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P31512

- FMO4_HUMAN

UniProt

P31512 - FMO4_HUMAN

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Protein
Dimethylaniline monooxygenase [N-oxide-forming] 4
Gene
FMO4, FMO2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

FAD.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FAD Reviewed prediction
Nucleotide bindingi191 – 1966NADP Reviewed prediction

GO - Molecular functioni

  1. N,N-dimethylaniline monooxygenase activity Source: UniProtKB
  2. NADP binding Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC:1.14.13.8)
    Alternative name(s):
    Dimethylaniline oxidase 4
    Hepatic flavin-containing monooxygenase 4
    Short name:
    FMO 4
    Gene namesi
    Name:FMO4
    Synonyms:FMO2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3772. FMO4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei517 – 53115Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Dimethylaniline monooxygenase [N-oxide-forming] 4
    PRO_0000147660Add
    BLAST

    Proteomic databases

    PaxDbiP31512.
    PRIDEiP31512.

    PTM databases

    PhosphoSiteiP31512.

    Expressioni

    Tissue specificityi

    Liver.

    Gene expression databases

    BgeeiP31512.
    CleanExiHS_FMO2.
    HS_FMO4.
    GenevestigatoriP31512.

    Organism-specific databases

    HPAiHPA049100.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356723.

    Structurei

    3D structure databases

    ProteinModelPortaliP31512.
    SMRiP31512. Positions 2-365.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FMO family.

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2072.
    HOGENOMiHOG000076537.
    HOVERGENiHBG002037.
    InParanoidiP31512.
    KOiK00485.
    OMAiVCTGHFL.
    OrthoDBiEOG7GXPB6.
    PhylomeDBiP31512.
    TreeFamiTF105285.

    Family and domain databases

    InterProiIPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002256. Flavin_mOase_4.
    [Graphical view]
    PfamiPF00743. FMO-like. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000332. FMO. 1 hit.
    PRINTSiPR00370. FMOXYGENASE.
    PR01124. FMOXYGENASE4.

    Sequencei

    Sequence statusi: Complete.

    P31512-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG    50
    MTRVYKSLVT NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL 100
    LKYIQFKTTV CSITKRPDFS ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF 150
    LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE GFQGKRVLVI GLGNTGGDIA 200
    VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC SFIAQVLPSR 250
    FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT 300
    SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF 350
    LYKQVFPLNL ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP 400
    SQKLMMEATE KEQLIKRGVF KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL 450
    FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD GARNAILTQW DRTLKPLKTR 500
    IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV RDKLQDRMSP 550
    YLVSLWRG 558
    Length:558
    Mass (Da):63,343
    Last modified:January 23, 2007 - v3
    Checksum:i6981AE9180C07802
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371I → T.1 Publication
    VAR_015367
    Natural varianti308 – 3081T → S.
    Corresponds to variant rs3737925 [ dbSNP | Ensembl ].
    VAR_049090
    Natural varianti323 – 3231V → A.2 Publications
    Corresponds to variant rs1042767 [ dbSNP | Ensembl ].
    VAR_015368
    Natural varianti339 – 3391E → Q.1 Publication
    Corresponds to variant rs61342270 [ dbSNP | Ensembl ].
    VAR_015369
    Natural varianti372 – 3721G → S.1 Publication
    Corresponds to variant rs45599742 [ dbSNP | Ensembl ].
    VAR_022305
    Natural varianti536 – 5361F → L.1 Publication
    Corresponds to variant rs45487792 [ dbSNP | Ensembl ].
    VAR_022306
    Natural varianti544 – 5441L → R.1 Publication
    VAR_022307

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11737 mRNA. Translation: CAA77797.1.
    AY882422 Genomic DNA. Translation: AAW56938.1.
    BT007444 mRNA. Translation: AAP36112.1.
    AL031274 Genomic DNA. Translation: CAB42008.1.
    CH471067 Genomic DNA. Translation: EAW90896.1.
    BC002780 mRNA. Translation: AAH02780.1.
    CCDSiCCDS1295.1.
    PIRiS29125.
    RefSeqiNP_002013.1. NM_002022.1.
    UniGeneiHs.386502.

    Genome annotation databases

    EnsembliENST00000367749; ENSP00000356723; ENSG00000076258.
    GeneIDi2329.
    KEGGihsa:2329.
    UCSCiuc001gho.3. human.

    Polymorphism databases

    DMDMi399506.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11737 mRNA. Translation: CAA77797.1 .
    AY882422 Genomic DNA. Translation: AAW56938.1 .
    BT007444 mRNA. Translation: AAP36112.1 .
    AL031274 Genomic DNA. Translation: CAB42008.1 .
    CH471067 Genomic DNA. Translation: EAW90896.1 .
    BC002780 mRNA. Translation: AAH02780.1 .
    CCDSi CCDS1295.1.
    PIRi S29125.
    RefSeqi NP_002013.1. NM_002022.1.
    UniGenei Hs.386502.

    3D structure databases

    ProteinModelPortali P31512.
    SMRi P31512. Positions 2-365.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000356723.

    PTM databases

    PhosphoSitei P31512.

    Polymorphism databases

    DMDMi 399506.

    Proteomic databases

    PaxDbi P31512.
    PRIDEi P31512.

    Protocols and materials databases

    DNASUi 2329.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367749 ; ENSP00000356723 ; ENSG00000076258 .
    GeneIDi 2329.
    KEGGi hsa:2329.
    UCSCi uc001gho.3. human.

    Organism-specific databases

    CTDi 2329.
    GeneCardsi GC01P171283.
    HGNCi HGNC:3772. FMO4.
    HPAi HPA049100.
    MIMi 136131. gene.
    neXtProti NX_P31512.
    PharmGKBi PA28188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2072.
    HOGENOMi HOG000076537.
    HOVERGENi HBG002037.
    InParanoidi P31512.
    KOi K00485.
    OMAi VCTGHFL.
    OrthoDBi EOG7GXPB6.
    PhylomeDBi P31512.
    TreeFami TF105285.

    Miscellaneous databases

    GeneWikii FMO4.
    GenomeRNAii 2329.
    NextBioi 9453.
    PROi P31512.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31512.
    CleanExi HS_FMO2.
    HS_FMO4.
    Genevestigatori P31512.

    Family and domain databases

    InterProi IPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002256. Flavin_mOase_4.
    [Graphical view ]
    Pfami PF00743. FMO-like. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000332. FMO. 1 hit.
    PRINTSi PR00370. FMOXYGENASE.
    PR01124. FMOXYGENASE4.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family."
      Dolphin C.T., Shephard E.A., Povey S., Smith R.L., Phillips I.R.
      Biochem. J. 287:261-267(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. NIEHS SNPs program
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-323; SER-372; LEU-536 AND ARG-544.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    7. "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
      Furnes B., Feng J., Sommer S.S., Schlenk D.
      Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-37; ALA-323 AND GLN-339.

    Entry informationi

    Entry nameiFMO4_HUMAN
    AccessioniPrimary (citable) accession number: P31512
    Secondary accession number(s): Q53XR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: July 9, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally (1 Publication) termed FMO2.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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