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Protein

pH 6 antigen

Gene

psaA

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Fibrillar structure, part of fimbriae, necessary for full virulence.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1292-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
pH 6 antigen
Alternative name(s):
Adhesin
Antigen 4
Gene namesi
Name:psaA
Ordered Locus Names:YPO1303, y2882, YP_1289
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815 Componenti: Chromosome UP000001019 Componenti: Chromosome UP000002490 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 158132pH 6 antigenPRO_0000009240Add
BLAST

Expressioni

Inductioni

Expressed inside macrophages under acidic pH and at 37 degrees Celsius.

Interactioni

Subunit structurei

Forms a homopolymer composed of subunits assembled in a large structure.

Protein-protein interaction databases

STRINGi214092.YPO1303.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 4014Combined sources
Beta strandi48 – 536Combined sources
Beta strandi59 – 624Combined sources
Beta strandi67 – 759Combined sources
Beta strandi82 – 876Combined sources
Helixi89 – 913Combined sources
Turni92 – 943Combined sources
Beta strandi95 – 984Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi107 – 1148Combined sources
Helixi115 – 1173Combined sources
Beta strandi119 – 1235Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi130 – 1367Combined sources
Beta strandi144 – 15815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F8LX-ray1.50A27-158[»]
4F8NX-ray2.50A27-158[»]
4F8OX-ray1.90A27-158[»]
4F8PX-ray2.05A/B27-158[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72060.
HOGENOMiHOG000219282.
OMAiTIKQGNT.
OrthoDBiEOG6GR38Z.

Family and domain databases

PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKCFAKNA LAVTTLMIAA CGMANASTVI NSKDVSGEVT VKQGNTFHVD
60 70 80 90 100
FAPNTGEIFA GKQPGDVTMF TLTMGDTAPH GGWRLIPTGD SKGGYMISAD
110 120 130 140 150
GDYVGLYSYM MSWVGIDNNW YINDDSPKDI KDHLYVKAGT VLKPTTYKFT

GRVEEYVF
Length:158
Mass (Da):17,233
Last modified:June 30, 1993 - v1
Checksum:iE475AEE11C5DC2FC
GO

Sequence cautioni

The sequence AAM86433.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS61532.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86713 Genomic DNA. Translation: AAA27662.1.
X97759 Genomic DNA. Translation: CAA66355.1.
AL590842 Genomic DNA. Translation: CAL19956.1.
AE009952 Genomic DNA. Translation: AAM86433.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61532.1. Different initiation.
PIRiAB0159.
S32926.
RefSeqiNP_670182.1. NC_004088.1.
NP_992655.1. NC_005810.1.
YP_002346328.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM86433; AAM86433; y2882.
AAS61532; AAS61532; YP_1289.
GeneIDi1174145.
KEGGiype:YPO1303.
ypk:y2882.
ypm:YP_1289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86713 Genomic DNA. Translation: AAA27662.1.
X97759 Genomic DNA. Translation: CAA66355.1.
AL590842 Genomic DNA. Translation: CAL19956.1.
AE009952 Genomic DNA. Translation: AAM86433.1. Different initiation.
AE017042 Genomic DNA. Translation: AAS61532.1. Different initiation.
PIRiAB0159.
S32926.
RefSeqiNP_670182.1. NC_004088.1.
NP_992655.1. NC_005810.1.
YP_002346328.1. NC_003143.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F8LX-ray1.50A27-158[»]
4F8NX-ray2.50A27-158[»]
4F8OX-ray1.90A27-158[»]
4F8PX-ray2.05A/B27-158[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214092.YPO1303.

Protocols and materials databases

DNASUi1147829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM86433; AAM86433; y2882.
AAS61532; AAS61532; YP_1289.
GeneIDi1174145.
KEGGiype:YPO1303.
ypk:y2882.
ypm:YP_1289.

Phylogenomic databases

eggNOGiNOG72060.
HOGENOMiHOG000219282.
OMAiTIKQGNT.
OrthoDBiEOG6GR38Z.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-1292-MONOMER.

Family and domain databases

PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yersinia pestis pH 6 antigen forms fimbriae and is induced by intracellular association with macrophages."
    Lindler L.E., Tall B.D.
    Mol. Microbiol. 8:311-324(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KIM5 / Biovar Mediaevalis.
  2. Cherepavov P.A.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EV 76.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  5. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiPSAA_YERPE
AccessioniPrimary (citable) accession number: P31522
Secondary accession number(s): Q0WHB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1993
Last sequence update: June 30, 1993
Last modified: March 31, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.