SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P31639

- SC5A2_HUMAN

UniProt

P31639 - SC5A2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium/glucose cotransporter 2

Gene
SLC5A2, SGLT2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei40 – 401Implicated in sodium coupling By similarity
Sitei300 – 3001Implicated in sodium coupling By similarity

GO - Molecular functioni

  1. low-affinity glucose:sodium symporter activity Source: ProtInc

GO - Biological processi

  1. carbohydrate metabolic process Source: ProtInc
  2. glucose transport Source: GOC
  3. transmembrane transport Source: Reactome
  4. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19165. Na+-dependent glucose transporters.
REACT_19188. Inositol transporters.
REACT_9441. Hexose transport.

Protein family/group databases

TCDBi2.A.21.3.16. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:SLC5A2
Synonyms:SGLT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11037. SLC5A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei26 – 4419Helical; Reviewed predictionAdd
BLAST
Topological domaini45 – 6117Extracellular Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Reviewed predictionAdd
BLAST
Topological domaini83 – 10220Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Topological domaini124 – 16845Extracellular Reviewed predictionAdd
BLAST
Transmembranei169 – 18820Helical; Reviewed predictionAdd
BLAST
Topological domaini189 – 20517Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Reviewed predictionAdd
BLAST
Topological domaini227 – 27044Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Reviewed predictionAdd
BLAST
Topological domaini292 – 31423Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei315 – 33420Helical; Reviewed predictionAdd
BLAST
Topological domaini335 – 42389Extracellular Reviewed predictionAdd
BLAST
Transmembranei424 – 44320Helical; Reviewed predictionAdd
BLAST
Topological domaini444 – 45512Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei456 – 47621Helical; Reviewed predictionAdd
BLAST
Topological domaini477 – 52650Extracellular Reviewed predictionAdd
BLAST
Transmembranei527 – 54721Helical; Reviewed predictionAdd
BLAST
Topological domaini548 – 650103Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei651 – 67121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Renal glucosuria (GLYS1) [MIM:233100]: Autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti654 – 6541N → S in GLYS1. 1 Publication
Corresponds to variant rs61742739 [ dbSNP | Ensembl ].
VAR_019310

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi233100. phenotype.
Orphaneti69076. Renal glucosuria.
PharmGKBiPA35902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Sodium/glucose cotransporter 2PRO_0000105372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi399 – 3991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP31639.
PRIDEiP31639.

PTM databases

PhosphoSiteiP31639.

Expressioni

Gene expression databases

ArrayExpressiP31639.
BgeeiP31639.
CleanExiHS_SLC5A2.
GenevestigatoriP31639.

Organism-specific databases

HPAiHPA041603.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327943.

Structurei

3D structure databases

ProteinModelPortaliP31639.
SMRiP31639. Positions 25-497.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4146.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP31639.
KOiK14382.
OMAiFFWGFYA.
OrthoDBiEOG77126J.
PhylomeDBiP31639.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31639-1 [UniParc]FASTAAdd to Basket

« Hide

MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG    50
TVGGYFLAGR SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW 100
NALFVVLLLG WLFAPVYLTA GVITMPQYLR KRFGGRRIRL YLSVLSLFLY 150
IFTKISVDMF SGAVFIQQAL GWNIYASVIA LLGITMIYTV TGGLAALMYT 200
DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL TVSEDPAVGN 250
ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR 300
CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV 350
CRRVCGTEVG CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS 400
SSTLFTMDIY TRLRPRAGDR ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG 450
QLFDYIQAVS SYLAPPVSAV FVLALFVPRV NEQGAFWGLI GGLLMGLARL 500
IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL TLTVSLCTAP 550
IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ 600
APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA 650
RVVNLNALLM MAVAVFLWGF YA 672
Length:672
Mass (Da):72,897
Last modified:July 1, 1993 - v1
Checksum:i233C65F1601B0337
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti654 – 6541N → S in GLYS1. 1 Publication
Corresponds to variant rs61742739 [ dbSNP | Ensembl ].
VAR_019310

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95549 mRNA. Translation: AAA36608.1.
CCDSiCCDS10714.1.
PIRiA56765.
RefSeqiNP_003032.1. NM_003041.3.
UniGeneiHs.709195.

Genome annotation databases

EnsembliENST00000330498; ENSP00000327943; ENSG00000140675.
GeneIDi6524.
KEGGihsa:6524.
UCSCiuc002ecf.4. human.

Polymorphism databases

DMDMi400337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95549 mRNA. Translation: AAA36608.1 .
CCDSi CCDS10714.1.
PIRi A56765.
RefSeqi NP_003032.1. NM_003041.3.
UniGenei Hs.709195.

3D structure databases

ProteinModelPortali P31639.
SMRi P31639. Positions 25-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000327943.

Chemistry

BindingDBi P31639.
ChEMBLi CHEMBL3884.
GuidetoPHARMACOLOGYi 916.

Protein family/group databases

TCDBi 2.A.21.3.16. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSitei P31639.

Polymorphism databases

DMDMi 400337.

Proteomic databases

PaxDbi P31639.
PRIDEi P31639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330498 ; ENSP00000327943 ; ENSG00000140675 .
GeneIDi 6524.
KEGGi hsa:6524.
UCSCi uc002ecf.4. human.

Organism-specific databases

CTDi 6524.
GeneCardsi GC16P031494.
HGNCi HGNC:11037. SLC5A2.
HPAi HPA041603.
MIMi 182381. gene.
233100. phenotype.
neXtProti NX_P31639.
Orphaneti 69076. Renal glucosuria.
PharmGKBi PA35902.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4146.
HOGENOMi HOG000025422.
HOVERGENi HBG052859.
InParanoidi P31639.
KOi K14382.
OMAi FFWGFYA.
OrthoDBi EOG77126J.
PhylomeDBi P31639.
TreeFami TF352855.

Enzyme and pathway databases

Reactomei REACT_19165. Na+-dependent glucose transporters.
REACT_19188. Inositol transporters.
REACT_9441. Hexose transport.

Miscellaneous databases

GeneWikii SLC5A2.
GenomeRNAii 6524.
NextBioi 25379.
PROi P31639.
SOURCEi Search...

Gene expression databases

ArrayExpressi P31639.
Bgeei P31639.
CleanExi HS_SLC5A2.
Genevestigatori P31639.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter."
    Wells R.G., Pajor A.M., Kanai Y., Turk E., Wright E.M., Hediger M.A.
    Am. J. Physiol. 263:F459-F465(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria."
    Calado J., Soto K., Clemente C., Correia P., Rueff J.
    Hum. Genet. 114:314-316(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLYS1 SER-654.

Entry informationi

Entry nameiSC5A2_HUMAN
AccessioniPrimary (citable) accession number: P31639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi