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Protein

Gag polyprotein

Gene

gag

Organism
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri507 – 52418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55118CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virus exit from host cell

Keywords - Ligandi

Metal-binding, Viral nucleoprotein, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyprotein
Cleaved into the following 6 chains:
Gene namesi
Name:gag
OrganismiSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Taxonomic identifieri11746 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiOvis aries (Sheep) [TaxID: 9940]
Proteomesi
  • UP000007215 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Matrix protein p10Sequence analysisPRO_0000040867Add
BLAST
Chaini148 – 16720Core protein p18Sequence analysisPRO_0000040868Add
BLAST
Chaini168 – 25689p12Sequence analysisPRO_0000040869Add
BLAST
Chaini257 – 476220Capsid protein p27Sequence analysisPRO_0000040870Add
BLAST
Chaini477 – 579103Nucleocapsid protein p14Sequence analysisPRO_0000040871Add
BLAST
Chaini580 – 61233p4Sequence analysisPRO_0000040872Add
BLAST

Structurei

Secondary structure

1
612
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi258 – 2603Combined sources
Beta strandi265 – 2673Combined sources
Helixi272 – 28413Combined sources
Helixi290 – 30011Combined sources
Helixi306 – 31611Combined sources
Helixi319 – 34325Combined sources
Helixi349 – 3535Combined sources
Helixi356 – 3583Combined sources
Helixi361 – 3633Combined sources
Beta strandi364 – 3674Combined sources
Helixi371 – 38414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V4XX-ray1.50A257-388[»]
ProteinModelPortaliP31622.
SMRiP31622. Positions 533-562.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31622.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi202 – 2054PTAP/PSAP motifSequence analysis
Motifi208 – 2114PPXY motifSequence analysis

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Gag-p12 contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase and a PTAP/PSAP motif, which potentially interacts with the UEV domain of TSG101 (Potential).Curated

Sequence similaritiesi

Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri507 – 52418CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55118CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR003322. B_retro_matrix.
IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 2 hits.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHTHSRQLF VHMLSVMLKH RGITVSKTKL INFLSFIEEV CPWFPREGTV
60 70 80 90 100
NLETWKKVGE QIRTHYTLHG PEKVPVETLS FWTLIRDCLD FDNDELKRLG
110 120 130 140 150
NLLKQEEDPL HTPDSVPSYD PPPPPPPSLK MHPSDNDDSL SSTDEAELDE
160 170 180 190 200
EAAKYHQEDW GFLAQEKGAL TSKDELVECF KNLTIALQNA GIQLPSNNNT
210 220 230 240 250
FPSAPPFPPA YTPTVMAGLD PPPGFPPPSK HMSPLQKALR QAQRLGEVVS
260 270 280 290 300
DFSLAFPVFE NNNQRYYESL PFKQLKELKI ACSQYGPTAP FTIAMIESLG
310 320 330 340 350
TQALPPNDWK QTARACLSGG DYLLWKSEFF EQCARIADVN RQQGIQTSYE
360 370 380 390 400
MLIGEGPYQA TDTQLNFLPG AYAQISNAAR QAWKKLPSSS TKTEDLSKVR
410 420 430 440 450
QGPDEPYQDF VARLLDTIGK IMSDEKAGMV LAKQLAFENA NSACQAALRP
460 470 480 490 500
YRKKGDLSDF IRICADIGPS YMQGIAMAAA LQGKSIKEVL FQQQARNKKG
510 520 530 540 550
LQKSGNSGCF VCGQPGHRAA VCPQKHQTSV NTPNLCPRCK KGKHWARDCR
560 570 580 590 600
SKTDVQGNPL PPVSGNWVRG QPLAPKQCYG ATLQVPKEPL QTSVEPQEAA
610
RDWTSVPPPI QY
Length:612
Mass (Da):68,089
Last modified:July 1, 1993 - v1
Checksum:i4CC6803A033EEFCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89180.1.
PIRiA42740. FOMVJA.
RefSeqiNP_041184.1. NC_001494.1.

Genome annotation databases

GeneIDi1490018.
KEGGivg:1490018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89180.1.
PIRiA42740. FOMVJA.
RefSeqiNP_041184.1. NC_001494.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V4XX-ray1.50A257-388[»]
ProteinModelPortaliP31622.
SMRiP31622. Positions 533-562.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1490018.
KEGGivg:1490018.

Miscellaneous databases

EvolutionaryTraceiP31622.

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR003322. B_retro_matrix.
IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 2 hits.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAG_JSRV
AccessioniPrimary (citable) accession number: P31622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 14, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.