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P31593

- GSA_TOBAC

UniProt

P31593 - GSA_TOBAC

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene
GSA
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:GSA
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 478Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticUniRule annotationPRO_0000001261
Transit peptidei1 – ?ChloroplastUniRule annotation

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei318 – 3181N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

ProMEXiP31593.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP31593.
SMRiP31593. Positions 52-478.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31593-1 [UniParc]FASTAAdd to Basket

« Hide

MAAVNGVGIS WPSKLTQGQR PKLVFSPSPR RCTPSSSTIK MTASVDEKKK    50
TFTLQKSEEA FSKAKELMPG GVNSPVRAFK SVGGQPIIID SVKGSRMRDI 100
DGNEYIDYVG SWGPAIIGHA DDEVLAALAE TMKKGTSFGA PCLLENTLAE 150
MVISAVPSIE MVRFVNSGTE ACMGVLRLAR AFTGRPKIIK FEGCYHGHAD 200
PFLVKAGSGV ATLGLPDSPG GPKAATSDTL TAPYNDISAV ESLFEEHKGE 250
VAAIILEPVV GNAGFIQPNL DFLAAIRKIT KENDALLIFD EVMTGFRLAY 300
GGAQEYFGIT PDLTTLGKII GGGLPVGAYG GRRDIMEMVA PAGPMYQAGT 350
LSGNPLAMTA GIHTLKRLQG PGTYEYLDKI TGELTQGILD AGKKTGHAMC 400
GGYIRGMFGF LFAEGPVNNF SDAKKSDTEK FGRFYRGMLE EGVYFAPSQF 450
EAGFTSLAHT SEDIQKTVAA AEKVLKQI 478
Length:478
Mass (Da):50,877
Last modified:July 1, 1993 - v1
Checksum:i459CBA43FE46E84A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181G → S in isozyme 2.
Natural varianti104 – 1041E → D in isozyme 2.
Natural varianti221 – 2211G → V in isozyme 2.
Natural varianti227 – 2271S → T in isozyme 2.
Natural varianti245 – 2451E → K in isozyme 2.
Natural varianti270 – 2701L → P in isozyme 2.
Natural varianti375 – 3751E → D in isozyme 2.
Natural varianti411 – 4111L → F in isozyme 2.
Natural varianti413 – 4131A → V in isozyme 2.
Natural varianti466 – 4661K → R in isozyme 2.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65973 mRNA. Translation: CAA46786.1.
X65974 mRNA. Translation: CAA46787.1.
PIRiS21454.
S21455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65973 mRNA. Translation: CAA46786.1 .
X65974 mRNA. Translation: CAA46787.1 .
PIRi S21454.
S21455.

3D structure databases

ProteinModelPortali P31593.
SMRi P31593. Positions 52-478.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P31593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A visible marker for antisense mRNA expression in plants: inhibition of chlorophyll synthesis with a glutamate-1-semialdehyde aminotransferase antisense gene."
    Hoefgen R., Axelsen K.B., Kannangara C.G., Schuettke I., Pohlenz H.-D., Willmitzer L., Grimm B., von Wettstein D.
    Proc. Natl. Acad. Sci. U.S.A. 91:1726-1730(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. SR1.

Entry informationi

Entry nameiGSA_TOBAC
AccessioniPrimary (citable) accession number: P31593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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