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P31629

- ZEP2_HUMAN

UniProt

P31629 - ZEP2_HUMAN

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Protein

Transcription factor HIVEP2

Gene

HIVEP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1799 – 182123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1827 – 185125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HIVEP2
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 2
Short name:
HIV-EP2
MHC-binding protein 2
Short name:
MBP-2
Gene namesi
Name:HIVEP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4921. HIVEP2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24462446Transcription factor HIVEP2PRO_0000047371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki2092 – 2092Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP31629.
PaxDbiP31629.
PRIDEiP31629.

PTM databases

PhosphoSiteiP31629.

Expressioni

Tissue specificityi

Expressed in brain and skeletal muscle.1 Publication

Inductioni

By mitogens and phorbol ester.

Gene expression databases

BgeeiP31629.
CleanExiHS_HIVEP2.
ExpressionAtlasiP31629. baseline and differential.
GenevestigatoriP31629.

Organism-specific databases

HPAiHPA055954.

Interactioni

Subunit structurei

Interacts with TCF4.By similarity

Protein-protein interaction databases

BioGridi109344. 9 interactions.
IntActiP31629. 12 interactions.
MINTiMINT-7027293.
STRINGi9606.ENSP00000012134.

Structurei

3D structure databases

ProteinModelPortaliP31629.
SMRiP31629. Positions 188-244, 1798-1854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2053 – 205641
Repeati2059 – 206242
Repeati2071 – 207443
Repeati2083 – 208644
Repeati2089 – 209245
Repeati2106 – 210946
Repeati2112 – 211547
Repeati2118 – 212148
Repeati2130 – 213349
Repeati2145 – 2148410

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2053 – 21489610 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi937 – 9437Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi950 – 98233Ser-richAdd
BLAST
Compositional biasi1510 – 158677Ser-richAdd
BLAST
Compositional biasi1899 – 192325Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi2073 – 214876Arg-richAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri217 – 23923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1799 – 182123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1827 – 185125C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG296349.
GeneTreeiENSGT00530000063161.
HOGENOMiHOG000155774.
HOVERGENiHBG007119.
InParanoidiP31629.
KOiK09239.
OMAiRKKCFLV.
OrthoDBiEOG7V1FPQ.
PhylomeDBiP31629.
TreeFamiTF331837.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31629-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTGDTALGQ KATSRSGETD KASGRWRQEQ SAVIKMSTFG SHEGQRQPQI
60 70 80 90 100
EPEQIGNTAS AQLFGSGKLA SPSEVVQQVA EKQYPPHRPS PYSCQHSLSF
110 120 130 140 150
PQHSLPQGVM HSTKPHQSLE GPPWLFPGPL PSVASEDLFP FPIHGHSGGY
160 170 180 190 200
PRKKISSLNP AYSQYSQKSI EQAEEAHKKE HKPKKPGKYI CPYCSRACAK
210 220 230 240 250
PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA HAIKAGLVPF
260 270 280 290 300
TESAVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKMSPGPP
310 320 330 340 350
IPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLPNE SSQYIGPDML
360 370 380 390 400
PNPSLNTKAD DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY
410 420 430 440 450
FSRSESAEQQ ISPPNTNAKS YEEIIFGKYC RLSPRNALSV TTTSQERAAM
460 470 480 490 500
GRKGIMEPLP HVNTRLDVKM FEDPVSQLIP SKGDVDPSQT SMLKSTKFNS
510 520 530 540 550
ESRQPQIIPS SIRNEGKLYP ANFQGSNPVL LEAPVDSSPL IRSNSVPTSS
560 570 580 590 600
ATNLTIPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS
610 620 630 640 650
VQEGHVEVEH HGRMLKGISS SSLKEKKLSP GDRVGYDYDV CRKPYKKWED
660 670 680 690 700
SETPKQNYRD ISCLSSLKHG GEYFMDPVVP LQGVPSMFGT TCENRKRRKE
710 720 730 740 750
KSVGDEEDTP MICSSIVSTP VGIMASDYDP KLQMQEGVRS GFAMAGHENL
760 770 780 790 800
SHGHTERFDP CRPQLQPGSP SLVSEESPSA IDSDKMSDLG GRKPPGNVIS
810 820 830 840 850
VIQHTNSLSR PNSFERSESA ELVACTQDKA PSPSETCDSE ISEAPVSPEW
860 870 880 890 900
APPGDGAESG GKPSPSQQVQ QQSYHTQPRL VRQHNIQVPE IRVTEEPDKP
910 920 930 940 950
EKEKEAQSKE PEKPVEEFQW PQRSETLSQL PAEKLPPKKK RLRLADMEHS
960 970 980 990 1000
SGESSFESTG TGLSRSPSQE SNLSHSSSFS MSFEREETSK LSALPKQDEF
1010 1020 1030 1040 1050
GKHSEFLTVP AGSYSLSVPG HHHQKEMRRC SSEQMPCPHP AEVPEVRSKS
1060 1070 1080 1090 1100
FDYGNLSHAP VSGAAASTVS PSRERKKCFL VRQASFSGSP EISQGEVGMD
1110 1120 1130 1140 1150
QSVKQEQLEH LHAGLRSGWH HGPPAVLPPL QQEDPGKQVA GPCPPLSSGP
1160 1170 1180 1190 1200
LHLAQPQIMH MDSQESLRNP LIQPTSYMTS KHLPEQPHLF PHQETIPFSP
1210 1220 1230 1240 1250
IQNALFQFQY PTVCMVHLPA QQPPWWQAHF PHPFAQHPQK SYGKPSFQTE
1260 1270 1280 1290 1300
IHSSYPLEHV AEHTGKKPAE YAHTKEQTYP CYSGASGLHP KNLLPKFPSD
1310 1320 1330 1340 1350
QSSKSTETPS EQVLQEDFAS ANAGSLQSLP GTVVPVRIQT HVPSYGSVMY
1360 1370 1380 1390 1400
TSISQILGQN SPAIVICKVD ENMTQRTLVT NAAMQGIGFN IAQVLGQHAG
1410 1420 1430 1440 1450
LEKYPIWKAP QTLPLGLESS IPLCLPSTSD SVATLGGSKR MLSPASSLEL
1460 1470 1480 1490 1500
FMETKQQKRV KEEKMYGQIV EELSAVELTN SDIKKDLSRP QKPQLVRQGC
1510 1520 1530 1540 1550
ASEPKDGLQS GSSSFSSLSP SSSQDYPSVS PSSREPFLPS KEMLSGSRAP
1560 1570 1580 1590 1600
LPGQKSSGPS ESKESSDELD IDETASDMSM SPQSSSLPAG DGQLEEEGKG
1610 1620 1630 1640 1650
HKRPVGMLVR MASAPSGNVA DSTLLLTDMA DFQQILQFPS LRTTTTVSWC
1660 1670 1680 1690 1700
FLNYTKPNYV QQATFKSSVY ASWCISSCNP NPSGLNTKTT LALLRSKQKI
1710 1720 1730 1740 1750
TAEIYTLAAM HRPGTGKLTS SSAWKQFTQM KPDASFLFGS KLERKLVGNI
1760 1770 1780 1790 1800
LKERGKGDIH GDKDIGSKQT EPIRIKIFEG GYKSNEDYVY VRGRGRGKYI
1810 1820 1830 1840 1850
CEECGIRCKK PSMLKKHIRT HTDVRPYVCK LCNFAFKTKG NLTKHMKSKA
1860 1870 1880 1890 1900
HMKKCLELGV SMTSVDDTET EEAENLEDLH KAAEKHSMSS ISTDHQFSDA
1910 1920 1930 1940 1950
EESDGEDGDD NDDDDEDEDD FDDQGDLTPK TRSRSTSPQP PRFSSLPVNV
1960 1970 1980 1990 2000
GAVPHGVPSD SSLGHSSLIS YLVTLPSIRV TQLMTPSDSC EDTQMTEYQR
2010 2020 2030 2040 2050
LFQSKSTDSE PDKDRLDIPS CMDEECMLPS EPSSSPRDFS PSSHHSSPGY
2060 2070 2080 2090 2100
DSSPCRDNSP KRYLIPKGDL SPRRHLSPRR DLSPMRHLSP RKEAALRREM
2110 2120 2130 2140 2150
SQRDVSPRRH LSPRRPVSPG KDITARRDLS PRRERRYMTT IRAPSPRRAL
2160 2170 2180 2190 2200
YHNPPLSMGQ YLQAEPIVLG PPNLRRGLPQ VPYFSLYGDQ EGAYEHPGSS
2210 2220 2230 2240 2250
LFPEGPNDYV FSHLPLHSQQ QVRAPIPMVP VGGIQMVHSM PPALSSLHPS
2260 2270 2280 2290 2300
PTLPLPMEGF EEKKGASGES FSKDPYVLSK QHEKRGPHAL QSSGPPSTPS
2310 2320 2330 2340 2350
SPRLLMKQST SEDSLNATER EQEENIQTCT KAIASLRIAT EEAALLGPDQ
2360 2370 2380 2390 2400
PARVQEPHQN PLGSAHVSIR HFSRPEPGQP CTSATHPDLH DGEKDNFGTS
2410 2420 2430 2440
QTPLAHSTFY SKSCVDDKQL DFHSSKELSS STEESKDPSS EKSQLH
Length:2,446
Mass (Da):269,053
Last modified:December 6, 2005 - v2
Checksum:i482E2C577EF9449A
GO

Sequence cautioni

The sequence AAB88218.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA46596.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2091 – 20911R → T in CAA46596. (PubMed:1409593)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461R → Q.
Corresponds to variant rs17072013 [ dbSNP | Ensembl ].
VAR_052754
Natural varianti1041 – 10411A → V.
Corresponds to variant rs34875559 [ dbSNP | Ensembl ].
VAR_052755
Natural varianti1293 – 12931L → I.
Corresponds to variant rs35675714 [ dbSNP | Ensembl ].
VAR_052756
Natural varianti1538 – 15381L → P.3 Publications
Corresponds to variant rs109836 [ dbSNP | Ensembl ].
VAR_052757

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60119 Genomic DNA. Translation: AAB88218.1. Different initiation.
X65644 mRNA. Translation: CAA46596.1. Different initiation.
AF153836 Genomic DNA. Translation: AAF81365.1.
AL023584 Genomic DNA. Translation: CAA19042.1.
M61744 mRNA. Translation: AAA36202.1.
CCDSiCCDS43510.1.
PIRiS26661. WMHUE2.
RefSeqiNP_006725.3. NM_006734.3.
XP_005267014.1. XM_005266957.1.
UniGeneiHs.510172.

Genome annotation databases

EnsembliENST00000012134; ENSP00000012134; ENSG00000010818.
ENST00000367603; ENSP00000356575; ENSG00000010818.
ENST00000367604; ENSP00000356576; ENSG00000010818.
GeneIDi3097.
KEGGihsa:3097.
UCSCiuc003qjd.3. human.

Polymorphism databases

DMDMi83305815.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60119 Genomic DNA. Translation: AAB88218.1 . Different initiation.
X65644 mRNA. Translation: CAA46596.1 . Different initiation.
AF153836 Genomic DNA. Translation: AAF81365.1 .
AL023584 Genomic DNA. Translation: CAA19042.1 .
M61744 mRNA. Translation: AAA36202.1 .
CCDSi CCDS43510.1.
PIRi S26661. WMHUE2.
RefSeqi NP_006725.3. NM_006734.3.
XP_005267014.1. XM_005266957.1.
UniGenei Hs.510172.

3D structure databases

ProteinModelPortali P31629.
SMRi P31629. Positions 188-244, 1798-1854.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109344. 9 interactions.
IntActi P31629. 12 interactions.
MINTi MINT-7027293.
STRINGi 9606.ENSP00000012134.

PTM databases

PhosphoSitei P31629.

Polymorphism databases

DMDMi 83305815.

Proteomic databases

MaxQBi P31629.
PaxDbi P31629.
PRIDEi P31629.

Protocols and materials databases

DNASUi 3097.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000012134 ; ENSP00000012134 ; ENSG00000010818 .
ENST00000367603 ; ENSP00000356575 ; ENSG00000010818 .
ENST00000367604 ; ENSP00000356576 ; ENSG00000010818 .
GeneIDi 3097.
KEGGi hsa:3097.
UCSCi uc003qjd.3. human.

Organism-specific databases

CTDi 3097.
GeneCardsi GC06M143072.
H-InvDB HIX0032889.
HGNCi HGNC:4921. HIVEP2.
HPAi HPA055954.
MIMi 143054. gene.
neXtProti NX_P31629.
PharmGKBi PA29298.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296349.
GeneTreei ENSGT00530000063161.
HOGENOMi HOG000155774.
HOVERGENi HBG007119.
InParanoidi P31629.
KOi K09239.
OMAi RKKCFLV.
OrthoDBi EOG7V1FPQ.
PhylomeDBi P31629.
TreeFami TF331837.

Miscellaneous databases

GeneWikii HIVEP2.
GenomeRNAii 3097.
NextBioi 12289.
PROi P31629.
SOURCEi Search...

Gene expression databases

Bgeei P31629.
CleanExi HS_HIVEP2.
ExpressionAtlasi P31629. baseline and differential.
Genevestigatori P31629.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1."
    Nomura N., Zhao M.-J., Nagase T., Maekawa T., Ishizaki R., Tabata S., Ishii S.
    J. Biol. Chem. 266:8590-8594(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-1538.
  2. "Structure and expression of MBP-2: a 275 kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class 1 genes."
    Van't Veer L.J., Lutz P., Isselbacher K.J., Bernards R.
    Proc. Natl. Acad. Sci. U.S.A. 89:8971-8975(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-1538.
  3. "Characterization of the human MBP-2/HIV-EP2 gene: identification of multiple promoters and alternative splicing of 5' untranslated region."
    Kukita Y., Komiya T., Tahira T., Asakawa S., Shimizu N., Suzuki Y., Sugano S., Hayashi K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-1538.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties."
    Rustgi A.K., Van't Veer L.J., Bernards R.
    Proc. Natl. Acad. Sci. U.S.A. 87:8707-8710(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1797-1936.
  6. "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain."
    Doerflinger U., Pscherer A., Moser M., Ruemmele P., Schuele R., Buettner R.
    Mol. Cell. Biol. 19:3736-3747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2092.
    Tissue: Mammary cancer.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZEP2_HUMAN
AccessioniPrimary (citable) accession number: P31629
Secondary accession number(s): Q02646, Q5THT5, Q9NS05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3