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P31641

- SC6A6_HUMAN

UniProt

P31641 - SC6A6_HUMAN

Protein

Sodium- and chloride-dependent taurine transporter

Gene

SLC6A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.1 Publication

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro
    2. taurine:sodium symporter activity Source: ProtInc
    3. taurine binding Source: Ensembl

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. cellular amino acid metabolic process Source: ProtInc
    3. ion transport Source: Reactome
    4. taurine transport Source: Ensembl
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Protein family/group databases

    TCDBi2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent taurine transporter
    Alternative name(s):
    Solute carrier family 6 member 6
    Gene namesi
    Name:SLC6A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11052. SLC6A6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. integral component of plasma membrane Source: InterPro
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35912.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 620620Sodium- and chloride-dependent taurine transporterPRO_0000214767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)1 Publication
    Modified residuei322 – 3221PhosphoserineBy similarity

    Post-translational modificationi

    Down-regulated upon Ser-322 phosphorylation.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP31641.
    PaxDbiP31641.
    PRIDEiP31641.

    PTM databases

    PhosphoSiteiP31641.

    Expressioni

    Tissue specificityi

    Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.1 Publication

    Gene expression databases

    ArrayExpressiP31641.
    BgeeiP31641.
    CleanExiHS_SLC6A6.
    GenevestigatoriP31641.

    Organism-specific databases

    HPAiHPA015028.
    HPA016488.

    Interactioni

    Protein-protein interaction databases

    BioGridi112424. 1 interaction.
    STRINGi9606.ENSP00000354107.

    Structurei

    3D structure databases

    ProteinModelPortaliP31641.
    SMRiP31641. Positions 40-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini143 – 21775ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini564 – 62057CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9720Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26218Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31518Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei327 – 34822Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei381 – 40020Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei430 – 44819Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei506 – 52520Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei545 – 56319Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiP31641.
    KOiK05039.
    OMAiIEFWERN.
    OrthoDBiEOG793B71.
    PhylomeDBiP31641.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P31641-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF    50
    VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII 100
    IGQYTSEGGI TCWEKICPLF SGIGYASVVI VSLLNVYYIV ILAWATYYLF 150
    QSFQKELPWA HCNHSWNTPH CMEDTMRKNK SVWITISSTN FTSPVIEFWE 200
    RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA 250
    TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF 300
    SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF 350
    MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL 400
    DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAFVCSISY LLGLTMVTEG 450
    GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP 500
    GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN WAIGLGWSLA 550
    LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS 600
    RTVMNGALVK PTHIIVETMM 620
    Length:620
    Mass (Da):69,830
    Last modified:February 1, 1996 - v2
    Checksum:i3CEB22BA46116AD1
    GO
    Isoform 2 (identifier: P31641-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-620: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:200
    Mass (Da):22,744
    Checksum:i9A57ABC8FADE6216
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281T → K in AAA50842. (PubMed:8010975)Curated
    Sequence conflicti272 – 2721A → R in CAA79481. (PubMed:8382624)Curated
    Sequence conflicti509 – 5091Missing in CAA79481. (PubMed:8382624)Curated
    Sequence conflicti538 – 5403YPN → SPT in CAA79481. (PubMed:8382624)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171I → M.
    Corresponds to variant rs1042350 [ dbSNP | Ensembl ].
    VAR_011767
    Natural varianti18 – 181L → V.
    Corresponds to variant rs1042351 [ dbSNP | Ensembl ].
    VAR_011768
    Natural varianti236 – 2361W → C.
    Corresponds to variant rs1042352 [ dbSNP | Ensembl ].
    VAR_011769

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei201 – 620420Missing in isoform 2. 1 PublicationVSP_044961Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18956 mRNA. Translation: CAA79481.1.
    U16120 mRNA. Translation: AAA50842.1.
    U09220 mRNA. Translation: AAC50443.1.
    AC090941 Genomic DNA. No translation available.
    AC090952 Genomic DNA. No translation available.
    AC093496 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64192.1.
    BC006252 mRNA. Translation: AAH06252.1.
    BC111489 mRNA. Translation: AAI11490.1.
    BC137128 mRNA. Translation: AAI37129.1.
    BC137129 mRNA. Translation: AAI37130.1.
    AF346763 mRNA. Translation: AAK30132.1.
    CCDSiCCDS33705.1. [P31641-1]
    CCDS46765.1. [P31641-2]
    PIRiG01426.
    S29839.
    S46487.
    RefSeqiNP_001127839.2. NM_001134367.3.
    NP_001127840.1. NM_001134368.3. [P31641-2]
    NP_003034.2. NM_003043.5. [P31641-1]
    UniGeneiHs.529488.

    Genome annotation databases

    EnsembliENST00000360861; ENSP00000354107; ENSG00000131389. [P31641-1]
    ENST00000416216; ENSP00000401167; ENSG00000131389. [P31641-2]
    ENST00000454876; ENSP00000398063; ENSG00000131389. [P31641-1]
    GeneIDi6533.
    KEGGihsa:6533.
    UCSCiuc003byp.4. human.
    uc003byq.4. human. [P31641-1]

    Polymorphism databases

    DMDMi1352535.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18956 mRNA. Translation: CAA79481.1 .
    U16120 mRNA. Translation: AAA50842.1 .
    U09220 mRNA. Translation: AAC50443.1 .
    AC090941 Genomic DNA. No translation available.
    AC090952 Genomic DNA. No translation available.
    AC093496 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64192.1 .
    BC006252 mRNA. Translation: AAH06252.1 .
    BC111489 mRNA. Translation: AAI11490.1 .
    BC137128 mRNA. Translation: AAI37129.1 .
    BC137129 mRNA. Translation: AAI37130.1 .
    AF346763 mRNA. Translation: AAK30132.1 .
    CCDSi CCDS33705.1. [P31641-1 ]
    CCDS46765.1. [P31641-2 ]
    PIRi G01426.
    S29839.
    S46487.
    RefSeqi NP_001127839.2. NM_001134367.3.
    NP_001127840.1. NM_001134368.3. [P31641-2 ]
    NP_003034.2. NM_003043.5. [P31641-1 ]
    UniGenei Hs.529488.

    3D structure databases

    ProteinModelPortali P31641.
    SMRi P31641. Positions 40-582.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112424. 1 interaction.
    STRINGi 9606.ENSP00000354107.

    Chemistry

    BindingDBi P31641.
    ChEMBLi CHEMBL5762.

    Protein family/group databases

    TCDBi 2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei P31641.

    Polymorphism databases

    DMDMi 1352535.

    Proteomic databases

    MaxQBi P31641.
    PaxDbi P31641.
    PRIDEi P31641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360861 ; ENSP00000354107 ; ENSG00000131389 . [P31641-1 ]
    ENST00000416216 ; ENSP00000401167 ; ENSG00000131389 . [P31641-2 ]
    ENST00000454876 ; ENSP00000398063 ; ENSG00000131389 . [P31641-1 ]
    GeneIDi 6533.
    KEGGi hsa:6533.
    UCSCi uc003byp.4. human.
    uc003byq.4. human. [P31641-1 ]

    Organism-specific databases

    CTDi 6533.
    GeneCardsi GC03P014444.
    HGNCi HGNC:11052. SLC6A6.
    HPAi HPA015028.
    HPA016488.
    MIMi 186854. gene.
    neXtProti NX_P31641.
    PharmGKBi PA35912.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi P31641.
    KOi K05039.
    OMAi IEFWERN.
    OrthoDBi EOG793B71.
    PhylomeDBi P31641.
    TreeFami TF343812.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.
    REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    GeneWikii SLC6A6.
    GenomeRNAii 6533.
    NextBioi 25419.
    PROi P31641.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31641.
    Bgeei P31641.
    CleanExi HS_SLC6A6.
    Genevestigatori P31641.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells."
      Jhiang S.M., Fithian L., Smanik P., McGill J., Tong Q., Mazzaferri E.L.
      FEBS Lett. 318:139-144(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Thyroid.
    2. "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta."
      Ramamoorthy S., Leibach F.H., Mahesh V.B., Han H., Yang-Feng T., Blakely R.D., Ganapathy V.
      Biochem. J. 300:893-900(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium."
      Miyamoto Y., Liou G.I., Sprinkle T.J.
      Curr. Eye Res. 15:345-349(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retinal pigment epithelium.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Blood, Brain and Ovary.
    7. "Taurine transporter expression in various organs."
      Kim H.W., An H.S., Park T.S., Park K.K.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-324.
    8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiSC6A6_HUMAN
    AccessioniPrimary (citable) accession number: P31641
    Secondary accession number(s): B2RNU7, Q9BRI2, Q9BXB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3