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P31625

- VPRT_JSRV

UniProt

P31625 - VPRT_JSRV

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Protein

Bifunctional protease/dUTPase

Gene

pro

Organism
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
  2. dUTP diphosphatase activity Source: UniProtKB-EC
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Biological processi

Nucleotide metabolism

Protein family/group databases

MEROPSiA02.060.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protease/dUTPase
Including the following 2 domains:
Aspartic protease (EC:3.4.23.-)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:pro
OrganismiSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Taxonomic identifieri11746 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiOvis aries (Sheep) [TaxID: 9940]
ProteomesiUP000007215: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Bifunctional protease/dUTPasePRO_0000199548Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP31625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 23377Peptidase A2PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 28946G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the dUTPase family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31625-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWGNTAGSK RTIADLCRAT RGSAGLDLCA TSYTVLTPEM GVQTLATGVF
60 70 80 90 100
GPLPPGTVGL LLGRSSASLK GILIHPGVID SDYTGEIKIL ASAPNKIIVI
110 120 130 140 150
NAGQRIAQLL LVPLVIQGKT INRDRQDKGF GSSDAYWVQN VTEARPELEL
160 170 180 190 200
RINANFFRGV LDTGADISVI SDKYWPTTWP KQMAISTLQG IGQTTNPEQS
210 220 230 240 250
SSLLTWKDKD GHTGQFKPYI LPYLPVNLWG RDILSKMGVY LYSPSPTVTD
260 270 280
LMLDQGLLPN QGLGKQHQGI ILPLDLKPNQ DRKGLGCFP
Length:289
Mass (Da):31,311
Last modified:July 13, 2010 - v2
Checksum:iF0573EE17DCB606E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89181.1.
PIRiB42740. PRMVJA.
RefSeqiNP_041185.1. NC_001494.1.

Genome annotation databases

GeneIDi1490019.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89181.1 .
PIRi B42740. PRMVJA.
RefSeqi NP_041185.1. NC_001494.1.

3D structure databases

ProteinModelPortali P31625.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi A02.060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1490019.

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR000467. G_patch_dom.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats."
    York D.F., Vigne R., Verwoerd D.W., Querat G.
    J. Virol. 66:4930-4939(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVPRT_JSRV
AccessioniPrimary (citable) accession number: P31625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3