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Protein

Sodium- and chloride-dependent GABA transporter 2

Gene

Slc6a13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport.1 Publication

GO - Molecular functioni

  • gamma-aminobutyric acid:sodium symporter activity Source: RGD
  • neurotransmitter:sodium symporter activity Source: InterPro
  • neurotransmitter binding Source: RGD

GO - Biological processi

  • chemical synaptic transmission Source: GO_Central
  • neurotransmitter transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 2
Short name:
GAT-2
Alternative name(s):
Solute carrier family 6 member 13
Gene namesi
Name:Slc6a13
Synonyms:Gabt2, Gat-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620788. Slc6a13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 206ExtracellularSequence analysisAdd BLAST65
Transmembranei207 – 227Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei282 – 302Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei319 – 339Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei366 – 386Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei418 – 438Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei490 – 510Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei528 – 548Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini549 – 602CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4889.
GuidetoPHARMACOLOGYi930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147941 – 602Sodium- and chloride-dependent GABA transporter 2Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi153 ↔ 162By similarity
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Modified residuei587PhosphothreonineBy similarity1
Modified residuei591PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31646.
PRIDEiP31646.

Expressioni

Tissue specificityi

Brain, retina, and peripheral tissues. Expressed in hepatocytes (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018083.

Chemistry databases

BindingDBiP31646.

Structurei

3D structure databases

ProteinModelPortaliP31646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31646.
KOiK05039.
PhylomeDBiP31646.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002981. Na/ntran_symport_GABA_GAT2.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01196. GAT2TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRVSGTTS NGETKPVCPV MEKVEEDGTL EREQWTNKME FVLSVAGEII
60 70 80 90 100
GLGNVWRFPY LCYKNGGGAF FIPYLIFLFT CGIPVFFLET ALGQYTNQGG
110 120 130 140 150
ITAWRKICPI FEGIGYASQM IVSLLNVYYI VVLAWALFYL FSSFTTDLPW
160 170 180 190 200
GSCSHEWNTE NCVEFQKTNN SLNVTSENAT SPVIEFWERR VLKISDGIQH
210 220 230 240 250
LGSLRWELVL CLLLAWIICY FCIWKGVKST GKVVYFTATF PYLMLVVLLI
260 270 280 290 300
RGVTLPGAAQ GIQFYLYPNI TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
310 320 330 340 350
GSYNKYHNNC YRDCVALCIL NSSTSFVAGF AIFSILGFMS QEQGVPISEV
360 370 380 390 400
AESGPGLAFI AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT
410 420 430 440 450
ALVDMYPRVF RKKNRREILI LIVSVVSFFI GLIMLTEGGM YVFQLFDYYA
460 470 480 490 500
ASGMCLLFVA IFESLCVAWV YGASRFYDNI EDMIGYKPWP LIKYCWLFFT
510 520 530 540 550
PAVCLATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS SMVCIPAWSI
560 570 580 590 600
YKLRTLKGPL RERLRQLVCP AEDLPQKSQP ELTSPATPMT SLLRLTELES

NC
Length:602
Mass (Da):68,263
Last modified:July 1, 1993 - v1
Checksum:iCB7510EFA6ABFE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95762 mRNA. Translation: AAA40602.1.
PIRiA45078.
RefSeqiNP_598307.1. NM_133623.1.
UniGeneiRn.10527.

Genome annotation databases

GeneIDi171163.
KEGGirno:171163.
UCSCiRGD:620788. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95762 mRNA. Translation: AAA40602.1.
PIRiA45078.
RefSeqiNP_598307.1. NM_133623.1.
UniGeneiRn.10527.

3D structure databases

ProteinModelPortaliP31646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018083.

Chemistry databases

BindingDBiP31646.
ChEMBLiCHEMBL4889.
GuidetoPHARMACOLOGYi930.

Proteomic databases

PaxDbiP31646.
PRIDEiP31646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171163.
KEGGirno:171163.
UCSCiRGD:620788. rat.

Organism-specific databases

CTDi6540.
RGDi620788. Slc6a13.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31646.
KOiK05039.
PhylomeDBiP31646.
TreeFamiTF343812.

Miscellaneous databases

PROiP31646.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002981. Na/ntran_symport_GABA_GAT2.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01196. GAT2TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS6A13_RAT
AccessioniPrimary (citable) accession number: P31646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 5, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.