Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium-dependent serotonin transporter

Gene

SLC6A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi94Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi96Sodium 2; via carbonyl oxygen1 Publication1
Metal bindingi97Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi101Sodium 21 Publication1
Metal bindingi336Sodium 21 Publication1
Metal bindingi368Sodium 21 Publication1
Metal bindingi434Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi437Sodium 1By similarity1
Metal bindingi438Sodium 1By similarity1

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • cocaine binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • monoamine transmembrane transporter activity Source: MGI
  • Rab GTPase binding Source: UniProtKB
  • serotonin:sodium symporter activity Source: UniProtKB
  • serotonin transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108576-MONOMER.
ReactomeiR-HSA-380615. Serotonin clearance from the synaptic cleft.
SIGNORiP31645.

Protein family/group databases

TCDBi2.A.22.1.1. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent serotonin transporter
Short name:
SERTBy similarity
Alternative name(s):
5HT transporter
Short name:
5HTT
Solute carrier family 6 member 4
Gene namesi
Name:SLC6A4
Synonyms:HTT, SERT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11050. SLC6A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicCuratedAdd BLAST87
Transmembranei88 – 112Helical; Name=11 PublicationAdd BLAST25
Topological domaini113 – 115ExtracellularCurated3
Transmembranei116 – 135Helical; Name=21 PublicationAdd BLAST20
Topological domaini136 – 160CytoplasmicCuratedAdd BLAST25
Transmembranei161 – 186Helical; Name=31 PublicationAdd BLAST26
Topological domaini187 – 252ExtracellularCuratedAdd BLAST66
Transmembranei253 – 271Helical; Name=41 PublicationAdd BLAST19
Topological domaini272 – 277CytoplasmicCurated6
Transmembranei278 – 297Helical; Name=51 PublicationAdd BLAST20
Topological domaini298 – 324ExtracellularCuratedAdd BLAST27
Transmembranei325 – 347Helical; Name=61 PublicationAdd BLAST23
Topological domaini348 – 360CytoplasmicCuratedAdd BLAST13
Transmembranei361 – 380Helical; Name=71 PublicationAdd BLAST20
Topological domaini381 – 421ExtracellularCuratedAdd BLAST41
Transmembranei422 – 443Helical; Name=81 PublicationAdd BLAST22
Topological domaini444 – 463CytoplasmicCuratedAdd BLAST20
Transmembranei464 – 483Helical; Name=91 PublicationAdd BLAST20
Topological domaini484 – 494ExtracellularCuratedAdd BLAST11
Transmembranei495 – 516Helical; Name=101 PublicationAdd BLAST22
Topological domaini517 – 538CytoplasmicCuratedAdd BLAST22
Transmembranei539 – 558Helical; Name=111 PublicationAdd BLAST20
Topological domaini559 – 574ExtracellularCuratedAdd BLAST16
Transmembranei575 – 595Helical; Name=121 PublicationAdd BLAST21
Topological domaini596 – 630CytoplasmicCuratedAdd BLAST35

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endomembrane system Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • neuron projection Source: GO_Central
  • plasma membrane Source: UniProtKB
  • presynapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi611S → A: Loss of 10 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-613 and A-616. 1 Publication1
Mutagenesisi611S → D: Loss of 61 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-613 and D-616. 1 Publication1
Mutagenesisi613T → A: Loss of 26 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-616. 1 Publication1
Mutagenesisi613T → D: Loss of 26 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-616. 1 Publication1
Mutagenesisi616T → A: No change. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-613. 1 Publication1
Mutagenesisi616T → D: No change. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-613. 1 Publication1

Organism-specific databases

DisGeNETi6532.
MalaCardsiSLC6A4.
MIMi103780. phenotype.
164230. phenotype.
OpenTargetsiENSG00000108576.
PharmGKBiPA312.

Chemistry databases

ChEMBLiCHEMBL228.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00289. Atomoxetine.
DB09016. Butriptyline.
DB01114. Chlorphenamine.
DB00215. Citalopram.
DB01242. Clomipramine.
DB00907. Cocaine.
DB01151. Desipramine.
DB06700. Desvenlafaxine.
DB01191. Dexfenfluramine.
DB06701. Dexmethylphenidate.
DB00514. Dextromethorphan.
DB00988. Dopamine.
DB01142. Doxepin.
DB00476. Duloxetine.
DB01363. Ephedra.
DB01175. Escitalopram.
DB00472. Fluoxetine.
DB00176. Fluvoxamine.
DB00458. Imipramine.
DB08918. Levomilnacipran.
DB00408. Loxapine.
DB00579. Mazindol.
DB01577. Methamphetamine.
DB00422. Methylphenidate.
DB06148. Mianserin.
DB04896. Milnacipran.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01149. Nefazodone.
DB00540. Nortriptyline.
DB00715. Paroxetine.
DB00454. Pethidine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB00852. Pseudoephedrine.
DB01104. Sertraline.
DB01105. Sibutramine.
DB06204. Tapentadol.
DB00193. Tramadol.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB06684. Vilazodone.
DB09068. Vortioxetine.
GuidetoPHARMACOLOGYi928.

Polymorphism and mutation databases

DMDMi400630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147571 – 630Sodium-dependent serotonin transporterAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Phosphotyrosine1 Publication1
Modified residuei142Phosphotyrosine1 Publication1
Disulfide bondi200 ↔ 209Combined sources
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1 Publication1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1 Publication1
Modified residuei276Phosphothreonine; by PKG1 Publication1
Modified residuei611Phosphoserine1 Publication1
Modified residuei613Phosphothreonine1 Publication1
Modified residuei616Phosphothreonine1 Publication1

Post-translational modificationi

Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.By similarity
Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31645.
PeptideAtlasiP31645.
PRIDEiP31645.

PTM databases

iPTMnetiP31645.
PhosphoSitePlusiP31645.

Expressioni

Tissue specificityi

Expressed in platelets (at protein level).1 Publication

Inductioni

Down-regulated when plasma serotonin is elevated.2 Publications

Gene expression databases

BgeeiENSG00000108576.
CleanExiHS_HTT.
HS_SLC6A4.
ExpressionAtlasiP31645. baseline and differential.
GenevisibleiP31645. HS.

Organism-specific databases

HPAiHPA054723.

Interactioni

Subunit structurei

Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.By similarity4 Publications

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112423. 5 interactors.
IntActiP31645. 2 interactors.
MINTiMINT-577123.
STRINGi9606.ENSP00000261707.

Chemistry databases

BindingDBiP31645.

Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi85 – 96Combined sources12
Helixi99 – 111Combined sources13
Helixi114 – 117Combined sources4
Helixi118 – 127Combined sources10
Helixi129 – 143Combined sources15
Helixi149 – 152Combined sources4
Helixi156 – 159Combined sources4
Helixi160 – 173Combined sources14
Helixi176 – 188Combined sources13
Helixi189 – 191Combined sources3
Beta strandi192 – 194Combined sources3
Turni196 – 198Combined sources3
Beta strandi202 – 204Combined sources3
Beta strandi207 – 209Combined sources3
Beta strandi212 – 214Combined sources3
Helixi227 – 234Combined sources8
Turni235 – 237Combined sources3
Helixi239 – 241Combined sources3
Beta strandi244 – 247Combined sources4
Helixi253 – 270Combined sources18
Helixi274 – 284Combined sources11
Helixi287 – 300Combined sources14
Turni303 – 305Combined sources3
Helixi306 – 313Combined sources8
Helixi317 – 321Combined sources5
Helixi323 – 337Combined sources15
Beta strandi340 – 342Combined sources3
Helixi343 – 349Combined sources7
Beta strandi353 – 355Combined sources3
Helixi358 – 389Combined sources32
Helixi396 – 398Combined sources3
Helixi403 – 407Combined sources5
Helixi409 – 415Combined sources7
Helixi420 – 453Combined sources34
Helixi462 – 477Combined sources16
Turni478 – 480Combined sources3
Helixi485 – 494Combined sources10
Helixi497 – 513Combined sources17
Turni514 – 517Combined sources4
Helixi518 – 528Combined sources11
Beta strandi529 – 531Combined sources3
Helixi535 – 542Combined sources8
Helixi544 – 558Combined sources15
Helixi574 – 583Combined sources10
Turni584 – 587Combined sources4
Helixi588 – 599Combined sources12
Helixi604 – 612Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I6XX-ray3.14A76-618[»]
5I6ZX-ray4.53A76-618[»]
5I71X-ray3.15A76-618[»]
5I73X-ray3.24A76-618[»]
5I74X-ray3.40A76-618[»]
5I75X-ray3.49A76-618[»]
ProteinModelPortaliP31645.
SMRiP31645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni611 – 630Required for serotonin uptake activity1 PublicationAdd BLAST20
Regioni616 – 624Interaction with RAB4A9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31645.
KOiK05037.
OMAiCRDVKEM.
OrthoDBiEOG091G08PX.
PhylomeDBiP31645.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR013086. Na/ntran_symport_serotonin_N.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF03491. 5HT_transport_N. 1 hit.
PF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01203. 5HTTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV
60 70 80 90 100
PSPGAGDDTR HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG
110 120 130 140 150
NVWRFPYICY QNGGGAFLLP YTIMAIFGGI PLFYMELALG QYHRNGCISI
160 170 180 190 200
WRKICPIFKG IGYAICIIAF YIASYYNTIM AWALYYLISS FTDQLPWTSC
210 220 230 240 250
KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH RSKGLQDLGG
260 270 280 290 300
ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA
310 320 330 340 350
TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY
360 370 380 390 400
NKFNNNCYQD ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD
410 420 430 440 450
AGPSLLFITY AEAIANMPAS TFFAIIFFLM LITLGLDSTF AGLEGVITAV
460 470 480 490 500
LDEFPHVWAK RRERFVLAVV ITCFFGSLVT LTFGGAYVVK LLEEYATGPA
510 520 530 540 550
VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC WVAISPLFLL
560 570 580 590 600
FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT
610 620 630
PGTFKERIIK SITPETPTEI PCGDIRLNAV
Length:630
Mass (Da):70,325
Last modified:July 1, 1993 - v1
Checksum:i0EB535B0A579BDA2
GO
Isoform 2 (identifier: P31645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQSRRVNPDDRELGGDLQIQAPRDQLGSLADGHQCHLLTSRM

Show »
Length:672
Mass (Da):74,979
Checksum:i142F04437BA1DE39
GO

Polymorphismi

A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.1 Publication
The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIMi:164230].3 Publications
Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIMi:103780].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01418156G → A.1 PublicationCorresponds to variant rs6355dbSNPEnsembl.1
Natural variantiVAR_029158201K → N.Corresponds to variant rs2228673dbSNPEnsembl.1
Natural variantiVAR_036788425I → L.Corresponds to variant rs28914832dbSNPEnsembl.1
Natural variantiVAR_026751425I → V Polymorphism linked with susceptibility to obsessive-compulsive disorder; increased serotonin transport capacity. 3 PublicationsCorresponds to variant rs28914832dbSNPEnsembl.1
Natural variantiVAR_036789465F → L.Corresponds to variant rs28914833dbSNPEnsembl.1
Natural variantiVAR_036790550L → V.Corresponds to variant rs28914834dbSNPEnsembl.1
Natural variantiVAR_014182605K → N.1 PublicationCorresponds to variant rs6352dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0465531M → MSQSRRVNPDDRELGGDLQI QAPRDQLGSLADGHQCHLLT SRM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70697 mRNA. Translation: CAA50029.1.
L05568 mRNA. Translation: AAA35492.1.
AY902473 mRNA. Translation: AAW80933.1.
EU099989 Genomic DNA. Translation: ABV02581.1.
BC069484 mRNA. Translation: AAH69484.1.
U79746 Genomic DNA. Translation: AAB93475.1.
AK308014 mRNA. No translation available.
CCDSiCCDS11256.1. [P31645-1]
PIRiA47398.
RefSeqiNP_001036.1. NM_001045.5. [P31645-1]
UniGeneiHs.134662.
Hs.29792.

Genome annotation databases

EnsembliENST00000261707; ENSP00000261707; ENSG00000108576. [P31645-1]
ENST00000401766; ENSP00000385822; ENSG00000108576. [P31645-1]
GeneIDi6532.
KEGGihsa:6532.
UCSCiuc002hey.6. human. [P31645-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Serotonin transporter entry

Protein Spotlight

Love, love, love... -Issue 123 of November 2010

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70697 mRNA. Translation: CAA50029.1.
L05568 mRNA. Translation: AAA35492.1.
AY902473 mRNA. Translation: AAW80933.1.
EU099989 Genomic DNA. Translation: ABV02581.1.
BC069484 mRNA. Translation: AAH69484.1.
U79746 Genomic DNA. Translation: AAB93475.1.
AK308014 mRNA. No translation available.
CCDSiCCDS11256.1. [P31645-1]
PIRiA47398.
RefSeqiNP_001036.1. NM_001045.5. [P31645-1]
UniGeneiHs.134662.
Hs.29792.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5I6XX-ray3.14A76-618[»]
5I6ZX-ray4.53A76-618[»]
5I71X-ray3.15A76-618[»]
5I73X-ray3.24A76-618[»]
5I74X-ray3.40A76-618[»]
5I75X-ray3.49A76-618[»]
ProteinModelPortaliP31645.
SMRiP31645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112423. 5 interactors.
IntActiP31645. 2 interactors.
MINTiMINT-577123.
STRINGi9606.ENSP00000261707.

Chemistry databases

BindingDBiP31645.
ChEMBLiCHEMBL228.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00289. Atomoxetine.
DB09016. Butriptyline.
DB01114. Chlorphenamine.
DB00215. Citalopram.
DB01242. Clomipramine.
DB00907. Cocaine.
DB01151. Desipramine.
DB06700. Desvenlafaxine.
DB01191. Dexfenfluramine.
DB06701. Dexmethylphenidate.
DB00514. Dextromethorphan.
DB00988. Dopamine.
DB01142. Doxepin.
DB00476. Duloxetine.
DB01363. Ephedra.
DB01175. Escitalopram.
DB00472. Fluoxetine.
DB00176. Fluvoxamine.
DB00458. Imipramine.
DB08918. Levomilnacipran.
DB00408. Loxapine.
DB00579. Mazindol.
DB01577. Methamphetamine.
DB00422. Methylphenidate.
DB06148. Mianserin.
DB04896. Milnacipran.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01149. Nefazodone.
DB00540. Nortriptyline.
DB00715. Paroxetine.
DB00454. Pethidine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB00852. Pseudoephedrine.
DB01104. Sertraline.
DB01105. Sibutramine.
DB06204. Tapentadol.
DB00193. Tramadol.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB06684. Vilazodone.
DB09068. Vortioxetine.
GuidetoPHARMACOLOGYi928.

Protein family/group databases

TCDBi2.A.22.1.1. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiP31645.
PhosphoSitePlusiP31645.

Polymorphism and mutation databases

DMDMi400630.

Proteomic databases

PaxDbiP31645.
PeptideAtlasiP31645.
PRIDEiP31645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261707; ENSP00000261707; ENSG00000108576. [P31645-1]
ENST00000401766; ENSP00000385822; ENSG00000108576. [P31645-1]
GeneIDi6532.
KEGGihsa:6532.
UCSCiuc002hey.6. human. [P31645-1]

Organism-specific databases

CTDi6532.
DisGeNETi6532.
GeneCardsiSLC6A4.
HGNCiHGNC:11050. SLC6A4.
HPAiHPA054723.
MalaCardsiSLC6A4.
MIMi103780. phenotype.
164230. phenotype.
182138. gene.
neXtProtiNX_P31645.
OpenTargetsiENSG00000108576.
PharmGKBiPA312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31645.
KOiK05037.
OMAiCRDVKEM.
OrthoDBiEOG091G08PX.
PhylomeDBiP31645.
TreeFamiTF343812.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108576-MONOMER.
ReactomeiR-HSA-380615. Serotonin clearance from the synaptic cleft.
SIGNORiP31645.

Miscellaneous databases

GeneWikiiSerotonin_transporter.
GenomeRNAii6532.
PROiP31645.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108576.
CleanExiHS_HTT.
HS_SLC6A4.
ExpressionAtlasiP31645. baseline and differential.
GenevisibleiP31645. HS.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR013086. Na/ntran_symport_serotonin_N.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF03491. 5HT_transport_N. 1 hit.
PF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01203. 5HTTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A4_HUMAN
AccessioniPrimary (citable) accession number: P31645
Secondary accession number(s): Q5EE02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.