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P31593

- GSA_TOBAC

UniProt

P31593 - GSA_TOBAC

Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene

GSA

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
    Short name:
    GSA
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase
    Short name:
    GSA-AT
    Gene namesi
    Name:GSA
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 478Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticPRO_0000001261
    Transit peptidei1 – ?Chloroplast

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei318 – 3181N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    ProMEXiP31593.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP31593.
    SMRiP31593. Positions 52-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31593-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVNGVGIS WPSKLTQGQR PKLVFSPSPR RCTPSSSTIK MTASVDEKKK    50
    TFTLQKSEEA FSKAKELMPG GVNSPVRAFK SVGGQPIIID SVKGSRMRDI 100
    DGNEYIDYVG SWGPAIIGHA DDEVLAALAE TMKKGTSFGA PCLLENTLAE 150
    MVISAVPSIE MVRFVNSGTE ACMGVLRLAR AFTGRPKIIK FEGCYHGHAD 200
    PFLVKAGSGV ATLGLPDSPG GPKAATSDTL TAPYNDISAV ESLFEEHKGE 250
    VAAIILEPVV GNAGFIQPNL DFLAAIRKIT KENDALLIFD EVMTGFRLAY 300
    GGAQEYFGIT PDLTTLGKII GGGLPVGAYG GRRDIMEMVA PAGPMYQAGT 350
    LSGNPLAMTA GIHTLKRLQG PGTYEYLDKI TGELTQGILD AGKKTGHAMC 400
    GGYIRGMFGF LFAEGPVNNF SDAKKSDTEK FGRFYRGMLE EGVYFAPSQF 450
    EAGFTSLAHT SEDIQKTVAA AEKVLKQI 478
    Length:478
    Mass (Da):50,877
    Last modified:July 1, 1993 - v1
    Checksum:i459CBA43FE46E84A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181G → S in isozyme 2.
    Natural varianti104 – 1041E → D in isozyme 2.
    Natural varianti221 – 2211G → V in isozyme 2.
    Natural varianti227 – 2271S → T in isozyme 2.
    Natural varianti245 – 2451E → K in isozyme 2.
    Natural varianti270 – 2701L → P in isozyme 2.
    Natural varianti375 – 3751E → D in isozyme 2.
    Natural varianti411 – 4111L → F in isozyme 2.
    Natural varianti413 – 4131A → V in isozyme 2.
    Natural varianti466 – 4661K → R in isozyme 2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65973 mRNA. Translation: CAA46786.1.
    X65974 mRNA. Translation: CAA46787.1.
    PIRiS21454.
    S21455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65973 mRNA. Translation: CAA46786.1 .
    X65974 mRNA. Translation: CAA46787.1 .
    PIRi S21454.
    S21455.

    3D structure databases

    ProteinModelPortali P31593.
    SMRi P31593. Positions 52-478.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi P31593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A visible marker for antisense mRNA expression in plants: inhibition of chlorophyll synthesis with a glutamate-1-semialdehyde aminotransferase antisense gene."
      Hoefgen R., Axelsen K.B., Kannangara C.G., Schuettke I., Pohlenz H.-D., Willmitzer L., Grimm B., von Wettstein D.
      Proc. Natl. Acad. Sci. U.S.A. 91:1726-1730(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. SR1.

    Entry informationi

    Entry nameiGSA_TOBAC
    AccessioniPrimary (citable) accession number: P31593
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3