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Protein

Probable crotonobetaine/carnitine-CoA ligase

Gene

caiC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

  • acid-thiol ligase activity Source: InterPro
  • carnitine-CoA ligase activity Source: EcoCyc
  • crotonobetaine-CoA ligase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Enzyme and pathway databases

BioCyciEcoCyc:CAIC-MONOMER.
ECOL316407:JW0036-MONOMER.
MetaCyc:CAIC-MONOMER.
UniPathwayiUPA00117.

Protein family/group databases

TCDBi4.C.1.1.6. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable crotonobetaine/carnitine-CoA ligase (EC:6.2.1.-)
Gene namesi
Name:caiC
Synonyms:yaaM
Ordered Locus Names:b0037, JW0036
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11558. caiC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930651 – 517Probable crotonobetaine/carnitine-CoA ligaseAdd BLAST517

Proteomic databases

EPDiP31552.
PaxDbiP31552.
PRIDEiP31552.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
allRP0ACN43EBI-1112975,EBI-561736

Protein-protein interaction databases

BioGridi4261017. 531 interactors.
DIPiDIP-9243N.
IntActiP31552. 5 interactors.
STRINGi511145.b0037.

Structurei

3D structure databases

ProteinModelPortaliP31552.
SMRiP31552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CEY. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000230001.
InParanoidiP31552.
KOiK02182.
OMAiTALIYES.
PhylomeDBiP31552.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SGGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLCEE
110 120 130 140 150
SAWILQNSQA CLLVTSAQFY PMYQQIQQED ATQLRHICLT DVALPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATVTECIP MMIRTLMVQP PSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRVGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGEIGEIC IKGIPGKTIF KEYFLNPQAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EDFFYFVDRR CNMIKRGGEN VSCVELENII AAHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FRFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,559
Last modified:August 21, 2007 - v2
Checksum:iC7A307D16200D8E9
GO

Sequence cautioni

The sequence BAB96606 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA52113 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti98C → R in strain: O44:K74. 1
Natural varianti252 – 253RA → PR in strain: O44:K74. 2
Natural varianti286Q → R in strain: O44:K74 and B. 1
Natural varianti328I → S in strain: O44:K74. 1
Natural varianti345V → A in strain: O44:K74 and B. 1
Natural varianti359R → C in strain: B. 1
Natural varianti374I → V in strain: O44:K74 and B. 1
Natural varianti388Q → K in strain: O44:K74 and B. 1
Natural varianti396A → V in strain: O44:K74. 1
Natural varianti408R → C in strain: O44:K74. 1
Natural varianti412D → G in strain: O44:K74 and B. 1
Natural varianti442A → T in strain: O44:K74 and B. 1
Natural varianti503L → LDL in strain: O44:K74. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73904 Genomic DNA. Translation: CAA52113.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73148.2.
AP009048 Genomic DNA. Translation: BAB96606.1. Different initiation.
AY625099 Genomic DNA. Translation: AAT42453.1.
PIRiE64724. S40558.
RefSeqiNP_414579.4. NC_000913.3.
WP_001350478.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73148; AAC73148; b0037.
BAB96606; BAB96606; BAB96606.
GeneIDi944886.
KEGGiecj:JW0036.
eco:b0037.
PATRICi32115169. VBIEscCol129921_0036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73904 Genomic DNA. Translation: CAA52113.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73148.2.
AP009048 Genomic DNA. Translation: BAB96606.1. Different initiation.
AY625099 Genomic DNA. Translation: AAT42453.1.
PIRiE64724. S40558.
RefSeqiNP_414579.4. NC_000913.3.
WP_001350478.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP31552.
SMRiP31552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261017. 531 interactors.
DIPiDIP-9243N.
IntActiP31552. 5 interactors.
STRINGi511145.b0037.

Protein family/group databases

TCDBi4.C.1.1.6. the proposed fatty acid transporter (fat) family.

Proteomic databases

EPDiP31552.
PaxDbiP31552.
PRIDEiP31552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73148; AAC73148; b0037.
BAB96606; BAB96606; BAB96606.
GeneIDi944886.
KEGGiecj:JW0036.
eco:b0037.
PATRICi32115169. VBIEscCol129921_0036.

Organism-specific databases

EchoBASEiEB1519.
EcoGeneiEG11558. caiC.

Phylogenomic databases

eggNOGiENOG4105CEY. Bacteria.
COG0318. LUCA.
HOGENOMiHOG000230001.
InParanoidiP31552.
KOiK02182.
OMAiTALIYES.
PhylomeDBiP31552.

Enzyme and pathway databases

UniPathwayiUPA00117.
BioCyciEcoCyc:CAIC-MONOMER.
ECOL316407:JW0036-MONOMER.
MetaCyc:CAIC-MONOMER.

Miscellaneous databases

PROiP31552.

Family and domain databases

HAMAPiMF_01524. CaiC. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAIC_ECOLI
AccessioniPrimary (citable) accession number: P31552
Secondary accession number(s): Q6IU50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.