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Protein

Thiamine import ATP-binding protein ThiQ

Gene

thiQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:SFUC-MONOMER
MetaCyc:SFUC-MONOMER

Protein family/group databases

TCDBi3.A.1.19.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine import ATP-binding protein ThiQUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:thiQUniRule annotation
Synonyms:yabJ
Ordered Locus Names:b0066, JW0065
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11572 thiQ

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930221 – 232Thiamine import ATP-binding protein ThiQAdd BLAST232

Proteomic databases

PaxDbiP31548
PRIDEiP31548

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).UniRule annotation

Protein-protein interaction databases

BioGridi4259729, 5 interactors
IntActiP31548, 6 interactors
STRINGi316407.85674311

Structurei

3D structure databases

ProteinModelPortaliP31548
SMRiP31548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 230ABC transporterUniRule annotationAdd BLAST229

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T0D Bacteria
COG3840 LUCA
InParanoidiP31548
KOiK02062
OMAiRPALMFQ
PhylomeDBiP31548

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005968 Thiamine_ABC_ThiQ
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01277 thiQ, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51288 THIQ, 1 hit

Sequencei

Sequence statusi: Complete.

P31548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLTDITWL YHHLPMRFSL TVERGEQVAI LGPSGAGKST LLNLIAGFLT
60 70 80 90 100
PASGSLTIDG VDHTTMPPSR RPVSMLFQEN NLFSHLTVAQ NIGLGLNPGL
110 120 130 140 150
KLNAVQQGKM HAIARQMGID NLMARLPGEL SGGQRQRVAL ARCLVREQPI
160 170 180 190 200
LLLDEPFSAL DPALRQEMLT LVSTSCQQQK MTLLMVSHSV EDAARIATRS
210 220 230
VVVADGRIAW QGMTNELLSG KASASALLGI TG
Length:232
Mass (Da):24,999
Last modified:November 1, 1997 - v2
Checksum:i22234D38F57B7C68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66M → T in AAT42474 (PubMed:12664169).Curated1
Sequence conflicti105V → A in AAT42474 (PubMed:12664169).Curated1
Sequence conflicti108G → E in AAT42474 (PubMed:12664169).Curated1
Sequence conflicti213M → K in AAT42474 (PubMed:12664169).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73177.1
AP009048 Genomic DNA Translation: BAB96635.2
AY625120 Genomic DNA Translation: AAT42474.1
PIRiB64728
RefSeqiNP_414608.1, NC_000913.3
WP_000916281.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73177; AAC73177; b0066
BAB96635; BAB96635; BAB96635
GeneIDi944785
KEGGiecj:JW0065
eco:b0066
PATRICifig|1411691.4.peg.2216

Similar proteinsi

Entry informationi

Entry nameiTHIQ_ECOLI
AccessioniPrimary (citable) accession number: P31548
Secondary accession number(s): P75635, Q6IU29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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