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P31512 (FMO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 4

EC=1.14.13.8
Alternative name(s):
Dimethylaniline oxidase 4
Hepatic flavin-containing monooxygenase 4
Short name=FMO 4
Gene names
Name:FMO4
Synonyms:FMO2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Catalytic activity

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactor

FAD.

Subcellular location

Microsome membrane. Endoplasmic reticulum membrane.

Tissue specificity

Liver.

Sequence similarities

Belongs to the FMO family.

Caution

Was originally (Ref.1) termed FMO2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Dimethylaniline monooxygenase [N-oxide-forming] 4
PRO_0000147660

Regions

Transmembrane517 – 53115Helical; Potential
Nucleotide binding9 – 146FAD Potential
Nucleotide binding191 – 1966NADP Potential

Natural variations

Natural variant371I → T. Ref.7
VAR_015367
Natural variant3081T → S.
Corresponds to variant rs3737925 [ dbSNP | Ensembl ].
VAR_049090
Natural variant3231V → A. Ref.2 Ref.7
Corresponds to variant rs1042767 [ dbSNP | Ensembl ].
VAR_015368
Natural variant3391E → Q. Ref.7
Corresponds to variant rs61342270 [ dbSNP | Ensembl ].
VAR_015369
Natural variant3721G → S. Ref.2
Corresponds to variant rs45599742 [ dbSNP | Ensembl ].
VAR_022305
Natural variant5361F → L. Ref.2
Corresponds to variant rs45487792 [ dbSNP | Ensembl ].
VAR_022306
Natural variant5441L → R. Ref.2
VAR_022307

Sequences

Sequence LengthMass (Da)Tools
P31512 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6981AE9180C07802

FASTA55863,343
        10         20         30         40         50         60 
MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG MTRVYKSLVT 

        70         80         90        100        110        120 
NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL LKYIQFKTTV CSITKRPDFS 

       130        140        150        160        170        180 
ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE 

       190        200        210        220        230        240 
GFQGKRVLVI GLGNTGGDIA VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC 

       250        260        270        280        290        300 
SFIAQVLPSR FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT 

       310        320        330        340        350        360 
SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF LYKQVFPLNL 

       370        380        390        400        410        420 
ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP SQKLMMEATE KEQLIKRGVF 

       430        440        450        460        470        480 
KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD 

       490        500        510        520        530        540 
GARNAILTQW DRTLKPLKTR IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV 

       550 
RDKLQDRMSP YLVSLWRG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family."
Dolphin C.T., Shephard E.A., Povey S., Smith R.L., Phillips I.R.
Biochem. J. 287:261-267(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]NIEHS SNPs program
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-323; SER-372; LEU-536 AND ARG-544.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[7]"Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
Furnes B., Feng J., Sommer S.S., Schlenk D.
Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS THR-37; ALA-323 AND GLN-339.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11737 mRNA. Translation: CAA77797.1.
AY882422 Genomic DNA. Translation: AAW56938.1.
BT007444 mRNA. Translation: AAP36112.1.
AL031274 Genomic DNA. Translation: CAB42008.1.
CH471067 Genomic DNA. Translation: EAW90896.1.
BC002780 mRNA. Translation: AAH02780.1.
PIRS29125.
RefSeqNP_002013.1. NM_002022.1.
UniGeneHs.386502.

3D structure databases

ProteinModelPortalP31512.
SMRP31512. Positions 2-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356723.

PTM databases

PhosphoSiteP31512.

Polymorphism databases

DMDM399506.

Proteomic databases

PaxDbP31512.
PRIDEP31512.

Protocols and materials databases

DNASU2329.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367749; ENSP00000356723; ENSG00000076258.
GeneID2329.
KEGGhsa:2329.
UCSCuc001gho.3. human.

Organism-specific databases

CTD2329.
GeneCardsGC01P171283.
HGNCHGNC:3772. FMO4.
HPAHPA049100.
MIM136131. gene.
neXtProtNX_P31512.
PharmGKBPA28188.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2072.
HOGENOMHOG000076537.
HOVERGENHBG002037.
InParanoidP31512.
KOK00485.
OMAVCTGHFL.
OrthoDBEOG7GXPB6.
PhylomeDBP31512.
TreeFamTF105285.

Gene expression databases

BgeeP31512.
CleanExHS_FMO2.
HS_FMO4.
GenevestigatorP31512.

Family and domain databases

InterProIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002256. Flavin_mOase_4.
[Graphical view]
PfamPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFPIRSF000332. FMO. 1 hit.
PRINTSPR00370. FMOXYGENASE.
PR01124. FMOXYGENASE4.
ProtoNetSearch...

Other

GeneWikiFMO4.
GenomeRNAi2329.
NextBio9453.
PROP31512.
SOURCESearch...

Entry information

Entry nameFMO4_HUMAN
AccessionPrimary (citable) accession number: P31512
Secondary accession number(s): Q53XR0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM