P31645 (SC6A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-dependent serotonin transporter

Alternative name(s):
5HT transporter
Short name=5HTT
Solute carrier family 6 member 4

Gene names

Name:	SLC6A4
Synonyms:	HTT, SERT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Ref.10 Ref.12 Ref.13
Subunit structure	Monomer or homooligomer By similarity. Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A By similarity. Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly. Ref.8 Ref.9 Ref.12 Ref.13
Subcellular location	Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note: Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. Ref.9 Ref.10 Ref.12 Ref.13
Tissue specificity	Expressed in platelets (at protein level). Ref.10
Induction	Down-regulated when plasma serotonin is elevated. Ref.12 Ref.13
Post-translational modification	Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms By similarity. Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.
Polymorphism	A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele. The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230]. Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].
Miscellaneous	This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Sequence similarities	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. [View classification]

Ontologies

Keywords
Biological process	Neurotransmitter transport Symport Transport
Cellular component	Cell membrane Endosome Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL cellular response to cGMP Inferred from electronic annotation. Source: Compara cellular response to retinoic acid Inferred from electronic annotation. Source: Compara circadian rhythm Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara negative regulation of cerebellar granule cell precursor proliferation Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara negative regulation of organ growth Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara protein oligomerization Inferred from sequence or structural similarity. Source: UniProtKB response to drug Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to toxin Inferred from direct assay PubMed 17575980. Source: UniProtKB serotonin uptake Inferred from direct assay Ref.9Ref.10Ref.12Ref.13PubMed 8987735. Source: UniProtKB social behavior Inferred from sequence or structural similarity. Source: BHF-UCL sperm ejaculation Inferred from electronic annotation. Source: Compara thalamus development Inferred from mutant phenotype PubMed 18378990. Source: UniProtKB vasoconstriction Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from direct assay Ref.13. Source: UniProtKB endomembrane system Inferred from direct assay Ref.10Ref.12. Source: UniProtKB endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred by curator Ref.13. Source: UniProtKB membrane raft Inferred from direct assay Ref.9. Source: UniProtKB neuron projection Inferred from electronic annotation. Source: Compara
Molecular_function	actin filament binding Inferred from sequence or structural similarity. Source: UniProtKB cocaine binding Inferred from electronic annotation. Source: Compara serotonin transmembrane transporter activity Inferred from direct assay PubMed 8987735. Source: UniProtKB serotonin:sodium symporter activity Inferred from direct assay PubMed 8987735. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Sodium-dependent serotonin transporter		PRO_0000214757
Regions
	Topological domain	1 – 87	87	Cytoplasmic Potential
	Transmembrane	88 – 108	21	Helical; Name=1; Potential
	Transmembrane	116 – 135	20	Helical; Name=2; Potential
	Transmembrane	160 – 180	21	Helical; Name=3; Potential
	Topological domain	181 – 252	72	Extracellular Potential
	Transmembrane	253 – 271	19	Helical; Name=4; Potential
	Transmembrane	280 – 297	18	Helical; Name=5; Potential
	Transmembrane	333 – 350	18	Helical; Name=6; Potential
	Transmembrane	362 – 383	22	Helical; Name=7; Potential
	Transmembrane	417 – 436	20	Helical; Name=8; Potential
	Transmembrane	464 – 482	19	Helical; Name=9; Potential
	Transmembrane	498 – 518	21	Helical; Name=10; Potential
	Transmembrane	539 – 558	20	Helical; Name=11; Potential
	Transmembrane	577 – 595	19	Helical; Name=12; Potential
	Topological domain	596 – 630	35	Cytoplasmic Potential
	Region	611 – 630	20	Required for serotonin uptake activity
	Region	616 – 624	9	Interaction with RAB4A
Amino acid modifications
	Modified residue	47	1	Phosphotyrosine Ref.14
	Modified residue	142	1	Phosphotyrosine Ref.14
	Modified residue	276	1	Phosphothreonine; by PKG Ref.11
	Modified residue	611	1	Phosphoserine Ref.13
	Modified residue	613	1	Phosphothreonine Ref.13
	Modified residue	616	1	Phosphothreonine Ref.13
	Glycosylation	208	1	N-linked (GlcNAc...) Potential
	Glycosylation	217	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	56	1	G → A. Ref.15 Corresponds to variant rs6355 [ dbSNP | Ensembl ].		VAR_014181
	Natural variant	201	1	K → N. Corresponds to variant rs2228673 [ dbSNP | Ensembl ].		VAR_029158
	Natural variant	425	1	I → L. Corresponds to variant rs28914832 [ dbSNP | Ensembl ].		VAR_036788
	Natural variant	425	1	I → V Polymorphism linked with susceptibility to obsessive-compulsive disorder; increased serotonin transport capacity. Ref.11 Ref.17 Ref.18		VAR_026751
	Natural variant	465	1	F → L. Corresponds to variant rs28914833 [ dbSNP | Ensembl ].		VAR_036789
	Natural variant	550	1	L → V. Corresponds to variant rs28914834 [ dbSNP | Ensembl ].		VAR_036790
	Natural variant	605	1	K → N. Ref.15 Corresponds to variant rs6352 [ dbSNP | Ensembl ].		VAR_014182
Experimental info
	Mutagenesis	611	1	S → A: Loss of 10 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-613 and A-616. Ref.13
	Mutagenesis	611	1	S → D: Loss of 61 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-613 and D-616. Ref.13
	Mutagenesis	613	1	T → A: Loss of 26 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-616. Ref.13
	Mutagenesis	613	1	T → D: Loss of 26 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-616. Ref.13
	Mutagenesis	616	1	T → A: No change. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-613. Ref.13
	Mutagenesis	616	1	T → D: No change. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-613. Ref.13

Sequences

	Sequence		Length	Mass (Da)
	P31645 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 0EB535B0A579BDA2	FASTA	630	70,325
	10 20 30 40 50 60 METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR 70 80 90 100 110 120 HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 130 140 150 160 170 180 YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM 190 200 210 220 230 240 AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH 250 260 270 280 290 300 RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 310 320 330 340 350 360 TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 370 380 390 400 410 420 ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 430 440 450 460 470 480 TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT 490 500 510 520 530 540 LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC 550 560 570 580 590 600 WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 610 620 630 PGTFKERIIK SITPETPTEI PCGDIRLNAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA encoding the human brain serotonin transporter." Lesch K.P., Wolozin B.L., Estler H.C., Murphy D.L., Riederer P. J. Neural Transm. 91:67-73(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization." Ramamoorthy S., Bauman A.L., Moore K.R., Han H., Yang-Feng T., Chang A.S., Ganapathy V., Blakely R.D. Proc. Natl. Acad. Sci. U.S.A. 90:2542-2546(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter." Lesch K.P., Wolozin B.L., Murphy D.L., Reiderer P. J. Neurochem. 60:2319-2322(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Platelet.
[4]	"Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells." Iceta R., Mesonero J.E., Aramayona J.J., Alcalde A.I. J. Physiol. Pharmacol. 57:119-130(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	NIEHS SNPs program Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	Bradley C.C., Blakely R.D. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114. Tissue: Placenta.
[8]	"Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter." Carneiro A.M.D., Blakely R.D. J. Biol. Chem. 281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TGFB1I1.
[9]	"Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2." Mueller H.K., Wiborg O., Haase J. J. Biol. Chem. 281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SCAMP2, SUBCELLULAR LOCATION.
[10]	"Plasma serotonin levels and the platelet serotonin transporter." Brenner B., Harney J.T., Ahmed B.A., Jeffus B.C., Unal R., Mehta J.L., Kilic F. J. Neurochem. 102:206-215(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[11]	"Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder." Zhang Y.W., Gesmonde J., Ramamoorthy S., Rudnick G. J. Neurosci. 27:10878-10886(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT THR-276, VARIANT VAL-425.
[12]	"Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter." Ahmed B.A., Jeffus B.C., Bukhari S.I., Harney J.T., Unal R., Lupashin V.V., van der Sluijs P., Kilic F. J. Biol. Chem. 283:9388-9398(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RAB4, SUBCELLULAR LOCATION, INDUCTION BY SEROTONIN.
[13]	"The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network." Ahmed B.A., Bukhari I.A., Jeffus B.C., Harney J.T., Thyparambil S., Ziu E., Fraer M., Rusch N.J., Zimniak P., Lupashin V., Tang D., Kilic F. PLoS ONE 4:E4730-E4730(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH VIM, SUBCELLULAR LOCATION, INDUCTION BY SEROTONIN, MUTAGENESIS OF SER-611; THR-613 AND THR-616, PHOSPHORYLATION AT SER-611; THR-613 AND THR-616.
[14]	"Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function." Annamalai B., Mannangatti P., Arapulisamy O., Shippenberg T.S., Jayanthi L.D., Ramamoorthy S. Mol. Pharmacol. 81:73-85(2012) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-47 AND TYR-142.
[15]	"Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ALA-56 AND ASN-605.
[16]	Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999)
[17]	"Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype." Ozaki N., Goldman D., Kaye W.H., Plotnicov K., Greenberg B.D., Lappalainen J., Rudnick G., Murphy D.L. Mol. Psychiatry 8:933-936(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT VAL-425.
[18]	"A human serotonin transporter mutation causes constitutive activation of transport activity." Kilic F., Murphy D.L., Rudnick G. Mol. Pharmacol. 64:440-446(2003) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT VAL-425.
[19]	"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene." Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Science 301:386-389(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM IN THE PROMOTER REGION.
[20]	"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence." Feinn R., Nellissery M., Kranzler H.R. Am. J. Med. Genet. B Neuropsychiatr. Genet. 133:79-84(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
+	Additional computationally mapped references.

Web resources

GeneReviews

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Serotonin transporter entry

Protein Spotlight

Love, love, love...-Issue 123 of November 2010

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70697 mRNA. Translation: CAA50029.1. L05568 mRNA. Translation: AAA35492.1. AY902473 mRNA. Translation: AAW80933.1. EU099989 Genomic DNA. Translation: ABV02581.1. BC069484 mRNA. Translation: AAH69484.1. U79746 Genomic DNA. Translation: AAB93475.1.
IPI	IPI00790986.
PIR	A47398.
RefSeq	NP_001036.1. NM_001045.5.
UniGene	Hs.134662.
3D structure databases
ProteinModelPortal	P31645.
SMR	P31645. Positions 79-590.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31645. 2 interactions.
MINT	MINT-577123.
STRING	9606.ENSP00000261707.
Protein family/group databases
TCDB	2.A.22.1.1. neurotransmitter:sodium symporter (NSS) family.
PTM databases
PhosphoSite	P31645.
Polymorphism databases
DMDM	400630.
Proteomic databases
PaxDb	P31645.
PRIDE	P31645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261707; ENSP00000261707; ENSG00000108576. ENST00000401766; ENSP00000385822; ENSG00000108576.
GeneID	6532.
KEGG	hsa:6532.
UCSC	uc002hey.4. human.
Organism-specific databases
CTD	6532.
GeneCards	GC17M028521.
HGNC	HGNC:11050. SLC6A4.
MIM	103780. phenotype. 164230. phenotype. 182138. gene.
neXtProt	NX_P31645.
PharmGKB	PA312.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0733.
HOGENOM	HOG000116406.
HOVERGEN	HBG071421.
InParanoid	P31645.
KO	K05037.
OrthoDB	EOG447FSX.
PhylomeDB	P31645.
Gene expression databases
ArrayExpress	P31645.
Bgee	P31645.
CleanEx	HS_HTT. HS_SLC6A4.
Genevestigator	P31645.
GermOnline	ENSG00000108576. Homo sapiens.
Family and domain databases
InterPro	IPR000175. Na/ntran_symport. IPR013086. Na/ntran_symport_serotonin_N. [Graphical view]
PANTHER	PTHR11616. PTHR11616. 1 hit.
Pfam	PF03491. 5HT_transporter. 1 hit. PF00209. SNF. 1 hit. [Graphical view]
PRINTS	PR01203. 5HTTRANSPORT. PR00176. NANEUSMPORT.
PROSITE	PS00610. NA_NEUROTRAN_SYMP_1. 1 hit. PS00754. NA_NEUROTRAN_SYMP_2. 1 hit. PS50267. NA_NEUROTRAN_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P31645.
ChEMBL	CHEMBL228.
DrugBank	DB04836. Amineptine. DB00321. Amitriptyline. DB00543. Amoxapine. DB00215. Citalopram. DB01242. Clomipramine. DB00907. Cocaine. DB01151. Desipramine. DB01191. Dexfenfluramine. DB00514. Dextromethorphan. DB01142. Doxepin. DB00476. Duloxetine. DB01175. Escitalopram. DB00472. Fluoxetine. DB00176. Fluvoxamine. DB00458. Imipramine. DB00422. Methylphenidate. DB04896. Milnacipran. DB00805. Minaprine. DB01149. Nefazodone. DB00540. Nortriptyline. DB00715. Paroxetine. DB00191. Phentermine. DB00344. Protriptyline. DB01104. Sertraline. DB01105. Sibutramine. DB01079. Tegaserod. DB00193. Tramadol. DB00656. Trazodone. DB00726. Trimipramine. DB00285. Venlafaxine. DB04832. Zimelidine.
GenomeRNAi	6532.
NextBio	25415.
SOURCE	Search...

Entry information

Entry name

SC6A4_HUMAN

Accession

Primary (citable) accession number: P31645
Secondary accession number(s): Q5EE02

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 132 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.