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P31574

- FIXB_ECOLI

UniProt

P31574 - FIXB_ECOLI

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Protein

Protein FixB

Gene
fixB, yaaR, b0042, JW0041
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for anaerobic carnitine reduction. May bring reductant to CaiA.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi255 – 28329FAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. carnitine metabolic process Source: EcoliWiki
  2. oxidation-reduction process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciEcoCyc:EG11563-MONOMER.
ECOL316407:JW0041-MONOMER.
UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FixB
Gene namesi
Name:fixB
Synonyms:yaaR
Ordered Locus Names:b0042, JW0041
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11563. fixB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Protein FixBUniRule annotationPRO_0000167861Add
BLAST

Proteomic databases

PaxDbiP31574.

Expressioni

Gene expression databases

GenevestigatoriP31574.

Interactioni

Subunit structurei

Heterodimer of FixA and FixB Inferred.

Binary interactionsi

WithEntry#Exp.IntActNotes
gssP0AES02EBI-554030,EBI-557080

Protein-protein interaction databases

DIPiDIP-9621N.
IntActiP31574. 12 interactions.
MINTiMINT-1240082.
STRINGi511145.b0042.

Structurei

3D structure databases

ProteinModelPortaliP31574.
SMRiP31574. Positions 2-313.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2025.
HOGENOMiHOG000247866.
KOiK03522.
OMAiPIAETEK.
OrthoDBiEOG68WR5D.
PhylomeDBiP31574.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_01056. FixB.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR001308. ETF_a.
IPR014730. ETF_a/b_N.
IPR014731. ETF_asu_C.
IPR018206. ETF_asu_C_CS.
IPR023461. ETF_FixBsu.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01012. ETF. 1 hit.
PF00766. ETF_alpha. 1 hit.
[Graphical view]
PIRSFiPIRSF000089. Electra_flavoP_a. 1 hit.
SMARTiSM00893. ETF. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS00696. ETF_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31574-1 [UniParc]FASTAAdd to Basket

« Hide

MNTFSQVWVF SDTPSRLPEL MNGAQALANQ INTFVLNDAD GAQAIQLGAN    50
HVWKLNGKPD DRMIEDYAGV MADTIRQHGA DGLVLLPNTR RGKLLAAKLG 100
YRLKAAVSND ASTVSVQDGK ATVKHMVYGG LAIGEERIAT PYAVLTISSG 150
TFDAAQPDAS RTGETHTVEW QAPAVAITRT ATQARQSNSV DLDKARLVVS 200
VGRGIGSKEN IALAEQLCKA IGAELACSRP VAENEKWMEH ERYVGISNLM 250
LKPELYLAVG ISGQIQHMVG ANASQTIFAI NKDKNAPIFQ YADYGIVGDA 300
VKILPALTAA LAR 313
Length:313
Mass (Da):33,513
Last modified:October 1, 1996 - v3
Checksum:i443DBBD7F97EDE16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71977 Genomic DNA. Translation: CAA50798.1.
U00096 Genomic DNA. Translation: AAC73153.1.
AP009048 Genomic DNA. Translation: BAE76037.1.
PIRiB64725.
RefSeqiNP_414584.1. NC_000913.3.
YP_488348.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73153; AAC73153; b0042.
BAE76037; BAE76037; BAE76037.
GeneIDi12933214.
948939.
KEGGiecj:Y75_p0042.
eco:b0042.
PATRICi32115183. VBIEscCol129921_0043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71977 Genomic DNA. Translation: CAA50798.1 .
U00096 Genomic DNA. Translation: AAC73153.1 .
AP009048 Genomic DNA. Translation: BAE76037.1 .
PIRi B64725.
RefSeqi NP_414584.1. NC_000913.3.
YP_488348.1. NC_007779.1.

3D structure databases

ProteinModelPortali P31574.
SMRi P31574. Positions 2-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9621N.
IntActi P31574. 12 interactions.
MINTi MINT-1240082.
STRINGi 511145.b0042.

Proteomic databases

PaxDbi P31574.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73153 ; AAC73153 ; b0042 .
BAE76037 ; BAE76037 ; BAE76037 .
GeneIDi 12933214.
948939.
KEGGi ecj:Y75_p0042.
eco:b0042.
PATRICi 32115183. VBIEscCol129921_0043.

Organism-specific databases

EchoBASEi EB1524.
EcoGenei EG11563. fixB.

Phylogenomic databases

eggNOGi COG2025.
HOGENOMi HOG000247866.
KOi K03522.
OMAi PIAETEK.
OrthoDBi EOG68WR5D.
PhylomeDBi P31574.

Enzyme and pathway databases

UniPathwayi UPA00117 .
BioCyci EcoCyc:EG11563-MONOMER.
ECOL316407:JW0041-MONOMER.

Miscellaneous databases

PROi P31574.

Gene expression databases

Genevestigatori P31574.

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_01056. FixB.
InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR001308. ETF_a.
IPR014730. ETF_a/b_N.
IPR014731. ETF_asu_C.
IPR018206. ETF_asu_C_CS.
IPR023461. ETF_FixBsu.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01012. ETF. 1 hit.
PF00766. ETF_alpha. 1 hit.
[Graphical view ]
PIRSFi PIRSF000089. Electra_flavoP_a. 1 hit.
SMARTi SM00893. ETF. 1 hit.
[Graphical view ]
SUPFAMi SSF52467. SSF52467. 1 hit.
PROSITEi PS00696. ETF_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The fix Escherichia coli region contains four genes related to carnitine metabolism."
    Eichler K., Buchet A., Bourgis F., Kleber H.-P., Mandrand-Berthelot M.-A.
    J. Basic Microbiol. 35:217-227(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: O44:K74.
  2. "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region."
    Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A.
    Nucleic Acids Res. 20:3305-3308(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli."
    Walt A., Kahn M.L.
    J. Bacteriol. 184:4044-4047(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiFIXB_ECOLI
AccessioniPrimary (citable) accession number: P31574
Secondary accession number(s): Q2MCG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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