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P31647 (S6A11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent GABA transporter 3

Short name=GAT-3
Alternative name(s):
Solute carrier family 6 member 11
Gene names
Name:Slc6a11
Synonyms:Gabt3, Gat-3, Gat-b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Brain and retina.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Sodium- and chloride-dependent GABA transporter 3
PRO_0000214786

Regions

Topological domain1 – 5353Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=1; Potential
Transmembrane82 – 10120Helical; Name=2; Potential
Transmembrane126 – 14621Helical; Name=3; Potential
Topological domain147 – 22074Extracellular Potential
Transmembrane221 – 23919Helical; Name=4; Potential
Transmembrane248 – 26518Helical; Name=5; Potential
Transmembrane301 – 31818Helical; Name=6; Potential
Transmembrane330 – 35122Helical; Name=7; Potential
Transmembrane384 – 40320Helical; Name=8; Potential
Transmembrane433 – 45119Helical; Name=9; Potential
Transmembrane468 – 48821Helical; Name=10; Potential
Transmembrane509 – 52820Helical; Name=11; Potential
Transmembrane548 – 56619Helical; Name=12; Potential
Topological domain567 – 62761Cytoplasmic Potential

Amino acid modifications

Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P31647 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: B0B3CC2F8B6D4327

FASTA62769,947
        10         20         30         40         50         60 
MTAEQALPLG NGKAAEEARG SEALGGGGGG AAGTREARDK AVHERGHWNN KVEFVLSVAG 

        70         80         90        100        110        120 
EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF LETALGQFTS EGGITCWRRV 

       130        140        150        160        170        180 
CPLFEGIGYA TQVIEAHLNV YYIIILAWAI FYLSNCFTTE LPWATCGHEW NTEKCVEFQK 

       190        200        210        220        230        240 
LNFSNYSHVS LQNATSPVME FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK 

       250        260        270        280        290        300 
GTKSTGKVVY VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 

       310        320        330        340        350        360 
IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV LGFMAYEQGV 

       370        380        390        400        410        420 
PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF LGLDSQFVCV ESLVTAVVDM 

       430        440        450        460        470        480 
YPKVFRRGYR RELLILALSI VSYFLGLVML TEGGMYIFQL FDSYAASGMC LLFVAIFECV 

       490        500        510        520        530        540 
CIGWVYGSNR FYDNIEDMIG YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT 

       550        560        570        580        590        600 
YPAWGYGIGW LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 

       610        620 
MVTVNDCEAK VKGDGTISAI TEKETHF 

« Hide

References

[1]"Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain."
Borden L.A., Smith K.E., Hartig P.R., Branchek T.A., Weinshank R.L.
J. Biol. Chem. 267:21098-21104(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter."
Clark J.A., Deutch A.Y., Gallipoli P.Z., Amara S.G.
Neuron 9:337-348(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95738 mRNA. Translation: AAA41183.1.
M95763 mRNA. Translation: AAA40607.1.
S42358 mRNA. Translation: AAB22850.1.
PIRJH0695.
RefSeqNP_077348.1. NM_024372.2.
UniGeneRn.10545.

3D structure databases

ProteinModelPortalP31647.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249422. 1 interaction.
STRING10116.ENSRNOP00000008342.

Chemistry

BindingDBP31647.
ChEMBLCHEMBL2111478.

PTM databases

PhosphoSiteP31647.

Proteomic databases

PaxDbP31647.
PRIDEP31647.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008342; ENSRNOP00000008342; ENSRNOG00000005697.
GeneID79213.
KEGGrno:79213.
UCSCRGD:628737. rat.

Organism-specific databases

CTD6538.
RGD628737. Slc6a11.

Phylogenomic databases

eggNOGCOG0733.
GeneTreeENSGT00730000110461.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidP31647.
KOK05039.
OMANIYTYPA.
OrthoDBEOG793B71.
PhylomeDBP31647.
TreeFamTF343812.

Gene expression databases

GenevestigatorP31647.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002982. Na/ntran_symport_GABA_GAT3.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01197. GAT3TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614612.
PROP31647.

Entry information

Entry nameS6A11_RAT
AccessionPrimary (citable) accession number: P31647
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families