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P31639 (SC5A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/glucose cotransporter 2

Short name=Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene names
Name:SLC5A2
Synonyms:SGLT2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length672 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Subcellular location

Membrane; Multi-pass membrane protein.

Involvement in disease

Renal glucosuria (GLYS1) [MIM:233100]: Autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 672672Sodium/glucose cotransporter 2
PRO_0000105372

Regions

Topological domain1 – 2525Cytoplasmic Potential
Transmembrane26 – 4419Helical; Potential
Topological domain45 – 6117Extracellular Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 10220Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 16845Extracellular Potential
Transmembrane169 – 18820Helical; Potential
Topological domain189 – 20517Cytoplasmic Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 27044Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 31423Cytoplasmic Potential
Transmembrane315 – 33420Helical; Potential
Topological domain335 – 42389Extracellular Potential
Transmembrane424 – 44320Helical; Potential
Topological domain444 – 45512Cytoplasmic Potential
Transmembrane456 – 47621Helical; Potential
Topological domain477 – 52650Extracellular Potential
Transmembrane527 – 54721Helical; Potential
Topological domain548 – 650103Cytoplasmic Potential
Transmembrane651 – 67121Helical; Potential

Sites

Site401Implicated in sodium coupling By similarity
Site3001Implicated in sodium coupling By similarity

Amino acid modifications

Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3991N-linked (GlcNAc...) Potential

Natural variations

Natural variant6541N → S in GLYS1. Ref.2
Corresponds to variant rs61742739 [ dbSNP | Ensembl ].
VAR_019310

Sequences

Sequence LengthMass (Da)Tools
P31639 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 233C65F1601B0337

FASTA67272,897
        10         20         30         40         50         60 
MEEHTEAGSA PEMGAQKALI DNPADILVIA AYFLLVIGVG LWSMCRTNRG TVGGYFLAGR 

        70         80         90        100        110        120 
SMVWWPVGAS LFASNIGSGH FVGLAGTGAA SGLAVAGFEW NALFVVLLLG WLFAPVYLTA 

       130        140        150        160        170        180 
GVITMPQYLR KRFGGRRIRL YLSVLSLFLY IFTKISVDMF SGAVFIQQAL GWNIYASVIA 

       190        200        210        220        230        240 
LLGITMIYTV TGGLAALMYT DTVQTFVILG GACILMGYAF HEVGGYSGLF DKYLGAATSL 

       250        260        270        280        290        300 
TVSEDPAVGN ISSFCYRPRP DSYHLLRHPV TGDLPWPALL LGLTIVSGWY WCSDQVIVQR 

       310        320        330        340        350        360 
CLAGKSLTHI KAGCILCGYL KLTPMFLMVM PGMISRILYP DEVACVVPEV CRRVCGTEVG 

       370        380        390        400        410        420 
CSNIAYPRLV VKLMPNGLRG LMLAVMLAAL MSSLASIFNS SSTLFTMDIY TRLRPRAGDR 

       430        440        450        460        470        480 
ELLLVGRLWV VFIVVVSVAW LPVVQAAQGG QLFDYIQAVS SYLAPPVSAV FVLALFVPRV 

       490        500        510        520        530        540 
NEQGAFWGLI GGLLMGLARL IPEFSFGSGS CVQPSACPAF LCGVHYLYFA IVLFFCSGLL 

       550        560        570        580        590        600 
TLTVSLCTAP IPRKHLHRLV FSLRHSKEER EDLDADEQQG SSLPVQNGCP ESAMEMNEPQ 

       610        620        630        640        650        660 
APAPSLFRQC LLWFCGMSRG GVGSPPPLTQ EEAAAAARRL EDISEDPSWA RVVNLNALLM 

       670 
MAVAVFLWGF YA 

« Hide

References

[1]"Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter."
Wells R.G., Pajor A.M., Kanai Y., Turk E., Wright E.M., Hediger M.A.
Am. J. Physiol. 263:F459-F465(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria."
Calado J., Soto K., Clemente C., Correia P., Rueff J.
Hum. Genet. 114:314-316(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT GLYS1 SER-654.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95549 mRNA. Translation: AAA36608.1.
CCDSCCDS10714.1.
PIRA56765.
RefSeqNP_003032.1. NM_003041.3.
UniGeneHs.709195.

3D structure databases

ProteinModelPortalP31639.
SMRP31639. Positions 25-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000327943.

Chemistry

BindingDBP31639.
ChEMBLCHEMBL3884.
GuidetoPHARMACOLOGY916.

Protein family/group databases

TCDB2.A.21.3.16. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSiteP31639.

Polymorphism databases

DMDM400337.

Proteomic databases

PaxDbP31639.
PRIDEP31639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330498; ENSP00000327943; ENSG00000140675.
GeneID6524.
KEGGhsa:6524.
UCSCuc002ecf.4. human.

Organism-specific databases

CTD6524.
GeneCardsGC16P031494.
HGNCHGNC:11037. SLC5A2.
HPAHPA041603.
MIM182381. gene.
233100. phenotype.
neXtProtNX_P31639.
Orphanet69076. Renal glucosuria.
PharmGKBPA35902.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4146.
HOGENOMHOG000025422.
HOVERGENHBG052859.
InParanoidP31639.
KOK14382.
OMAFFWGFYA.
OrthoDBEOG77126J.
PhylomeDBP31639.
TreeFamTF352855.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP31639.
BgeeP31639.
CleanExHS_SLC5A2.
GenevestigatorP31639.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC5A2.
GenomeRNAi6524.
NextBio25379.
PROP31639.
SOURCESearch...

Entry information

Entry nameSC5A2_HUMAN
AccessionPrimary (citable) accession number: P31639
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM