P31625 (VPRT_JSRV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bifunctional protease/dUTPase

Including the following 2 domains:

1. Aspartic protease
   EC=3.4.23.-
2. Deoxyuridine 5'-triphosphate nucleotidohydrolase
   Short name=dUTPase
   EC=3.6.1.23
   Alternative name(s):
   dUTP pyrophosphatase

Gene names

Name:

pro

Organism

Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV) [Complete proteome]

Taxonomic identifier

11746 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Betaretrovirus

Virus host

Ovis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Sequence similarities	In the C-terminal section; belongs to the dUTPase family. Contains 1 G-patch domain. Contains 1 peptidase A2 domain.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Coding sequence diversity	Ribosomal frameshifting
Molecular function	Aspartyl protease Hydrolase Protease
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dUTP diphosphatase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Bifunctional protease/dUTPase		PRO_0000199548
Regions
	Domain	157 – 233	77	Peptidase A2
	Domain	244 – 289	46	G-patch
Sites
	Active site	162	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P31625 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: F0573EE17DCB606E	FASTA	289	31,311
	10 20 30 40 50 60 MLWGNTAGSK RTIADLCRAT RGSAGLDLCA TSYTVLTPEM GVQTLATGVF GPLPPGTVGL 70 80 90 100 110 120 LLGRSSASLK GILIHPGVID SDYTGEIKIL ASAPNKIIVI NAGQRIAQLL LVPLVIQGKT 130 140 150 160 170 180 INRDRQDKGF GSSDAYWVQN VTEARPELEL RINANFFRGV LDTGADISVI SDKYWPTTWP 190 200 210 220 230 240 KQMAISTLQG IGQTTNPEQS SSLLTWKDKD GHTGQFKPYI LPYLPVNLWG RDILSKMGVY 250 260 270 280 LYSPSPTVTD LMLDQGLLPN QGLGKQHQGI ILPLDLKPNQ DRKGLGCFP

References

[1]	"Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats." York D.F., Vigne R., Verwoerd D.W., Querat G. J. Virol. 66:4930-4939(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M80216 Genomic RNA. Translation: AAA89181.1.
PIR	PRMVJA. B42740.
RefSeq	NP_041185.1. NC_001494.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1490019.
Family and domain databases
Gene3D	2.40.70.10. 1 hit.
InterPro	IPR008180. dUTP_pyroPase. IPR000467. G_patch_dom. IPR018061. Pept_A2A_retrovirus_sg. IPR001995. Peptidase_A2_cat. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. PF01585. G-patch. 1 hit. PF00077. RVP. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. [Graphical view]
SUPFAM	SSF50630. Pept_Aspartic. 1 hit.
PROSITE	PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VPRT_JSRV

Accession

Primary (citable) accession number: P31625

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program