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P31646 (S6A13_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent GABA transporter 2
Short name=GAT-2
Alternative name(s):
Solute carrier family 6 member 13
Gene names
Name:Slc6a13
Synonyms:Gabt2, Gat-2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length602 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.2.

Tissue specificity

Brain, retina, and peripheral tissues. Expressed in hepatocytes (at protein level). Ref.2

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 602602Sodium- and chloride-dependent GABA transporter 2
PRO_0000214794

Regions

Topological domain1 – 4040Cytoplasmic Potential
Transmembrane41 – 6121Helical; Name=1; Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Transmembrane121 – 14121Helical; Name=3; Potential
Topological domain142 – 20665Extracellular Potential
Transmembrane207 – 22721Helical; Name=4; Potential
Transmembrane233 – 25321Helical; Name=5; Potential
Transmembrane282 – 30221Helical; Name=6; Potential
Transmembrane319 – 33921Helical; Name=7; Potential
Transmembrane366 – 38621Helical; Name=8; Potential
Transmembrane418 – 43821Helical; Name=9; Potential
Transmembrane453 – 47321Helical; Name=10; Potential
Transmembrane490 – 51021Helical; Name=11; Potential
Transmembrane528 – 54821Helical; Name=12; Potential
Topological domain549 – 60254Cytoplasmic Potential

Amino acid modifications

Modified residue5871Phosphothreonine By similarity
Modified residue5911Phosphoserine By similarity
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P31646 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: CB7510EFA6ABFE8C

FASTA60268,263
        10         20         30         40         50         60 
MDNRVSGTTS NGETKPVCPV MEKVEEDGTL EREQWTNKME FVLSVAGEII GLGNVWRFPY 

        70         80         90        100        110        120 
LCYKNGGGAF FIPYLIFLFT CGIPVFFLET ALGQYTNQGG ITAWRKICPI FEGIGYASQM 

       130        140        150        160        170        180 
IVSLLNVYYI VVLAWALFYL FSSFTTDLPW GSCSHEWNTE NCVEFQKTNN SLNVTSENAT 

       190        200        210        220        230        240 
SPVIEFWERR VLKISDGIQH LGSLRWELVL CLLLAWIICY FCIWKGVKST GKVVYFTATF 

       250        260        270        280        290        300 
PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNI TRLWDPQVWM DAGTQIFFSF AICLGCLTAL 

       310        320        330        340        350        360 
GSYNKYHNNC YRDCVALCIL NSSTSFVAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI 

       370        380        390        400        410        420 
AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPRVF RKKNRREILI 

       430        440        450        460        470        480 
LIVSVVSFFI GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGASRFYDNI 

       490        500        510        520        530        540 
EDMIGYKPWP LIKYCWLFFT PAVCLATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS 

       550        560        570        580        590        600 
SMVCIPAWSI YKLRTLKGPL RERLRQLVCP AEDLPQKSQP ELTSPATPMT SLLRLTELES 


NC

« Hide

References

[1]"Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain."
Borden L.A., Smith K.E., Hartig P.R., Branchek T.A., Weinshank R.L.
J. Biol. Chem. 267:21098-21104(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents."
Zhou Y., Holmseth S., Guo C., Hassel B., Hofner G., Huitfeldt H.S., Wanner K.T., Danbolt N.C.
J. Biol. Chem. 287:35733-35746(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M95762 mRNA. Translation: AAA40602.1.
IPIIPI00214460.
PIRA45078.
RefSeqNP_598307.1. NM_133623.1.
UniGeneRn.10527.

3D structure databases

ProteinModelPortalP31646.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018083.

Proteomic databases

PaxDbP31646.
PRIDEP31646.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171163.
KEGGrno:171163.
UCSCRGD:620788. rat.

Organism-specific databases

CTD6540.
RGD620788. Slc6a13.

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidP31646.
KOK05039.
OMARIRQLMC.
OrthoDBEOG43N7CD.

Gene expression databases

GenevestigatorP31646.
GermOnlineENSRNOG00000012876. Rattus norvegicus.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002981. Na/ntran_symport_GABA_GAT2.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01196. GAT2TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP31646.
ChEMBLCHEMBL4889.
NextBio622015.

Entry information

Entry nameS6A13_RAT
AccessionPrimary (citable) accession number: P31646
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents