNOP00000008342; ENSRNOG00000005697.
GeneIDi79213.
KEGGirno:79213.
UCSCiRGD:628737. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95738 mRNA. Translation: AAA41183.1.
M95763 mRNA. Translation: AAA40607.1.
S42358 mRNA. Translation: AAB22850.1.
PIRiJH0695.
RefSeqiNP_077348.1. NM_024372.2.
UniGeneiRn.10545.

3D structure databases

ProteinModelPortaliP31647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249422. 1 interaction.
STRINGi10116.ENSRNOP00000008342.

Chemistry

ChEMBLiCHEMBL2111478.

PTM databases

PhosphoSiteiP31647.

Proteomic databases

PaxDbiP31647.
PRIDEiP31647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008342; ENSRNOP00000008342; ENSRNOG00000005697.
GeneIDi79213.
KEGGirno:79213.
UCSCiRGD:628737. rat.

Organism-specific databases

CTDi6538.
RGDi628737. Slc6a11.

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31647.
KOiK05039.
OMAiNIYTYPA.
OrthoDBiEOG793B71.
PhylomeDBiP31647.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_319222. Na+/Cl- dependent neurotransmitter transporters.
REACT_340081. Reuptake of GABA.

Miscellaneous databases

NextBioi614612.
PROiP31647.

Gene expression databases

GenevestigatoriP31647.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain."
    Borden L.A., Smith K.E., Hartig P.R., Branchek T.A., Weinshank R.L.
    J. Biol. Chem. 267:21098-21104(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter."
    Clark J.A., Deutch A.Y., Gallipoli P.Z., Amara S.G.
    Neuron 9:337-348(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS6A11_RAT
AccessioniPrimary (citable) accession number: P31647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.