Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P31641 (SC6A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene names
Name:SLC6A6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver. Ref.1

Post-translational modification

Down-regulated upon Ser-322 phosphorylation By similarity.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P31641-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P31641-2)

The sequence of this isoform differs from the canonical sequence as follows:
     201-620: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Sodium- and chloride-dependent taurine transporter
PRO_0000214767

Regions

Topological domain1 – 4949Cytoplasmic Potential
Transmembrane50 – 7021Helical; Name=1; Potential
Transmembrane78 – 9720Helical; Name=2; Potential
Transmembrane122 – 14221Helical; Name=3; Potential
Topological domain143 – 21775Extracellular Potential
Transmembrane218 – 23619Helical; Name=4; Potential
Transmembrane245 – 26218Helical; Name=5; Potential
Transmembrane298 – 31518Helical; Name=6; Potential
Transmembrane327 – 34822Helical; Name=7; Potential
Transmembrane381 – 40020Helical; Name=8; Potential
Transmembrane430 – 44819Helical; Name=9; Potential
Transmembrane465 – 48521Helical; Name=10; Potential
Transmembrane506 – 52520Helical; Name=11; Potential
Transmembrane545 – 56319Helical; Name=12; Potential
Topological domain564 – 62057Cytoplasmic Potential

Amino acid modifications

Modified residue3221Phosphoserine By similarity
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Ref.8

Natural variations

Alternative sequence201 – 620420Missing in isoform 2.
VSP_044961
Natural variant171I → M.
Corresponds to variant rs1042350 [ dbSNP | Ensembl ].
VAR_011767
Natural variant181L → V.
Corresponds to variant rs1042351 [ dbSNP | Ensembl ].
VAR_011768
Natural variant2361W → C.
Corresponds to variant rs1042352 [ dbSNP | Ensembl ].
VAR_011769

Experimental info

Sequence conflict281T → K in AAA50842. Ref.2
Sequence conflict2721A → R in CAA79481. Ref.1
Sequence conflict5091Missing in CAA79481. Ref.1
Sequence conflict538 – 5403YPN → SPT in CAA79481. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 3CEB22BA46116AD1

FASTA62069,830
        10         20         30         40         50         60 
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF VLSVAGGFVG 

        70         80         90        100        110        120 
LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII IGQYTSEGGI TCWEKICPLF 

       130        140        150        160        170        180 
SGIGYASVVI VSLLNVYYIV ILAWATYYLF QSFQKELPWA HCNHSWNTPH CMEDTMRKNK 

       190        200        210        220        230        240 
SVWITISSTN FTSPVIEFWE RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR 

       250        260        270        280        290        300 
STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 

       310        320        330        340        350        360 
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 

       370        380        390        400        410        420 
DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 

       430        440        450        460        470        480 
FLRKGYRREI FIAFVCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 

       490        500        510        520        530        540 
WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN 

       550        560        570        580        590        600 
WAIGLGWSLA LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS 

       610        620 
RTVMNGALVK PTHIIVETMM 

« Hide

Isoform 2 [UniParc].

Checksum: 9A57ABC8FADE6216
Show »

FASTA20022,744

References

« Hide 'large scale' references
[1]"Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells."
Jhiang S.M., Fithian L., Smanik P., McGill J., Tong Q., Mazzaferri E.L.
FEBS Lett. 318:139-144(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Thyroid.
[2]"Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta."
Ramamoorthy S., Leibach F.H., Mahesh V.B., Han H., Yang-Feng T., Blakely R.D., Ganapathy V.
Biochem. J. 300:893-900(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium."
Miyamoto Y., Liou G.I., Sprinkle T.J.
Curr. Eye Res. 15:345-349(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retinal pigment epithelium.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Blood, Brain and Ovary.
[7]"Taurine transporter expression in various organs."
Kim H.W., An H.S., Park T.S., Park K.K.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-324.
[8]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18956 mRNA. Translation: CAA79481.1.
U16120 mRNA. Translation: AAA50842.1.
U09220 mRNA. Translation: AAC50443.1.
AC090941 Genomic DNA. No translation available.
AC090952 Genomic DNA. No translation available.
AC093496 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64192.1.
BC006252 mRNA. Translation: AAH06252.1.
BC111489 mRNA. Translation: AAI11490.1.
BC137128 mRNA. Translation: AAI37129.1.
BC137129 mRNA. Translation: AAI37130.1.
AF346763 mRNA. Translation: AAK30132.1.
CCDSCCDS33705.1. [P31641-1]
CCDS46765.1. [P31641-2]
PIRG01426.
S29839.
S46487.
RefSeqNP_001127839.2. NM_001134367.3. [P31641-1]
NP_001127840.1. NM_001134368.3. [P31641-2]
NP_003034.2. NM_003043.5. [P31641-1]
UniGeneHs.529488.

3D structure databases

ProteinModelPortalP31641.
SMRP31641. Positions 40-582.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112424. 1 interaction.
STRING9606.ENSP00000354107.

Chemistry

BindingDBP31641.
ChEMBLCHEMBL5762.

Protein family/group databases

TCDB2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteP31641.

Polymorphism databases

DMDM1352535.

Proteomic databases

MaxQBP31641.
PaxDbP31641.
PRIDEP31641.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360861; ENSP00000354107; ENSG00000131389. [P31641-1]
ENST00000416216; ENSP00000401167; ENSG00000131389. [P31641-2]
ENST00000454876; ENSP00000398063; ENSG00000131389. [P31641-1]
GeneID6533.
KEGGhsa:6533.
UCSCuc003byp.4. human.
uc003byq.4. human. [P31641-1]

Organism-specific databases

CTD6533.
GeneCardsGC03P014444.
HGNCHGNC:11052. SLC6A6.
HPAHPA015028.
HPA016488.
MIM186854. gene.
neXtProtNX_P31641.
PharmGKBPA35912.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidP31641.
KOK05039.
OMAIEFWERN.
OrthoDBEOG793B71.
PhylomeDBP31641.
TreeFamTF343812.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.
REACT_20679. Amine compound SLC transporters.

Gene expression databases

ArrayExpressP31641.
BgeeP31641.
CleanExHS_SLC6A6.
GenevestigatorP31641.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC6A6.
GenomeRNAi6533.
NextBio25419.
PROP31641.
SOURCESearch...

Entry information

Entry nameSC6A6_HUMAN
AccessionPrimary (citable) accession number: P31641
Secondary accession number(s): B2RNU7, Q9BRI2, Q9BXB0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM