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Protein

Sodium/myo-inositol cotransporter

Gene

SLC5A3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Implicated in sodium couplingBy similarity1
Sitei285Implicated in sodium couplingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-CFA-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.21.3.5. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:SLC5A3
Synonyms:SMIT
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 31

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 29HelicalSequence analysisAdd BLAST20
Topological domaini30 – 38CytoplasmicSequence analysis9
Transmembranei39 – 57HelicalSequence analysisAdd BLAST19
Topological domaini58 – 86ExtracellularSequence analysisAdd BLAST29
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Topological domaini111 – 123CytoplasmicSequence analysisAdd BLAST13
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 157ExtracellularSequence analysisAdd BLAST13
Transmembranei158 – 183HelicalSequence analysisAdd BLAST26
Topological domaini184 – 186CytoplasmicSequence analysis3
Transmembranei187 – 205HelicalSequence analysisAdd BLAST19
Topological domaini206 – 303ExtracellularSequence analysisAdd BLAST98
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 353CytoplasmicSequence analysisAdd BLAST29
Transmembranei354 – 376HelicalSequence analysisAdd BLAST23
Topological domaini377 – 406ExtracellularSequence analysisAdd BLAST30
Transmembranei407 – 430HelicalSequence analysisAdd BLAST24
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 462HelicalSequence analysisAdd BLAST19
Topological domaini463 – 510ExtracellularSequence analysisAdd BLAST48
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22
Topological domaini533 – 695CytoplasmicSequence analysisAdd BLAST163
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Topological domaini717 – 718ExtracellularSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053801 – 718Sodium/myo-inositol cotransporterAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei594PhosphoserineBy similarity1
Modified residuei632PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP31637.

Expressioni

Tissue specificityi

Brain and kidney.

Inductioni

Medium hypertonicity.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014029.

Structurei

3D structure databases

ProteinModelPortaliP31637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP31637.
KOiK14383.
OMAiVHKFDLS.
OrthoDBiEOG091G077U.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLETADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LILYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIVGALTLM
210 220 230 240 250
IISMMEIGGF EEVKRRYMLA SPNVTSILLT YNLSNTNSCN VHPKKDALKM
260 270 280 290 300
LRNPTDEDVP WPGFVLGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RILFADDIAC INPEHCMQVC GSRAGCSNIA
360 370 380 390 400
YPRLVMKLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRR
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLTLAFA YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATALFW VTGLITVIVS LLTPPPTKEQ IRTTTFWSKK
560 570 580 590 600
SLVVKESCSP KDEPYKMQEK SILRCSENSE ATNHIIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETED
660 670 680 690 700
GGRYWKFIDW FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE PPQVKLILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,546
Last modified:July 1, 1993 - v1
Checksum:i4C1B5CC4485CD268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85068 mRNA. No translation available.
PIRiA42163.
RefSeqiNP_001182069.1. NM_001195140.1.
XP_005638794.1. XM_005638737.2.
XP_005638920.1. XM_005638863.2.
XP_013965244.1. XM_014109769.1.
XP_013965245.1. XM_014109770.1.
UniGeneiCfa.33627.

Genome annotation databases

EnsembliENSCAFT00000015160; ENSCAFP00000014029; ENSCAFG00000009546.
GeneIDi100856716.
445542.
KEGGicfa:100856716.
cfa:445542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85068 mRNA. No translation available.
PIRiA42163.
RefSeqiNP_001182069.1. NM_001195140.1.
XP_005638794.1. XM_005638737.2.
XP_005638920.1. XM_005638863.2.
XP_013965244.1. XM_014109769.1.
XP_013965245.1. XM_014109770.1.
UniGeneiCfa.33627.

3D structure databases

ProteinModelPortaliP31637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014029.

Protein family/group databases

TCDBi2.A.21.3.5. the solute:sodium symporter (sss) family.

Proteomic databases

PaxDbiP31637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015160; ENSCAFP00000014029; ENSCAFG00000009546.
GeneIDi100856716.
445542.
KEGGicfa:100856716.
cfa:445542.

Organism-specific databases

CTDi6526.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP31637.
KOiK14383.
OMAiVHKFDLS.
OrthoDBiEOG091G077U.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-CFA-429593. Inositol transporters.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A3_CANLF
AccessioniPrimary (citable) accession number: P31637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.