Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P31625 (VPRT_JSRV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional protease/dUTPase

Including the following 2 domains:

  1. Aspartic protease
    EC=3.4.23.-
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase
    Short name=dUTPase
    EC=3.6.1.23
    Alternative name(s):
    dUTP pyrophosphatase
Gene names
Name:pro
OrganismSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV) [Complete proteome]
Taxonomic identifier11746 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostOvis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Sequence similarities

In the C-terminal section; belongs to the dUTPase family.

Contains 1 G-patch domain.

Contains 1 peptidase A2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Bifunctional protease/dUTPase
PRO_0000199548

Regions

Domain157 – 23377Peptidase A2
Domain244 – 28946G-patch

Sites

Active site1621 By similarity

Sequences

Sequence LengthMass (Da)Tools
P31625 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: F0573EE17DCB606E

FASTA28931,311
        10         20         30         40         50         60 
MLWGNTAGSK RTIADLCRAT RGSAGLDLCA TSYTVLTPEM GVQTLATGVF GPLPPGTVGL 

        70         80         90        100        110        120 
LLGRSSASLK GILIHPGVID SDYTGEIKIL ASAPNKIIVI NAGQRIAQLL LVPLVIQGKT 

       130        140        150        160        170        180 
INRDRQDKGF GSSDAYWVQN VTEARPELEL RINANFFRGV LDTGADISVI SDKYWPTTWP 

       190        200        210        220        230        240 
KQMAISTLQG IGQTTNPEQS SSLLTWKDKD GHTGQFKPYI LPYLPVNLWG RDILSKMGVY 

       250        260        270        280 
LYSPSPTVTD LMLDQGLLPN QGLGKQHQGI ILPLDLKPNQ DRKGLGCFP 

« Hide

References

[1]"Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats."
York D.F., Vigne R., Verwoerd D.W., Querat G.
J. Virol. 66:4930-4939(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80216 Genomic RNA. Translation: AAA89181.1.
PIRPRMVJA. B42740.
RefSeqNP_041185.1. NC_001494.1.

3D structure databases

ProteinModelPortalP31625.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1490019.

Family and domain databases

Gene3D2.40.70.10. 1 hit.
InterProIPR001969. Aspartic_peptidase_AS.
IPR008180. dUTP_pyroPase.
IPR000467. G_patch_dom.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
PF01585. G-patch. 1 hit.
PF00077. RVP. 1 hit.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMSSF50630. SSF50630. 1 hit.
PROSITEPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVPRT_JSRV
AccessionPrimary (citable) accession number: P31625
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 13, 2010
Last modified: October 16, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries