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Protein

Probable transport protein HsrA

Gene

hsrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Overexpression causes homocysteine accumulation and reverses rspA-mediated suppression of rpoS.1 Publication

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YIEO-MONOMER

Protein family/group databases

TCDBi2.A.1.3.51 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transport protein HsrA
Alternative name(s):
High-copy suppressor of rspA
Gene namesi
Name:hsrA1 Publication
Synonyms:yieO
Ordered Locus Names:b3754, JW3733
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11732 hsrA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 49PeriplasmicSequence analysisAdd BLAST19
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 77CytoplasmicSequence analysis7
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160PeriplasmicSequence analysis1
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 197CytoplasmicSequence analysisAdd BLAST16
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 221PeriplasmicSequence analysis3
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 280CytoplasmicSequence analysisAdd BLAST38
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 328CytoplasmicSequence analysis6
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 393CytoplasmicSequence analysisAdd BLAST23
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Topological domaini415 – 428PeriplasmicSequence analysisAdd BLAST14
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 475CytoplasmicSequence analysis1 PublicationAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734091 – 475Probable transport protein HsrAAdd BLAST475

Proteomic databases

PaxDbiP31474
PRIDEiP31474

Interactioni

Protein-protein interaction databases

BioGridi4262603, 137 interactors
DIPiDIP-12470N
IntActiP31474, 1 interactor
STRINGi316385.ECDH10B_3943

Structurei

3D structure databases

ProteinModelPortaliP31474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C0R Bacteria
ENOG410XNN3 LUCA
HOGENOMiHOG000193484
InParanoidiP31474
OMAiTALFMEN
PhylomeDBiP31474

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004638 Drug-R_transpt_efflux_EmrB
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00711 efflux_EmrB, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P31474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKKKRSMA GLPWIAAMAF FMQALDATIL NTALPAIAHS LNRSPLAMQS
60 70 80 90 100
AIISYTLTVA MLIPVSGWLA DRFGTRRIFT LAVSLFTLGS LACALSNSLP
110 120 130 140 150
QLVVFRVIQG IGGAMMMPVA RLALLRAYPR NELLPVLNFV AMPGLVGPIL
160 170 180 190 200
GPVLGGVLVT WATWHWIFLI NIPIGIAGLL YARKHMPNFT TARRRFDITG
210 220 230 240 250
FLLFGLSLVL FSSGIELFGE KIVASWIALT VIVTSIGLLL LYILHARRTP
260 270 280 290 300
NPLISLDLFK TRTFSIGIVG NIATRLGTGC VPFLMPLMLQ VGFGYQAFIA
310 320 330 340 350
GCMMAPTALG SIIAKSMVTQ VLRRLGYRHT LVGITVIIGL MIAQFSLQSP
360 370 380 390 400
AMAIWMLILP LFILGMAMST QFTAMNTITL ADLTDDNASS GNSVLAVTQQ
410 420 430 440 450
LSISLGVAVS AAVLRVYEGM EGTTTVEQFH YTFITMGIIT VASAAMFMLL
460 470
KTTDGNNLIK RQRKSKPNRV PSESE
Length:475
Mass (Da):51,462
Last modified:July 1, 1993 - v1
Checksum:iBA3F43F5ADAE9E24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA Translation: AAA62107.1
U00096 Genomic DNA Translation: AAC76777.1
AP009048 Genomic DNA Translation: BAE77534.1
PIRiC65179
RefSeqiNP_418210.1, NC_000913.3
WP_001280852.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76777; AAC76777; b3754
BAE77534; BAE77534; BAE77534
GeneIDi948265
KEGGiecj:JW3733
eco:b3754
PATRICifig|1411691.4.peg.2946

Entry informationi

Entry nameiHSRA_ECOLI
AccessioniPrimary (citable) accession number: P31474
Secondary accession number(s): Q2M872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health