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P31629

- ZEP2_HUMAN

UniProt

P31629 - ZEP2_HUMAN

Protein

Transcription factor HIVEP2

Gene

HIVEP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1799 – 182123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1827 – 185125C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor HIVEP2
    Alternative name(s):
    Human immunodeficiency virus type I enhancer-binding protein 2
    Short name:
    HIV-EP2
    MHC-binding protein 2
    Short name:
    MBP-2
    Gene namesi
    Name:HIVEP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4921. HIVEP2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24462446Transcription factor HIVEP2PRO_0000047371Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki2092 – 2092Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP31629.
    PaxDbiP31629.
    PRIDEiP31629.

    PTM databases

    PhosphoSiteiP31629.

    Expressioni

    Tissue specificityi

    Expressed in brain and skeletal muscle.1 Publication

    Inductioni

    By mitogens and phorbol ester.

    Gene expression databases

    ArrayExpressiP31629.
    BgeeiP31629.
    CleanExiHS_HIVEP2.
    GenevestigatoriP31629.

    Organism-specific databases

    HPAiHPA055954.

    Interactioni

    Subunit structurei

    Interacts with TCF4.By similarity

    Protein-protein interaction databases

    BioGridi109344. 9 interactions.
    IntActiP31629. 12 interactions.
    MINTiMINT-7027293.
    STRINGi9606.ENSP00000012134.

    Structurei

    3D structure databases

    ProteinModelPortaliP31629.
    SMRiP31629. Positions 188-244, 1798-1854.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2053 – 205641
    Repeati2059 – 206242
    Repeati2071 – 207443
    Repeati2083 – 208644
    Repeati2089 – 209245
    Repeati2106 – 210946
    Repeati2112 – 211547
    Repeati2118 – 212148
    Repeati2130 – 213349
    Repeati2145 – 2148410

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2053 – 21489610 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi937 – 9437Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi950 – 98233Ser-richAdd
    BLAST
    Compositional biasi1510 – 158677Ser-richAdd
    BLAST
    Compositional biasi1899 – 192325Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi2073 – 214876Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1799 – 182123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1827 – 185125C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG296349.
    HOGENOMiHOG000155774.
    HOVERGENiHBG007119.
    InParanoidiP31629.
    KOiK09239.
    OMAiRKKCFLV.
    OrthoDBiEOG7V1FPQ.
    PhylomeDBiP31629.
    TreeFamiTF331837.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTGDTALGQ KATSRSGETD KASGRWRQEQ SAVIKMSTFG SHEGQRQPQI     50
    EPEQIGNTAS AQLFGSGKLA SPSEVVQQVA EKQYPPHRPS PYSCQHSLSF 100
    PQHSLPQGVM HSTKPHQSLE GPPWLFPGPL PSVASEDLFP FPIHGHSGGY 150
    PRKKISSLNP AYSQYSQKSI EQAEEAHKKE HKPKKPGKYI CPYCSRACAK 200
    PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA HAIKAGLVPF 250
    TESAVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKMSPGPP 300
    IPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLPNE SSQYIGPDML 350
    PNPSLNTKAD DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY 400
    FSRSESAEQQ ISPPNTNAKS YEEIIFGKYC RLSPRNALSV TTTSQERAAM 450
    GRKGIMEPLP HVNTRLDVKM FEDPVSQLIP SKGDVDPSQT SMLKSTKFNS 500
    ESRQPQIIPS SIRNEGKLYP ANFQGSNPVL LEAPVDSSPL IRSNSVPTSS 550
    ATNLTIPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS 600
    VQEGHVEVEH HGRMLKGISS SSLKEKKLSP GDRVGYDYDV CRKPYKKWED 650
    SETPKQNYRD ISCLSSLKHG GEYFMDPVVP LQGVPSMFGT TCENRKRRKE 700
    KSVGDEEDTP MICSSIVSTP VGIMASDYDP KLQMQEGVRS GFAMAGHENL 750
    SHGHTERFDP CRPQLQPGSP SLVSEESPSA IDSDKMSDLG GRKPPGNVIS 800
    VIQHTNSLSR PNSFERSESA ELVACTQDKA PSPSETCDSE ISEAPVSPEW 850
    APPGDGAESG GKPSPSQQVQ QQSYHTQPRL VRQHNIQVPE IRVTEEPDKP 900
    EKEKEAQSKE PEKPVEEFQW PQRSETLSQL PAEKLPPKKK RLRLADMEHS 950
    SGESSFESTG TGLSRSPSQE SNLSHSSSFS MSFEREETSK LSALPKQDEF 1000
    GKHSEFLTVP AGSYSLSVPG HHHQKEMRRC SSEQMPCPHP AEVPEVRSKS 1050
    FDYGNLSHAP VSGAAASTVS PSRERKKCFL VRQASFSGSP EISQGEVGMD 1100
    QSVKQEQLEH LHAGLRSGWH HGPPAVLPPL QQEDPGKQVA GPCPPLSSGP 1150
    LHLAQPQIMH MDSQESLRNP LIQPTSYMTS KHLPEQPHLF PHQETIPFSP 1200
    IQNALFQFQY PTVCMVHLPA QQPPWWQAHF PHPFAQHPQK SYGKPSFQTE 1250
    IHSSYPLEHV AEHTGKKPAE YAHTKEQTYP CYSGASGLHP KNLLPKFPSD 1300
    QSSKSTETPS EQVLQEDFAS ANAGSLQSLP GTVVPVRIQT HVPSYGSVMY 1350
    TSISQILGQN SPAIVICKVD ENMTQRTLVT NAAMQGIGFN IAQVLGQHAG 1400
    LEKYPIWKAP QTLPLGLESS IPLCLPSTSD SVATLGGSKR MLSPASSLEL 1450
    FMETKQQKRV KEEKMYGQIV EELSAVELTN SDIKKDLSRP QKPQLVRQGC 1500
    ASEPKDGLQS GSSSFSSLSP SSSQDYPSVS PSSREPFLPS KEMLSGSRAP 1550
    LPGQKSSGPS ESKESSDELD IDETASDMSM SPQSSSLPAG DGQLEEEGKG 1600
    HKRPVGMLVR MASAPSGNVA DSTLLLTDMA DFQQILQFPS LRTTTTVSWC 1650
    FLNYTKPNYV QQATFKSSVY ASWCISSCNP NPSGLNTKTT LALLRSKQKI 1700
    TAEIYTLAAM HRPGTGKLTS SSAWKQFTQM KPDASFLFGS KLERKLVGNI 1750
    LKERGKGDIH GDKDIGSKQT EPIRIKIFEG GYKSNEDYVY VRGRGRGKYI 1800
    CEECGIRCKK PSMLKKHIRT HTDVRPYVCK LCNFAFKTKG NLTKHMKSKA 1850
    HMKKCLELGV SMTSVDDTET EEAENLEDLH KAAEKHSMSS ISTDHQFSDA 1900
    EESDGEDGDD NDDDDEDEDD FDDQGDLTPK TRSRSTSPQP PRFSSLPVNV 1950
    GAVPHGVPSD SSLGHSSLIS YLVTLPSIRV TQLMTPSDSC EDTQMTEYQR 2000
    LFQSKSTDSE PDKDRLDIPS CMDEECMLPS EPSSSPRDFS PSSHHSSPGY 2050
    DSSPCRDNSP KRYLIPKGDL SPRRHLSPRR DLSPMRHLSP RKEAALRREM 2100
    SQRDVSPRRH LSPRRPVSPG KDITARRDLS PRRERRYMTT IRAPSPRRAL 2150
    YHNPPLSMGQ YLQAEPIVLG PPNLRRGLPQ VPYFSLYGDQ EGAYEHPGSS 2200
    LFPEGPNDYV FSHLPLHSQQ QVRAPIPMVP VGGIQMVHSM PPALSSLHPS 2250
    PTLPLPMEGF EEKKGASGES FSKDPYVLSK QHEKRGPHAL QSSGPPSTPS 2300
    SPRLLMKQST SEDSLNATER EQEENIQTCT KAIASLRIAT EEAALLGPDQ 2350
    PARVQEPHQN PLGSAHVSIR HFSRPEPGQP CTSATHPDLH DGEKDNFGTS 2400
    QTPLAHSTFY SKSCVDDKQL DFHSSKELSS STEESKDPSS EKSQLH 2446
    Length:2,446
    Mass (Da):269,053
    Last modified:December 6, 2005 - v2
    Checksum:i482E2C577EF9449A
    GO

    Sequence cautioni

    The sequence AAB88218.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA46596.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2091 – 20911R → T in CAA46596. (PubMed:1409593)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461R → Q.
    Corresponds to variant rs17072013 [ dbSNP | Ensembl ].
    VAR_052754
    Natural varianti1041 – 10411A → V.
    Corresponds to variant rs34875559 [ dbSNP | Ensembl ].
    VAR_052755
    Natural varianti1293 – 12931L → I.
    Corresponds to variant rs35675714 [ dbSNP | Ensembl ].
    VAR_052756
    Natural varianti1538 – 15381L → P.3 Publications
    Corresponds to variant rs109836 [ dbSNP | Ensembl ].
    VAR_052757

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60119 Genomic DNA. Translation: AAB88218.1. Different initiation.
    X65644 mRNA. Translation: CAA46596.1. Different initiation.
    AF153836 Genomic DNA. Translation: AAF81365.1.
    AL023584 Genomic DNA. Translation: CAA19042.1.
    M61744 mRNA. Translation: AAA36202.1.
    CCDSiCCDS43510.1.
    PIRiS26661. WMHUE2.
    RefSeqiNP_006725.3. NM_006734.3.
    XP_005267014.1. XM_005266957.1.
    UniGeneiHs.510172.

    Genome annotation databases

    EnsembliENST00000012134; ENSP00000012134; ENSG00000010818.
    ENST00000367603; ENSP00000356575; ENSG00000010818.
    ENST00000367604; ENSP00000356576; ENSG00000010818.
    GeneIDi3097.
    KEGGihsa:3097.
    UCSCiuc003qjd.3. human.

    Polymorphism databases

    DMDMi83305815.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60119 Genomic DNA. Translation: AAB88218.1 . Different initiation.
    X65644 mRNA. Translation: CAA46596.1 . Different initiation.
    AF153836 Genomic DNA. Translation: AAF81365.1 .
    AL023584 Genomic DNA. Translation: CAA19042.1 .
    M61744 mRNA. Translation: AAA36202.1 .
    CCDSi CCDS43510.1.
    PIRi S26661. WMHUE2.
    RefSeqi NP_006725.3. NM_006734.3.
    XP_005267014.1. XM_005266957.1.
    UniGenei Hs.510172.

    3D structure databases

    ProteinModelPortali P31629.
    SMRi P31629. Positions 188-244, 1798-1854.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109344. 9 interactions.
    IntActi P31629. 12 interactions.
    MINTi MINT-7027293.
    STRINGi 9606.ENSP00000012134.

    PTM databases

    PhosphoSitei P31629.

    Polymorphism databases

    DMDMi 83305815.

    Proteomic databases

    MaxQBi P31629.
    PaxDbi P31629.
    PRIDEi P31629.

    Protocols and materials databases

    DNASUi 3097.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000012134 ; ENSP00000012134 ; ENSG00000010818 .
    ENST00000367603 ; ENSP00000356575 ; ENSG00000010818 .
    ENST00000367604 ; ENSP00000356576 ; ENSG00000010818 .
    GeneIDi 3097.
    KEGGi hsa:3097.
    UCSCi uc003qjd.3. human.

    Organism-specific databases

    CTDi 3097.
    GeneCardsi GC06M143114.
    H-InvDB HIX0032889.
    HGNCi HGNC:4921. HIVEP2.
    HPAi HPA055954.
    MIMi 143054. gene.
    neXtProti NX_P31629.
    PharmGKBi PA29298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296349.
    HOGENOMi HOG000155774.
    HOVERGENi HBG007119.
    InParanoidi P31629.
    KOi K09239.
    OMAi RKKCFLV.
    OrthoDBi EOG7V1FPQ.
    PhylomeDBi P31629.
    TreeFami TF331837.

    Miscellaneous databases

    GeneWikii HIVEP2.
    GenomeRNAii 3097.
    NextBioi 12289.
    PROi P31629.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31629.
    Bgeei P31629.
    CleanExi HS_HIVEP2.
    Genevestigatori P31629.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1."
      Nomura N., Zhao M.-J., Nagase T., Maekawa T., Ishizaki R., Tabata S., Ishii S.
      J. Biol. Chem. 266:8590-8594(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-1538.
    2. "Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes."
      Van't Veer L.J., Lutz P., Isselbacher K.J., Bernards R.
      Proc. Natl. Acad. Sci. U.S.A. 89:8971-8975(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-1538.
    3. "Characterization of the human MBP-2/HIV-EP2 gene: identification of multiple promoters and alternative splicing of 5' untranslated region."
      Kukita Y., Komiya T., Tahira T., Asakawa S., Shimizu N., Suzuki Y., Sugano S., Hayashi K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-1538.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties."
      Rustgi A.K., Van't Veer L.J., Bernards R.
      Proc. Natl. Acad. Sci. U.S.A. 87:8707-8710(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1797-1936.
    6. "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."
      Doerflinger U., Pscherer A., Moser M., Ruemmele P., Schuele R., Buettner R.
      Mol. Cell. Biol. 19:3736-3747(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Tissue: Brain.
    7. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2092.
      Tissue: Mammary cancer.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZEP2_HUMAN
    AccessioniPrimary (citable) accession number: P31629
    Secondary accession number(s): Q02646, Q5THT5, Q9NS05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3