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P31647

- S6A11_RAT

UniProt

P31647 - S6A11_RAT

Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

Slc6a11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

    GO - Molecular functioni

    1. gamma-aminobutyric acid:sodium symporter activity Source: RGD
    2. neurotransmitter:sodium symporter activity Source: InterPro
    3. neurotransmitter binding Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. gamma-aminobutyric acid transport Source: GOC
    3. neurotransmitter transport Source: RGD
    4. response to drug Source: RGD

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent GABA transporter 3
    Short name:
    GAT-3
    Alternative name(s):
    Solute carrier family 6 member 11
    Gene namesi
    Name:Slc6a11
    Synonyms:Gabt3, Gat-3, Gat-b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi628737. Slc6a11.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: RGD
    2. cytoplasm Source: RGD
    3. integral component of plasma membrane Source: InterPro
    4. membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Sodium- and chloride-dependent GABA transporter 3PRO_0000214786Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP31647.
    PRIDEiP31647.

    PTM databases

    PhosphoSiteiP31647.

    Expressioni

    Tissue specificityi

    Brain and retina.

    Gene expression databases

    GenevestigatoriP31647.

    Interactioni

    Protein-protein interaction databases

    BioGridi249422. 1 interaction.
    STRINGi10116.ENSRNOP00000008342.

    Structurei

    3D structure databases

    ProteinModelPortaliP31647.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 22074ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini567 – 62761CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10120Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 23919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26518Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 31818Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 35122Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei384 – 40320Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45119Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei468 – 48821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52820Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei548 – 56619Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00730000110461.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31647.
    KOiK05039.
    OMAiNIYTYPA.
    OrthoDBiEOG793B71.
    PhylomeDBiP31647.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAEQALPLG NGKAAEEARG SEALGGGGGG AAGTREARDK AVHERGHWNN    50
    KVEFVLSVAG EIIGLGNVWR FPYLCYKNGG GAFLIPYVVF FICCGIPVFF 100
    LETALGQFTS EGGITCWRRV CPLFEGIGYA TQVIEAHLNV YYIIILAWAI 150
    FYLSNCFTTE LPWATCGHEW NTEKCVEFQK LNFSNYSHVS LQNATSPVME 200
    FWERRVLAIS DGIEHIGNLR WELALCLLAA WTICYFCIWK GTKSTGKVVY 250
    VTATFPYIML LILLIRGVTL PGASEGIKFY LYPDLSRLSD PQVWVDAGTQ 300
    IFFSYAICLG CLTALGSYNN YNNNCYRDCI MLCCLNSGTS FVAGFAIFSV 350
    LGFMAYEQGV PIAEVAESGP GLAFIAYPKA VTMMPLSPLW ATLFFMMLIF 400
    LGLDSQFVCV ESLVTAVVDM YPKVFRRGYR RELLILALSI VSYFLGLVML 450
    TEGGMYIFQL FDSYAASGMC LLFVAIFECV CIGWVYGSNR FYDNIEDMIG 500
    YRPLSLIKWC WKVVTPGICA GIFIFFLVKY KPLKYNNVYT YPAWGYGIGW 550
    LMALSSMLCI PLWIFIKLWK TEGTLPEKLQ KLTVPSADLK MRGKLGASPR 600
    MVTVNDCEAK VKGDGTISAI TEKETHF 627
    Length:627
    Mass (Da):69,947
    Last modified:July 1, 1993 - v1
    Checksum:iB0B3CC2F8B6D4327
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95738 mRNA. Translation: AAA41183.1.
    M95763 mRNA. Translation: AAA40607.1.
    S42358 mRNA. Translation: AAB22850.1.
    PIRiJH0695.
    RefSeqiNP_077348.1. NM_024372.2.
    UniGeneiRn.10545.

    Genome annotation databases

    EnsembliENSRNOT00000008342; ENSRNOP00000008342; ENSRNOG00000005697.
    GeneIDi79213.
    KEGGirno:79213.
    UCSCiRGD:628737. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95738 mRNA. Translation: AAA41183.1 .
    M95763 mRNA. Translation: AAA40607.1 .
    S42358 mRNA. Translation: AAB22850.1 .
    PIRi JH0695.
    RefSeqi NP_077348.1. NM_024372.2.
    UniGenei Rn.10545.

    3D structure databases

    ProteinModelPortali P31647.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249422. 1 interaction.
    STRINGi 10116.ENSRNOP00000008342.

    Chemistry

    BindingDBi P31647.
    ChEMBLi CHEMBL2111478.

    PTM databases

    PhosphoSitei P31647.

    Proteomic databases

    PaxDbi P31647.
    PRIDEi P31647.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008342 ; ENSRNOP00000008342 ; ENSRNOG00000005697 .
    GeneIDi 79213.
    KEGGi rno:79213.
    UCSCi RGD:628737. rat.

    Organism-specific databases

    CTDi 6538.
    RGDi 628737. Slc6a11.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00730000110461.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi P31647.
    KOi K05039.
    OMAi NIYTYPA.
    OrthoDBi EOG793B71.
    PhylomeDBi P31647.
    TreeFami TF343812.

    Miscellaneous databases

    NextBioi 614612.
    PROi P31647.

    Gene expression databases

    Genevestigatori P31647.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002982. Na/ntran_symport_GABA_GAT3.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01197. GAT3TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain."
      Borden L.A., Smith K.E., Hartig P.R., Branchek T.A., Weinshank R.L.
      J. Biol. Chem. 267:21098-21104(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter."
      Clark J.A., Deutch A.Y., Gallipoli P.Z., Amara S.G.
      Neuron 9:337-348(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiS6A11_RAT
    AccessioniPrimary (citable) accession number: P31647
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3