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Protein

Thiamine transport system permease protein ThiP

Gene

thiP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:SFUB-MONOMER
MetaCyc:SFUB-MONOMER

Protein family/group databases

TCDBi3.A.1.19.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transport system permease protein ThiP
Gene namesi
Name:thiP
Synonyms:yabK
Ordered Locus Names:b0067, JW0066
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11573 thiP

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei58 – 78HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei95 – 115HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei199 – 219HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei240 – 260HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei334 – 354HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei374 – 394HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei404 – 424HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei463 – 483HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei506 – 526HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602301 – 536Thiamine transport system permease protein ThiPAdd BLAST536

Proteomic databases

PaxDbiP31549
PRIDEiP31549

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).Curated

Protein-protein interaction databases

BioGridi4263358, 12 interactors
DIPiDIP-10989N
IntActiP31549, 1 interactor
STRINGi316407.85674312

Structurei

3D structure databases

ProteinModelPortaliP31549
SMRiP31549
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 261ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST206
Domaini331 – 525ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106SMU Bacteria
COG1178 LUCA
HOGENOMiHOG000272487
InParanoidiP31549
KOiK02063
OMAiSYLWHVI
PhylomeDBiP31549

Family and domain databases

CDDicd06261 TM_PBP2, 2 hits
Gene3Di1.10.3720.10, 2 hits
InterProiView protein in InterPro
IPR000515 MetI-like
IPR035906 MetI-like_sf
IPR005947 ThiP_ABC_transpt
PfamiView protein in Pfam
PF00528 BPD_transp_1, 2 hits
SUPFAMiSSF161098 SSF161098, 2 hits
TIGRFAMsiTIGR01253 thiP, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 2 hits

Sequencei

Sequence statusi: Complete.

P31549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRQPLIP GWLIPGVSAT TLVVAVALAA FLALWWNAPQ DDWVAVWQDS
60 70 80 90 100
YLWHVVRFSF WQAFLSALLS VIPAIFLARA LYRRRFPGRL ALLRLCAMTL
110 120 130 140 150
ILPVLVAVFG ILSVYGRQGW LATLCQSLGL EWTFSPYGLQ GILLAHVFFN
160 170 180 190 200
LPMASRLLLQ ALENIPGEQR QLAAQLGMRS WHFFRFVEWP WLRRQIPPVA
210 220 230 240 250
ALIFMLCFAS FATVLSLGGG PQATTIELAI YQALSYDYDP ARAAMLALLQ
260 270 280 290 300
MVCCLGLVLL SQRLSKAIAP GTTLLQGWRD PDDRLHSRIC DTVLIVLALL
310 320 330 340 350
LLLPPLLAVI VDGVNRQLPE VLAQPVLWQA LWTSLRIALA AGVLCVVLTM
360 370 380 390 400
MLLWSSRELR ARQKMLAGQV LEMSGMLILA MPGIVLATGF FLLLNNTIGL
410 420 430 440 450
PQSADGIVIF TNALMAIPYA LKVLENPMRD ITARYSMLCQ SLGIEGWSRL
460 470 480 490 500
KVVELRALKR PLAQALAFAC VLSIGDFGVV ALFGNDDFRT LPFYLYQQIG
510 520 530
SYRSQDGAVT ALILLLLCFL LFTVIEKLPG RNVKTD
Length:536
Mass (Da):59,533
Last modified:November 1, 1997 - v2
Checksum:iF6F559EDA92B8C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73178.1
AP009048 Genomic DNA Translation: BAB96636.2
PIRiC64728
RefSeqiNP_414609.1, NC_000913.3
WP_000235721.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73178; AAC73178; b0067
BAB96636; BAB96636; BAB96636
GeneIDi944784
KEGGiecj:JW0066
eco:b0067
PATRICifig|1411691.4.peg.2215

Similar proteinsi

Entry informationi

Entry nameiTHIP_ECOLI
AccessioniPrimary (citable) accession number: P31549
Secondary accession number(s): P75636
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health