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Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake (By similarity).By similarity

GO - Molecular functioni

  • neurotransmitter:sodium symporter activity Source: InterPro
  • taurine:sodium symporter activity Source: RGD
  • taurine binding Source: RGD

GO - Biological processi

  • organic acid transmembrane transport Source: GOC
  • taurine transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:Slc6a6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi61912. Slc6a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 21775ExtracellularSequence analysisAdd
BLAST
Transmembranei218 – 23619Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei245 – 26218Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei298 – 31518Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei327 – 34822Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei381 – 40020Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei430 – 44819Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei465 – 48521Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei506 – 52520Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei545 – 56319Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini564 – 62158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Sodium- and chloride-dependent taurine transporterPRO_0000214769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence analysis
Modified residuei322 – 3221PhosphoserineBy similarity

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31643.
PRIDEiP31643.

Expressioni

Tissue specificityi

Brain and peripheral tissues.1 Publication

Gene expression databases

ExpressionAtlasiP31643. baseline and differential.
GenevisibleiP31643. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012875.

Structurei

3D structure databases

ProteinModelPortaliP31643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31643.
KOiK05039.
OMAiLSSMMCV.
OrthoDBiEOG793B71.
PhylomeDBiP31643.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF
60 70 80 90 100
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI
110 120 130 140 150
IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF
160 170 180 190 200
QSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSAAN FTSPVIEFWE
210 220 230 240 250
RNVLSLSSGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
260 270 280 290 300
TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP NISRLEDPQV WIDAGTQIFF
310 320 330 340 350
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
360 370 380 390 400
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
410 420 430 440 450
DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAIVCSISY LLGLTMVTEG
460 470 480 490 500
GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
510 520 530 540 550
GPWMKYSWAV ITPALCVGCF IFSLVKYVPL TYNKVYRYPD WAIGLGWGLA
560 570 580 590 600
LSSMVCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS
610 620
RATLMNGALM KPSHVIVETM M
Length:621
Mass (Da):69,869
Last modified:July 1, 1993 - v1
Checksum:iEA5613F20DC5C7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96601 mRNA. Translation: AAA42304.1.
PIRiI57939.
RefSeqiNP_058902.1. NM_017206.1.
XP_006236965.1. XM_006236903.2.
UniGeneiRn.9968.

Genome annotation databases

EnsembliENSRNOT00000012875; ENSRNOP00000012875; ENSRNOG00000009019.
GeneIDi29464.
KEGGirno:29464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96601 mRNA. Translation: AAA42304.1.
PIRiI57939.
RefSeqiNP_058902.1. NM_017206.1.
XP_006236965.1. XM_006236903.2.
UniGeneiRn.9968.

3D structure databases

ProteinModelPortaliP31643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012875.

Proteomic databases

PaxDbiP31643.
PRIDEiP31643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012875; ENSRNOP00000012875; ENSRNOG00000009019.
GeneIDi29464.
KEGGirno:29464.

Organism-specific databases

CTDi6533.
RGDi61912. Slc6a6.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31643.
KOiK05039.
OMAiLSSMMCV.
OrthoDBiEOG793B71.
PhylomeDBiP31643.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.
R-RNO-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

NextBioi609268.
PROiP31643.

Gene expression databases

ExpressionAtlasiP31643. baseline and differential.
GenevisibleiP31643. RN.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a high affinity taurine transporter from rat brain."
    Smith K.E., Borden L.A., Wang C.H.D., Hartig P.R., Branchek T.A., Weinshank R.L.
    Mol. Pharmacol. 42:563-569(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSC6A6_RAT
AccessioniPrimary (citable) accession number: P31643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.