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Protein

Sodium- and chloride-dependent taurine transporter

Gene

SLC6A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.1 Publication

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. taurine:sodium symporter activity Source: ProtInc
  3. taurine binding Source: Ensembl

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. cellular amino acid metabolic process Source: ProtInc
  3. ion transport Source: Reactome
  4. organic acid transmembrane transport Source: GOC
  5. taurine transport Source: Ensembl
  6. transmembrane transport Source: Reactome
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:SLC6A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11052. SLC6A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei78 – 9720Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini143 – 21775ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23619Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei245 – 26218Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei298 – 31518Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei327 – 34822Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei381 – 40020Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei430 – 44819Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei506 – 52520Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei545 – 56319Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini564 – 62057CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. integral component of plasma membrane Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Sodium- and chloride-dependent taurine transporterPRO_0000214767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)1 Publication
Modified residuei322 – 3221PhosphoserineBy similarity

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31641.
PaxDbiP31641.
PRIDEiP31641.

PTM databases

PhosphoSiteiP31641.

Expressioni

Tissue specificityi

Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.1 Publication

Gene expression databases

BgeeiP31641.
CleanExiHS_SLC6A6.
ExpressionAtlasiP31641. baseline and differential.
GenevestigatoriP31641.

Organism-specific databases

HPAiHPA015028.
HPA016488.

Interactioni

Protein-protein interaction databases

BioGridi112424. 2 interactions.
STRINGi9606.ENSP00000354107.

Structurei

3D structure databases

ProteinModelPortaliP31641.
SMRiP31641. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31641.
KOiK05039.
OMAiIEFWERN.
OrthoDBiEOG793B71.
PhylomeDBiP31641.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31641-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEAEGKPPQ REKWSSKIDF
60 70 80 90 100
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEII
110 120 130 140 150
IGQYTSEGGI TCWEKICPLF SGIGYASVVI VSLLNVYYIV ILAWATYYLF
160 170 180 190 200
QSFQKELPWA HCNHSWNTPH CMEDTMRKNK SVWITISSTN FTSPVIEFWE
210 220 230 240 250
RNVLSLSPGI DHPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
260 270 280 290 300
TFPFAMLLVL LVRGLTLPGA GAGIKFYLYP DITRLEDPQV WIDAGTQIFF
310 320 330 340 350
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
360 370 380 390 400
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
410 420 430 440 450
DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAFVCSISY LLGLTMVTEG
460 470 480 490 500
GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
510 520 530 540 550
GPWMKYSWAV ITPVLCVGCF IFSLVKYVPL TYNKTYVYPN WAIGLGWSLA
560 570 580 590 600
LSSMLCVPLV IVIRLCQTEG PFLVRVKYLL TPREPNRWAV EREGATPYNS
610 620
RTVMNGALVK PTHIIVETMM
Length:620
Mass (Da):69,830
Last modified:February 1, 1996 - v2
Checksum:i3CEB22BA46116AD1
GO
Isoform 2 (identifier: P31641-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-620: Missing.

Note: No experimental confirmation available.

Show »
Length:200
Mass (Da):22,744
Checksum:i9A57ABC8FADE6216
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281T → K in AAA50842 (PubMed:8010975).Curated
Sequence conflicti272 – 2721A → R in CAA79481 (PubMed:8382624).Curated
Sequence conflicti509 – 5091Missing in CAA79481 (PubMed:8382624).Curated
Sequence conflicti538 – 5403YPN → SPT in CAA79481 (PubMed:8382624).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171I → M.
Corresponds to variant rs1042350 [ dbSNP | Ensembl ].
VAR_011767
Natural varianti18 – 181L → V.
Corresponds to variant rs1042351 [ dbSNP | Ensembl ].
VAR_011768
Natural varianti236 – 2361W → C.
Corresponds to variant rs1042352 [ dbSNP | Ensembl ].
VAR_011769

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 620420Missing in isoform 2. 1 PublicationVSP_044961Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18956 mRNA. Translation: CAA79481.1.
U16120 mRNA. Translation: AAA50842.1.
U09220 mRNA. Translation: AAC50443.1.
AC090941 Genomic DNA. No translation available.
AC090952 Genomic DNA. No translation available.
AC093496 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64192.1.
BC006252 mRNA. Translation: AAH06252.1.
BC111489 mRNA. Translation: AAI11490.1.
BC137128 mRNA. Translation: AAI37129.1.
BC137129 mRNA. Translation: AAI37130.1.
AF346763 mRNA. Translation: AAK30132.1.
CCDSiCCDS33705.1. [P31641-1]
CCDS46765.1. [P31641-2]
PIRiG01426.
S29839.
S46487.
RefSeqiNP_001127839.2. NM_001134367.3.
NP_001127840.1. NM_001134368.3. [P31641-2]
NP_003034.2. NM_003043.5. [P31641-1]
UniGeneiHs.529488.

Genome annotation databases

EnsembliENST00000621751; ENSP00000482560; ENSG00000131389. [P31641-2]
ENST00000622186; ENSP00000480890; ENSG00000131389. [P31641-1]
GeneIDi6533.
KEGGihsa:6533.
UCSCiuc003byp.4. human.
uc003byq.4. human. [P31641-1]

Polymorphism databases

DMDMi1352535.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18956 mRNA. Translation: CAA79481.1.
U16120 mRNA. Translation: AAA50842.1.
U09220 mRNA. Translation: AAC50443.1.
AC090941 Genomic DNA. No translation available.
AC090952 Genomic DNA. No translation available.
AC093496 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64192.1.
BC006252 mRNA. Translation: AAH06252.1.
BC111489 mRNA. Translation: AAI11490.1.
BC137128 mRNA. Translation: AAI37129.1.
BC137129 mRNA. Translation: AAI37130.1.
AF346763 mRNA. Translation: AAK30132.1.
CCDSiCCDS33705.1. [P31641-1]
CCDS46765.1. [P31641-2]
PIRiG01426.
S29839.
S46487.
RefSeqiNP_001127839.2. NM_001134367.3.
NP_001127840.1. NM_001134368.3. [P31641-2]
NP_003034.2. NM_003043.5. [P31641-1]
UniGeneiHs.529488.

3D structure databases

ProteinModelPortaliP31641.
SMRiP31641. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112424. 2 interactions.
STRINGi9606.ENSP00000354107.

Chemistry

BindingDBiP31641.
ChEMBLiCHEMBL5762.

Protein family/group databases

TCDBi2.A.22.3.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteiP31641.

Polymorphism databases

DMDMi1352535.

Proteomic databases

MaxQBiP31641.
PaxDbiP31641.
PRIDEiP31641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621751; ENSP00000482560; ENSG00000131389. [P31641-2]
ENST00000622186; ENSP00000480890; ENSG00000131389. [P31641-1]
GeneIDi6533.
KEGGihsa:6533.
UCSCiuc003byp.4. human.
uc003byq.4. human. [P31641-1]

Organism-specific databases

CTDi6533.
GeneCardsiGC03P014444.
HGNCiHGNC:11052. SLC6A6.
HPAiHPA015028.
HPA016488.
MIMi186854. gene.
neXtProtiNX_P31641.
PharmGKBiPA35912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP31641.
KOiK05039.
OMAiIEFWERN.
OrthoDBiEOG793B71.
PhylomeDBiP31641.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.
REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSLC6A6. human.
GeneWikiiSLC6A6.
GenomeRNAii6533.
NextBioi25419.
PROiP31641.
SOURCEiSearch...

Gene expression databases

BgeeiP31641.
CleanExiHS_SLC6A6.
ExpressionAtlasiP31641. baseline and differential.
GenevestigatoriP31641.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells."
    Jhiang S.M., Fithian L., Smanik P., McGill J., Tong Q., Mazzaferri E.L.
    FEBS Lett. 318:139-144(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Thyroid.
  2. "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta."
    Ramamoorthy S., Leibach F.H., Mahesh V.B., Han H., Yang-Feng T., Blakely R.D., Ganapathy V.
    Biochem. J. 300:893-900(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium."
    Miyamoto Y., Liou G.I., Sprinkle T.J.
    Curr. Eye Res. 15:345-349(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retinal pigment epithelium.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Blood, Brain and Ovary.
  7. "Taurine transporter expression in various organs."
    Kim H.W., An H.S., Park T.S., Park K.K.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-324.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSC6A6_HUMAN
AccessioniPrimary (citable) accession number: P31641
Secondary accession number(s): B2RNU7, Q9BRI2, Q9BXB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.