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Protein

Excitatory amino acid transporter 3

Gene

SLC1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transports L-glutamate, L- and D-aspartate and L-cystein. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cysteine transmembrane transport Source: GOC
  • cysteine transport Source: UniProtKB
  • D-aspartate import Source: CACAO
  • L-glutamate transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 3
Alternative name(s):
Excitatory amino-acid carrier 1
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1
Gene namesi
Name:SLC1A1
Synonyms:EAAC1, EAAT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3820HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 20995ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 22920HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27320HelicalSequence analysisAdd
BLAST
Transmembranei290 – 30920HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33520HelicalSequence analysisAdd
BLAST
Transmembranei362 – 38120HelicalSequence analysisAdd
BLAST
Transmembranei392 – 41120HelicalSequence analysisAdd
BLAST
Transmembranei420 – 43920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Excitatory amino acid transporter 3PRO_0000202068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei522 – 5221PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Brain, but also small intestine, kidney, liver and heart.

Interactioni

Subunit structurei

Interacts with ARL6IP5.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022489.

Structurei

3D structure databases

ProteinModelPortaliP31597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP31597.
KOiK05612.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPARKGCD SKRFLKNNWL LLSTVVAVVL GIVIGVLVRE YSNLSTLDKF
60 70 80 90 100
YFAFPGEILM RMLKLVILPL IVSSMITGVA ALDSNVSGKI GLRAVLYYFC
110 120 130 140 150
TTIIAVILGI VLVVSIKPGV TQKVDEIDRT GSTPEVSTVD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTTREEVT ASDDTGKNGT EESVTAVMTT AVSENRTKEY
210 220 230 240 250
RVVGLYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI
260 270 280 290 300
VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMVTVL SGLAIHSIVI
310 320 330 340 350
LPLIYFIVVR KNPFRFAMGM TQALLTALMI SSSSATLPVT FRCAEEKNRV
360 370 380 390 400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDMDLS IGQIITISVT
410 420 430 440 450
ATAASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTVV
460 470 480 490 500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALESA TLDNEDSDTK
510 520
KSYINGGFAV DKSDTISFTQ TSQF
Length:524
Mass (Da):56,939
Last modified:July 1, 1993 - v1
Checksum:iF4F483777EFE62D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12411 mRNA. Translation: AAA31257.1.
PIRiS28902.
RefSeqiNP_001075718.1. NM_001082249.1.
UniGeneiOcu.1980.

Genome annotation databases

GeneIDi100009070.
KEGGiocu:100009070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12411 mRNA. Translation: AAA31257.1.
PIRiS28902.
RefSeqiNP_001075718.1. NM_001082249.1.
UniGeneiOcu.1980.

3D structure databases

ProteinModelPortaliP31597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009070.
KEGGiocu:100009070.

Organism-specific databases

CTDi6505.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP31597.
KOiK05612.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure and functional characterization of a high-affinity glutamate transporter."
    Kanai Y., Hediger M.A.
    Nature 360:467-471(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiEAA3_RABIT
AccessioniPrimary (citable) accession number: P31597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.