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P31625

- VPRT_JSRV

UniProt

P31625 - VPRT_JSRV

Protein

Bifunctional protease/dUTPase

Gene

pro

Organism
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei162 – 1621PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW
    2. dUTP diphosphatase activity Source: UniProtKB-EC
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Keywords - Biological processi

    Nucleotide metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protease/dUTPase
    Including the following 2 domains:
    Aspartic protease (EC:3.4.23.-)
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:pro
    OrganismiSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
    Taxonomic identifieri11746 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
    Virus hostiOvis aries (Sheep) [TaxID: 9940]
    ProteomesiUP000007215: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Bifunctional protease/dUTPasePRO_0000199548Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP31625.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini157 – 23377Peptidase A2PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 28946G-patchPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the dUTPase family.Curated
    Contains 1 G-patch domain.PROSITE-ProRule annotation
    Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.40.70.10. 1 hit.
    2.70.40.10. 1 hit.
    InterProiIPR001969. Aspartic_peptidase_AS.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR000467. G_patch_dom.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    PF01585. G-patch. 1 hit.
    PF00077. RVP. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    SSF51283. SSF51283. 1 hit.
    PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWGNTAGSK RTIADLCRAT RGSAGLDLCA TSYTVLTPEM GVQTLATGVF    50
    GPLPPGTVGL LLGRSSASLK GILIHPGVID SDYTGEIKIL ASAPNKIIVI 100
    NAGQRIAQLL LVPLVIQGKT INRDRQDKGF GSSDAYWVQN VTEARPELEL 150
    RINANFFRGV LDTGADISVI SDKYWPTTWP KQMAISTLQG IGQTTNPEQS 200
    SSLLTWKDKD GHTGQFKPYI LPYLPVNLWG RDILSKMGVY LYSPSPTVTD 250
    LMLDQGLLPN QGLGKQHQGI ILPLDLKPNQ DRKGLGCFP 289
    Length:289
    Mass (Da):31,311
    Last modified:July 13, 2010 - v2
    Checksum:iF0573EE17DCB606E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80216 Genomic RNA. Translation: AAA89181.1.
    PIRiB42740. PRMVJA.
    RefSeqiNP_041185.1. NC_001494.1.

    Genome annotation databases

    GeneIDi1490019.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80216 Genomic RNA. Translation: AAA89181.1 .
    PIRi B42740. PRMVJA.
    RefSeqi NP_041185.1. NC_001494.1.

    3D structure databases

    ProteinModelPortali P31625.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1490019.

    Family and domain databases

    Gene3Di 2.40.70.10. 1 hit.
    2.70.40.10. 1 hit.
    InterProi IPR001969. Aspartic_peptidase_AS.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR000467. G_patch_dom.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    PF01585. G-patch. 1 hit.
    PF00077. RVP. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    SSF51283. SSF51283. 1 hit.
    PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats."
      York D.F., Vigne R., Verwoerd D.W., Querat G.
      J. Virol. 66:4930-4939(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVPRT_JSRV
    AccessioniPrimary (citable) accession number: P31625
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3