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P31522

- PSAA_YERPE

UniProt

P31522 - PSAA_YERPE

Protein

pH 6 antigen

Gene

psaA

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Fibrillar structure, part of fimbriae, necessary for full virulence.

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciYPES214092:GKDD-1292-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    pH 6 antigen
    Alternative name(s):
    Adhesin
    Antigen 4
    Gene namesi
    Name:psaA
    Ordered Locus Names:YPO1303, y2882, YP_1289
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pilus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Fimbrium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Add
    BLAST
    Chaini27 – 158132pH 6 antigenPRO_0000009240Add
    BLAST

    Expressioni

    Inductioni

    Expressed inside macrophages under acidic pH and at 37 degrees Celsius.

    Interactioni

    Subunit structurei

    Forms a homopolymer composed of subunits assembled in a large structure.

    Protein-protein interaction databases

    STRINGi214092.YPO1303.

    Structurei

    Secondary structure

    1
    158
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 4014
    Beta strandi48 – 536
    Beta strandi59 – 624
    Beta strandi67 – 759
    Beta strandi82 – 876
    Helixi89 – 913
    Turni92 – 943
    Beta strandi95 – 984
    Beta strandi103 – 1053
    Beta strandi107 – 1148
    Helixi115 – 1173
    Beta strandi119 – 1235
    Beta strandi126 – 1283
    Beta strandi130 – 1367
    Beta strandi144 – 15815

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F8LX-ray1.50A27-158[»]
    4F8NX-ray2.50A27-158[»]
    4F8OX-ray1.90A27-158[»]
    4F8PX-ray2.05A/B27-158[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72060.
    HOGENOMiHOG000219282.
    OMAiTIKQGNT.
    OrthoDBiEOG6GR38Z.

    Family and domain databases

    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31522-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMKCFAKNA LAVTTLMIAA CGMANASTVI NSKDVSGEVT VKQGNTFHVD    50
    FAPNTGEIFA GKQPGDVTMF TLTMGDTAPH GGWRLIPTGD SKGGYMISAD 100
    GDYVGLYSYM MSWVGIDNNW YINDDSPKDI KDHLYVKAGT VLKPTTYKFT 150
    GRVEEYVF 158
    Length:158
    Mass (Da):17,233
    Last modified:July 1, 1993 - v1
    Checksum:iE475AEE11C5DC2FC
    GO

    Sequence cautioni

    The sequence AAM86433.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAS61532.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86713 Genomic DNA. Translation: AAA27662.1.
    X97759 Genomic DNA. Translation: CAA66355.1.
    AL590842 Genomic DNA. Translation: CAL19956.1.
    AE009952 Genomic DNA. Translation: AAM86433.1. Different initiation.
    AE017042 Genomic DNA. Translation: AAS61532.1. Different initiation.
    PIRiAB0159.
    S32926.
    RefSeqiNP_670182.1. NC_004088.1.
    NP_992655.1. NC_005810.1.
    YP_002346328.1. NC_003143.1.

    Genome annotation databases

    EnsemblBacteriaiAAM86433; AAM86433; y2882.
    AAS61532; AAS61532; YP_1289.
    GeneIDi1147829.
    1174145.
    2766170.
    KEGGiype:YPO1303.
    ypk:y2882.
    ypm:YP_1289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86713 Genomic DNA. Translation: AAA27662.1 .
    X97759 Genomic DNA. Translation: CAA66355.1 .
    AL590842 Genomic DNA. Translation: CAL19956.1 .
    AE009952 Genomic DNA. Translation: AAM86433.1 . Different initiation.
    AE017042 Genomic DNA. Translation: AAS61532.1 . Different initiation.
    PIRi AB0159.
    S32926.
    RefSeqi NP_670182.1. NC_004088.1.
    NP_992655.1. NC_005810.1.
    YP_002346328.1. NC_003143.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F8L X-ray 1.50 A 27-158 [» ]
    4F8N X-ray 2.50 A 27-158 [» ]
    4F8O X-ray 1.90 A 27-158 [» ]
    4F8P X-ray 2.05 A/B 27-158 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 214092.YPO1303.

    Protocols and materials databases

    DNASUi 1147829.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM86433 ; AAM86433 ; y2882 .
    AAS61532 ; AAS61532 ; YP_1289 .
    GeneIDi 1147829.
    1174145.
    2766170.
    KEGGi ype:YPO1303.
    ypk:y2882.
    ypm:YP_1289.

    Phylogenomic databases

    eggNOGi NOG72060.
    HOGENOMi HOG000219282.
    OMAi TIKQGNT.
    OrthoDBi EOG6GR38Z.

    Enzyme and pathway databases

    BioCyci YPES214092:GKDD-1292-MONOMER.

    Family and domain databases

    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yersinia pestis pH 6 antigen forms fimbriae and is induced by intracellular association with macrophages."
      Lindler L.E., Tall B.D.
      Mol. Microbiol. 8:311-324(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: KIM5 / Biovar Mediaevalis.
    2. Cherepavov P.A.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: EV 76.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    5. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiPSAA_YERPE
    AccessioniPrimary (citable) accession number: P31522
    Secondary accession number(s): Q0WHB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3