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Protein

Sodium/myo-inositol cotransporter

Gene

SLC5A3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Implicated in sodium couplingBy similarity
Sitei285 – 2851Implicated in sodium couplingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-CFA-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.21.3.5. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:SLC5A3
Synonyms:SMIT
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 31

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence analysis
Transmembranei10 – 2920HelicalSequence analysisAdd
BLAST
Topological domaini30 – 389CytoplasmicSequence analysis
Transmembranei39 – 5719HelicalSequence analysisAdd
BLAST
Topological domaini58 – 8629ExtracellularSequence analysisAdd
BLAST
Transmembranei87 – 11024HelicalSequence analysisAdd
BLAST
Topological domaini111 – 12313CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 15713ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 18326HelicalSequence analysisAdd
BLAST
Topological domaini184 – 1863CytoplasmicSequence analysis
Transmembranei187 – 20519HelicalSequence analysisAdd
BLAST
Topological domaini206 – 30398ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 35329CytoplasmicSequence analysisAdd
BLAST
Transmembranei354 – 37623HelicalSequence analysisAdd
BLAST
Topological domaini377 – 40630ExtracellularSequence analysisAdd
BLAST
Transmembranei407 – 43024HelicalSequence analysisAdd
BLAST
Topological domaini431 – 44313CytoplasmicSequence analysisAdd
BLAST
Transmembranei444 – 46219HelicalSequence analysisAdd
BLAST
Topological domaini463 – 51048ExtracellularSequence analysisAdd
BLAST
Transmembranei511 – 53222HelicalSequence analysisAdd
BLAST
Topological domaini533 – 695163CytoplasmicSequence analysisAdd
BLAST
Transmembranei696 – 71621HelicalSequence analysisAdd
BLAST
Topological domaini717 – 7182ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Sodium/myo-inositol cotransporterPRO_0000105380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP31637.

Expressioni

Tissue specificityi

Brain and kidney.

Inductioni

Medium hypertonicity.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014029.

Structurei

3D structure databases

ProteinModelPortaliP31637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP31637.
KOiK14383.
OMAiVHKFDLS.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLETADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LILYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIVGALTLM
210 220 230 240 250
IISMMEIGGF EEVKRRYMLA SPNVTSILLT YNLSNTNSCN VHPKKDALKM
260 270 280 290 300
LRNPTDEDVP WPGFVLGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RILFADDIAC INPEHCMQVC GSRAGCSNIA
360 370 380 390 400
YPRLVMKLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRR
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLTLAFA YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATALFW VTGLITVIVS LLTPPPTKEQ IRTTTFWSKK
560 570 580 590 600
SLVVKESCSP KDEPYKMQEK SILRCSENSE ATNHIIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETED
660 670 680 690 700
GGRYWKFIDW FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE PPQVKLILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,546
Last modified:July 1, 1993 - v1
Checksum:i4C1B5CC4485CD268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85068 mRNA. No translation available.
PIRiA42163.
RefSeqiNP_001182069.1. NM_001195140.1.
XP_005638794.1. XM_005638737.2.
XP_005638920.1. XM_005638863.2.
XP_013965244.1. XM_014109769.1.
XP_013965245.1. XM_014109770.1.
UniGeneiCfa.33627.

Genome annotation databases

EnsembliENSCAFT00000015160; ENSCAFP00000014029; ENSCAFG00000009546.
GeneIDi100856716.
445542.
KEGGicfa:100856716.
cfa:445542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85068 mRNA. No translation available.
PIRiA42163.
RefSeqiNP_001182069.1. NM_001195140.1.
XP_005638794.1. XM_005638737.2.
XP_005638920.1. XM_005638863.2.
XP_013965244.1. XM_014109769.1.
XP_013965245.1. XM_014109770.1.
UniGeneiCfa.33627.

3D structure databases

ProteinModelPortaliP31637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014029.

Protein family/group databases

TCDBi2.A.21.3.5. the solute:sodium symporter (sss) family.

Proteomic databases

PaxDbiP31637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015160; ENSCAFP00000014029; ENSCAFG00000009546.
GeneIDi100856716.
445542.
KEGGicfa:100856716.
cfa:445542.

Organism-specific databases

CTDi6526.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP31637.
KOiK14383.
OMAiVHKFDLS.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-CFA-429593. Inositol transporters.

Miscellaneous databases

NextBioi20832183.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the cDNA for a Na+/myo-inositol cotransporter, a hypertonicity stress protein."
    Kwon H.M., Yamauchi A., Uchida S., Preston A.S., Garcia-Perez A., Burg M.B., Handler J.S.
    J. Biol. Chem. 267:6297-6301(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Cocker spaniel.
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A3_CANLF
AccessioniPrimary (citable) accession number: P31637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 16, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.