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Protein

Serum amyloid A-4 protein

Gene

Saa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-4 protein
Alternative name(s):
Amyloid A-5 protein
Gene namesi
Name:Saa4
Synonyms:Saa5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98224. Saa4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 130112Serum amyloid A-4 proteinPRO_0000031592Add
BLAST

Proteomic databases

EPDiP31532.
MaxQBiP31532.
PaxDbiP31532.
PRIDEiP31532.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiP31532.
CleanExiMM_SAA4.
GenevisibleiP31532. MM.

Interactioni

Protein-protein interaction databases

IntActiP31532. 1 interaction.
MINTiMINT-4133743.
STRINGi10090.ENSMUSP00000006952.

Structurei

3D structure databases

ProteinModelPortaliP31532.
SMRiP31532. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDSY. Eukaryota.
ENOG4111APX. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP31532.
KOiK17310.
OMAiWFSFFKE.
OrthoDBiEOG7QVM4V.
PhylomeDBiP31532.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLATVIVLC SLFLGVSGDG WYSFFREAVQ GTWDLWRAYR DNLEANYQNA
60 70 80 90 100
DQYFYARGNY EAQQRGSGGI WAAKIISTSR KYFQGLLNRY YFGIRNHGLE
110 120 130
TLQATQKAEE WGRSGKNPNH FRPEGLPEKF
Length:130
Mass (Da):15,088
Last modified:November 1, 1995 - v2
Checksum:i675235BD36DAEFCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281Missing AA sequence (PubMed:1741755).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02554 mRNA. Translation: AAA17564.1.
U40397 Genomic DNA. Translation: AAC52904.1.
U65403 Genomic DNA. Translation: AAB17555.1.
BC019212 mRNA. Translation: AAH19212.1.
CCDSiCCDS21283.1.
PIRiA53167.
RefSeqiNP_035446.1. NM_011316.3.
UniGeneiMm.3489.

Genome annotation databases

EnsembliENSMUST00000006952; ENSMUSP00000006952; ENSMUSG00000040017.
GeneIDi20211.
KEGGimmu:20211.
UCSCiuc009gyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02554 mRNA. Translation: AAA17564.1.
U40397 Genomic DNA. Translation: AAC52904.1.
U65403 Genomic DNA. Translation: AAB17555.1.
BC019212 mRNA. Translation: AAH19212.1.
CCDSiCCDS21283.1.
PIRiA53167.
RefSeqiNP_035446.1. NM_011316.3.
UniGeneiMm.3489.

3D structure databases

ProteinModelPortaliP31532.
SMRiP31532. Positions 21-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP31532. 1 interaction.
MINTiMINT-4133743.
STRINGi10090.ENSMUSP00000006952.

Proteomic databases

EPDiP31532.
MaxQBiP31532.
PaxDbiP31532.
PRIDEiP31532.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006952; ENSMUSP00000006952; ENSMUSG00000040017.
GeneIDi20211.
KEGGimmu:20211.
UCSCiuc009gyy.1. mouse.

Organism-specific databases

CTDi6291.
MGIiMGI:98224. Saa4.

Phylogenomic databases

eggNOGiENOG410JDSY. Eukaryota.
ENOG4111APX. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP31532.
KOiK17310.
OMAiWFSFFKE.
OrthoDBiEOG7QVM4V.
PhylomeDBiP31532.
TreeFamiTF332544.

Miscellaneous databases

NextBioi297809.
PROiP31532.
SOURCEiSearch...

Gene expression databases

BgeeiP31532.
CleanExiMM_SAA4.
GenevisibleiP31532. MM.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse serum amyloid A protein (SAA5) structure and expression."
    de Beer M.C., Kindy M.S., Lane W.S., de Beer F.C.
    J. Biol. Chem. 269:4661-4667(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family."
    de Beer M.C., de Beer F.C., Gerardot C.J., Cecil D.R., Webb N.R., Goodson M.L., Kindy M.S.
    Genomics 34:139-142(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  3. "Structure of the mouse serum amyloid A 5 (Saa5) gene: relationship to other members of the serum amyloid A family."
    Butler A., Whitehead A.S.
    Scand. J. Immunol. 45:160-165(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A/J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  5. "Identification of a novel serum amyloid A protein in BALB/c mice."
    de Beer M.C., Beach C.M., Shedlofsky S.I., de Beer F.C.
    Biochem. J. 280:45-49(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-74 AND 96-130.
    Strain: BALB/cJ.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Lung and Testis.

Entry informationi

Entry nameiSAA4_MOUSE
AccessioniPrimary (citable) accession number: P31532
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

SAA4 used to be called SAA5. What was SAA4 is a pseudogene which is now called SAA-ps.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.