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P31641

- SC6A6_HUMAN

UniProt

P31641 - SC6A6_HUMAN

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Protein
Sodium- and chloride-dependent taurine transporter
Gene
SLC6A6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.1 Publication

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. taurine binding Source: Ensembl
  3. taurine:sodium symporter activity Source: ProtInc

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. cellular amino acid metabolic process Source: ProtInc
  3. ion transport Source: Reactome
  4. taurine transport Source: Ensembl
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:SLC6A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11052. SLC6A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei50 – 7021Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei78 – 9720Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini143 – 21775Extracellular Reviewed prediction
Add
BLAST
Transmembranei218 – 23619Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei245 – 26218Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei298 – 31518Helical; Name=6; Reviewed prediction
Add
BLAST
Transmembranei327 – 34822Helical; Name=7; Reviewed prediction
Add
BLAST
Transmembranei381 – 40020Helical; Name=8; Reviewed prediction
Add
BLAST
Transmembranei430 – 44819Helical; Name=9; Reviewed prediction
Add
BLAST
Transmembranei465 – 48521Helical; Name=10; Reviewed prediction
Add
BLAST
Transmembranei506 – 52520Helical; Name=11; Reviewed prediction
Add
BLAST
Transmembranei545 – 56319Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini564 – 62057Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. integral component of plasma membrane Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Sodium- and chloride-dependent taurine transporter
PRO_0000214767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...)1 Publication
Modified residuei322 – 3221Phosphoserine By similarity

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31641.
PaxDbiP31641.
PRIDEiP31641.

PTM databases

PhosphoSiteiP31641.

Expressioni

Tissue specificityi

Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.1 Publication

Gene expression databases

ArrayExpressiP31641.
BgeeiP31641.
CleanExiHS_SLC6A6.
GenevestigatoriP31641.

Organism-specific databases

HPAiHPA015028.
HPA016488.

Interactioni

Protein-protein interaction databases

BioGridi112424. 1 interaction.
STRINGi9606.ENSP00000354107.

Structurei

3D structure databases

ProteinModelPortaliP31641.
SMRiP31641. Positions 40-582.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31641.
KOiK05039.
OMAiIEFWERN.
OrthoDBiEOG793B71.
PhylomeDBiP31641.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P31641-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF    50
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII 100
IGQYTSEGGI TCWEKICPLF SGIGYASVVI VSLLNVYYIV ILAWATYYLF 150
QSFQKELPWA HCNHSWNTPH CMEDTMRKNK SVWITISSTN FTSPVIEFWE 200
RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA 250
TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 300
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF 350
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL 400
DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAFVCSISY LLGLTMVTEG 450
GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP 500
GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN WAIGLGWSLA 550
LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS 600
RTVMNGALVK PTHIIVETMM 620
Length:620
Mass (Da):69,830
Last modified:February 1, 1996 - v2
Checksum:i3CEB22BA46116AD1
GO
Isoform 2 (identifier: P31641-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-620: Missing.

Note: No experimental confirmation available.

Show »
Length:200
Mass (Da):22,744
Checksum:i9A57ABC8FADE6216
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171I → M.
Corresponds to variant rs1042350 [ dbSNP | Ensembl ].
VAR_011767
Natural varianti18 – 181L → V.
Corresponds to variant rs1042351 [ dbSNP | Ensembl ].
VAR_011768
Natural varianti236 – 2361W → C.
Corresponds to variant rs1042352 [ dbSNP | Ensembl ].
VAR_011769

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 620420Missing in isoform 2.
VSP_044961Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281T → K in AAA50842. 1 Publication
Sequence conflicti272 – 2721A → R in CAA79481. 1 Publication
Sequence conflicti509 – 5091Missing in CAA79481. 1 Publication
Sequence conflicti538 – 5403YPN → SPT in CAA79481. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18956 mRNA. Translation: CAA79481.1.
U16120 mRNA. Translation: AAA50842.1.
U09220 mRNA. Translation: AAC50443.1.
AC090941 Genomic DNA. No translation available.
AC090952 Genomic DNA. No translation available.
AC093496 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64192.1.
BC006252 mRNA. Translation: AAH06252.1.
BC111489 mRNA. Translation: AAI11490.1.
BC137128 mRNA. Translation: AAI37129.1.
BC137129 mRNA. Translation: AAI37130.1.
AF346763 mRNA. Translation: AAK30132.1.
CCDSiCCDS33705.1. [P31641-1]
CCDS46765.1. [P31641-2]
PIRiG01426.
S29839.
S46487.
RefSeqiNP_001127839.2. NM_001134367.3.
NP_001127840.1. NM_001134368.3. [P31641-2]
NP_003034.2. NM_003043.5. [P31641-1]
UniGeneiHs.529488.

Genome annotation databases

EnsembliENST00000360861; ENSP00000354107; ENSG00000131389. [P31641-1]
ENST00000416216; ENSP00000401167; ENSG00000131389. [P31641-2]
ENST00000454876; ENSP00000398063; ENSG00000131389. [P31641-1]
GeneIDi6533.
KEGGihsa:6533.
UCSCiuc003byp.4. human.
uc003byq.4. human. [P31641-1]

Polymorphism databases

DMDMi1352535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z18956 mRNA. Translation: CAA79481.1 .
U16120 mRNA. Translation: AAA50842.1 .
U09220 mRNA. Translation: AAC50443.1 .
AC090941 Genomic DNA. No translation available.
AC090952 Genomic DNA. No translation available.
AC093496 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64192.1 .
BC006252 mRNA. Translation: AAH06252.1 .
BC111489 mRNA. Translation: AAI11490.1 .
BC137128 mRNA. Translation: AAI37129.1 .
BC137129 mRNA. Translation: AAI37130.1 .
AF346763 mRNA. Translation: AAK30132.1 .
CCDSi CCDS33705.1. [P31641-1 ]
CCDS46765.1. [P31641-2 ]
PIRi G01426.
S29839.
S46487.
RefSeqi NP_001127839.2. NM_001134367.3.
NP_001127840.1. NM_001134368.3. [P31641-2 ]
NP_003034.2. NM_003043.5. [P31641-1 ]
UniGenei Hs.529488.

3D structure databases

ProteinModelPortali P31641.
SMRi P31641. Positions 40-582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112424. 1 interaction.
STRINGi 9606.ENSP00000354107.

Chemistry

BindingDBi P31641.
ChEMBLi CHEMBL5762.

Protein family/group databases

TCDBi 2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSitei P31641.

Polymorphism databases

DMDMi 1352535.

Proteomic databases

MaxQBi P31641.
PaxDbi P31641.
PRIDEi P31641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360861 ; ENSP00000354107 ; ENSG00000131389 . [P31641-1 ]
ENST00000416216 ; ENSP00000401167 ; ENSG00000131389 . [P31641-2 ]
ENST00000454876 ; ENSP00000398063 ; ENSG00000131389 . [P31641-1 ]
GeneIDi 6533.
KEGGi hsa:6533.
UCSCi uc003byp.4. human.
uc003byq.4. human. [P31641-1 ]

Organism-specific databases

CTDi 6533.
GeneCardsi GC03P014444.
HGNCi HGNC:11052. SLC6A6.
HPAi HPA015028.
HPA016488.
MIMi 186854. gene.
neXtProti NX_P31641.
PharmGKBi PA35912.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0733.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi P31641.
KOi K05039.
OMAi IEFWERN.
OrthoDBi EOG793B71.
PhylomeDBi P31641.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

GeneWikii SLC6A6.
GenomeRNAii 6533.
NextBioi 25419.
PROi P31641.
SOURCEi Search...

Gene expression databases

ArrayExpressi P31641.
Bgeei P31641.
CleanExi HS_SLC6A6.
Genevestigatori P31641.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells."
    Jhiang S.M., Fithian L., Smanik P., McGill J., Tong Q., Mazzaferri E.L.
    FEBS Lett. 318:139-144(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Thyroid.
  2. "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta."
    Ramamoorthy S., Leibach F.H., Mahesh V.B., Han H., Yang-Feng T., Blakely R.D., Ganapathy V.
    Biochem. J. 300:893-900(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium."
    Miyamoto Y., Liou G.I., Sprinkle T.J.
    Curr. Eye Res. 15:345-349(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retinal pigment epithelium.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood, Brain and Ovary.
  7. "Taurine transporter expression in various organs."
    Kim H.W., An H.S., Park T.S., Park K.K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-324.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSC6A6_HUMAN
AccessioniPrimary (citable) accession number: P31641
Secondary accession number(s): B2RNU7, Q9BRI2, Q9BXB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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