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P31645 (SC6A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent serotonin transporter
Alternative name(s):
5HT transporter
Short name=5HTT
Solute carrier family 6 member 4
Gene names
Name:SLC6A4
Synonyms:HTT, SERT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length630 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Ref.11 Ref.13 Ref.14

Subunit structure

Monomer or homooligomer By similarity. Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A By similarity. Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly. Ref.9 Ref.10 Ref.13 Ref.14

Subcellular location

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note: Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. Ref.10 Ref.11 Ref.13 Ref.14

Tissue specificity

Expressed in platelets (at protein level). Ref.11

Induction

Down-regulated when plasma serotonin is elevated. Ref.13 Ref.14

Post-translational modification

Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms By similarity.

Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.

Polymorphism

A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.

The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].

Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. [View classification]

Ontologies

Keywords
   Biological processNeurotransmitter transport
Symport
Transport
   Cellular componentCell membrane
Endosome
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular response to cGMP

Inferred from electronic annotation. Source: Ensembl

cellular response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

monoamine transport

Inferred from direct assay PubMed 16024787. Source: MGI

negative regulation of cerebellar granule cell precursor proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of organ growth

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of synaptic transmission, dopaminergic

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

protein oligomerization

Inferred from sequence or structural similarity. Source: UniProtKB

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from direct assay PubMed 17575980. Source: UniProtKB

serotonin transport

Inferred from direct assay Ref.14. Source: UniProtKB

serotonin uptake

Inferred from direct assay Ref.10Ref.11Ref.13Ref.14PubMed 8987735. Source: UniProtKB

social behavior

Inferred from sequence or structural similarity. Source: BHF-UCL

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

thalamus development

Inferred from mutant phenotype PubMed 18378990. Source: UniProtKB

vasoconstriction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from direct assay Ref.14. Source: UniProtKB

endomembrane system

Inferred from direct assay Ref.11Ref.13. Source: UniProtKB

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Inferred by curator Ref.14. Source: UniProtKB

membrane raft

Inferred from direct assay Ref.10. Source: UniProtKB

neuron projection

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay Ref.10Ref.11Ref.13Ref.14. Source: UniProtKB

   Molecular_functionRab GTPase binding

Inferred from physical interaction Ref.13. Source: UniProtKB

actin filament binding

Inferred from sequence or structural similarity. Source: UniProtKB

cocaine binding

Inferred from electronic annotation. Source: Ensembl

monoamine transmembrane transporter activity

Inferred from direct assay PubMed 16024787. Source: MGI

protein binding

Inferred from physical interaction PubMed 11343649PubMed 12177201Ref.10PubMed 16882008Ref.14. Source: UniProtKB

serotonin transmembrane transporter activity

Inferred from direct assay PubMed 8987735. Source: UniProtKB

serotonin:sodium symporter activity

Inferred from direct assay PubMed 8987735. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P31645-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P31645-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSQSRRVNPDDRELGGDLQIQAPRDQLGSLADGHQCHLLTSRM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 630630Sodium-dependent serotonin transporter
PRO_0000214757

Regions

Topological domain1 – 8787Cytoplasmic Potential
Transmembrane88 – 10821Helical; Name=1; Potential
Transmembrane116 – 13520Helical; Name=2; Potential
Transmembrane160 – 18021Helical; Name=3; Potential
Topological domain181 – 25272Extracellular Potential
Transmembrane253 – 27119Helical; Name=4; Potential
Transmembrane280 – 29718Helical; Name=5; Potential
Transmembrane333 – 35018Helical; Name=6; Potential
Transmembrane362 – 38322Helical; Name=7; Potential
Transmembrane417 – 43620Helical; Name=8; Potential
Transmembrane464 – 48219Helical; Name=9; Potential
Transmembrane498 – 51821Helical; Name=10; Potential
Transmembrane539 – 55820Helical; Name=11; Potential
Transmembrane577 – 59519Helical; Name=12; Potential
Topological domain596 – 63035Cytoplasmic Potential
Region611 – 63020Required for serotonin uptake activity
Region616 – 6249Interaction with RAB4A

Amino acid modifications

Modified residue471Phosphotyrosine Ref.15
Modified residue1421Phosphotyrosine Ref.15
Modified residue2761Phosphothreonine; by PKG Ref.12
Modified residue6111Phosphoserine Ref.14
Modified residue6131Phosphothreonine Ref.14
Modified residue6161Phosphothreonine Ref.14
Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation2171N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence11M → MSQSRRVNPDDRELGGDLQI QAPRDQLGSLADGHQCHLLT SRM in isoform 2.
VSP_046553
Natural variant561G → A. Ref.16
Corresponds to variant rs6355 [ dbSNP | Ensembl ].
VAR_014181
Natural variant2011K → N.
Corresponds to variant rs2228673 [ dbSNP | Ensembl ].
VAR_029158
Natural variant4251I → L.
Corresponds to variant rs28914832 [ dbSNP | Ensembl ].
VAR_036788
Natural variant4251I → V Polymorphism linked with susceptibility to obsessive-compulsive disorder; increased serotonin transport capacity. Ref.12 Ref.18 Ref.19
VAR_026751
Natural variant4651F → L.
Corresponds to variant rs28914833 [ dbSNP | Ensembl ].
VAR_036789
Natural variant5501L → V.
Corresponds to variant rs28914834 [ dbSNP | Ensembl ].
VAR_036790
Natural variant6051K → N. Ref.16
Corresponds to variant rs6352 [ dbSNP | Ensembl ].
VAR_014182

Experimental info

Mutagenesis6111S → A: Loss of 10 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-613 and A-616. Ref.14
Mutagenesis6111S → D: Loss of 61 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-613 and D-616. Ref.14
Mutagenesis6131T → A: Loss of 26 % of serotonin uptake activity. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-616. Ref.14
Mutagenesis6131T → D: Loss of 26 % of serotonin uptake activity. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-616. Ref.14
Mutagenesis6161T → A: No change. Loss of 5 % of serotonin uptake activity; when associated with A-611 and A-613. Ref.14
Mutagenesis6161T → D: No change. Loss of 95 % of serotonin uptake activity and lack of association between VIM and the plasma membrane; when associated with D-611 and D-613. Ref.14

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 0EB535B0A579BDA2

FASTA63070,325
        10         20         30         40         50         60 
METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR 

        70         80         90        100        110        120 
HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 

       130        140        150        160        170        180 
YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM 

       190        200        210        220        230        240 
AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH 

       250        260        270        280        290        300 
RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 

       310        320        330        340        350        360 
TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 

       370        380        390        400        410        420 
ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 

       430        440        450        460        470        480 
TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT 

       490        500        510        520        530        540 
LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC 

       550        560        570        580        590        600 
WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 

       610        620        630 
PGTFKERIIK SITPETPTEI PCGDIRLNAV 

« Hide

Isoform 2 [UniParc].

Checksum: 142F04437BA1DE39
Show »

FASTA67274,979

References

« Hide 'large scale' references
[1]"Isolation of a cDNA encoding the human brain serotonin transporter."
Lesch K.P., Wolozin B.L., Estler H.C., Murphy D.L., Riederer P.
J. Neural Transm. 91:67-73(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization."
Ramamoorthy S., Bauman A.L., Moore K.R., Han H., Yang-Feng T., Chang A.S., Ganapathy V., Blakely R.D.
Proc. Natl. Acad. Sci. U.S.A. 90:2542-2546(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter."
Lesch K.P., Wolozin B.L., Murphy D.L., Reiderer P.
J. Neurochem. 60:2319-2322(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Platelet.
[4]"Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells."
Iceta R., Mesonero J.E., Aramayona J.J., Alcalde A.I.
J. Physiol. Pharmacol. 57:119-130(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]NIEHS SNPs program
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]Bradley C.C., Blakely R.D.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114.
Tissue: Placenta.
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-317 (ISOFORM 2).
Tissue: Lung.
[9]"Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter."
Carneiro A.M.D., Blakely R.D.
J. Biol. Chem. 281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TGFB1I1.
[10]"Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2."
Mueller H.K., Wiborg O., Haase J.
J. Biol. Chem. 281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCAMP2, SUBCELLULAR LOCATION.
[11]"Plasma serotonin levels and the platelet serotonin transporter."
Brenner B., Harney J.T., Ahmed B.A., Jeffus B.C., Unal R., Mehta J.L., Kilic F.
J. Neurochem. 102:206-215(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[12]"Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder."
Zhang Y.W., Gesmonde J., Ramamoorthy S., Rudnick G.
J. Neurosci. 27:10878-10886(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-276, VARIANT VAL-425.
[13]"Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter."
Ahmed B.A., Jeffus B.C., Bukhari S.I., Harney J.T., Unal R., Lupashin V.V., van der Sluijs P., Kilic F.
J. Biol. Chem. 283:9388-9398(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RAB4, SUBCELLULAR LOCATION, INDUCTION BY SEROTONIN.
[14]"The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network."
Ahmed B.A., Bukhari I.A., Jeffus B.C., Harney J.T., Thyparambil S., Ziu E., Fraer M., Rusch N.J., Zimniak P., Lupashin V., Tang D., Kilic F.
PLoS ONE 4:E4730-E4730(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH VIM, SUBCELLULAR LOCATION, INDUCTION BY SEROTONIN, MUTAGENESIS OF SER-611; THR-613 AND THR-616, PHOSPHORYLATION AT SER-611; THR-613 AND THR-616.
[15]"Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function."
Annamalai B., Mannangatti P., Arapulisamy O., Shippenberg T.S., Jayanthi L.D., Ramamoorthy S.
Mol. Pharmacol. 81:73-85(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-47 AND TYR-142.
[16]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-56 AND ASN-605.
[17]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[18]"Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype."
Ozaki N., Goldman D., Kaye W.H., Plotnicov K., Greenberg B.D., Lappalainen J., Rudnick G., Murphy D.L.
Mol. Psychiatry 8:933-936(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-425.
[19]"A human serotonin transporter mutation causes constitutive activation of transport activity."
Kilic F., Murphy D.L., Rudnick G.
Mol. Pharmacol. 64:440-446(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT VAL-425.
[20]"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene."
Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R.
Science 301:386-389(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM IN THE PROMOTER REGION.
[21]"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence."
Feinn R., Nellissery M., Kranzler H.R.
Am. J. Med. Genet. B Neuropsychiatr. Genet. 133:79-84(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Serotonin transporter entry

Protein Spotlight

Love, love, love... -Issue 123 of November 2010

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70697 mRNA. Translation: CAA50029.1.
L05568 mRNA. Translation: AAA35492.1.
AY902473 mRNA. Translation: AAW80933.1.
EU099989 Genomic DNA. Translation: ABV02581.1.
BC069484 mRNA. Translation: AAH69484.1.
U79746 Genomic DNA. Translation: AAB93475.1.
AK308014 mRNA. No translation available.
CCDSCCDS11256.1. [P31645-1]
PIRA47398.
RefSeqNP_001036.1. NM_001045.5. [P31645-1]
UniGeneHs.134662.
Hs.29792.

3D structure databases

ProteinModelPortalP31645.
SMRP31645. Positions 78-614.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112423. 5 interactions.
IntActP31645. 2 interactions.
MINTMINT-577123.
STRING9606.ENSP00000261707.

Chemistry

BindingDBP31645.
ChEMBLCHEMBL2111346.
DrugBankDB04836. Amineptine.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00215. Citalopram.
DB01242. Clomipramine.
DB00907. Cocaine.
DB01151. Desipramine.
DB01191. Dexfenfluramine.
DB00514. Dextromethorphan.
DB01142. Doxepin.
DB00476. Duloxetine.
DB01175. Escitalopram.
DB00472. Fluoxetine.
DB00176. Fluvoxamine.
DB00458. Imipramine.
DB00422. Methylphenidate.
DB04896. Milnacipran.
DB00805. Minaprine.
DB01149. Nefazodone.
DB00540. Nortriptyline.
DB00715. Paroxetine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB01104. Sertraline.
DB01105. Sibutramine.
DB01079. Tegaserod.
DB00193. Tramadol.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00285. Venlafaxine.
DB04832. Zimelidine.
GuidetoPHARMACOLOGY928.

Protein family/group databases

TCDB2.A.22.1.1. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteP31645.

Polymorphism databases

DMDM400630.

Proteomic databases

PaxDbP31645.
PRIDEP31645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261707; ENSP00000261707; ENSG00000108576. [P31645-1]
ENST00000401766; ENSP00000385822; ENSG00000108576. [P31645-1]
GeneID6532.
KEGGhsa:6532.
UCSCuc002hey.5. human. [P31645-1]

Organism-specific databases

CTD6532.
GeneCardsGC17M028521.
HGNCHGNC:11050. SLC6A4.
MIM103780. phenotype.
164230. phenotype.
182138. gene.
neXtProtNX_P31645.
PharmGKBPA312.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidP31645.
KOK05037.
OMATSCKNSW.
OrthoDBEOG793B71.
PhylomeDBP31645.
TreeFamTF343812.

Gene expression databases

ArrayExpressP31645.
BgeeP31645.
CleanExHS_HTT.
HS_SLC6A4.
GenevestigatorP31645.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR013086. Na/ntran_symport_serotonin_N.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF03491. 5HT_transporter. 1 hit.
PF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01203. 5HTTRANSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSerotonin_transporter.
GenomeRNAi6532.
NextBio25415.
PROP31645.
SOURCESearch...

Entry information

Entry nameSC6A4_HUMAN
AccessionPrimary (citable) accession number: P31645
Secondary accession number(s): Q5EE02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM