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Protein

Citrate-sodium symporter

Gene

citS

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of citrate across the boundary membrane with the concomitant uptake of a sodium ion (symport system).

Miscellaneous

Allows the utilization of citrate as a sole source of carbon and energy.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCitrate utilization, Symport, Transport

Protein family/group databases

TCDBi2.A.24.1.1. the 2-hydroxycarboxylate transporter (2-hct) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate-sodium symporter
Alternative name(s):
Citrate carrier protein
Citrate transporter
Gene namesi
Name:citS
Encoded oniPlasmid pES30 Publication
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22Cytoplasmic1 PublicationAdd BLAST22
Transmembranei23 – 43Helical; Name=ICuratedAdd BLAST21
Topological domaini44 – 45Periplasmic1 Publication2
Transmembranei46 – 66Helical; Name=IICuratedAdd BLAST21
Topological domaini67 – 78Cytoplasmic1 PublicationAdd BLAST12
Transmembranei79 – 99Helical; Name=IIICuratedAdd BLAST21
Topological domaini100 – 109Periplasmic1 Publication10
Transmembranei110 – 130Helical; Name=IVCuratedAdd BLAST21
Topological domaini131 – 147Cytoplasmic1 PublicationAdd BLAST17
Transmembranei148 – 168Helical; Name=VCuratedAdd BLAST21
Topological domaini169 – 212Periplasmic1 PublicationAdd BLAST44
Transmembranei213 – 233Helical; Name=VICuratedAdd BLAST21
Topological domaini234 – 266Cytoplasmic1 PublicationAdd BLAST33
Transmembranei267 – 287Helical; Name=VIICuratedAdd BLAST21
Topological domaini288 – 360Periplasmic1 PublicationAdd BLAST73
Transmembranei361 – 379Helical; Name=VIIICuratedAdd BLAST19
Topological domaini380 – 426Cytoplasmic1 PublicationAdd BLAST47
Transmembranei427 – 446Helical; Name=IXCuratedAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887551 – 446Citrate-sodium symporterAdd BLAST446

Interactioni

Protein-protein interaction databases

DIPiDIP-60559N.

Structurei

Secondary structure

1446
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 20Combined sources4
Beta strandi24 – 26Combined sources3
Helixi28 – 43Combined sources16
Helixi51 – 71Combined sources21
Turni73 – 75Combined sources3
Helixi78 – 81Combined sources4
Helixi83 – 95Combined sources13
Helixi101 – 111Combined sources11
Helixi116 – 131Combined sources16
Helixi137 – 165Combined sources29
Helixi170 – 176Combined sources7
Helixi178 – 182Combined sources5
Helixi185 – 188Combined sources4
Helixi190 – 200Combined sources11
Helixi205 – 236Combined sources32
Turni238 – 240Combined sources3
Helixi265 – 288Combined sources24
Beta strandi293 – 296Combined sources4
Helixi300 – 314Combined sources15
Helixi319 – 334Combined sources16
Helixi337 – 347Combined sources11
Helixi351 – 355Combined sources5
Helixi360 – 384Combined sources25
Helixi388 – 394Combined sources7
Helixi397 – 400Combined sources4
Helixi403 – 413Combined sources11
Helixi417 – 419Combined sources3
Helixi420 – 445Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X9RX-ray3.98A/B13-446[»]
5XARX-ray3.62A/B/C/D13-446[»]
5XASX-ray3.47A/B13-446[»]
5XATX-ray3.76A/B/C/D13-446[»]
ProteinModelPortaliP31602.
SMRiP31602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D2K. Bacteria.
COG3493. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR018025. 2-OHcarbox_trans_Prot/Firm.
IPR004679. 2-OHcarboxylate_transport.
PANTHERiPTHR40033. PTHR40033. 1 hit.
PfamiView protein in Pfam
PF03390. 2HCT. 1 hit.
PIRSFiPIRSF005348. YxkH. 1 hit.
TIGRFAMsiTIGR00783. ccs. 1 hit.

Sequencei

Sequence statusi: Complete.

P31602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNMSQPPAT EKKGVSDLLG FKIFGMPLPL YAFALITLLL SHFYNALPTD
60 70 80 90 100
IVGGFAIMFI IGAIFGEIGK RLPIFNKYIG GAPVMIFLVA AYFVYAGIFT
110 120 130 140 150
QKEIDAISNV MDKSNFLNLF IAVLITGAIL SVNRRLLLKS LLGYIPTILM
160 170 180 190 200
GIVGASIFGI AIGLVFGIPV DRIMMLYVLP IMGGGNGAGA VPLSEIYHSV
210 220 230 240 250
TGRSREEYYS TAIAILTIAN IFAIVFAAVL DIIGKKHTWL SGEGELVRKA
260 270 280 290 300
SFKVEEDEKT GQITHRETAV GLVLSTTCFL LAYVVAKKIL PSIGGVAIHY
310 320 330 340 350
FAWMVLIVAA LNASGLCSPE IKAGAKRLSD FFSKQLLWVL MVGVGVCYTD
360 370 380 390 400
LQEIINAITF ANVVIAAIIV IGAVLGAAIG GWLMGFFPIE SAITAGLCMA
410 420 430 440
NRGGSGDLEV LSACNRMNLI SYAQISSRLG GGIVLVIASI VFGMMI
Length:446
Mass (Da):47,558
Last modified:July 1, 1993 - v1
Checksum:iD90AB990BDDDE879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83146 Genomic DNA. Translation: AAA25060.1.
PIRiA38244.

Similar proteinsi

Entry informationi

Entry nameiCITN_KLEPN
AccessioniPrimary (citable) accession number: P31602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families