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Protein

Gamma-aminobutyric acid receptor subunit alpha-5

Gene

GABRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: Ensembl
  • GABA receptor binding Source: Ensembl
  • receptor activity Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314. Neurotransmitter receptors and postsynaptic signal transmission.
R-HSA-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-5
Alternative name(s):
GABA(A) receptor subunit alpha-5
Gene namesi
Name:GABRA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000186297.11.
HGNCiHGNC:4079. GABRA5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 259ExtracellularSequence analysisAdd BLAST228
Transmembranei260 – 281HelicalSequence analysisAdd BLAST22
Transmembranei286 – 307HelicalSequence analysisAdd BLAST22
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Topological domaini342 – 427CytoplasmicSequence analysisAdd BLAST86
Transmembranei428 – 449HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2558.
GeneReviewsiGABRA5.
OpenTargetsiENSG00000186297.
PharmGKBiPA28493.

Chemistry databases

ChEMBLiCHEMBL5112.
DrugBankiDB00659. Acamprosate.
DB00546. Adinazolam.
DB06579. Adipiplon.
DB00404. Alprazolam.
DB01351. Amobarbital.
DB00543. Amoxapine.
DB01352. Aprobarbital.
DB01483. Barbital.
DB01496. Barbituric acid derivative.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB01353. Butethal.
DB00475. Chlordiazepoxide.
DB01594. Cinolazepam.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01559. Clotiazepam.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01567. Fludiazepam.
DB01205. Flumazenil.
DB01544. Flunitrazepam.
DB00690. Flurazepam.
DB05087. Ganaxolone.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB01354. Heptabarbital.
DB01355. Hexobarbital.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB00463. Metharbital.
DB01028. Methoxyflurane.
DB00849. Methylphenobarbital.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01708. Prasterone.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB00418. Secobarbital.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB11582. Thiocolchicoside.
DB00599. Thiopental.
DB00273. Topiramate.
DB00897. Triazolam.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi408.

Polymorphism and mutation databases

BioMutaiGABRA5.
DMDMi399519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000044432 – 462Gamma-aminobutyric acid receptor subunit alpha-5Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi173 ↔ 187By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP31644.
MaxQBiP31644.
PaxDbiP31644.
PeptideAtlasiP31644.
PRIDEiP31644.

PTM databases

iPTMnetiP31644.
PhosphoSitePlusiP31644.

Expressioni

Gene expression databases

BgeeiENSG00000186297.
CleanExiHS_GABRA5.
ExpressionAtlasiP31644. baseline and differential.
GenevisibleiP31644. HS.

Organism-specific databases

HPAiHPA077031.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108832. 1 interactor.
STRINGi9606.ENSP00000335592.

Chemistry databases

BindingDBiP31644.

Structurei

3D structure databases

ProteinModelPortaliP31644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP31644.
KOiK05175.
OMAiMTHPPNI.
OrthoDBiEOG091G0805.
PhylomeDBiP31644.
TreeFamiTF315453.

Family and domain databases

Gene3Di1.20.58.390. 1 hit.
2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR001390. GABAAa_rcpt.
IPR005435. GABBAa5_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR036734. Neur_chan_lig-bd_sf.
IPR006201. Neur_channel.
IPR036719. Neuro-gated_channel_TM_sf.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR01079. GABAARALPHA.
PR01618. GABAARALPHA5.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNGMFSGFI MIKNLLLFCI SMNLSSHFGF SQMPTSSVKD ETNDNITIFT
60 70 80 90 100
RILDGLLDGY DNRLRPGLGE RITQVRTDIY VTSFGPVSDT EMEYTIDVFF
110 120 130 140 150
RQSWKDERLR FKGPMQRLPL NNLLASKIWT PDTFFHNGKK SIAHNMTTPN
160 170 180 190 200
KLLRLEDDGT LLYTMRLTIS AECPMQLEDF PMDAHACPLK FGSYAYPNSE
210 220 230 240 250
VVYVWTNGST KSVVVAEDGS RLNQYHLMGQ TVGTENISTS TGEYTIMTAH
260 270 280 290 300
FHLKRKIGYF VIQTYLPCIM TVILSQVSFW LNRESVPART VFGVTTVLTM
310 320 330 340 350
TTLSISARNS LPKVAYATAM DWFIAVCYAF VFSALIEFAT VNYFTKRGWA
360 370 380 390 400
WDGKKALEAA KIKKKREVIL NKSTNAFTTG KMSHPPNIPK EQTPAGTSNT
410 420 430 440 450
TSVSVKPSEE KTSESKKTYN SISKIDKMSR IVFPVLFGTF NLVYWATYLN
460
REPVIKGAAS PK
Length:462
Mass (Da):52,146
Last modified:July 1, 1993 - v1
Checksum:i260A8B554113AFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08485 mRNA. Translation: AAA58490.1.
AK290453 mRNA. Translation: BAF83142.1.
BT009830 mRNA. Translation: AAP88832.1.
BC111979 mRNA. Translation: AAI11980.1.
BC113422 mRNA. Translation: AAI13423.1.
AF061785 Genomic DNA. Translation: AAC31809.1.
AF228447 Genomic DNA. Translation: AAF62508.1.
AF228448 Genomic DNA. Translation: AAF62509.1.
AF228449 Genomic DNA. Translation: AAF62510.1.
CCDSiCCDS45194.1.
PIRiA48933.
RefSeqiNP_000801.1. NM_000810.3.
NP_001158509.1. NM_001165037.1.
XP_005268315.1. XM_005268258.2.
XP_006720522.1. XM_006720459.2.
UniGeneiHs.24969.

Genome annotation databases

EnsembliENST00000335625; ENSP00000335592; ENSG00000186297.
ENST00000355395; ENSP00000347557; ENSG00000186297.
ENST00000400081; ENSP00000382953; ENSG00000186297.
GeneIDi2558.
KEGGihsa:2558.
UCSCiuc001zbd.3. human.

Similar proteinsi

Entry informationi

Entry nameiGBRA5_HUMAN
AccessioniPrimary (citable) accession number: P31644
Secondary accession number(s): A8K338
, Q14DC2, Q53XL6, Q9NYT3, Q9NYT4, Q9NYT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 22, 2017
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families