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Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake (By similarity).By similarity

GO - Molecular functioni

  • neurotransmitter:sodium symporter activity Source: InterPro
  • taurine:sodium symporter activity Source: RGD
  • taurine binding Source: RGD

GO - Biological processi

  • amino acid transmembrane transport Source: GO_Central
  • taurine transport Source: RGD

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230 Amino acid transport across the plasma membrane
R-RNO-442660 Na+/Cl- dependent neurotransmitter transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:Slc6a6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61912 Slc6a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei122 – 142Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini143 – 217ExtracellularSequence analysisAdd BLAST75
Transmembranei218 – 236Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei245 – 262Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei298 – 315Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei327 – 348Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei381 – 400Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei430 – 448Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei465 – 485Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei506 – 525Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei545 – 563Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini564 – 621CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147691 – 621Sodium- and chloride-dependent taurine transporterAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei322PhosphoserineBy similarity1

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31643
PRIDEiP31643

PTM databases

iPTMnetiP31643
PhosphoSitePlusiP31643

Expressioni

Tissue specificityi

Brain and peripheral tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000009019
ExpressionAtlasiP31643 baseline and differential
GenevisibleiP31643 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012875

Structurei

3D structure databases

ProteinModelPortaliP31643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP31643
KOiK05039
PhylomeDBiP31643
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002434 Na/ntran_symport_taurine
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01200 TAUTRANSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P31643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF
60 70 80 90 100
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI
110 120 130 140 150
IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF
160 170 180 190 200
QSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSAAN FTSPVIEFWE
210 220 230 240 250
RNVLSLSSGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
260 270 280 290 300
TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP NISRLEDPQV WIDAGTQIFF
310 320 330 340 350
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
360 370 380 390 400
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
410 420 430 440 450
DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAIVCSISY LLGLTMVTEG
460 470 480 490 500
GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
510 520 530 540 550
GPWMKYSWAV ITPALCVGCF IFSLVKYVPL TYNKVYRYPD WAIGLGWGLA
560 570 580 590 600
LSSMVCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS
610 620
RATLMNGALM KPSHVIVETM M
Length:621
Mass (Da):69,869
Last modified:July 1, 1993 - v1
Checksum:iEA5613F20DC5C7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96601 mRNA Translation: AAA42304.1
PIRiI57939
RefSeqiNP_058902.1, NM_017206.1
XP_006236965.1, XM_006236903.3
UniGeneiRn.9968

Genome annotation databases

EnsembliENSRNOT00000012875; ENSRNOP00000012875; ENSRNOG00000009019
GeneIDi29464
KEGGirno:29464

Similar proteinsi

Entry informationi

Entry nameiSC6A6_RAT
AccessioniPrimary (citable) accession number: P31643
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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