Sodium/glucose cotransporter 2 - Homo sapiens (Human)

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P31639 (SC5A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium/glucose cotransporter 2
Short name=Na(+)/glucose cotransporter 2

Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2

Gene names

Name:	SLC5A2
Synonyms:	SGLT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sodium-dependent glucose transporter. Has a Na⁺ to glucose coupling ratio of 1:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na⁺/glucose cotransporter arranged in series along kidney proximal tubules.
Subcellular location	Membrane; Multi-pass membrane protein.
Involvement in disease	Renal glucosuria (GLYS1) [MIM:233100]: Autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2
Sequence similarities	Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Sugar transport Symport Transport
Cellular component	Membrane
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement PubMed 8244402. Source: ProtInc
Cellular_component	integral to membrane Traceable author statement PubMed 8244402. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	low-affinity glucose:sodium symporter activity Traceable author statement PubMed 8244402. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 672

672

Sodium/glucose cotransporter 2

PRO_0000105372

Regions

Topological domain

1 – 25

Cytoplasmic Potential

Transmembrane

26 – 44

Helical; Potential

Topological domain

45 – 61

Extracellular Potential

Transmembrane

62 – 82

Helical; Potential

Topological domain

83 – 102

Cytoplasmic Potential

Transmembrane

103 – 123

Helical; Potential

Topological domain

124 – 168

Extracellular Potential

Transmembrane

169 – 188

Helical; Potential

Topological domain

189 – 205

Cytoplasmic Potential

Transmembrane

206 – 226

Helical; Potential

Topological domain

227 – 270

Extracellular Potential

Transmembrane

271 – 291

Helical; Potential

Topological domain

292 – 314

Cytoplasmic Potential

Transmembrane

315 – 334

Helical; Potential

Topological domain

335 – 423

Extracellular Potential

Transmembrane

424 – 443

Helical; Potential

Topological domain

444 – 455

Cytoplasmic Potential

Transmembrane

456 – 476

Helical; Potential

Topological domain

477 – 526

Extracellular Potential

Transmembrane

527 – 547

Helical; Potential

Topological domain

548 – 650

103

Cytoplasmic Potential

Transmembrane

651 – 671

Helical; Potential

Sites

Site

Implicated in sodium coupling By similarity

Site

300

Implicated in sodium coupling By similarity

Amino acid modifications

Glycosylation

250

N-linked (GlcNAc...) Potential

Glycosylation

399

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

654

N → S in GLYS1. Ref.2

VAR_019310

Sequences

Sequence

Length

Mass (Da)

Tools

P31639 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 233C65F1601B0337
Show »

FASTA

672

72,897

        10         20         30         40         50         60 
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR 

        70         80         90        100        110        120 
SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA 

       130        140        150        160        170        180 
GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA 

       190        200        210        220        230        240 
LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL 

       250        260        270        280        290        300 
TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR 

       310        320        330        340        350        360 
CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG 

       370        380        390        400        410        420 
CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR 

       430        440        450        460        470        480 
ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV 

       490        500        510        520        530        540 
NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL 

       550        560        570        580        590        600 
TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ 

       610        620        630        640        650        660 
APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM 

       670 
MAVAVFLWGF YA

« Hide

References

[1]	"Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter." Wells R.G., Pajor A.M., Kanai Y., Turk E., Wright E.M., Hediger M.A. Am. J. Physiol. 263:F459-F465(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria." Calado J., Soto K., Clemente C., Correia P., Rueff J. Hum. Genet. 114:314-316(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLYS1 SER-654.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95549 mRNA. Translation: AAA36608.1.
IPI	IPI00012449.
PIR	A56765.
RefSeq	NP_003032.1. NM_003041.3.
UniGene	Hs.709195.
3D structure databases
ProteinModelPortal	P31639.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000327943.
PTM databases
PhosphoSite	P31639.
Polymorphism databases
DMDM	400337.
Proteomic databases
PaxDb	P31639.
PRIDE	P31639.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330498; ENSP00000327943; ENSG00000140675.
GeneID	6524.
KEGG	hsa:6524.
UCSC	uc002ecf.4. human.
Organism-specific databases
CTD	6524.
GeneCards	GC16P031494.
HGNC	HGNC:11037. SLC5A2.
HPA	HPA041603.
MIM	182381. gene. 233100. phenotype.
neXtProt	NX_P31639.
Orphanet	69076. Renal glucosuria.
PharmGKB	PA35902.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4146.
HOGENOM	HOG000025422.
HOVERGEN	HBG052859.
InParanoid	P31639.
KO	K14382.
OMA	TTWVVIS.
OrthoDB	EOG4C2H9F.
PhylomeDB	P31639.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P31639.
Bgee	P31639.
CleanEx	HS_SLC5A2.
Genevestigator	P31639.
GermOnline	ENSG00000140675. Homo sapiens.
Family and domain databases
InterPro	IPR001734. Na/solute_symporter. IPR018212. Na/solute_symporter_CS. IPR019900. Na/solute_symporter_subgr. [Graphical view]
PANTHER	PTHR11819. PTHR11819. 1 hit.
Pfam	PF00474. SSF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00813. sss. 1 hit.
PROSITE	PS00456. NA_SOLUT_SYMP_1. 1 hit. PS00457. NA_SOLUT_SYMP_2. 1 hit. PS50283. NA_SOLUT_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P31639.
ChEMBL	CHEMBL3884.
GenomeRNAi	6524.
NextBio	25379.
SOURCE	Search...

Entry information

Entry name

SC5A2_HUMAN

Accession

Primary (citable) accession number: P31639

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents