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Protein

Bifunctional protease/dUTPase

Gene

pro

Organism
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
Biological processNucleotide metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protease/dUTPase
Including the following 2 domains:
Aspartic protease (EC:3.4.23.-)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:pro
OrganismiSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Taxonomic identifieri11746 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiOvis aries (Sheep) [TaxID: 9940]
Proteomesi
  • UP000007215 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995481 – 289Bifunctional protease/dUTPaseAdd BLAST289

Structurei

3D structure databases

ProteinModelPortaliP31625.
SMRiP31625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 233Peptidase A2PROSITE-ProRule annotationAdd BLAST77
Domaini244 – 289G-patchPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

In the C-terminal section; belongs to the dUTPase family.Curated

Phylogenomic databases

OrthoDBiVOG09000135.

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
cd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
SMARTiView protein in SMART
SM00443. G_patch. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.

Sequencei

Sequence statusi: Complete.

P31625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWGNTAGSK RTIADLCRAT RGSAGLDLCA TSYTVLTPEM GVQTLATGVF
60 70 80 90 100
GPLPPGTVGL LLGRSSASLK GILIHPGVID SDYTGEIKIL ASAPNKIIVI
110 120 130 140 150
NAGQRIAQLL LVPLVIQGKT INRDRQDKGF GSSDAYWVQN VTEARPELEL
160 170 180 190 200
RINANFFRGV LDTGADISVI SDKYWPTTWP KQMAISTLQG IGQTTNPEQS
210 220 230 240 250
SSLLTWKDKD GHTGQFKPYI LPYLPVNLWG RDILSKMGVY LYSPSPTVTD
260 270 280
LMLDQGLLPN QGLGKQHQGI ILPLDLKPNQ DRKGLGCFP
Length:289
Mass (Da):31,311
Last modified:July 13, 2010 - v2
Checksum:iF0573EE17DCB606E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89181.1.
PIRiB42740. PRMVJA.
RefSeqiNP_041185.1. NC_001494.1.

Genome annotation databases

GeneIDi1490019.
KEGGivg:1490019.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89181.1.
PIRiB42740. PRMVJA.
RefSeqiNP_041185.1. NC_001494.1.

3D structure databases

ProteinModelPortaliP31625.
SMRiP31625.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1490019.
KEGGivg:1490019.

Phylogenomic databases

OrthoDBiVOG09000135.

Family and domain databases

CDDicd05482. HIV_retropepsin_like. 1 hit.
cd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.40.70.10. 1 hit.
2.70.40.10. 1 hit.
InterProiView protein in InterPro
IPR001969. Aspartic_peptidase_AS.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
IPR000467. G_patch_dom.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR034170. Retropepsin-like_cat_dom.
IPR018061. Retropepsins.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
SMARTiView protein in SMART
SM00443. G_patch. 1 hit.
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF51283. SSF51283. 1 hit.
PROSITEiView protein in PROSITE
PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVPRT_JSRV
AccessioniPrimary (citable) accession number: P31625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 13, 2010
Last modified: March 15, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.