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Protein

Sodium- and chloride-dependent GABA transporter 2

Gene

Slc6a13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport.1 Publication

GO - Molecular functioni

  • gamma-aminobutyric acid:sodium symporter activity Source: RGD
  • neurotransmitter binding Source: RGD

GO - Biological processi

  • neurotransmitter transport Source: RGD

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 2
Short name:
GAT-2
Alternative name(s):
Solute carrier family 6 member 13
Gene namesi
Name:Slc6a13
Synonyms:Gabt2, Gat-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620788 Slc6a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 206ExtracellularSequence analysisAdd BLAST65
Transmembranei207 – 227Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei282 – 302Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei319 – 339Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei366 – 386Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei418 – 438Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei490 – 510Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei528 – 548Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini549 – 602CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4889
GuidetoPHARMACOLOGYi930

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147941 – 602Sodium- and chloride-dependent GABA transporter 2Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi153 ↔ 162By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei587PhosphothreonineBy similarity1
Modified residuei591PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31646
PRIDEiP31646

Expressioni

Tissue specificityi

Brain, retina, and peripheral tissues. Expressed in hepatocytes (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018083

Chemistry databases

BindingDBiP31646

Structurei

3D structure databases

ProteinModelPortaliP31646
SMRiP31646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP31646
KOiK05039
PhylomeDBiP31646
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002981 Na/ntran_symport_GABA_GAT2
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01196 GAT2TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P31646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRVSGTTS NGETKPVCPV MEKVEEDGTL EREQWTNKME FVLSVAGEII
60 70 80 90 100
GLGNVWRFPY LCYKNGGGAF FIPYLIFLFT CGIPVFFLET ALGQYTNQGG
110 120 130 140 150
ITAWRKICPI FEGIGYASQM IVSLLNVYYI VVLAWALFYL FSSFTTDLPW
160 170 180 190 200
GSCSHEWNTE NCVEFQKTNN SLNVTSENAT SPVIEFWERR VLKISDGIQH
210 220 230 240 250
LGSLRWELVL CLLLAWIICY FCIWKGVKST GKVVYFTATF PYLMLVVLLI
260 270 280 290 300
RGVTLPGAAQ GIQFYLYPNI TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
310 320 330 340 350
GSYNKYHNNC YRDCVALCIL NSSTSFVAGF AIFSILGFMS QEQGVPISEV
360 370 380 390 400
AESGPGLAFI AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT
410 420 430 440 450
ALVDMYPRVF RKKNRREILI LIVSVVSFFI GLIMLTEGGM YVFQLFDYYA
460 470 480 490 500
ASGMCLLFVA IFESLCVAWV YGASRFYDNI EDMIGYKPWP LIKYCWLFFT
510 520 530 540 550
PAVCLATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS SMVCIPAWSI
560 570 580 590 600
YKLRTLKGPL RERLRQLVCP AEDLPQKSQP ELTSPATPMT SLLRLTELES

NC
Length:602
Mass (Da):68,263
Last modified:July 1, 1993 - v1
Checksum:iCB7510EFA6ABFE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95762 mRNA Translation: AAA40602.1
PIRiA45078
RefSeqiNP_598307.1, NM_133623.1
UniGeneiRn.10527

Genome annotation databases

GeneIDi171163
KEGGirno:171163
UCSCiRGD:620788 rat

Similar proteinsi

Entry informationi

Entry nameiS6A13_RAT
AccessioniPrimary (citable) accession number: P31646
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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