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Protein

Gag polyprotein

Gene

gag

Organism
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 524CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri534 – 551CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexes, Virus exit from host cell

Keywords - Ligandi

Metal-binding, Viral nucleoprotein, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyprotein
Cleaved into the following 6 chains:
Gene namesi
Name:gag
OrganismiSheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
Taxonomic identifieri11746 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeBetaretrovirus
Virus hostiOvis aries (Sheep) [TaxID: 9940]
Proteomesi
  • UP000007215 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000408671 – 147Matrix protein p10Sequence analysisAdd BLAST147
ChainiPRO_0000040868148 – 167Core protein p18Sequence analysisAdd BLAST20
ChainiPRO_0000040869168 – 256p12Sequence analysisAdd BLAST89
ChainiPRO_0000040870257 – 476Capsid protein p27Sequence analysisAdd BLAST220
ChainiPRO_0000040871477 – 579Nucleocapsid protein p14Sequence analysisAdd BLAST103
ChainiPRO_0000040872580 – 612p4Sequence analysisAdd BLAST33

Structurei

Secondary structure

1612
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi258 – 260Combined sources3
Beta strandi265 – 267Combined sources3
Helixi272 – 284Combined sources13
Helixi290 – 300Combined sources11
Helixi306 – 316Combined sources11
Helixi319 – 343Combined sources25
Helixi349 – 353Combined sources5
Helixi356 – 358Combined sources3
Helixi361 – 363Combined sources3
Beta strandi364 – 367Combined sources4
Helixi371 – 384Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V4XX-ray1.50A257-388[»]
ProteinModelPortaliP31622.
SMRiP31622.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31622.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi202 – 205PTAP/PSAP motifSequence analysis4
Motifi208 – 211PPXY motifSequence analysis4

Domaini

Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Gag-p12 contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase and a PTAP/PSAP motif, which potentially interacts with the UEV domain of TSG101 (Potential).Curated

Sequence similaritiesi

Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri507 – 524CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri534 – 551CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR003322. B_retro_matrix.
IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 2 hits.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHTHSRQLF VHMLSVMLKH RGITVSKTKL INFLSFIEEV CPWFPREGTV
60 70 80 90 100
NLETWKKVGE QIRTHYTLHG PEKVPVETLS FWTLIRDCLD FDNDELKRLG
110 120 130 140 150
NLLKQEEDPL HTPDSVPSYD PPPPPPPSLK MHPSDNDDSL SSTDEAELDE
160 170 180 190 200
EAAKYHQEDW GFLAQEKGAL TSKDELVECF KNLTIALQNA GIQLPSNNNT
210 220 230 240 250
FPSAPPFPPA YTPTVMAGLD PPPGFPPPSK HMSPLQKALR QAQRLGEVVS
260 270 280 290 300
DFSLAFPVFE NNNQRYYESL PFKQLKELKI ACSQYGPTAP FTIAMIESLG
310 320 330 340 350
TQALPPNDWK QTARACLSGG DYLLWKSEFF EQCARIADVN RQQGIQTSYE
360 370 380 390 400
MLIGEGPYQA TDTQLNFLPG AYAQISNAAR QAWKKLPSSS TKTEDLSKVR
410 420 430 440 450
QGPDEPYQDF VARLLDTIGK IMSDEKAGMV LAKQLAFENA NSACQAALRP
460 470 480 490 500
YRKKGDLSDF IRICADIGPS YMQGIAMAAA LQGKSIKEVL FQQQARNKKG
510 520 530 540 550
LQKSGNSGCF VCGQPGHRAA VCPQKHQTSV NTPNLCPRCK KGKHWARDCR
560 570 580 590 600
SKTDVQGNPL PPVSGNWVRG QPLAPKQCYG ATLQVPKEPL QTSVEPQEAA
610
RDWTSVPPPI QY
Length:612
Mass (Da):68,089
Last modified:July 1, 1993 - v1
Checksum:i4CC6803A033EEFCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89180.1.
PIRiA42740. FOMVJA.
RefSeqiNP_041184.1. NC_001494.1.

Genome annotation databases

GeneIDi1490018.
KEGGivg:1490018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80216 Genomic RNA. Translation: AAA89180.1.
PIRiA42740. FOMVJA.
RefSeqiNP_041184.1. NC_001494.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V4XX-ray1.50A257-388[»]
ProteinModelPortaliP31622.
SMRiP31622.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1490018.
KEGGivg:1490018.

Miscellaneous databases

EvolutionaryTraceiP31622.

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR003322. B_retro_matrix.
IPR000721. Gag_p24.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02337. Gag_p10. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
ProDomiPD004265. B_retro_matrix_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 2 hits.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAG_JSRV
AccessioniPrimary (citable) accession number: P31622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.